LOCUS       NM_001271274            1857 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus motor neuron and pancreas homeobox 1 (Mnx1),
            mRNA.
ACCESSION   NM_001271274 XM_001059733 XM_003749670
VERSION     NM_001271274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Desai,S.S., Modali,S.D., Parekh,V.I., Kebebew,E. and Agarwal,S.K.
  TITLE     GSK-3beta protein phosphorylates and stabilizes HLXB9 protein in
            insulinoma cells to form a targetable mechanism of controlling
            insulinoma cell proliferation
  JOURNAL   J Biol Chem 289 (9), 5386-5398 (2014)
   PUBMED   24425879
  REMARK    GeneRIF: Both pHLXB9 and active GSK-3beta are elevated in beta
            cells with menin knockdown, in MEN1-associated beta cell tumors
            (insulinomas)
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Kelly,C.E., Thymiakou,E., Dixon,J.E., Tanaka,S., Godwin,J. and
            Episkopou,V.
  TITLE     Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon
            extension
  JOURNAL   PLoS Biol 11 (4), e1001538 (2013)
   PUBMED   23610558
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Cho,A., Ko,H.W. and Eggenschwiler,J.T.
  TITLE     FKBP8 cell-autonomously controls neural tube patterning through a
            Gli2- and Kif3a-dependent mechanism
  JOURNAL   Dev Biol 321 (1), 27-39 (2008)
   PUBMED   18590716
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Lee,S., Lee,B., Joshi,K., Pfaff,S.L., Lee,J.W. and Lee,S.K.
  TITLE     A regulatory network to segregate the identity of neuronal subtypes
  JOURNAL   Dev Cell 14 (6), 877-889 (2008)
   PUBMED   18539116
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Winseck,A.K. and Oppenheim,R.W.
  TITLE     An in vivo analysis of Schwann cell programmed cell death in
            embryonic mice: the role of axons, glial growth factor, and the
            pro-apoptotic gene Bax
  JOURNAL   Eur J Neurosci 24 (8), 2105-2117 (2006)
   PUBMED   17042795
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Yang,X., Arber,S., William,C., Li,L., Tanabe,Y., Jessell,T.M.,
            Birchmeier,C. and Burden,S.J.
  TITLE     Patterning of muscle acetylcholine receptor gene expression in the
            absence of motor innervation
  JOURNAL   Neuron 30 (2), 399-410 (2001)
   PUBMED   11395002
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Li,H., Arber,S., Jessell,T.M. and Edlund,H.
  TITLE     Selective agenesis of the dorsal pancreas in mice lacking homeobox
            gene Hlxb9
  JOURNAL   Nat Genet 23 (1), 67-70 (1999)
   PUBMED   10471501
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Arber,S., Han,B., Mendelsohn,M., Smith,M., Jessell,T.M. and
            Sockanathan,S.
  TITLE     Requirement for the homeobox gene Hb9 in the consolidation of motor
            neuron identity
  JOURNAL   Neuron 23 (4), 659-674 (1999)
   PUBMED   10482234
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474057.1.
