LOCUS       NM_001401762            5041 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus modulator of smoothened (Mosmo), mRNA.
ACCESSION   NM_001401762 XM_006230181
VERSION     NM_001401762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5041)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    Erratum:[Dev Cell. 2018 Jan 22;44(2):271. PMID: 29401421]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 24, 2022 this sequence version replaced XM_006230181.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.730339.1,
                                           SRR26360194.1003410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000001.1  184648985-184649112
            129-341             JAXUCZ010000001.1  184710227-184710439
            342-5041            JAXUCZ010000001.1  184715121-184719820
FEATURES             Location/Qualifiers
     source          1..5041
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..5041
                     /gene="Mosmo"
                     /note="modulator of smoothened"
                     /db_xref="GeneID:102547219"
                     /db_xref="RGD:7606925"
     exon            1..128
                     /gene="Mosmo"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..526
                     /gene="Mosmo"
                     /note="uncharacterized protein C16orf52 homolog"
                     /codon_start=1
                     /product="modulator of smoothened protein precursor"
                     /protein_id="NP_001388691.1"
                     /db_xref="GeneID:102547219"
                     /db_xref="RGD:7606925"
                     /translation="MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVR
                     QCQTIHGRDRTCIPPRLPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWI
                     AFTGMILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFA
                     GKVCLPG"
     exon            129..341
                     /gene="Mosmo"
                     /inference="alignment:Splign:2.1.0"
     exon            342..5041
                     /gene="Mosmo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggggag cggggcgggg cgatggataa actgaccatc atctcaggat gtctctttct
       61 ggccgccgat atcttcgcca tcgccagcat cgccaacccg gactggatca acaccgggga
      121 gtcggcggga gcacttactg tgggccttgt gcggcagtgt cagacaatcc atggacgaga
      181 ccggacctgc atcccccctc ggcttccccc agagtgggtc accaccctgt tctttatcat
      241 catggggatc atttccttga ctgtcacatg tggcttgctg gtggcttccc actggcgaag
      301 agaagctaca aaatatgctc gatggatagc attcactgga atgatccttt tctgtatggc
      361 tgccctaata tttccaatag gattttacat caatgaagtc ggaggtcaac cttataagtt
      421 acccaacaac acagtagttg ggtcatcata tgtacttttt gtcttatcga ttttcttcac
      481 aatagtagga cttctgtttg ctggcaaagt ctgtttacca ggctgacgaa tgtctaaaca
      541 gcttaacttt ttattttttt attttatttt ttatttttag aggttgggag gacaaagaga
      601 aggcatctgg gcagtcctct cataggaaga tgcttagatg aacctgatgc cgaaaaggaa
      661 aaattgcttt gatttgttct cactatgcac tttggatttt aacaaaagaa cgagagcctt
      721 ttccataacc aaatacaata gtgactaaat ctcctgaacg tattcaggca ggcagtctgc
      781 actgtgatag tgacctagtg acggagagtg ctttactgaa gcatgtggcc cctggtgact
      841 gttgatctgt ttttaatgtc taatgattca tttgagaggg gggaaagtgt agtatttatg
      901 aatcatgatg gaccagaagg gtgcgggagg ttcgtgtggg gctggcctca cctcctaaga
      961 cattagtgtt ctcaatttcc ttgtcatgtt aggagccttt ggcaccacag tggattgccg
     1021 tggcattact gcaccaagaa gccaatagat caaaacttgt ttgctaaact gtatgtaaaa
     1081 attctaaaac tccctaatct ctgtgtacaa aagaaaaaag aaaacactaa gaaacaagtt
     1141 tggggtgggt gggggaaatc ttccttatat ttatataaat atatatataa tatatatatt
     1201 ttgctgatgc agtatacagt gtgtatatgt gtgtgtgtgt atgtgtgtgt acatttgtat
     1261 atgcacacat gcaaacagtt cctggacgag aactctgaat gcttgctagc aaaacactgt
     1321 ggtgtgcaac ctagaactca atagaaaaaa gccatttatc tgaaggctgc atagtggaga
     1381 gagtcttcag tttacctcat tctttgtagc agcccttgat tttgacaggt ttctgtaata
     1441 ggtacaaata actccatacc tttctaggtg caattttaag ttaagctaaa gattctttct
     1501 aggtttaatt tatttgtata tgatagtaaa ggtaaggtca tgtcaaacct tatagtttgg
     1561 ggaatctgac actgttgaaa tgagtatcaa ctatcatgta ttgtacagac attcattctt
     1621 accactggtt cagtctgcta cattaacagt gcattgtata tgttcaagca tacagcttca
