LOCUS       NM_001389273             783 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myelin-associated oligodendrocyte basic protein
            (Mobp), transcript variant 3, mRNA.
ACCESSION   NM_001389273 XM_006244065
VERSION     NM_001389273.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Irwin,D.J., McMillan,C.T., Suh,E., Powers,J., Rascovsky,K.,
            Wood,E.M., Toledo,J.B., Arnold,S.E., Lee,V.M., Van Deerlin,V.M.,
            Trojanowski,J.Q. and Grossman,M.
  TITLE     Myelin oligodendrocyte basic protein and prognosis in
            behavioral-variant frontotemporal dementia
  JOURNAL   Neurology 83 (6), 502-509 (2014)
   PUBMED   24994843
REFERENCE   2  (bases 1 to 783)
  AUTHORS   Lee,N.E., Park,Y.J., Chung,I.Y., Seo,S.W., Park,J.M., Yoo,J.M. and
            Song,J.K.
  TITLE     Gene expression changes in a rat model of oxygen-induced
            retinopathy
  JOURNAL   Korean J Ophthalmol 25 (1), 42-47 (2011)
   PUBMED   21350694
REFERENCE   3  (bases 1 to 783)
  AUTHORS   Lin,K.Y., Chen,K.M., Lan,K.P., Lee,H.H. and Lai,S.C.
  TITLE     Alterations of myelin proteins in inflammatory demyelination of
            BALB/c mice caused by Angiostrongylus cantonensis
  JOURNAL   Vet Parasitol 171 (1-2), 74-80 (2010)
   PUBMED   20399564
REFERENCE   4  (bases 1 to 783)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 783)
  AUTHORS   Montague,P., McCallion,A.S., Barrie,J.E., Edgar,J.M.,
            McLaughlin,M., Davies,R.W. and Griffiths,I.R.
  TITLE     Characterization of the murine splice variant Mobp155:
            developmental CNS expression pattern and subcellular localization
            of epitope-tagged protein
  JOURNAL   Glia 50 (1), 80-85 (2005)
   PUBMED   15625715
REFERENCE   6  (bases 1 to 783)
  AUTHORS   Gould,R.M., Freund,C.M. and Barbarese,E.
  TITLE     Myelin-associated oligodendrocytic basic protein mRNAs reside at
            different subcellular locations
  JOURNAL   J Neurochem 73 (5), 1913-1924 (1999)
   PUBMED   10537049
REFERENCE   7  (bases 1 to 783)
  AUTHORS   Montague,P., Kirkham,D., McCallion,A.S., Davies,R.W., Kennedy,P.G.,
            Klugmann,M., Nave,K. and Griffiths,I.R.
  TITLE     Reduced levels of a specific myelin-associated oligodendrocytic
            basic protein isoform in shiverer myelin
  JOURNAL   Dev Neurosci 21 (1), 36-42 (1999)
   PUBMED   10077700
REFERENCE   8  (bases 1 to 783)
  AUTHORS   Holz,A. and Schwab,M.E.
  TITLE     Developmental expression of the myelin gene MOBP in the rat nervous
            system
  JOURNAL   J Neurocytol 26 (7), 467-477 (1997)
   PUBMED   9306245
REFERENCE   9  (bases 1 to 783)
  AUTHORS   Holz,A., Schaeren-Wiemers,N., Schaefer,C., Pott,U., Colello,R.J.
            and Schwab,M.E.
  TITLE     Molecular and developmental characterization of novel cDNAs of the
            myelin-associated/oligodendrocytic basic protein
  JOURNAL   J Neurosci 16 (2), 467-477 (1996)
   PUBMED   8551331
REFERENCE   10 (bases 1 to 783)
  AUTHORS   Yamamoto,Y., Mizuno,R., Nishimura,T., Ogawa,Y., Yoshikawa,H.,
            Fujimura,H., Adachi,E., Kishimoto,T., Yanagihara,T. and Sakoda,S.
  TITLE     Cloning and expression of myelin-associated oligodendrocytic basic
            protein. A novel basic protein constituting the central nervous
            system myelin
  JOURNAL   J Biol Chem 269 (50), 31725-31730 (1994)
   PUBMED   7989345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 8, 2020 this sequence version replaced XM_006244065.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1383483.1,
                                           SRR26360176.758232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000008.1  128747232-128747287
            57-133              JAXUCZ010000008.1  128752441-128752517
            134-343             JAXUCZ010000008.1  128764635-128764844
            344-783             JAXUCZ010000008.1  128765055-128765494
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..783
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /note="myelin-associated oligodendrocyte basic protein"
                     /db_xref="GeneID:25037"
                     /db_xref="RGD:3101"
     exon            1..56
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /inference="alignment:Splign:2.1.0"
     exon            57..133
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /inference="alignment:Splign:2.1.0"
     exon            134..343
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..650
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /note="isoform 2 is encoded by transcript variant 3;
                     myelin-associated oligodendrocytic basic protein;
                     Myelin-associated/Oligodendrocytic Basic Protein-81;
                     RNMOBP81P"
                     /codon_start=1
                     /product="myelin-associated oligodendrocyte basic protein
                     isoform 2"
                     /protein_id="NP_001376202.1"
                     /db_xref="GeneID:25037"
                     /db_xref="RGD:3101"
                     /translation="MSQKVAKEGPRLSKNQKFSEHFSIHCCPPFTFLNSKREIVDRKY
                     SICKSGCFYQKKEEDWICCACQKTSRRATSPQKPKHQPAASPVVVRAPPAKPKSPPRP
                     AKPRSPPIPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQPARSSPLRGPGTSRG
                     GSPTRAPRFW"
     exon            344..783
                     /gene="Mobp"
                     /gene_synonym="Mobp81; Mobp81p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccacca gggcccgcta tccacaggaa cctttcacag cagccaatac ctgcagggca
       61 acaaagaatc aaatgagagc gagacaagct gggaatgaag tcctggttgc cagatgggag
      121 cttgaaaata cagtaagatg agtcaaaaag tggccaagga gggccccagg ctctccaaga
      181 accagaagtt ctcagagcac ttcagcatcc actgctgccc acccttcacc ttcctcaact
      241 ccaagcgtga gatcgtggac cgcaagtaca gcatctgcaa gagcggttgc ttttaccaga
      301 agaaggagga ggactggatc tgctgtgcct gccagaagac cagccgccgt gccacatccc
      361 ctcagaagcc caagcaccag ccagctgcat cccctgtggt ggtcagagcg ccgccagcca
      421 agccaaagtc ccctccgagg ccagccaagc caaggtcccc tccgattcca gccaagccaa
      481 ggtccccttc aaggactgag cgccagccgc gtccccgccc agaggtccga ccaccaccag
      541 ccaagcagaa gccccctcag aagtctaaac agccagcacg aagcagcccc ctcagagggc
      601 caggcaccag ccgcgggggg tctcccacca gagctcctag gttctggtaa caccatctct
      661 tgccttttgt cccccctagc ctaaggtcag tagctgctct ctgcaagtac taacatgggg
      721 gatctctcca cagtaccaag cctgtgtaat ctactccctg cattaaaccc cctctgtttg
      781 aaa
//
