LOCUS       NM_001105807            4567 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MAX network transcriptional repressor (Mnt),
            mRNA.
ACCESSION   NM_001105807 XM_001080632 XM_008767959 XM_220698
VERSION     NM_001105807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4567)
  AUTHORS   Takayanagi,T., Eguchi,A., Takaguri,A., Hinoki,A., Bourne,A.M.,
            Elliott,K.J., Hurlin,P.J. and Eguchi,S.
  TITLE     A repressor protein, Mnt, is a novel negative regulator of vascular
            smooth muscle cell hypertrophy by angiotensin II and neointimal
            hyperplasia by arterial injury
  JOURNAL   Atherosclerosis 228 (1), 90-93 (2013)
   PUBMED   23535568
  REMARK    GeneRIF: These data identify Mnt as a previously unrecognized
            negative regulator of pathological vascular remodeling.
REFERENCE   2  (bases 1 to 4567)
  AUTHORS   Popov,N., Wahlstrom,T., Hurlin,P.J. and Henriksson,M.
  TITLE     Mnt transcriptional repressor is functionally regulated during cell
            cycle progression
  JOURNAL   Oncogene 24 (56), 8326-8337 (2005)
   PUBMED   16103876
REFERENCE   3  (bases 1 to 4567)
  AUTHORS   Hurlin,P.J., Zhou,Z.Q., Toyo-oka,K., Ota,S., Walker,W.L.,
            Hirotsune,S. and Wynshaw-Boris,A.
  TITLE     Deletion of Mnt leads to disrupted cell cycle control and
            tumorigenesis
  JOURNAL   EMBO J 22 (18), 4584-4596 (2003)
   PUBMED   12970171
REFERENCE   4  (bases 1 to 4567)
  AUTHORS   Meroni,G., Reymond,A., Alcalay,M., Borsani,G., Tanigami,A.,
            Tonlorenzi,R., Lo Nigro,C., Messali,S., Zollo,M., Ledbetter,D.H.,
            Brent,R., Ballabio,A. and Carrozzo,R.
  TITLE     Rox, a novel bHLHZip protein expressed in quiescent cells that
            heterodimerizes with Max, binds a non-canonical E box and acts as a
            transcriptional repressor
  JOURNAL   EMBO J 16 (10), 2892-2906 (1997)
   PUBMED   9184233
  REMARK    Erratum:[EMBO J 1997 Oct 1;16(19):6055]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XM_008767959.2, NM_001105807.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.43801.1,
                                           SRR26643298.61980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               JAXUCZ010000010.1  60197959-60198435
            478-1063            JAXUCZ010000010.1  60203597-60204182
            1064-1105           JAXUCZ010000010.1  60204647-60204688
            1106-1217           JAXUCZ010000010.1  60204826-60204937
            1218-1410           JAXUCZ010000010.1  60209659-60209851
            1411-4567           JAXUCZ010000010.1  60210053-60213209
FEATURES             Location/Qualifiers
     source          1..4567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4567
                     /gene="Mnt"
                     /note="MAX network transcriptional repressor"
                     /db_xref="GeneID:287521"
                     /db_xref="RGD:1308683"
     exon            1..477
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2177
                     /gene="Mnt"
                     /note="max binding protein; MNT, MAX dimerization protein"
                     /codon_start=1
                     /product="max-binding protein MNT"
                     /protein_id="NP_001099277.2"
                     /db_xref="GeneID:287521"
                     /db_xref="RGD:1308683"
                     /translation="MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKR
                     ASNLARLAHALPVEEPRVEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQS
                     LPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVPLPTRPQVPTPAPLLPDSKTTVA
                     PTGSPKPLQPLPTPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRP
                     GGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRK
                     EKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTA
                     SEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKAALPTPSTAPAPLPAHPHPHPHPVA
                     LSPAHLPVQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTH
                     ASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGS
                     QLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLV
                     GQTVLNPVTMVTMPSFPVSTLKLA"
     exon            478..1063
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1105
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1217
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1410
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..4567
                     /gene="Mnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcc gggggcagcg cggctccttc ccttgttgtg tgtgtcggtg cctcctcgcc
       61 atcttgttgc aaagcccttt cttgtcggcg ggactccggg ggccgcgggg cgggaggcat
      121 cggaagagag gaagaggaag aaggaaggaa gaaggcagtg cgcctttttt attttttgca
      181 tcaaaatttt ttttaatttg caaattttta ttttgcaaat attttggaga cattgatttt
      241 tctccccgtg ctcccccgtt ctttcctgag gagtgcgctg ctccgcccag ccctgtcgcc
      301 ccccggaggt gatccctccc tcctgccggc ccgccagcct gacctgtgct tggctcgcgg
      361 gccgcagcct tggccccggc gcgcccccgg ctgctctcgg cgcgatgagc atagagacgc
      421 tactggaggc ggcccgcttc ctggaatggc aagcgcagca acaacagaga gcacgtgagg
      481 agcaggagcg ccttcgtctg gagcgggaac gtgagagaga gcaggagcag aagagggcaa
      541 gtaacctggc aaggttggcc catgccctgc ctgtggagga accccgagtc gaggctccac
      601 cactaccttt gtctccaccg gcaccaccgc ctgcaccacc accaccactt gccacccctg
      661 ctccactgac tgtcattcct attcctgtag tgaccaattc cccacagtcc ctacccccgc
      721 ctccacctct gccccccgca gcccagcctc ttcccttggc acctcgtcag ccagccctgg
      781 tcagcacccc tggactcagc attaaggagc cagtccccct gcccaccaga ccacaggtgc
      841 ccacccctgc tcccttactg cctgattcga agaccacagt agcccccact ggcagtccca
      901 agcctttgca gcccctccct acgcccatcc taaccattgc accacaccct ggagtccagc
      961 ctcagctggc tccccagcaa ccacccccgc ccacacttgg aaccctgaag ttggcaccag
     1021 ccgaagaagc caaatccagt gaacaaaaga agaggcctgg ggggatcgga accagagaag
     1081 tccacaacaa attggagaag aacaggaggg cccatctgaa ggaatgtttt gagactctga
     1141 agcgcaacat ccccaacgtg gacgacaaaa agacttcaaa tctgagcgtg ctgcggacgg
     1201 cgctgcggta catccagtcc ctgaagagga aggagaagga gtatgagcat gagatggagc
     1261 ggcttgcacg ggagaagatt gccacacagc agcgcctggc agagctcaag catgagctga
     1321 gccagtggat ggatgtgttg gagattgacc gtgtgctccg gcagacgggc cagcctgagg
     1381 atgaccaggc ctccacctcc acagcctctg agggcgagga caacgttgac gaggagatgg
     1441 agggagaccg ggcaggcctg ggcccaccta agctgaacca tcgtccccag ccggagctgc
     1501 tgaaagccgc cctgccaacc cccagcaccg cccctgcgcc tctgcctgcc catccgcacc
     1561 ctcaccccca cccagtggcc ctgtctcctg cccacctccc tgtgcagcag cagccaccac
     1621 agcaaaagac ccctctgcca gcccctcctc ccccacctgc caccccaacc cagacgctag
     1681 tgccagctcc agcccatctg gtggccacgg ctgggggcgg ctccacagtc atcgcccaca
     1741 cagccacgac ccatgcctca gtcatccaga ctgtgaacca tgttctgcag gggccggggg
     1801 gcaagcacat cgcccacatc gccccctccg cccccagccc tgctgtgcag ctggcacccg