     1681 cattaaggtc actggcaaac atctggctgt tttggctatt gacaacacta attctgctct
     1741 cccataaaaa ttgcatttta tctgtattat tagtagatct tcaccaaatt cttgagcaat
     1801 acaatatttc ctctatatgc attatacctg tgtttgctaa aaagctaaca ttcttgcatt
     1861 tgtttgaagg ctgcattaaa cccacagcct taagggtttt ttctagaaac agcaatgcag
     1921 ccaattctga actcacaagt acttttaaaa cagagccctt tcctccccac attcccatgc
     1981 ctgcgtcaac accgagattc ttcctggtga acacttgttt gaatctggtc acaaggatgt
     2041 ttgatggcag tggagcctga atttgtcctc tctatagtga atggcaatcc aagtgtccct
     2101 gttggtggac agagtacaag tcccacatag cccgagcttc atacacacga atgattccta
     2161 agcagctcga ttatccctca cgggatggtt attgagagcc aacctagagt ggaagacttg
     2221 agtcagtcct caccagtgtg tttgctattc acctgtctca gtattaaatt gtgaatgaaa
     2281 agccagtgtt tgggctcata ccggaacctt ggaggagtgg acccttctag aagtgtgaga
     2341 accctgcagt caatcggagg aaggacactt tccaccacct gttccatcca ggcagttcta
     2401 aggccaccac tatacatgtc ctatggacat tcaggattgg gctttgatta gtcgtcagtc
     2461 agatgggtca ctctgaagga aaggtttggt agttggcact ataccactga taaaaagtat
     2521 tagcaaagta tacttcaaat taactgacat gaccaagagc ttttctcttt aaaaagatgg
     2581 attttattgt atatagtttc tcaaaatatt tttaactgga tcatgagcat ggggagagaa
     2641 agattctcag ctgctatgaa tttccccact gtttacttct ctcatttaca gtggtattgt
     2701 gtaagattac aaaattttag gttttatttg tatctattac ccaaaccatt aaattgtctt
     2761 taatttcatc attgtcttag aagcccagtg catgaagagc tgatgggggg aagcccctct
     2821 agccactcag cgctctgacc caggattaaa accacccatc aaatagtgtg tgaagtccag
     2881 tctttgtaaa ctctctcaga ccaaacgtta ttgaagtgaa ctcatccata taatctaagt
     2941 cctgtaagtg gaaggacaaa cagctgccag cagctgcttt taaagggtca ctatgatcac
     3001 tacatagcac agtattaatt tatagcagga atcatatctt gtaaaatgta tatataaaac
     3061 acttttatgg tgcaatcatt tgtcagattt tgtctgttac attgttctta gagtgtacat
     3121 tctctcatgc ctaagaatat cactgtaaaa tctgctgaaa actattttta ggttttattt
     3181 gcacaagact gaactagttt gagtttttgg gaagctccta tcgaacaagc ctacacatct
     3241 gtaaagataa aaaccttcag ttcattaaaa gcaaccatta gtacaattct ttcaaggtaa
     3301 tccacgttct gtgttgttag tgtgtgggtg ggatgtttct gactttccca tctctcacaa
     3361 ttctttccaa ggtaatccat gttctgtgtt gttggtgtgt gggtggaatg tttctgactc
     3421 tcccatctct cacaaaccta ttttctgttc catctgtttt gtttttgaag gatgccttct
     3481 ttttcttttg taatgttcta gatgaccaaa acacattctt gggttttgcc tacagctttg
     3541 atttctccgt gtgttgttgt atgagttcac tgtttaatct cttcagtgaa atagatagtc
     3601 ctggtgacag gcaatctgtt ggtttagagg aaaggtcctg aaaaagtgtt ggaaattaac
     3661 tttggatctg ttcttagctg ttattttgca tcatgggctt catgagaaga acatgttgca
     3721 tttattttgt ctttattaaa agactactag tcaccagtta ctctggtcat agtaactgtt
     3781 ttatcaaccc actttgatct tttttttaag gattaaattt tcattcacaa gtcaaaacag
     3841 taagctgtct tttagaaaag ttttgaagga taaaaatata tgaaggagaa aggcggtctg
     3901 tgtaggtgga atcgtctaca cagaatttta gttgtgtggc cttgagagac tttaggttgt
     3961 ggtcaaggac tgtatattat ccaaaacttt attaagaatt gttttctaat tggttataac
     4021 attttttcaa ttaatagttt caaaacaaat tgttaataca actgtataaa gtgaacataa
     4081 ttttcttcac ttgtattttt gttattgagc aagtttatca aaataaattg tctactaaag
     4141 aaactaaaaa ggcttctatt acttttaata aattttgatt ttaaatgctt atttctaggg
     4201 tgtagctctc ttgttaaaga agtaacctgg tagagtgtgc accgagccct gtgttcagtc
     4261 cccagcactg agtaaaccag gtatagtggg actcgcctgt aattctagca ttcaggaggt
     4321 agaagcaaag gcttaaggta accttcaact tcatagggag ttcaaggcta gcctgtcgca
     4381 aaacaaaaca gtattgtagc actgtcactt acagagacct tgcctcttgg tggactttgt
     4441 gttagcattc tgtgtgaggg agctcccccc ttccatgtct actctttgct cacctttagt
     4501 caagaactgt tacagctgga atgacactgt gccccatagt ctcagatgtt tggattcttg
     4561 atcccagttg gtggctgttt ggggaggttt aaaaagaggt gcctcgttga ggagaaagca
     4621 tgtcactggg ggtgggcttt gagatgtcaa agcctcgtgc tgtttccagt cctctgctcc
     4681 agccttgcag ttcaagatgt gagacctcag cttttgctcc agccaccatg cctgctgctg
     4741 ccaccactgc tgctgccact gccgctgccg ccatacttcc ccgccacagt tgacttagtc
     4801 ctctggaacc gtaagccaaa taaacctttt cttctataag ttgctttagt cgttgtgttt
     4861 tatcacagca acagaaaagt aacagtatag ttgttattaa gatttcaatg taatgattag
     4921 aacagttttc cagtaaagta aatactgtgc ccttttctct ggcacttttc atattgctta
     4981 aacatttcgt attaattgtt taagacagat tgtttgtcca ttaaagcagc tctttcttat
     5041 a
//
