LOCUS       NM_001415108            5154 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus MORC family CW-type zinc finger 2 (Morc2), mRNA.
ACCESSION   NM_001415108 XM_006251198
VERSION     NM_001415108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5154)
  AUTHORS   Fukuda,K., Okuda,A., Yusa,K. and Shinkai,Y.
  TITLE     A CRISPR knockout screen identifies SETDB1-target retroelement
            silencing factors in embryonic stem cells
  JOURNAL   Genome Res 28 (6), 846-858 (2018)
   PUBMED   29728365
REFERENCE   2  (bases 1 to 5154)
  AUTHORS   Douse,C.H., Bloor,S., Liu,Y., Shamin,M., Tchasovnikarova,I.A.,
            Timms,R.T., Lehner,P.J. and Modis,Y.
  TITLE     Neuropathic MORC2 mutations perturb GHKL ATPase dimerization
            dynamics and epigenetic silencing by multiple structural mechanisms
  JOURNAL   Nat Commun 9 (1), 651 (2018)
   PUBMED   29440755
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5154)
  AUTHORS   Liu,N., Lee,C.H., Swigut,T., Grow,E., Gu,B., Bassik,M.C. and
            Wysocka,J.
  TITLE     Selective silencing of euchromatic L1s revealed by genome-wide
            screens for L1 regulators
  JOURNAL   Nature 553 (7687), 228-232 (2018)
   PUBMED   29211708
REFERENCE   4  (bases 1 to 5154)
  AUTHORS   Tchasovnikarova,I.A., Timms,R.T., Douse,C.H., Roberts,R.C.,
            Dougan,G., Kingston,R.E., Modis,Y. and Lehner,P.J.
  TITLE     Hyperactivation of HUSH complex function by Charcot-Marie-Tooth
            disease mutation in MORC2
  JOURNAL   Nat Genet 49 (7), 1035-1044 (2017)
   PUBMED   28581500
REFERENCE   5  (bases 1 to 5154)
  AUTHORS   Li,D.Q., Nair,S.S., Ohshiro,K., Kumar,A., Nair,V.S., Pakala,S.B.,
            Reddy,S.D., Gajula,R.P., Eswaran,J., Aravind,L. and Kumar,R.
  TITLE     MORC2 signaling integrates phosphorylation-dependent,
            ATPase-coupled chromatin remodeling during the DNA damage response
  JOURNAL   Cell Rep 2 (6), 1657-1669 (2012)
   PUBMED   23260667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 21, 2022 this sequence version replaced XM_006251198.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1175003.1,
                                           SRR26643293.57648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               JAXUCZ010000014.1  82753210-82753970
            762-815             JAXUCZ010000014.1  82761815-82761868
            816-850             JAXUCZ010000014.1  82764792-82764826
            851-919             JAXUCZ010000014.1  82772571-82772639
            920-1010            JAXUCZ010000014.1  82773140-82773230
            1011-1119           JAXUCZ010000014.1  82776181-82776289
            1120-1279           JAXUCZ010000014.1  82779885-82780044
            1280-1391           JAXUCZ010000014.1  82780161-82780272
            1392-1517           JAXUCZ010000014.1  82780723-82780848
            1518-1597           JAXUCZ010000014.1  82781464-82781543
            1598-1680           JAXUCZ010000014.1  82782342-82782424
            1681-1766           JAXUCZ010000014.1  82782646-82782731
            1767-1907           JAXUCZ010000014.1  82783772-82783912
            1908-2062           JAXUCZ010000014.1  82783997-82784151
            2063-2191           JAXUCZ010000014.1  82784301-82784429
            2192-2297           JAXUCZ010000014.1  82785118-82785223
            2298-2430           JAXUCZ010000014.1  82785720-82785852
            2431-2505           JAXUCZ010000014.1  82787644-82787718
            2506-2883           JAXUCZ010000014.1  82787800-82788177
            2884-3015           JAXUCZ010000014.1  82788704-82788835
