LOCUS       NM_001007633            1492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus molybdenum cofactor synthesis 2 (Mocs2),
            transcript variant 2, mRNA.
ACCESSION   NM_001007633 XM_215479
VERSION     NM_001007633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Mendel,R.R. and Bittner,F.
  TITLE     Cell biology of molybdenum
  JOURNAL   Biochim Biophys Acta 1763 (7), 621-635 (2006)
   PUBMED   16784786
  REMARK    Review article
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Matthies,A., Rajagopalan,K.V., Mendel,R.R. and Leimkuhler,S.
  TITLE     Evidence for the physiological role of a rhodanese-like protein for
            the biosynthesis of the molybdenum cofactor in humans
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 5946-5951 (2004)
   PUBMED   15073332
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Leimkuhler,S., Freuer,A., Araujo,J.A., Rajagopalan,K.V. and
            Mendel,R.R.
  TITLE     Mechanistic studies of human molybdopterin synthase reaction and
            characterization of mutants identified in group B patients of
            molybdenum cofactor deficiency
  JOURNAL   J Biol Chem 278 (28), 26127-26134 (2003)
   PUBMED   12732628
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Reiss,J. and Johnson,J.L.
  TITLE     Mutations in the molybdenum cofactor biosynthetic genes MOCS1,
            MOCS2, and GEPH
  JOURNAL   Hum Mutat 21 (6), 569-576 (2003)
   PUBMED   12754701
  REMARK    Review article
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Reiss,J., Dorche,C., Stallmeyer,B., Mendel,R.R., Cohen,N. and
            Zabot,M.T.
  TITLE     Human molybdopterin synthase gene: genomic structure and mutations
            in molybdenum cofactor deficiency type B
  JOURNAL   Am J Hum Genet 64 (3), 706-711 (1999)
   PUBMED   10053004
REFERENCE   7  (bases 1 to 1492)
  AUTHORS   Sloan,J., Kinghorn,J.R. and Unkles,S.E.
  TITLE     The two subunits of human molybdopterin synthase: evidence for a
            bicistronic messenger RNA with overlapping reading frames
  JOURNAL   Nucleic Acids Res 27 (3), 854-858 (1999)
   PUBMED   9889283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO554692.1, FM123325.1 and BC079181.1.
            
            On Jun 23, 2009 this sequence version replaced NM_001007633.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' end, compared to variant 1, and encodes the large subunit
            (Mocs2B).
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230755.1, FM123325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CO554692.1         1-46
            47-654              FM123325.1         1-608
            655-1492            BC079181.1         743-1580
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..1492
                     /gene="Mocs2"
                     /note="molybdenum cofactor synthesis 2"
                     /db_xref="GeneID:294753"
                     /db_xref="RGD:1359477"
     exon            1..98
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..276
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..748
                     /gene="Mocs2"
                     /EC_number="2.8.1.12"
                     /note="isoform Mocs2B-1 is encoded by transcript variant
                     2; MOCS2B; molybdenum cofactor synthesis protein 2B;
                     molybdenum cofactor synthesis protein 2 large subunit;
                     molybdopterin synthase catalytic subunit; molybdopterin
                     synthase sulfur carrier subunit"
                     /codon_start=1
                     /product="molybdopterin synthase catalytic subunit isoform
                     Mocs2B-1"
                     /protein_id="NP_001007634.1"
                     /db_xref="GeneID:294753"
                     /db_xref="RGD:1359477"
                     /translation="MSSLEINNSCFSLETKLPSSHQSVEDSASEPSGYEAKDPPQDTL
                     KDVDDVLEKPKDIIQFTAKKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLE
                     YEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLE
                     AVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAADD"
     exon            277..404
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..555
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..679
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1470
                     /gene="Mocs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagcatc cggctgcgca tgcgccctga gtcaccggct ccgacggggt tggtgaactg
       61 gctcccggca gtgtagcggg atggttccta ggtgtcaggt tggctgatgt tagaaaccag
      121 gtgatatttg ctgttcgtca agagtatgtc gagcttggag atcaacaact cctgcttcag
      181 cctggagacg aagttgccat catcccacca atcagtggag gatagtgcgt ctgagccatc
      241 ggggtatgag gcgaaggacc ctccacagga taccttgaaa gatgtggatg atgtgctgga
      301 gaaacctaag gacataatac agttcactgc caagaagctc tcagtggggg aagtgtcaca
      361 gctggtggtg tcccctctgt gtggcgcagt gtctctcttt gtagggacta caagaaataa
      421 cttcgaaggc aagaaagtca ttagcttaga atatgaagca tatctaccca tggcagaaaa
      481 tgaaatcaga aaaatttgca atgacattcg acagaaatgg ccagtgaggc acatagcggt
      541 gttccatcgg cttggtctgg ttccagtgtc agaagcaagc acagttattg ctgtgtcctc
      601 agctcacaga gccgcgtccc ttgaagccgt gagctacgcc attgattctt taaaagccaa
      661 ggtgcccata tggaagaagg aaatatatga agaatcaaca tcatcttgga aaagaaacaa
      721 ggaatgcttc tgggcagctg atgactagtc aagttttggt gcactgaatc ttaaatttgg
      781 taaataatcg cttaggttac accaatggag agctagggaa gtgcccaagt gtgtgggatg
      841 aggagctgcg taggacctaa agctgggaag acatggctta acttgaacct tctgtgacta
      901 actcctagtc gtagccagct cacaacgagc tgcagccttc ctttcaccat cagctgtccc
      961 aggaagacct actgtcccac agggtattga cgcatcgtga taagacatgt gttacaaaaa
     1021 attgacggaa tcagaaaatc attctcagtt gtgacattac atattttaca taacttagaa
     1081 gtgaacctaa ataaatcatg atttaaatta aaaatagatt ctgtttctct tttagtcagt
     1141 gataatacct aaggggtttt acattacaga cacctctctg acttcagaat ccataattac
     1201 acacagtaag gcttttttta tatctcattg gttgtcaata ttctcatcac tgtacagatt
     1261 agcataaaac tgttctaaaa ctaaccagca gcaaggtggt ttatgttaaa atgatgtatg
     1321 atgcttaaaa gttggcccac aactatttga ggacactgtg taattattta ctaaagtagt
     1381 ttggatagtt ttcataatgt ttatgtaaca ctggcctgtg tgaaattatt actaaacaaa
     1441 ttaaattttc tgcaagattt ttataccaaa aaaaaaaaaa aaaaaaaaaa aa
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