LOCUS       NM_022668               1598 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus myelin oligodendrocyte glycoprotein (Mog), mRNA.
ACCESSION   NM_022668
VERSION     NM_022668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Ntountaniotis,D., Vanioti,Mu., Kordopati,G.G., Kellici,T.F.,
            Marousis,K.D., Mavromoustakos,T., Spyroulias,G.A., Golic
            Grdadolnik,S. and Tselios,T.V.
  TITLE     A combined NMR and molecular dynamics simulation study to determine
            the conformational properties of rat/mouse 35-55 myelin
            oligodendrocyte glycoprotein epitope implicated in the induction of
            experimental autoimmune encephalomyelitis
  JOURNAL   J Biomol Struct Dyn 35 (7), 1559-1567 (2017)
   PUBMED   27483998
  REMARK    GeneRIF: The aim of this work was to explore the conformational
            characteristics of rat/mouse MOG35-55 immunodominant epitope. The
            results are discussed in terms of rational design of altered
            peptide ligands or non-peptide mimetics based on rat MOG35-55 that
            could be served as potential inhibitors of experimental autoimmune
            encephalomyelitis.
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   von Budingen,H.C., Mei,F., Greenfield,A., Jahn,S., Shen,Y.A.,
            Reid,H.H., McKemy,D.D. and Chan,J.R.
  TITLE     The myelin oligodendrocyte glycoprotein directly binds nerve growth
            factor to modulate central axon circuitry
  JOURNAL   J Cell Biol 210 (6), 891-898 (2015)
   PUBMED   26347141
  REMARK    GeneRIF: Identify nerve growth factor as a binding partner for MOG
            and demonstrate that this interaction is capable of sequestering
            NGF from TrkA-expressing neurons to modulate axon growth and
            survival.
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Mony,J.T., Khorooshi,R. and Owens,T.
  TITLE     MOG extracellular domain (p1-125) triggers elevated frequency of
            CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater
            incidence of severe EAE
  JOURNAL   Mult Scler 20 (10), 1312-1321 (2014)
   PUBMED   24552747
  REMARK    GeneRIF: MOG(1-125) immunization resulted in an increased incidence
            of severe experimental autoimmune encephalomyelitis and was
            accompanied by an increased percentage of CXCR3-expressing CD4+ T
            cells producing IFNgamma in the CNS.
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Miki,T., Yokoyama,T., Kusaka,T., Suzuki,S., Ohta,K., Warita,K.,
            Wang,Z.Y., Ueki,M., Sumitani,K., Bellinger,F.P., Tamai,M.,
            Liu,J.Q., Yakura,T. and Takeuchi,Y.
  TITLE     Early postnatal repeated maternal deprivation causes a transient
            increase in OMpg and BDNF in rat cerebellum suggesting precocious
            myelination
  JOURNAL   J Neurol Sci 336 (1-2), 62-67 (2014)
   PUBMED   24157309
  REMARK    GeneRIF: Mog levels are significantly increased in cerebellum
            following maternal deprivation.
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Salvati,S., Sanchez,M., Campeggi,L.M., Suchanek,G., Breitschop,H.
            and Lassmann,H.
  TITLE     Accelerated myelinogenesis by dietary lipids in rat brain
  JOURNAL   J Neurochem 67 (4), 1744-1750 (1996)
   PUBMED   8858961
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Birling,M.C. and Nussbaum,J.L.
  TITLE     Comparative immunohistochemical study of C1G5F2 antigen and
            myelin/oligodendrocyte glycoprotein (MOG) expression in brain of
            several animal species
  JOURNAL   Neurosci Lett 185 (1), 9-12 (1995)
   PUBMED   7731558
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Pham-Dinh,D., Mattei,M.G., Nussbaum,J.L., Roussel,G.,
            Pontarotti,P., Roeckel,N., Mather,I.H., Artzt,K., Lindahl,K.F. and
            Dautigny,A.
  TITLE     Myelin/oligodendrocyte glycoprotein is a member of a subset of the
            immunoglobulin superfamily encoded within the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 7990-7994 (1993)
   PUBMED   8367453
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Gardinier,M.V., Amiguet,P., Linington,C. and Matthieu,J.M.
  TITLE     Myelin/oligodendrocyte glycoprotein is a unique member of the
            immunoglobulin superfamily
  JOURNAL   J Neurosci Res 33 (1), 177-187 (1992)
   PUBMED   1453482
REFERENCE   10 (bases 1 to 1598)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087717.1.
