LOCUS       NM_001107804            1961 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus molybdenum cofactor synthesis 3 (Mocs3), mRNA.
ACCESSION   NM_001107804 XM_001073889 XM_230874
VERSION     NM_001107804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Schlieker CD, Van der Veen AG, Damon JR, Spooner E and Ploegh HL.
  TITLE     A functional proteomics approach links the ubiquitin-related
            modifier Urm1 to a tRNA modification pathway
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18255-18260 (2008)
   PUBMED   19017811
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Marelja Z, Stocklein W, Nimtz M and Leimkuhler S.
  TITLE     A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur
            donor for MOCS3, a protein involved in molybdenum cofactor
            biosynthesis
  JOURNAL   J Biol Chem 283 (37), 25178-25185 (2008)
   PUBMED   18650437
REFERENCE   3  (bases 1 to 1961)
  AUTHORS   Krepinsky K and Leimkuhler S.
  TITLE     Site-directed mutagenesis of the active site loop of the
            rhodanese-like domain of the human molybdopterin synthase sulfurase
            MOCS3. Major differences in substrate specificity between
            eukaryotic and bacterial homologs
  JOURNAL   FEBS J 274 (11), 2778-2787 (2007)
   PUBMED   17459099
REFERENCE   4  (bases 1 to 1961)
  AUTHORS   Mendel RR and Bittner F.
  TITLE     Cell biology of molybdenum
  JOURNAL   Biochim Biophys Acta 1763 (7), 621-635 (2006)
   PUBMED   16784786
  REMARK    Review article
REFERENCE   5  (bases 1 to 1961)
  AUTHORS   Matthies A, Nimtz M and Leimkuhler S.
  TITLE     Molybdenum cofactor biosynthesis in humans: identification of a
            persulfide group in the rhodanese-like domain of MOCS3 by mass
            spectrometry
  JOURNAL   Biochemistry 44 (21), 7912-7920 (2005)
   PUBMED   15910006
REFERENCE   6  (bases 1 to 1961)
  AUTHORS   Matthies A, Rajagopalan KV, Mendel RR and Leimkuhler S.
  TITLE     Evidence for the physiological role of a rhodanese-like protein for
            the biosynthesis of the molybdenum cofactor in humans
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 5946-5951 (2004)
   PUBMED   15073332
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230874.3, XM_001073889.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1961
                     /gene="Mocs3"
                     /note="molybdenum cofactor synthesis 3"
                     /db_xref="GeneID:311655"
                     /db_xref="RGD:1307044"
     exon            1..1961
                     /gene="Mocs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1391
                     /gene="Mocs3"
                     /EC_number="2.7.7.80"
                     /codon_start=1
                     /product="adenylyltransferase and sulfurtransferase MOCS3"
                     /protein_id="NP_001101274.1"
                     /db_xref="GeneID:311655"
                     /db_xref="RGD:1307044"
                     /translation="MAAPEDVAALQDEIARREEELASLKQRLAAALAVEPEPERPIPV