            3016-3070           JAXUCZ010000014.1  82789204-82789258
            3071-3212           JAXUCZ010000014.1  82789767-82789908
            3213-3437           JAXUCZ010000014.1  82790020-82790244
            3438-3531           JAXUCZ010000014.1  82790335-82790428
            3532-3720           JAXUCZ010000014.1  82792558-82792746
            3721-5154           JAXUCZ010000014.1  82793547-82794980
FEATURES             Location/Qualifiers
     source          1..5154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5154
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /note="MORC family CW-type zinc finger 2"
                     /db_xref="GeneID:289736"
                     /db_xref="RGD:1310842"
     exon            1..761
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             694..3789
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /EC_number="3.6.1.3"
                     /note="zinc finger, CW-type with coiled-coil domain 1;
                     microrchidia 2A; MORC family CW-type zinc finger protein
                     2"
                     /codon_start=1
                     /product="ATPase MORC2"
                     /protein_id="NP_001402037.1"
                     /db_xref="GeneID:289736"
                     /db_xref="RGD:1310842"
                     /translation="MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDAD
                     ATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGN
                     GLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITD
                     NVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIIS
                     NPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRM
                     YKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQ
                     VQNAAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIK
                     MYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQY
                     WKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTL
                     PFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKSQEEKQKQLTE
                     KIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIKN
                     APSRPPSIQTPRPATQLRKTSVISSPKPPATAARGETSTSRILQPAEAPRKPANLPIK
                     TVPRPTPTVQTPSPSLIPNSKNLREVPAQKAIKTPMVKKPEPPAKQSMASSGRKRSLV
                     VSDEEEAEEEAEKRKERCKRGKLAVKEEKKEANELSDSAGEDDPAELKKAQKDKGLHV
                     EVRVNREWYTGRVTAVEMGKNVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSP
                     EHQSPDTQQEGGEEEEAMVAQQAVALPEPSTSDGLPIEPDTTATSTSHETIDLLVQIL
                     RNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRA
                     KASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG
                     D"
     exon            762..815
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..850
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..919
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1010
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1119
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1279
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1391
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1517
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1597
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1680
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1766
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1907
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2062
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2191
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2297