            
            On Oct 13, 2007 this sequence version replaced NM_022668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087717.1, FQ214199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1598
                     /gene="Mog"
                     /note="myelin oligodendrocyte glycoprotein"
                     /db_xref="GeneID:24558"
                     /db_xref="RGD:3102"
     exon            1..170
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..826
                     /gene="Mog"
                     /note="dystonia 2, torsion (autosomal recessive)"
                     /codon_start=1
                     /product="myelin-oligodendrocyte glycoprotein precursor"
                     /protein_id="NP_073159.2"
                     /db_xref="GeneID:24558"
                     /db_xref="RGD:3102"
                     /translation="MAGVWSLSLPSCLLSLLLLLQLSCSYAGQFRVIGPGHPIRALVG
                     DEAELPCRISPGKNATGMEVGWYRSPFSRVVHLYRNGKDQDAEQAPEYRGRTELLKES
                     IGEGKVALRIQNVRFSDEGGYTCFFRDHSYQEEAAVELKVEDPFYWINPGVLALIALV
                     PMLLLQVSVGLVFLFLQHRLRGKLRAEVENLHRTFDPHFLRVPCWKITLFVIVPVLGP
                     LVALIICYNWLHRRLAGQFLEELRNPF"
     exon            171..518
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            519..632
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            633..653
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            654..674
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            675..791
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            792..812
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1575
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcttgg ggtaagggac atgcagccag agggccttag cttggcctga tcctgctgtc
       61 agggaccctg tccccagtaa ccataaagat ggccggtgtg tggagccttt ctctgcccag
      121 ctgcctcctg tccctgctcc tcctcctcca gttgtcatgc agctacgcag gacagttcag
      181 agtgataggg ccagggcatc ccatccgggc tttagttggg gatgaagcag aactgccgtg
      241 ccgtatatct cctgggaaga atgccacggg catggaggtg gggtggtacc gttctccctt
      301 ttcaagagtg gttcatctgt accgaaatgg caaggaccaa gacgcagagc aagcgcctga
      361 ataccgggga cgcacagagc ttctgaaaga gtctatcggc gagggaaagg ttgccctcag
      421 gatccagaac gtgaggttct cggatgaagg aggctacaca tgcttcttca gagaccactc
      481 ctaccaagaa gaagccgccg tggagttgaa agtagaagat cccttctact ggatcaaccc
      541 tggcgtgctg gctctcattg cccttgtgcc tatgctgctc ctgcaggtct ctgtaggcct
      601 tgtattcctc ttcctgcagc acagactgag aggaaaactc cgtgcagaag tcgagaatct
      661 ccatcggact tttgatcctc acttcctgag agtgccctgc tggaagataa cactgtttgt
      721 tattgtccct gttcttggac ccctggttgc tttgatcatc tgctacaact ggctgcaccg
      781 aagactggca ggacagtttc ttgaagagct aagaaacccc ttttgagtga tggtgcatct
      841 tcctggagcg aaggaaagcc tggcaggtcc ttggggatgt ctctcactgg cctctctgtt
      901 atggacacat tccaatctac atctacagaa acactcggga tcctgagtag aacttgattt
      961 tcctcccaca actgtctttc tttcctcagc tccttcctct aaatcttttt tgactcctgt
     1021 cttagtctgc ctctagaaaa caccccatga ctaaggccag ggagtctatc aggagacacc
     1081 tatgtaccag agtaatacag gagtgattct gccaaccagg acacccagcg cttcaacatt
     1141 acgatctaca gaacatcagc tctgcaaatg gtggatattt cttccagagc cacagtcttg
     1201 actgggaaga atatcagtgg ggagagtaag ggggtgaggg acagaagaac ccacaacatg
     1261 agggaaagct aaatgagcca gggtatgaat atgggagcct gaaccaaaac ctggagatta
     1321 aaaaaaaaag tcaaaagaat actgactgga tcagagcaac accatcttgc tttggcagcc
     1381 tggtgggagg accttgagaa gcaagggtcg agaactgggt ctgttctctc atttttctcc
     1441 tatcttattt gagtacccac tgtttggttt tttttttttt tttcttcttc gttttttcaa
     1501 caattactac ttggtggtgt atcagacaca aacaagctag gtgctaatta ataataatac
     1561 aagtttcttt gtgcaaaaaa aaaaaaaaaa aaaaaaaa
//
