LOCUS       NM_001107711            3533 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Mov10 RNA helicase (Mov10), transcript variant 1,
            mRNA.
ACCESSION   NM_001107711 XM_001068860 XM_227549
VERSION     NM_001107711.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3533)
  AUTHORS   Kute,P.M., Ramakrishna,S., Neelagandan,N., Chattarji,S. and
            Muddashetty,R.S.
  TITLE     NMDAR mediated translation at the synapse is regulated by MOV10 and
            FMRP
  JOURNAL   Mol Brain 12 (1), 65 (2019)
   PUBMED   31291981
  REMARK    GeneRIF: FMRP and MOV10 have an important regulatory role in NMDAR
            mediated translation at the synapse.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3533)
  AUTHORS   Warkocki,Z., Krawczyk,P.S., Adamska,D., Bijata,K.,
            Garcia-Perez,J.L. and Dziembowski,A.
  TITLE     Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s
  JOURNAL   Cell 174 (6), 1537-1548 (2018)
   PUBMED   30122351
REFERENCE   3  (bases 1 to 3533)
  AUTHORS   Skariah,G., Seimetz,J., Norsworthy,M., Lannom,M.C., Kenny,P.J.,
            Elrakhawy,M., Forsthoefel,C., Drnevich,J., Kalsotra,A. and Ceman,S.
  TITLE     Mov10 suppresses retroelements and regulates neuronal development
            and function in the developing brain
  JOURNAL   BMC Biol 15 (1), 54 (2017)
   PUBMED   28662698
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3533)
  AUTHORS   Balinsky,C.A., Schmeisser,H., Wells,A.I., Ganesan,S., Jin,T.,
            Singh,K. and Zoon,K.C.
  TITLE     IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral
            Activity against Dengue Virus, Interacts with MOV10
  JOURNAL   J Virol 91 (5), e01606-16 (2017)
   PUBMED   27974568
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3533)
  AUTHORS   Gregersen,L.H., Schueler,M., Munschauer,M., Mastrobuoni,G.,
            Chen,W., Kempa,S., Dieterich,C. and Landthaler,M.
  TITLE     MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target
            degradation by translocation along 3' UTRs
  JOURNAL   Mol Cell 54 (4), 573-585 (2014)
   PUBMED   24726324
REFERENCE   6  (bases 1 to 3533)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   7  (bases 1 to 3533)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 3533)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 3533)
  AUTHORS   Chendrimada,T.P., Finn,K.J., Ji,X., Baillat,D., Gregory,R.I.,
            Liebhaber,S.A., Pasquinelli,A.E. and Shiekhattar,R.
  TITLE     MicroRNA silencing through RISC recruitment of eIF6
  JOURNAL   Nature 447 (7146), 823-828 (2007)
   PUBMED   17507929
REFERENCE   10 (bases 1 to 3533)
  AUTHORS   Meister,G., Landthaler,M., Peters,L., Chen,P.Y., Urlaub,H.,
            Luhrmann,R. and Tuschl,T.
  TITLE     Identification of novel argonaute-associated proteins
  JOURNAL   Curr Biol 15 (23), 2149-2155 (2005)
   PUBMED   16289642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 16, 2021 this sequence version replaced NM_001107711.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1105398.1,
                                           SRR26360190.2991642.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               JAXUCZ010000002.1  195002847-195003177 c
            332-535             JAXUCZ010000002.1  194991657-194991860 c
            536-771             JAXUCZ010000002.1  194991167-194991402 c
            772-1033            JAXUCZ010000002.1  194990791-194991052 c
            1034-1168           JAXUCZ010000002.1  194989639-194989773 c
            1169-1337           JAXUCZ010000002.1  194989237-194989405 c
            1338-1492           JAXUCZ010000002.1  194988276-194988430 c
            1493-1669           JAXUCZ010000002.1  194987848-194988024 c
            1670-1817           JAXUCZ010000002.1  194987579-194987726 c
            1818-1976           JAXUCZ010000002.1  194987134-194987292 c
            1977-2080           JAXUCZ010000002.1  194986845-194986948 c
            2081-2178           JAXUCZ010000002.1  194986583-194986680 c
            2179-2395           JAXUCZ010000002.1  194986278-194986494 c
            2396-2513           JAXUCZ010000002.1  194984509-194984626 c
            2514-2705           JAXUCZ010000002.1  194984165-194984356 c