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2430
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2505
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2883
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3015
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3070
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3212
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3437
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3531
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3720
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..5154
                     /gene="Morc2"
                     /gene_synonym="Morc2a; Zcwcc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattctggag ggtacattgt gaggtgtttc tgtgggccac tgtgagtaat ttcacctgct
       61 acctgtggtg attgtggcat aatagcaagc tgtgttgggg cggggtttgg gaaaagaaat
      121 ctgtcagtca gcaccaagga cctttctgtt gagaagccgt gaagccagaa gtagcatcct
      181 ctccattgca ctgtccagta gagcactttt tttgaggagc ctgatgtctt cggtggtgac
      241 aaagtcttcg gtggtaatga tgtagatgga ccgtcagctt tatgacagaa gtaggtcaat
      301 ttcctgaatt taggagaaca gaaaaggact tgaagaacgt gaagttgaag ctgtaataaa
      361 ccgccaagtt tgaagaccat tcagaaccgt tcacttttga tgtacgtcgg aattgtgtga
      421 aggaagcttg atccccagag cactttaacg actgtagttt agaatatagt actttccaaa
      481 gtaatacatc agagtcatcg aagtacgtaa atcactcgca gtttcaaata tctgactaat
      541 atccaatatt ttggatagat atttgggaaa ttttgtttca tgtgtcacta agaaaggaca
      601 aacttaccct ttactggaca gaatcctggg gaaatctatt tcactatatg tactttcctg
      661 tttacggaca aagactgaag actcatcgca gtcatggcct tcaccaatta cagcagtctc
      721 aaccgagccc aactaacctt tgaatatctc cacacaaatt caaccactca tgaattctta
      781 tttggtgctc ttgctgaact ggttgataat gcaagagatg ctgatgccac cagaatagac
      841 atttatgctg agaggcggga agaccttcga ggaggattta tgctttgctt tttggatgat
      901 ggagcaggaa tggatccgag tgatgctgct agtgtgatcc agtttgggaa gtcagccaaa
      961 agaactcccg agtccaccca aattgggcag tatggcaatg gattaaaatc gggctcaatg
     1021 cggattggga aggattttat cctcttcact aagaaggaag ataccatgac ttgcctcttc
     1081 ctgtctcgaa cctttcatga ggaagaaggc attgatgaag tgattgtccc attgcctacc
     1141 tggaatgctc gaacacggga acctatcaca gacaatgtgg agaagtttgc cattgagaca
     1201 gaacttgtgt acaagtactc ccccttccac actgaggagc aagtgatgaa ccagttcatg
     1261 aagattccgg ggaatagtgg aacactggtg atcatcttta atctcaagct tatggataat
     1321 ggagagccag aactagacat aatctcaaat ccaaaagata tccagatggc agaaacctcc
     1381 ccagagggca cgaaaccaga gcgacgctcc ttccgagcct atgctgctgt actttatatt
     1441 gacccccgga tgaggatctt catccatgga cacaaggtgc agaccaagag actctcctgc
     1501 tgcctgtata agcccaggat gtacaagtat acatcaagtc gtttcaagac tcgggcagaa
     1561 caggaagtga agaaagcaga gcatgtagcc cggattgctg aagagaaggc ccgggaggca
     1621 gagagcaaag ctcggacttt agaagtacgc atgggtgggg acctgacacg ggactccagg
     1681 gtgatgttgc ggcaggtgca gaatgcagct atcaccctgc gtagagaagc cgatgtcaag
     1741 aaaaggatca aggatgccaa gcagcgagca ctcaaagaac ccaaggaact gaattttgtt
     1801 tttggggtca atattgaaca ccgggactta gatggcatgt ttatctacaa ctgtagccgc
     1861 ctgatcaaga tgtatgagaa agtgggccca cagctggaag ggggcatggc atgcggtggg
     1921 gttgtcgggg ttgtcgatgt gccctacctg gttctggagc ctacgcataa caagcaggac
     1981 tttgctgatg ccaaggagta ccggcacctg ctgcgagcaa tgggggagca cttggcacag
     2041 tactggaagg acatcgccat cgcccagcgt gggatcatca agttttggga tgaatttggc
     2101 tatctttccg ccaactggaa ccaacccccg tccagtgagc tgcgtttcaa acgccggagg
     2161 gctatggaaa ttccaaccac catccagtgt gatttgtgtt tgaaatggag gactcttccc
     2221 ttccagctga gttcagtaga aaaagattac cctgatactt gggtttgctc catgaaccct