            
            On or before Sep 13, 2012 this sequence version replaced
            XM_001059733.1, XM_003749670.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434,
                              SAMN12840114 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1857
                     /gene="Mnx1"
                     /gene_synonym="Hlxb9"
                     /note="motor neuron and pancreas homeobox 1"
                     /db_xref="GeneID:682076"
                     /db_xref="RGD:1588091"
     exon            1..728
                     /gene="Mnx1"
                     /gene_synonym="Hlxb9"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1249
                     /gene="Mnx1"
                     /gene_synonym="Hlxb9"
                     /note="homeobox gene HB9; motor neuron and pancreas
                     homeobox protein 1; homeobox protein HB9"
                     /codon_start=1
                     /product="motor neuron and pancreas homeobox 1"
                     /protein_id="NP_001258203.1"
                     /db_xref="GeneID:682076"
                     /db_xref="RGD:1588091"
                     /translation="MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLAATPSGPGRG
                     GSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLTAHCALLPKPGFLGAGG
                     GGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYG
                     HPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRAST
                     AGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVAT
                     SLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGSGGGAGKGGTEEKTEEELL
                     GPPVSGDKASGRRLRDLRDSDPDEDEDDEEDHFPYSNGVGAHAASSDCSSEDDSPPPR
                     PGGPGHQPLPQ"
     exon            729..889
                     /gene="Mnx1"
                     /gene_synonym="Hlxb9"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1857
                     /gene="Mnx1"
                     /gene_synonym="Hlxb9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccttggg ccctgatcgt cagctccaaa cgagccgatg gaaaaatcca aaaatttccg
       61 catcgacgcc ttgctggcgg tggatccccc gcgagccgcc tccacgcaga gcgcgcctct
      121 ggccttggtc acttccctcg ccgctacacc atctggtccc ggccgcggcg gtagcggtgg
      181 cgggggaacc agtagcgggg cgagccgcag ctgcagtccc gcgtcctcgg aggccaccgc
      241 agcacccggt gatagactga gggctgagag cccgtcgcct ccgcgcttgc tgactgcaca
      301 ctgcgcgctg ctgcccaagc ctggatttct aggcgccggg ggaggcggcg gcgcggcggg
      361 tgggccgggc actccacacc accacgcgca ccctggtgcc gccgccgccg ccgctgctgc
      421 cgcggctgcc gccgcagccg ggggcctggc actggggctg caccccgggg gcgcacaggg
      481 cggcgcgggc ctcccggcac aggcagctct ctacggacac ccggtctaca gttactcggc
      541 agcagctgca gcggccgcgc tagctggcca gcacccggcg ctttcctact cgtatcctca
      601 ggtgcagggc gcgcaccctg ctcaccctgc cgaccccatc aagctgggtg ccggcacctt
      661 tcaactggac cagtggctgc gcgcgtctac tgcgggcatg atcctgccca agatgccgga
      721 cttcagctcc caggcgcaat cgaacctctt ggggaagtgc cgaaggcctc gcacggcctt
      781 caccagccag cagctgttgg agctggaaca ccagttcaag ctcaacaagt acctgtcgcg
      841 acccaagcgt tttgaggtgg ctacctcgct catgctcacc gagacccagg tgaagatttg
      901 gttccagaac cgccgaatga aatggaaacg cagcaaaaag gccaaagagc aggctgcgca
      961 ggaggcagag aagcagaagg gcagcggcgg gggcgccggc aaaggcggca ctgaggagaa
     1021 gacggaggag gagctgctgg gacctccagt ttcgggggac aaggccagcg gccgtcgcct
     1081 gcgggacttg cgggacagtg acccagatga ggatgaggat gatgaagaag accacttccc
     1141 ctacagcaat ggggtcggtg cccacgctgc ctcatccgat tgctcatctg aggacgactc
     1201 gcctccccca aggccaggag ggcccgggca ccaacctctg ccccagtagt tgtcccaaag
     1261 gcggcagcag gaatgtgcaa aatggcgacc tgggacctgg gctgcggggg ttcaaacttc
     1321 atccagtggc ctgcagccag gctgacagcc tctccccgga ctatgtatgc atccaggtgt
     1381 gggctggagt gcgaatactt tttggaccct cgaaggacag caagagagaa tgaaagaggg
     1441 gctccaatgt gaactttcgt tcttttacat ttaatttcgg gtcatgttgg ccagaggtgt
     1501 ttgtgagaag aatctaccct ttctaggagt ggctcctgcc tgactcttct ctcatcaaag
     1561 aaaggggaaa aaatgacagt gttaagtgac ctagaaactt gaacccgcca ttggagacaa
     1621 ccattctgtt gagaattgaa aacacaggtt gaataaaggt gttatgccta tgtatgggat
     1681 agggtgggat ggggtggggt gttatggcat gagcattcag attgctgcaa aatctcagaa
     1741 tggtagtgta tttttgtata ttgtatttat atataaagaa agaaacgtct acttatgcat
     1801 gctaaattat tatttagctt tcccgttccc caggatagag atgaaatgta aaataaa
//
