LOCUS       NM_001395110            1703 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MOK protein kinase (Mok), transcript variant 1,
            mRNA.
ACCESSION   NM_001395110 XM_006240589
VERSION     NM_001395110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Broekhuis,J.R., Verhey,K.J. and Jansen,G.
  TITLE     Regulation of cilium length and intraflagellar transport by the
            RCK-kinases ICK and MOK in renal epithelial cells
  JOURNAL   PLoS One 9 (9), e108470 (2014)
   PUBMED   25243405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Wang,L., Li,S. and Jungalwala,F.B.
  TITLE     Receptor for advanced glycation end products (RAGE) mediates
            neuronal differentiation and neurite outgrowth
  JOURNAL   J Neurosci Res 86 (6), 1254-1266 (2008)
   PUBMED   18058943
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Wautier,M.P., Khodabandehlou,T., Le Devehat,C. and Wautier,J.L.
  TITLE     Modulation of RAGE expression influences the adhesion of red blood
            cells from diabetic patients
  JOURNAL   Clin Hemorheol Microcirc 35 (3), 379-386 (2006)
   PUBMED   16899960
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Oehlrich,N., Devitt,G., Linnebacher,M., Schwitalle,Y.,
            Grosskinski,S., Stevanovic,S. and Zoller,M.
  TITLE     Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic
            T-lymphocyte lines for transfer in patients with renal cell
            carcinoma
  JOURNAL   Int J Cancer 117 (2), 256-264 (2005)
   PUBMED   15900605
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Uesaka,T. and Kageyama,N.
  TITLE     Cdx2 homeodomain protein regulates the expression of MOK, a member
            of the mitogen-activated protein kinase superfamily, in the
            intestinal epithelial cells
  JOURNAL   FEBS Lett 573 (1-3), 147-154 (2004)
   PUBMED   15327990
  REMARK    GeneRIF: identification of MOK, a member of the mitogen-activated
            protein kinase superfamily, as one of the genes induced by a
            caudal-related homeobox transcription factor, Cdx2 [MOK]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006240589.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.64874.1,
                                           SRR26643293.37431.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000006.1  135675690-135675894 c
            206-320             JAXUCZ010000006.1  135667181-135667295 c
            321-410             JAXUCZ010000006.1  135661999-135662088 c
            411-481             JAXUCZ010000006.1  135660406-135660476 c
            482-560             JAXUCZ010000006.1  135651968-135652046 c
            561-609             JAXUCZ010000006.1  135651807-135651855 c
            610-788             JAXUCZ010000006.1  135650620-135650798 c
            789-890             JAXUCZ010000006.1  135648892-135648993 c
            891-1064            JAXUCZ010000006.1  135647754-135647927 c
            1065-1179           JAXUCZ010000006.1  135647073-135647187 c
            1180-1377           JAXUCZ010000006.1  135645426-135645623 c
            1378-1703           JAXUCZ010000006.1  135645018-135645343 c
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1703
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /note="MOK protein kinase"
                     /db_xref="GeneID:362787"
                     /db_xref="RGD:1309274"
     exon            1..205
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1458
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /EC_number="2.7.11.22"
                     /note="renal tumor antigen"
                     /codon_start=1
                     /product="MAPK/MAK/MRK overlapping kinase"
                     /protein_id="NP_001382039.1"
                     /db_xref="GeneID:362787"
                     /db_xref="RGD:1309274"
                     /translation="MKNYKAIGKIGEGTFSEVLKMQSLRDGNYYACKQMKQHFESIEQ
                     VNNLREIQALRRLNPHPNILTLHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSE
                     KKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILVKQDVLKLGDFGSCRSVYSKQPYTE
                     YISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVI
                     GTPCQKTLTKFKQSRAMSFDFPFKKGSGIPLLTTNLTPQCLSLLHAMVAYDPDERIAA
                     HQALQHPYFQVQRAAETQTLAKHRRAFYPKYSMVPESSSHNWSFSKEGRKQQPLRQEE
                     GRARRQGPTSLTELPKLRLSGMTKLSSCSSPALRSVLGTGANGRVPVLRPLKCAVVNK
                     KTDTQKDIKPHLKHCHLPTINRKGGEY"
     exon            206..320
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            321..410
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            411..481
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            482..560
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            561..609
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            610..788
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            789..890
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1064
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1179
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1377
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1703
                     /gene="Mok"
                     /gene_synonym="Rage"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctaagg gtctggcggt tgccagggcg acaggaatac aatatggcgg ctggatccta
       61 acgctcccca gccagggacc actgcgaagg tcctcgagcc ggaagccacc tctggaaagg
      121 agaaggcctt taccacagtc tcctcttttc ttttcggccc ggggcgacca ggggctgacg
      181 gcgtcatccg cgttcaggat gaagaactac aaagcaattg gcaagatagg agaggggaca
      241 ttttctgaag ttctgaagat gcagagcctg agagatggaa actactatgc atgtaaacaa
      301 atgaagcagc actttgaaag tattgagcaa gtgaacaatc tccgagagat acaagcactg
      361 aggcgcctga atccgcaccc gaacattctt acgttgcatg aagtggtttt tgacagaaaa
      421 tctgggtctc ttgcactaat atgtgaactt atggacatga atatttatga gctaatacga
      481 gggagaagac atccgttgtc agagaaaaag atcatgcact acatgtacca gttgtgcaaa
      541 tcgctggacc atatgcacag aaacgggata tttcacagag atgtaaaacc agaaaatata
      601 ctagtaaagc aggatgtcct gaaactaggg gactttgggt cgtgccggag tgtctattcc
      661 aagcagccct acacagagta catctcaacc cggtggtacc gggccccaga gtgtctcctc
      721 actgacgggt tctacacata caagatggac ctgtggagcg ctggctgcgt gttctatgag
      781 attgccagcc tgcagcccct ctttcctggt gtgaatgaac tggaccagat ctcaaaaatc
      841 cacgatgtca tcggcacccc ttgtcagaag accctcacta agttcaaaca gtcgagagct
      901 atgagttttg attttccttt taaaaaggga tcaggaatac ctctactgac aaccaatctg
      961 accccgcaat gcctctccct cctgcatgca atggtggctt atgaccctga tgaacgaatc
     1021 gcggctcacc aagcccttca gcacccctat ttccaggtgc agagggcagc tgagacacag
     1081 accctggcca agcacagaag agctttctac cccaagtact ccatggtgcc agaatcatcc
     1141 agtcacaact ggtcattctc aaaggagggc agaaagcagc agcccctgag gcaagaggag
     1201 ggccgtgcca ggcgacaggg gccgactagt ctgacggagc tccccaaact gaggctgtct
     1261 gggatgacca aactgtcatc ttgctccagt cctgcactgc ggtcggtgtt gggcactggg
     1321 gcaaatggaa gagtccccgt gctgagaccc ctgaagtgcg ctgtcgtgaa caagaagaca
     1381 gacactcaga aggacatcaa acctcacctg aaacactgtc acctgcccac gatcaacagg
     1441 aaagggggag agtactgaac agcccaccac ctggccatcc tcttggacag caagggctgg
     1501 cactgtggac aggcttaggc ctctgtggcc gagggcggat gggccagagg acgctcatgt
     1561 gctgctgttc ctcacaatgc tggtggccca ggacatgctg ccctgcagcc cgtctctatc
     1621 cacaacctgg agccatatgt gtttgcaact ccaatgcagc tgtactgaat gtttcagttt
     1681 aatatatttg taaaaccacc tca
//