     2281 gatcctgagc aggaccgctg tgaagcttct gaacagaagc aaaaggttcc cttggggaca
     2341 ttaaaaaagg acccaaagtc ccaggaagaa aagcagaagc agctgacaga gaaaattcgc
     2401 cagcagcagg aaaagctaga agctcttcag aaaaccacgc ccatccgctc acaagctgac
     2461 ctgaagaaac tgcccttaga agtgactaca agaccttcta ctgaagaacc tgtacggaga
     2521 cctcagcgtc ctcggtcacc tcctttacct gcagtgatca agaatgctcc tagcagaccc
     2581 ccttctattc agactcccag accagctacc cagctccgaa agacgtctgt tatcagctct
     2641 ccaaaaccac ctgctacagc agcccgagga gaaactagta cttccaggat actccagcca
     2701 gctgaggcac cccgaaagcc tgcaaacctt cccatcaaga ccgtaccccg acccacccct
     2761 actgtccaga ctccctcacc atctctaatc cccaattcca agaacctccg ggaggtccct
     2821 gctcaaaaag ccatcaaaac tccaatggtc aagaagccgg agccgcctgc taaacagtcc
     2881 atggcatcct caggtcggaa gcggagtctc gtagtctcag atgaggaaga ggctgaagaa
     2941 gaagctgaga agaggaaaga gagatgcaag cggggcaaac ttgctgtgaa ggaggagaag
     3001 aaggaggcaa acgagctctc agacagtgct ggggaagatg acccggctga actcaagaag
     3061 gctcagaaag ataaaggact gcatgtagag gtccgtgtga accgggagtg gtatacaggc
     3121 cgtgtcacag ctgtggagat gggcaagaat gtggttcgat ggaaagtgaa gtttgactat
     3181 gtgcccacag acacaacacc aagagaccgc tgggtggaga aaggcagtga agatgtacga
     3241 ctgatgaagc caccttcccc agagcatcag agccctgaca cgcagcaaga aggtggagag
     3301 gaggaggagg ctatggtggc ccagcaggct gtggccttgc cagagccttc cacctctgat
     3361 ggtcttccca ttgagcctga caccactgcc accagtacca gccatgagac tattgacctc
     3421 cttgtccaga ttcttcggaa ttgcctgcgg tacttcttgc ctccaagttt cccgatctcc
     3481 aagaaggagc tgagtgttat gaactcagaa gaactaatat cctttcctct gaaagaatac
     3541 ttcaagcagt atgaggtagg gctccagaat ctgtgccatt cctaccagag ccgtgctgat
     3601 tcacgggcaa aagcctccga ggagagccta cgcacatcgg agaaaaagct tcgtgagaca
     3661 gaggagaagt tacagaagtt gaggaccaac attgtagctc tcctgcaaaa agtgcaggag
     3721 gacatagaca tcaacacaga tgatgagctg gatgcctaca ttgaagacct catcaccaaa
     3781 ggggactgag gagctgggag taagatcaac tccttcgcac acccacccct caacacagca
     3841 gcttctgggg aggggaattt catttgtgag ttggtggact taatcttggt ttgagtcatg
     3901 tgagacattt gtgctttggg aaggagattc tttgaatctt cttccctaag tttacataaa
     3961 tatttatttt ttaaaagaga agatgttaat gcctgctgtg agaccgtact ttttttgtgt
     4021 gactcttgaa agggcacaga gtctgagcca ttcagctcct ggcacctcaa gataggatga
     4081 agaaagcgcc atcctgaagt tggagaggct ccaagggcat caacaatggg atatgaaaga
     4141 tatatggccc cagggactca gctctgcaag accctccagg ggtaatcaaa acaggcccag
     4201 tatcagaaag actttccctg taacagatct cctggtgtcc agtcagggct gtgaaggtct
     4261 gtaggctacc tgagcagctg tcagtcatcc tggatgtggc agtatccaga cagcttggag
     4321 atgtttgtta atgctcaaat ttcccaatac accacctact ttgtactgga agagccattt
     4381 cctgagtcaa ccacattatc caagctcaag catagacagc tctgactggt cagaccctgg
     4441 gctagatggc tctgaatgtt gaactccaaa gattctcagg gtgtgcaagg tgtgagagag
     4501 ctctctggag gagacggctt cctcagtggt gctagttcct ggagagcctt tgctgctgct
     4561 tttctactat gtactctctg ggctccagag agccctgcac ctcccatgct ctggaagtga
     4621 ggaggaggga ccatgtgctt cagacaacta ctcagagcca gaaaggcaag agcttcatct
     4681 gaaggctgct ggaagaattc tggttccagt cccaactctt cacacctctg ttcaagactg
     4741 attttgtact cttgacccaa accaccttgg gatttgtatc catcaaagcg aggctgccac
     4801 cttgtgtccc gtggtctctg cagaagatgg gggagtggtg gtgagggaac tgcacacgtg
     4861 gctggaagtg cctgcttgag ctctgccatc atgtttaggg ggtagcattc agaatagttc
     4921 tctgaaacat tctccaatag atgggttttc tgagttggtg cactcacccc cgcatcgccc
     4981 ccatccaact ttctgttgac cctatccagg cagggtgtgg tccatttttg tccgtaaacc
     5041 cactgtttaa aaggaaattg gccctgcatt tttattggca ggtaatactc actttgattt
     5101 tttttactta cacatgtaat caaaatgtat tactataaat ttctactggt gaga
//