            2706-2780           JAXUCZ010000002.1  194983960-194984034 c
            2781-2906           JAXUCZ010000002.1  194983037-194983162 c
            2907-2995           JAXUCZ010000002.1  194982871-194982959 c
            2996-3117           JAXUCZ010000002.1  194982509-194982630 c
            3118-3533           JAXUCZ010000002.1  194982014-194982429 c
FEATURES             Location/Qualifiers
     source          1..3533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3533
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /note="Mov10 RNA helicase"
                     /db_xref="GeneID:310756"
                     /db_xref="RGD:1598327"
     exon            1..331
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..3209
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /EC_number="3.6.4.13"
                     /note="capping protein (actin filament) muscle Z-line,
                     alpha 1; Mov10, Moloney leukemia virus 10; putative
                     helicase MOV-10; Mov10 RISC complex RNA helicase"
                     /codon_start=1
                     /product="helicase MOV-10"
                     /protein_id="NP_001101181.1"
                     /db_xref="GeneID:310756"
                     /db_xref="RGD:1598327"
                     /translation="MPSKFSCRKLRETGQGFESFLAERGLDLETDRERLRAIYNRDFK
                     PSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSSISKQ
                     HRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGT
                     KPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHVYCKTSIVGYFPATVLWEL
                     LGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNPVSTNRIEEGE
                     RPDRAKGYELELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKS
                     RNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSV
                     LRGDHLFALLSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVNFTF
                     NRQPLRVQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAM
                     KHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQ
                     RLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTL
                     ITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDP
                     RQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTIL
                     DIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNP
                     EEAATVTSYLRQLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLD
                     DIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAK
                     ALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPS
                     TSGPRRHQRLPQEREGEEGLPLQVEPEWRNEL"
     exon            332..535
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..771
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1033
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1168
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1337
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1492
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1669
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1817
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1976
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2080
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2178
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2395
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2513
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2705
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2780
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2906
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..2995
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3117
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3533
                     /gene="Mov10"
                     /gene_synonym="Capza1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagagaccg aaaggaaggc tcaggtagaa ggacggagga ggggaggcag gcggggagaa
       61 ggtgctggcc gaagcagacg tcagaggtag ggggcttttc ccctttgcac cctcaccagc
      121 caactctaaa ccgcggcggc gactttcagt ttcatttccc ggaccctcct gcctgggccg
