LOCUS       NM_001413768            2545 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus molybdenum cofactor synthesis 1 (Mocs1), mRNA.
ACCESSION   NM_001413768 XM_006244416
VERSION     NM_001413768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Kugler,S., Hahnewald,R., Garrido,M. and Reiss,J.
  TITLE     Long-term rescue of a lethal inherited disease by adeno-associated
            virus-mediated gene transfer in a mouse model of
            molybdenum-cofactor deficiency
  JOURNAL   Am J Hum Genet 80 (2), 291-297 (2007)
   PUBMED   17236133
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Mendel,R.R. and Bittner,F.
  TITLE     Cell biology of molybdenum
  JOURNAL   Biochim Biophys Acta 1763 (7), 621-635 (2006)
   PUBMED   16784786
  REMARK    Review article
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Leimkuhler,S., Charcosset,M., Latour,P., Dorche,C., Kleppe,S.,
            Scaglia,F., Szymczak,I., Schupp,P., Hahnewald,R. and Reiss,J.
  TITLE     Ten novel mutations in the molybdenum cofactor genes MOCS1 and
            MOCS2 and in vitro characterization of a MOCS2 mutation that
            abolishes the binding ability of molybdopterin synthase
  JOURNAL   Hum Genet 117 (6), 565-570 (2005)
   PUBMED   16021469
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Reiss,J., Bonin,M., Schwegler,H., Sass,J.O., Garattini,E.,
            Wagner,S., Lee,H.J., Engel,W., Riess,O. and Schwarz,G.
  TITLE     The pathogenesis of molybdenum cofactor deficiency, its delay by
            maternal clearance, and its expression pattern in microarray
            analysis
  JOURNAL   Mol Genet Metab 85 (1), 12-20 (2005)
   PUBMED   15862276
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Hanzelmann,P., Hernandez,H.L., Menzel,C., Garcia-Serres,R.,
            Huynh,B.H., Johnson,M.K., Mendel,R.R. and Schindelin,H.
  TITLE     Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein
            involved in human molybdenum cofactor biosynthesis
  JOURNAL   J Biol Chem 279 (33), 34721-34732 (2004)
   PUBMED   15180982
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Reiss,J. and Johnson,J.L.
  TITLE     Mutations in the molybdenum cofactor biosynthetic genes MOCS1,
            MOCS2, and GEPH
  JOURNAL   Hum Mutat 21 (6), 569-576 (2003)
   PUBMED   12754701
  REMARK    Review article
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Lee,H.J., Adham,I.M., Schwarz,G., Kneussel,M., Sass,J.O., Engel,W.
            and Reiss,J.
  TITLE     Molybdenum cofactor-deficient mice resemble the phenotype of human
            patients
  JOURNAL   Hum Mol Genet 11 (26), 3309-3317 (2002)
   PUBMED   12471057
REFERENCE   9  (bases 1 to 2545)
  AUTHORS   Reiss,J., Christensen,E., Kurlemann,G., Zabot,M.T. and Dorche,C.
  TITLE     Genomic structure and mutational spectrum of the bicistronic MOCS1
            gene defective in molybdenum cofactor deficiency type A
  JOURNAL   Hum Genet 103 (6), 639-644 (1998)
   PUBMED   9921896
REFERENCE   10 (bases 1 to 2545)
  AUTHORS   Reiss,J., Cohen,N., Dorche,C., Mandel,H., Mendel,R.R.,
            Stallmeyer,B., Zabot,M.T. and Dierks,T.
  TITLE     Mutations in a polycistronic nuclear gene associated with
            molybdenum cofactor deficiency
  JOURNAL   Nat Genet 20 (1), 51-53 (1998)
   PUBMED   9731530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 8, 2022 this sequence version replaced XM_006244416.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.38239.1,
                                           SRR26643288.36653.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000009.1  19065277-19065449   c
            174-300             JAXUCZ010000009.1  19060625-19060751   c
            301-468             JAXUCZ010000009.1  19058768-19058935   c
            469-633             JAXUCZ010000009.1  19054986-19055150   c
            634-695             JAXUCZ010000009.1  19052838-19052899   c
            696-807             JAXUCZ010000009.1  19052436-19052547   c
            808-920             JAXUCZ010000009.1  19052135-19052247   c
            921-1031            JAXUCZ010000009.1  19051654-19051764   c
            1032-1152           JAXUCZ010000009.1  19049045-19049165   c
            1153-1200           JAXUCZ010000009.1  19048261-19048308   c
            1201-2545           JAXUCZ010000009.1  19045223-19046567   c
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2545
                     /gene="Mocs1"
                     /note="molybdenum cofactor synthesis 1"
                     /db_xref="GeneID:301221"
                     /db_xref="RGD:1308471"
     exon            1..173
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1961
                     /gene="Mocs1"
                     /EC_number="4.1.99.18"
                     /codon_start=1
                     /product="molybdenum cofactor biosynthesis protein 1"
                     /protein_id="NP_001400697.1"
