LOCUS       NM_001108357            2704 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus MOB kinase activator 1B (Mob1b), mRNA.
ACCESSION   NM_001108357 XM_001073264 XM_341194
VERSION     NM_001108357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Yang BC, Kuang MJ, Kang JY, Zhao J, Ma JX and Ma XL.
  TITLE     Human umbilical cord mesenchymal stem cell-derived exosomes act via
            the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in
            disuse osteoporosis
  JOURNAL   Biochem Biophys Res Commun 524 (4), 883-889 (2020)
   PUBMED   32057365
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cell-derived
            exosomes act via the miR-1263/Mob1/Hippo signaling pathway to
            prevent apoptosis in disuse osteoporosis.
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Chow A, Hao Y and Yang X.
  TITLE     Molecular characterization of human homologs of yeast MOB1
  JOURNAL   Int J Cancer 126 (9), 2079-2089 (2010)
   PUBMED   19739119
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Bichsel SJ, Tamaskovic R, Stegert MR and Hemmings BA.
  TITLE     Mechanism of activation of NDR (nuclear Dbf2-related) protein
            kinase by the hMOB1 protein
  JOURNAL   J Biol Chem 279 (34), 35228-35235 (2004)
   PUBMED   15197186
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Devroe E, Erdjument-Bromage H, Tempst P and Silver PA.
  TITLE     Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
            kinases
  JOURNAL   J Biol Chem 279 (23), 24444-24451 (2004)
   PUBMED   15067004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474060.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341194.3, XM_001073264.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2704
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /note="MOB kinase activator 1B"
                     /db_xref="GeneID:360920"
                     /db_xref="RGD:1305114"
     exon            1..266
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..903
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /note="mps one binder kinase activator-like 1A; MOB1, Mps
                     One Binder kinase activator-like 1A"
                     /codon_start=1
                     /product="MOB kinase activator 1B"
                     /protein_id="NP_001101827.1"
                     /db_xref="GeneID:360920"
                     /db_xref="RGD:1305114"
                     /translation="MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMA
                     VMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTN
                     IKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYA
                     HIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR"
     exon            267..433
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            434..527
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            528..661
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            662..825
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2704
                     /gene="Mob1b"
                     /gene_synonym="Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggagctgg cggagaggac gcggcgggcg gcgcttcctc caccgctcgg tttccagtcc
       61 gccgagctag ccgaatccag gtcttccatt tccgcccgcc ggtccgctgg ccgctggaag
      121 tagcgaagcc gaagaagtcg cggccgcccc gccgccggcg cgcgtcctcc tcccgccctt
      181 gcttttcctc tgattcaggc ccgccgcccc aagcttcgct ctgccgagcc cgcagcccac
      241 gccgcggccg acatgagctt cttgtttggt agtcgctctt ctaaaacttt taaaccaaag
      301 aagaacatac cagaggggtc tcaccagtat gagctcttaa aacatgcaga agccacactg
      361 ggcagtggca acctgcggat ggccgttatg cttcctgagg gagaggatct gaatgagtgg
      421 gttgcagtta acactgtgga ttttttcaat caaatcaata tgctttatgg aactatcaca
      481 gacttctgta cagaggagag ctgtccggtg atgtcagctg gaccaaaata tgagtatcac
      541 tgggcagatg gaacaaacat aaaaaagccc atcaagtgtt ctgcaccgaa gtatattgat
      601 tacctgatga catgggttca ggaccagctg gatgatgaga cattatttcc atcaaaaatt
      661 ggtgttccat tccccaagaa tttcatgtca gtggcaaaaa ccatactcaa acgactcttc
      721 agagtctacg ctcacattta tcatcaacat tttgaccccg tgatccagct tcaggaggaa
      781 gcacatctca atacatcttt caagcacttt attttttttg ttcaggagtt caaccttatt
      841 gacagacgag agttggcacc actgcaagag ctgattgaaa aactcacctc aaaggacaga
      901 tagaggatgc aaagctgtgt actcttcttc agatggagct gcgtgcacac agtgtcgttg
      961 gctttgttat atttcacttt tgtctagagt gtttctgttt taggttttag ggcttgcttg
     1021 ggttcccttt tttcttctga atatataaaa tcatattctg ttgctagagg aagctgagaa
     1081 ccatttgaaa agagcagatt ttgtcttagt ggtatccagt atttttttct gttttatttt
     1141 tatgaacctg gttttggtta cttgagaagt ttatatgata gtatacgcta gaaatagatg
     1201 cgaactgact gaagtgctga tggactgggc actgtgtgtg cagactgtgg cccactttgg
     1261 agtccctaaa agacttacgt gtttttaagt gccttgatag gctcacttct aaggtgcaaa
     1321 gcacagatat aggactgaac agagcttgaa acaatattag aatttctatc tagggcactt
     1381 acttgtgcat gttataaagt aatctgttat aaaagccata gtttactcaa attgttgatc
     1441 tccagctttt actatgttga gaaagacata atttgtaaaa ttgtgcatgt agaacataaa
     1501 tataaaacaa caaattattt cttaattatt tttgacataa tttgtaaagg tgtgcatgta
     1561 gaacataaat gtaaaacaac aaaattctta attatttttg atattgacta atatattctg
     1621 ttcaacagac gtttaaagtt ctacaagcag gtcttttccc atctcttaat atctgtgata
     1681 ttgaaatatg aagatgttga aatgtaatag atactgcatt tcagcttctt tctacatata
     1741 agtgcactgt aagtgtaaaa cttcaggtta tatatagaat cgccatcttc attaaggatg
     1801 ttgaactgtg aggtttccta gcaattgcca aatgagctgt aagtgcagaa tccctttgta
     1861 cttcaaagag gaaaggaaag tgagacctgt cacagcaggc attagtttgg gaaattacag
     1921 aggattagtg tgggagtaaa attctagaaa gtcctgtttt agagccctgg gatagattgg
     1981 tgtctattac ttacagtctg ggggacttcc ttttagagat cagcttccat gagaagttaa
     2041 acataagtaa ttagttttag gtacagacgt taaacatgta atttaactat ttggggaaat
     2101 aatccacttt ttagcatttc cattcagtga atggagctgg tatttgcctg tcattttaaa
     2161 tgatacacta ccttgattat tggtgcagtt tgaagcatcc tgactcctta tttttccact
     2221 gtgagaaatc ttttttcttt gtagtgatat gtcagctcaa gtcaagtagt gaaaatgtca
     2281 gctcagtagt taatagcttt taaatgttgg ctgagatgac accctgtcaa atgatcatta
     2341 tcaactacag gttcagcagt ttggttttag agtaaatact gaggatagct gcccttcagt
     2401 tttgttcttg agaaatactc ttttaagact gagtgttaat tttatcagtt tggataaatc
     2461 agcctccctc aattttccct ctttctagtt agagatacac actttcaaac ttgtgaacta
     2521 gaaatgcttg ctgtgaattt gtatacaaac acttagtgga agagagttta aaatgaacaa
     2581 gtggacaatg atacaattag atgcccttgc agttatgatc actaggaact gcctttttct
     2641 ccatttgatt tttgtaatgg caattgctta ccatgtactg atcatagaag gaacaaaaga
     2701 gctt
//