     1861 ccacaccccc catcggccac atcacagtgc accctgccac cctcaaccat gtggcccacc
     1921 tcggctccca gctgcccttg tacccacagc cggtggccgt gagccagccc gtggcagtga
     1981 gccacattgc ccacaccctt tcgcaccagc aagtaaatgg cacagcaggg ctggggcccc
     2041 cagccactgt catggcaaag ccagctgtgg gggcccaggt ggtgcaccac ccccagctgg
     2101 tgggccaaac agtgctcaac cctgtgacga tggtcaccat gccctccttt ccggtcagca
     2161 cactcaagct ggcttgagga tgaggccatt taggccccca gtgggggcag ggaaggggac
     2221 ctgactgcct cttttcccac ccaccagctc cacacattcc agccaggccc aggcccgccc
     2281 cacccacatc acccccaggc ctccttaggg gaagggggtg cggagactct gagccagggg
     2341 aagggaggga ccccagggag ttgggtgcag gcaggaaacc atcctgctgc actaggactt
     2401 ggtagacatg aggatgctat ggtggacatt cctgcctacc cagcctggtg ccggttctgg
     2461 tgccatccac ctccctgctt tgtccccccc cccaggaagt ctgcactgtg gcttacgttc
     2521 tctggcttct ccttccctgg cctgccttcc tgtgctgttg ctgctattgc tctgtctggt
     2581 gaggtggcta agctccctgg cctcccctcc ccagcctcgg agtcctatgg gacctctgta
     2641 taggaaacag ggagccccag aaagatggga aatgggtagg aggggcccag ttctgagcac
     2701 aggtgacaga tctggagtca ggctaggaca agtgaatgcc tgggcctggg gcactctgac
     2761 ccacctgtgg tcactgattg gttacagcag aaactgttca gaatgagtct caaccagtaa
     2821 acaaagtcca ggctgttgtc aggtttccca agcctgcctc tgcgctggga cttccctagc
     2881 gcttcccctg gcccccgggg ttaggtactg cctgaagctt gggaggcgtg gaccagcaat
     2941 ggctctagga actaagccac actgctgagg tatcagtgag ctgaaatccc agggcttttc
     3001 ccatctccct tctcagtggt gatttcgaga ccccttcctg gtgggtgctg cagtgtccat
     3061 ggtggaaagg gcctttgctg ggtgaagaca aggcttagcc tgtgtttggt tacggtgagg
     3121 gtgctgtgct taggggatgc tgtgtttcct gcctctgctt ttgcagactg ctttggcttc
     3181 tctctttaag tgaatattta ttacaagtgg ccttgtgtca gacactcagt tacacgtgtg
     3241 cacattcagc tcctcactgg acactcacca atggcctttc agtatggggc aggaagcaag
     3301 tgtccctaag gtgtgaagtt tgcactgggg gcttaggcag tcgggaggcc agaggggaag
     3361 gctcagggtc cttcagatga cattgtgagc gggcactgag gccagcgaag gtcttgaata
     3421 cattctccct taaaataatg actcctcagg tgcctcagag ctcacaggtc ctcctggccc
     3481 tggaaacccc ccagggcact ttattattat tattgtctcc ccggggtagg gaatggtggc
     3541 taggcccagg tctctactcc ggcggcgcag gaaccccagc gagctggctg ccttcctgtg
     3601 gccgcagccg gccacctcta cccgcactct gactctgggg gccaccactc tctgctctgt
     3661 gttgtgacaa ggggcagagt ctggtgctgg ctgggtcaga ccacttgtcc catttaccct
     3721 tctctctgtc tgaggccagt tccagagttc acaccattgt gttggccccc aggcctgcac
     3781 agatacctca tcatccaccc agccctccct ccccccagca ggggttcctc cagatctagt
     3841 gccgaatgac tatgtccaga ttggtggtga tgggtgttgt tgctgttttt gttatttgtg
     3901 actgctgtgt gcccaagtgg gcagccacct cccagccctt tcttgggcat ctcccctttg
     3961 agagctgtta ggaccacatc tgtcctcacc ctgtgggacc gcctggccct tcccttccta
     4021 ttccttccag cctgggacac acacacatac acatacacac accttacctc tcatgcgtgt
     4081 tttacctgtg ctgtttggag tggctcactg cctgggatct ttacctcggg gaggaaaggg
     4141 gagagtgggt ccctgggggc caaagaaggg caggggatgc ctggagggca gttgggtcac
     4201 catagtctct ctctctaggg acagctgctt cccccacccc aatcccaggg tcccactccc
     4261 aatccccaaa gaggtggccc ttgtttacag tgaggacttg gtcactgtgt ctctgtttcc
     4321 tgaaatatga attgtagcga ccccagactg tagagatttt tatgtgtttg ggtacatctg
     4381 ctgtgtggga aaaaaaaaaa aactacaaaa accctaattt tgtacatatt gtatttttac
     4441 tattgaactg tactctagtg gctgttcatg ctctgagttt aggtattgag acatgaatac
     4501 tatccatgta ataagcactt gcctggaata aaatataaaa ctgaaataaa tctgcactga
     4561 aacctga
//
