LOCUS       NM_020102               1308 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus MOS proto-oncogene, serine/threonine kinase
            (Mos), mRNA.
ACCESSION   NM_020102 XM_346731
VERSION     NM_020102.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Zhang,Y.L., Zheng,W., Ren,P., Hu,H., Tong,X., Zhang,S.P., Li,X.,
            Wang,H., Jiang,J.C., Jin,J., Yang,W., Cao,L., He,Y., Ma,Y.,
            Zhang,Y., Gu,Y., Hu,L., Luo,K., Gong,F., Lu,G.X., Lin,G., Fan,H.Y.
            and Zhang,S.
  TITLE     Biallelic mutations in MOS cause female infertility characterized
            by human early embryonic arrest and fragmentation
  JOURNAL   EMBO Mol Med 13 (12), e14887 (2021)
   PUBMED   34779126
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Suzuki,T., Suzuki,E., Yoshida,N., Kubo,A., Li,H., Okuda,E.,
            Amanai,M. and Perry,A.C.
  TITLE     Mouse Emi2 as a distinctive regulatory hub in second meiotic
            metaphase
  JOURNAL   Development 137 (19), 3281-3291 (2010)
   PUBMED   20724447
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Perrard,M.H., Chassaing,E., Montillet,G., Sabido,O. and Durand,P.
  TITLE     Cytostatic factor proteins are present in male meiotic cells and
            beta-nerve growth factor increases mos levels in rat late
            spermatocytes
  JOURNAL   PLoS One 4 (10), e7237 (2009)
   PUBMED   19802389
  REMARK    GeneRIF: NGF, by enhancing Mos in late spermatocytes, is one of the
            intra-testicular factors which adjusts the number of round
            spermatids that can be supported by Sertoli cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Nishimura,T., Shimaoka,T., Kano,K. and Naito,K.
  TITLE     Insufficient amount of Cdc2 and continuous activation of Wee1 B are
            the cause of meiotic failure in porcine growing oocytes
  JOURNAL   J Reprod Dev 55 (5), 553-557 (2009)
   PUBMED   19550110
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Ito,J., Kaneko,R. and Hirabayashi,M.
  TITLE     The regulation of calcium/calmodulin-dependent protein kinase II
            during oocyte activation in the rat
  JOURNAL   J Reprod Dev 52 (3), 439-447 (2006)
   PUBMED   16603805
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Leibovitch,M.P., Solhonne,B., Guillier,M., Verrelle,P.,
            Leibovitch,S.A. and Verelle P [corrected to Verrelle,P.].
  TITLE     Direct relationship between the expression of tumor suppressor H19
            mRNA and c-mos proto-oncogene during myogenesis
  JOURNAL   Oncogene 10 (2), 251-260 (1995)
   PUBMED   7838525
  REMARK    Erratum:[Oncogene 1995 Aug 3;11(3):605]
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Sonakul,D. and Fucharoen,S.
  TITLE     Brain pathology in 6 fatal cases of post-transfusion hypertension,
            convulsion and cerebral hemorrhage syndrome
  JOURNAL   Southeast Asian J Trop Med Public Health 23 Suppl 2, 116-119 (1992)
   PUBMED   1298984
  REMARK    Review article
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Leibovitch,S.A., Lenormand,J.L., Leibovitch,M.P., Guiller,M.,
            Mallard,L. and Harel,J.
  TITLE     Rat myogenic c-mos cDNA: cloning sequence analysis and regulation
            during muscle development
  JOURNAL   Oncogene 5 (8), 1149-1157 (1990)
   PUBMED   1697408
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   van der Hoorn,F.A. and Firzlaff,J.