                     /db_xref="GeneID:301221"
                     /db_xref="RGD:1308471"
                     /translation="MAARPASRMLRQLLRSNVRSCSSGAPMTQPRPGEPSRPTREGLS
                     MRLQFLQEHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCRYCMPEEGVSLTPKADLL
                     TTEEILTLARLFVKEGVDKIRLTGGEPLIRPDVVDIVARLHQLEGLRTIGVTTNGINL
                     ARLLPSLQQAGLSAVNVSLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYKPVKVNC
                     VVMRGLNEDELLDFVALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDAIRQRWP
                     GLEKLPEEDSSTAKAFKIPGFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNS
                     EVSLRDHLRAGASEEELLRIIGVAVGRKKRQHAGMFNIAQMKNRPMILIGVLLMLQDS
                     PPASWSTLSWDPLHVRNPGAKQCLSDQMATLWKRHSVPMALPLSQQCLGSGSPQRHYS
                     SYPDPDTHPKCLSTGSRAPDVPSGPGPTSDQLTHVDSAGRATMVDVGGKPETERVAVA
                     SAMVLLGPKAFKLVQQNQLKKGDALVVAQLAGVQAAKLTSQLIPLCHHVALSHVQVHL
                     ELDSTRHAVLIQVSCRARGPTGVEMEALTSAAMAALTVYDMCKAVSRDIVVTEVKLIS
                     KTGGQRGDFHRT"
     exon            174..300
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..468
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..633
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..695
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..807
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..920
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1031
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1152
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1200
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..2545
                     /gene="Mocs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgctct ggaggcccac ttcagaccgg gtacttcctt tgctgacttc atggcggcgc
       61 ggcctgcgtc ccggatgctg cggcagctct tgaggtctaa tgtacggagc tgcagctccg
      121 gggctccgat gacgcagccc cgccccgggg agccctcgag acctaccagg gaggggctgt
      181 ccatgaggct ccagttcctc caggaacatg cagctccctt ctccgccttc ctcaccgaca
      241 gctttggccg gcagcacagt tacctacgga tctctctcac agagaagtgc aacctccgat
      301 gtcggtattg catgcctgag gagggtgtgt ccctgacccc caaagctgac ctactgacca
      361 cagaggagat cctgaccctt gcccgcctct tcgtgaagga aggtgtggac aaaatccgtc
      421 tcactggtgg ggaacctctc atccgaccag atgtggtgga catcgtggcc agacttcatc
      481 agctagaagg gctgagaacc attggcgtta ccaccaacgg catcaaccta gcccggctgc
      541 taccctcact tcagcaggct gggctcagtg ctgtgaacgt cagcctggac accctggttc
      601 ctgccaagtt tgagttcatt gtccgcagaa aaggcttcca caaagtcatg gagggtatcc
      661 acaaagccat cgagctgggt tacaaacctg tgaaggtgaa ctgtgtggtg atgcgaggcc
      721 tgaatgaaga cgagcttctg gacttcgtag ccctgacaga gggccttccc ttggacgtgc
      781 gcttcattga gtacatgccg tttgacggca acaagtggaa cttcaagaag atggtcagct
      841 acaaggagat gctggacgcc atccgacagc ggtggccagg gctggagaag ctgccagagg
      901 aggactctag cactgccaag gcctttaaga tcccgggctt ccagggacag atcagcttca
      961 tcacgtccat gtcagagcat ttctgcggga cctgcaaccg gcttcgcatc acagctgatg
     1021 ggaacctcaa ggtctgcctc ttcgggaact ctgaggtgtc actgcgggac cacctgcggg
     1081 caggggcctc tgaggaggag ctgctgagaa tcattggggt cgcagtgggt aggaagaaga
     1141 ggcagcacgc aggcatgttc aatattgccc agatgaagaa ccggcccatg atcctcatcg
     1201 gggtactttt gatgcttcaa gattccccac cagctagttg gagcactctc tcctgggatc
     1261 ccctccacgt tcggaatcca ggtgccaaac agtgtctttc cgaccagatg gcaactttgt
     1321 ggaagagaca ctctgtccct atggcccttc ctctgtctca gcagtgcctg gggtctggat
     1381 ccccccaaag acactacagc tcctacccag accctgacac tcacccaaag tgccttagca
     1441 cagggtcccg ggcccctgat gtcccctcag gcccagggcc gacctcagat cagctaactc
     1501 atgtggattc agcagggcga gctactatgg tagatgtggg tgggaagcca gagacagagc
     1561 gggtggctgt ggcctctgcc atggttctcc ttggacccaa agccttcaag ctcgtccagc
     1621 agaaccaact gaagaaggga gatgctctgg tggtggccca gctggctggg gtccaggcag
     1681 ccaagctaac gagtcagctg atccctctct gccaccacgt ggccctgagc catgtgcagg
     1741 tacacttgga gctagacagc actcgccatg ctgtgctgat ccaggtatcc tgccgggccc
     1801 ggggccccac tggggtagag atggaggcgc tgacctcggc ggccatggcc gcccttaccg
     1861 tgtatgacat gtgcaaggcg gtcagcaggg acattgtggt gacagaggta aagctcatca
     1921 gtaagactgg agggcagcgg ggggacttcc atcggaccta gagtgccaca ctctctggtc
     1981 atgtctcccg ttgggccgag taaaagatgt cctccagatc tagagattag accgagggtc
     2041 accctgtctc tttaccacta acctgtgagg tgtcgtcagc agaagacacc tgaggccttg
     2101 accccttcca ggactctggc agtgggagtt ttgatactgg ataccctgcc ccccacccaa
     2161 caccacatgt cacagcactc gggctgtttc agacaggcag ctctaggcag cccttctcat
     2221 gcgggatcct ctcttctctt cgctggtgag agaacaaggg ctcattaagt agaggaaccc
     2281 gctttgagga aggaaaagca cacgctccct agagaatgta tcacagaccg cctcccccgc
     2341 ctcaggccct ctcctccaac aagatgcaca cgtatggact gcagccctaa ggacctgtgc
     2401 caacttctac ccacacctgg ttccgctcgc tgtggtctgc ccatacctct ctactctggc
     2461 acgtatcagg gaaagaggag ttgaaggtga cctttgccct cacaacgcac aaataaaacc
     2521 acgacgccag ctttgtagat gagaa
//