                     MPLPSRAALSRDEILRYSRQLLLPELGVRGQLRLAAASVLVVGCGGLGCPLAQYLAAA
                     GVGRLGLVDHDVVETSNLARQVLHGEAQAGHAKAWSAAAALRRLNSAVEYVPYARALS
                     EAWALDLVRGYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQMTVYHYDDG
                     PCYRCVFPRPPPAETVTNCADGGVLGVVPGVLGCVQALEVLKIAAGLGTTYSGSMLLF
                     DGLGGHFRRIRLRRRRPDCVVCGQQPTVTCLKNYEAFCGSSATDKCRSLKLLSPEERI
                     SVTDYKRLLDSGVPHVLLDVRPQVEVDICRLQHSLHIPLSLLERRDADSLKLLGAALQ
                     EEKRNSQEGAALAVYVICKLGNDSQKAVRVLQSLTAVPELDSLKVQDISGGLMAWAAK
                     IDGTFPQY"
ORIGIN      
        1 cggaagacgc tgtcatggct gccccggagg acgtagcagc cttacaagat gagattgccc
       61 ggcgtgagga agagctagct tcgctaaagc agaggctggc tgcagcccta gcggttgagc
      121 cggagcccga gcgtccgatc ccggtaatgc cgctgccgtc cagggccgcg ctgtcgcggg
      181 acgagatcct acgctatagc cgccagctgc tgctgccgga gctgggcgtg cgaggtcagc
      241 tgcgcctggc agccgcttct gtgctggtgg tgggctgcgg cgggctgggc tgcccgcttg
      301 ctcagtacct ggcggcggcc ggcgtgggcc gtttgggttt ggtggaccac gacgtggtgg
      361 agacgagcaa tctagcccgt caggtgctgc acggggaggc gcaggcaggg catgccaagg
      421 cttggtcggc ggccgcggcg ctgcgccgcc tcaactcggc ggtggagtat gtgccctatg
      481 cgcgcgcgct cagcgaggct tgggcgctcg acctggtccg tggctacgat gtggtggccg
      541 actgctcgga caatgtgccc acgcgctacc tggtgaacga tgcgtgcgtg ctggccggcc
      601 ggccgctagt gtctgccagt gcgctgcgct tcgagggtca gatgaccgtc tatcactacg
      661 atgatgggcc ctgctaccgc tgcgtgttcc ctcggccgcc cccggccgag acggtgacta
      721 attgtgcgga tggcggcgtg ctcggagtgg tgcccggtgt actaggctgc gtgcaagccc
      781 tcgaggtgct caagatcgct gctggcctcg ggaccaccta cagcggtagc atgctactct
      841 tcgacggcct cgggggccat ttccgcagga tccggctgcg gcgccgtcgg cccgactgcg
      901 tcgtgtgcgg tcagcagccc accgtgacct gcctgaagaa ctatgaggcc ttctgcggct
      961 cctcagccac cgacaagtgc cgctccttga agctcctgag ccccgaggag cggatttctg
     1021 tgactgacta caagcggctt ctggattctg gggtacccca cgtgttgctg gacgttcggc
     1081 ctcaagtaga ggtggacatt tgccgtctgc agcattctct ccacatccct ttgagtctgt
     1141 tggaacgcag ggatgcagac agcctgaaac tcttaggggc tgccctccag gaggagaagc
     1201 gaaattcaca ggaaggagct gctcttgccg tgtatgtgat ttgcaaactg gggaacgact
     1261 cacagaaagc tgtgagggtc ctgcagtcct taacagcagt gccagagtta gactctttaa
     1321 aggttcaaga catttcgggg ggactcatgg cctgggctgc caaaattgat gggacttttc
     1381 cacagtactg aggggagagc tgtgatccca gtagatgatg gctgtggtag cctttcctat
     1441 aatgtagaag agcctggatc cacaatctct gaataagtgg actctttctt tgcaaggagc
     1501 ctttcgagaa aacaagatgg cgtcgtctct gagagctgcc ttgatttagg cactcatgta
     1561 gtaccttcga tatgtgacat ggaatatgac gggatttttg tttcctgtgt ggtccgatca
     1621 aagtgctctc cgggccatcc agtgctctcc gggccatcca tcttctactt ggaattaaga
     1681 tgcagctctt actgtgtctt agtctaaccg aatcacttgc attcagcccg tttttaaatt
     1741 acgatgttct ttgcagagat ggcttagcac tggctgtccc ccgtggggga tcctggtttg
     1801 actcccagga ctctttgtgt tggcttggaa ctgcctgtaa ctccagttgc acgtgatcat
     1861 atgcagtctc cctgcctact ccagctccag gcagggtctt ggtgcacaga catatatgca
     1921 gtcaaaacac aaaggtttaa aatctaagga aaaaagtttt t
//
