LOCUS       NM_133561                919 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus mitochondrial pyruvate carrier 1 (Mpc1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_133561
VERSION     NM_133561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Xu,L., Yang,M., Wei,A., Wei,Z., Qin,Y., Wang,K., Li,B., Chen,K.,
            Liu,C., Li,C. and Wang,T.
  TITLE     Aerobic exercise-induced HIF-1alpha upregulation in heart failure:
            exploring potential impacts on MCT1 and MPC1 regulation
  JOURNAL   Mol Med 30 (1), 83 (2024)
   PUBMED   38867145
  REMARK    GeneRIF: Aerobic exercise-induced HIF-1alpha upregulation in heart
            failure: exploring potential impacts on MCT1 and MPC1 regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Liu,Y., Yuan,Y., Yan,Y., Wang,R., Wang,Z., Liu,X., Zhang,Y.,
            Hua,J., Wang,Y. and Zhao,L.
  TITLE     Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain
            injury in rats
  JOURNAL   Life Sci 325, 121686 (2023)
   PUBMED   37030616
  REMARK    GeneRIF: Mitochondrial pyruvate carrier 1 alleviates
            hypoxic-ischemic brain injury in rats.
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Mansour,H.M., Fawzy,H.M., El-Khatib,A.S. and Khattab,M.M.
  TITLE     Inhibition of mitochondrial pyruvate carrier 1 by lapatinib
            ditosylate mitigates Alzheimer's-like disease in
            D-galactose/ovariectomized rats
  JOURNAL   Neurochem Int 150, 105178 (2021)
   PUBMED   34481907
  REMARK    GeneRIF: Inhibition of mitochondrial pyruvate carrier 1 by
            lapatinib ditosylate mitigates Alzheimer's-like disease in
            D-galactose/ovariectomized rats.
REFERENCE   4  (bases 1 to 919)
  AUTHORS   Bricker,D.K., Taylor,E.B., Schell,J.C., Orsak,T., Boutron,A.,
            Chen,Y.C., Cox,J.E., Cardon,C.M., Van Vranken,J.G., Dephoure,N.,
            Redin,C., Boudina,S., Gygi,S.P., Brivet,M., Thummel,C.S. and
            Rutter,J.
  TITLE     A mitochondrial pyruvate carrier required for pyruvate uptake in
            yeast, Drosophila, and humans
  JOURNAL   Science 337 (6090), 96-100 (2012)
   PUBMED   22628558
REFERENCE   5  (bases 1 to 919)
  AUTHORS   Herzig,S., Raemy,E., Montessuit,S., Veuthey,J.L., Zamboni,N.,
            Westermann,B., Kunji,E.R. and Martinou,J.C.
  TITLE     Identification and functional expression of the mitochondrial
            pyruvate carrier
  JOURNAL   Science 337 (6090), 93-96 (2012)
   PUBMED   22628554
REFERENCE   6  (bases 1 to 919)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 919)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_133561.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304429.1, CB608719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000001.1  54996795-54996958   c
            165-168             JAXUCZ010000001.1  54989413-54989416   c
            169-265             JAXUCZ010000001.1  54986320-54986416   c
            266-398             JAXUCZ010000001.1  54986000-54986132   c
            399-919             JAXUCZ010000001.1  54985307-54985827   c
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..919
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /note="mitochondrial pyruvate carrier 1"
                     /db_xref="GeneID:171087"
                     /db_xref="RGD:620902"
     exon            1..164
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..423
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /note="brain protein 44-like protein; apoptosis-regulating
                     basic protein; solute carrier family 54 member 1"
                     /codon_start=1
                     /product="mitochondrial pyruvate carrier 1"
                     /protein_id="NP_598245.1"
                     /db_xref="GeneID:171087"
                     /db_xref="RGD:620902"
                     /translation="MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDM
                     KKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHVTNEVAQLIQGGRLINYE
                     MSKRPSA"
     exon            165..168
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..265
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..398
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..919
                     /gene="Mpc1"
                     /gene_synonym="Brp44l; SLC54A1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggggg tgagagcgca gagggcctca gctggccggg tcgaccctgg tgtcatccgt
       61 ttaggaagcg gcttcaccgc caacagcacg gccatggctg gagctctggt gcgcaaagca
      121 gcggactatg tccggagcaa ggacttccgg gactatctca tgagtacgca cttctggggc
      181 ccagttgcca actggggtct ccccattgct gctatcaatg acatgaagaa atctccagag
      241 attatcagtg ggcggatgac tttcgccctc tgttgctatt ctctgacatt catgagattt
      301 gcctacaagg tacaaccccg aaactggctt ctgtttgcgt gccatgtgac aaacgaagtc
      361 gctcagctca ttcagggagg acgacttatc aactacgaga tgagtaagcg gccatctgca
      421 tagcagtgca aggaccagct cttgaaaggg acagtgctcc agccactgtt gcggccacag
      481 atcacgtcag catgaatagt cgtgctgagg ggaaaacacg gaagactatc tttaatgacc
      541 atgccaacat tattgaatag ccaagaatcc ccaaaccaac tctcggctgc cttatcaatg
      601 ctaaacttta tttgtcttca tcaggagtag ttcaaaatat gcagctaatt taataatttt
      661 gaatgatgtt atctatagca atctgtagta atatgtatat tatctattgg gatttgtgta
      721 ataaaaaatc taagggaaca aaactttata actacaagca cttaagtcct caaaattctt
      781 gactttttct ttaatgacta tagtataacc ctcagttggt cacatgtcta cacataattt
      841 ccagtgataa caagtagcgg tgttttccat atgtaattca gatctgaact taatggcaat
      901 aaatggttta aatatttgc
//