      181 cagccgccgc cgcgatgccc agcaagttca gctgccgaaa gctccgggag accggccagg
      241 ggttcgagag tttcctggcc gaacggggac tggacctgga gacagatcgc gagcggctgc
      301 gggcgattta caaccgcgac ttcaagccca gctatgggac ccccgcccct ggcttctcct
      361 ccatgctgta cggaatgaag atcgctaatc tggccttcgt caccaagact cgggtcaggt
      421 tcttcaaact ggaccgctgg gctgatgtgc aactaccaga aaagcggcgg ataaagccag
      481 ggtcgagcat cagcaaacag cacagatccc tgctggccag aatcttccat gacagggctg
      541 agtatcttca tggaaagcat ggggtggatg tggaggtcca ggggccccat gaagcccggg
      601 atgggcagct ccttatccgc ctggatttga accgcaagga ggtcctaacc ctacggctgc
      661 ggaacggagg gaccaagcct gtcaccctca ctcatctgtt cccactgtgc tggacacccc
      721 agtttgtctt ctaccatggg gaacaggacc tgccctgccc actgggccca ggtgaaagct
      781 atgaacttca tgtctactgt aagacaagca ttgtgggtta cttcccagcc actgtcctct
      841 gggaacttct gggaccaggg gagtcgggag cagaaggagc agaaaccttc tacattgccc
      901 gcttcctggc tgctgtcgcc cacagccccc tggctgcaca gttgaaaccc acaactccct
      961 tcaaacgccc ccctcggctc actagaaacc ctgtctcaac caaccggata gaggaaggag
     1021 agaggccgga ccgagccaag ggttatgaac tagagctaag tttggccctg gggacctatt
     1081 acccacccat ccgcctccga caactgctcc ctacccttct tcagggacca agtatcttca
     1141 cgtccccaaa ggaagttgct gagatcaagg cccagttgga gacaaccctg aaatccagga
     1201 actatgaggt gaagctccga ctgctgctgc acctggagga gctgcaaatg gagcatgaca
     1261 tccggcacta tgacctggag tcggtaccca tgacctggga ccctgtggac cagaatccca
     1321 ggctgctcac actggaggtt cctggtgtga cagagagccg tccctcagtg ctacggggtg
     1381 accacctttt tgccctgttg tcctctgaga tccaacagga ggaccctgtc acctacaagg
     1441 gtttcgtgca caaggtggag ctggaccgtg tcaagctgag cttttctcca agcctcctga
     1501 gccgattcgt ggatgggctg accttcaagg tgaactttac cttcaaccgc cagccccttc
     1561 gggtccagca ccgtgcccta gagttgacgg ggcgctgggt gctatggccc acgctttttc
     1621 ctgtggcctc ccgtggggtc tcgctgctgc cctcagatgt gaagttcaag ctgtatgatc
     1681 ggagtctgga gtcaaaccca gagcagctgc aggccatgaa gcacattgtg aggggcacca
     1741 cccggcccgc cccctacatc atctttgggc ctccaggtac cggcaagact gtcacattag
     1801 tggaggccat caagcaggta gtgaagcact tgcccaaagc ccacatcctg gcctgcactc
     1861 catccaactc aggggctgac ctcctgtgtc agcggctccg ggtccacctg cccagctcca
     1921 tctatcgcct cctggccccc agcagggaca tccgaatggt accggaggac attaagacct
     1981 gctgtaactg ggatcctaag aagggagagt atgtgtatcc tgccaagaag catctgcagc
     2041 agtatcgggt cttgattacc accctcatca ctgccagcag gttggtgtca gcccagtttc
     2101 ccatcgatca cttcacacac atcttcatcg atgaggctgg ccactgcatg gagcctgaga
     2161 gtctggtggc catagcagga ctgatggatg tcaaggaaac aggcaatcct ggagggcagc
     2221 tggtgctggc aggagaccct cggcagctgg ggcctgtgct tcggtcaccg ctagcccaga
     2281 agcatggact cggctactct ctgctagagc gcctgctcac ctacaactcc ttgtataaga
     2341 agggtcccaa tggctatgac ccccagttca tcaccaaact gctccgtaac tacaggtctc
     2401 atcccaccat cctggacatc cctaaccagc tgtactatga tggagagcta caggcctgcg
     2461 cagatgtggt ggatcgagaa cggttctgcc gttgggaggg gctacctcaa cagggcttcc
     2521 ccatcatctt ccatggtgta atgggcaaag atgagagaga gggcaatagc ccatccttct
     2581 tcaaccctga agaggctgct acagtgacgt catacctcag acagctcctc gccccttcct
     2641 ccaagaaggg taaagcccgc ctgagccccc gaagtgtggg cgtcatctcc ccgtaccgga
     2701 agcaggtaga aaaaatccgt tactgcatca caaaacttga ccgagaactt cgaggactgg
     2761 atgacatcaa agacttgaag gtgggctctg tggaagaatt ccaagggcaa gaacgcagtg
     2821 tcatcctcat ctctaccgtc cgaagcagcc agagttttgt acagctggat ctagatttta
     2881 acctcggttt cctcaagaac cccaagaggt tcaatgttgc tgtgacccgg gccaaggctc
     2941 tgctcattgt agtgggcaac cccctcctcc taggccacga cccggactgg aaaacattcc
     3001 tggagttctg taaagaaaat gggggttaca ccggatgccc ctttcctgcc aaactggacc
     3061 tgcagcaggg acaggacttg ctccaaggtc tgagcaaact cagcccctct acctcagggc
     3121 cccgccgtca ccagcgtctc ccccaggagc gggagggtga agagggcctg cccttacaag
     3181 tagagccaga gtggagaaat gagctctgag gacacagccg ccggcccacc cgcttgcctt
     3241 ctcacaccag ccaagcctta ttgctgccta cccctgaccc agaacccagc tcacctgtcc
     3301 ccgcaagaga cgggaaggcc gggaagttta cagcccagac tctgctaggg aaaataacca
     3361 accccttcct ctgctaggga aaataaccca agctgctaaa acttggagga agggggttgg
     3421 aagaaagctt ttttaaccct gtcctttgcg gtactgggga ttgaacccag agcctcaaat
     3481 acgctaggca agcactctac tgctttaaga aaaacatgct gttctatgca aaa
//