  TITLE     Complete c-mos (rat) nucleotide sequence: presence of conserved
            domains in c-mos proteins
  JOURNAL   Nucleic Acids Res 12 (4), 2147-2156 (1984)
   PUBMED   6322135
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 20, 2014 this sequence version replaced NM_020102.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X52952.1, SRR26360190.1163247.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1308              JAXUCZ010000005.1  21657549-21658856   c
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..1308
                     /gene="Mos"
                     /note="MOS proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:24559"
                     /db_xref="RGD:3103"
     exon            1..1308
                     /gene="Mos"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1199
                     /gene="Mos"
                     /EC_number="2.7.11.1"
                     /note="c-mos; oocyte maturation factor mos; proto-oncogene
                     c-Mos; v-mos moloney murine sarcoma viral oncogene
                     homolog; Moloney murine sarcoma viral (v-mos) oncogene
                     homolog; Moloney sarcoma oncogene"
                     /codon_start=1
                     /product="proto-oncogene serine/threonine-protein kinase
                     mos"
                     /protein_id="NP_064487.3"
                     /db_xref="GeneID:24559"
                     /db_xref="RGD:3103"
                     /translation="MPSPLILCRYLPRELSPTVDSRSCSSPLVASRKAGKFLGATPPR
                     APRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRNLRASQ
                     RSFWAELNIARLHHDNIVRVVAASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSP
                     EPLSCREQLSLGKCLKYSLDIVNGLLFLHSQSILHLDLKPANILISEKDVCKISDFGC
                     SQKLQDLRCRQASLHHIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTTREVPYS
                     GEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIVQSCWEARALQRPGAELLQKDL
                     KAFRGALG"
ORIGIN      
        1 accttgctga gcagcaagac gtgagagcac agttgtggct ggttttgaga atacaagaag
       61 aagggaaatg ggatgaaggc ggaaaccttc agccatgctt ccaaacttcc ctgggtgttc
      121 ctggtcattt ctctctagcg tctcttgtga ctgtcccatc tgagggtgta atgccttcgc
      181 ctctcatcct gtgtcgctac ctccctcgcg agctgtcgcc aacggtggac tcgaggtcct
      241 gcagcagccc cttggtggcc tcgaggaagg cggggaagtt cctgggggcc actcctcctc
      301 gggccccgcg gctgtcacgc cggctggcct ggtgcttcat agactgggga caggtatgcc
      361 tgctgcatag gctgggttct ggagggtttg gctcggtgta caaagccact taccacggtg
      421 ttcctgtggc catcaagcaa gtgaacaagt gcaccaggaa cctacgtgca tcccagcgga
      481 gtttctgggc tgaactgaac attgcaaggc tgcaccacga caacatagtc cgggttgtgg
      541 ctgccagcac gcgcacgccg gaaggttcca acagccttgg taccataatc atggagtttg
      601 ggggcaatgt gactctacac caagtcatct acggtgccac ccgctcccca gagcctctca
      661 gctgcagaga gcaactgagt ttgggaaagt gcctcaagta ttccctagat attgttaacg
      721 gcctgctttt tctccactca caaagcattt tgcacttgga cctgaagcca gcgaacattt
      781 tgatcagtga gaaggacgtt tgtaagataa gtgacttcgg ctgctcccag aagcttcagg
      841 atctgcggtg ccggcaggcg tcccttcacc acatcggggg cacgtacacg caccaagctc
      901 cggagctcct gaaaggagag atcgccacgc ccaaagccga catctactct tttggcatca
      961 ccctgtggca gatgaccacc agggaggtgc cttactccgg cgagcctcag tacgtgcagt
     1021 acgcagtggt agcctacaat ctgcgcccgt cactggcagg ggcggtgttc accgcctccc
     1081 tgactgggaa gacgctgcag aacatcgtcc agagctgctg ggaggcccgc gccctgcaga
     1141 ggccgggtgc agaactgctc cagaaggacc tgaaggcttt ccgaggggca ctgggctgac
     1201 tccatcgagc ctgtgtgcag ataagctttt cgtttctgtt tatttttaaa taagtaagga
     1261 tgggctttta gggcatattt ttagaaaata aagttactac aaacttca
//
