LOCUS       NP_001099277             590 aa            linear   ROD 31-MAR-2024
DEFINITION  max-binding protein MNT [Rattus norvegicus].
ACCESSION   NP_001099277 XP_001080632 XP_008766181 XP_220698
VERSION     NP_001099277.2
DBSOURCE    REFSEQ: accession NM_001105807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 590)
  AUTHORS   Takayanagi,T., Eguchi,A., Takaguri,A., Hinoki,A., Bourne,A.M.,
            Elliott,K.J., Hurlin,P.J. and Eguchi,S.
  TITLE     A repressor protein, Mnt, is a novel negative regulator of vascular
            smooth muscle cell hypertrophy by angiotensin II and neointimal
            hyperplasia by arterial injury
  JOURNAL   Atherosclerosis 228 (1), 90-93 (2013)
   PUBMED   23535568
  REMARK    GeneRIF: These data identify Mnt as a previously unrecognized
            negative regulator of pathological vascular remodeling.
REFERENCE   2  (residues 1 to 590)
  AUTHORS   Popov,N., Wahlstrom,T., Hurlin,P.J. and Henriksson,M.
  TITLE     Mnt transcriptional repressor is functionally regulated during cell
            cycle progression
  JOURNAL   Oncogene 24 (56), 8326-8337 (2005)
   PUBMED   16103876
REFERENCE   3  (residues 1 to 590)
  AUTHORS   Hurlin,P.J., Zhou,Z.Q., Toyo-oka,K., Ota,S., Walker,W.L.,
            Hirotsune,S. and Wynshaw-Boris,A.
  TITLE     Deletion of Mnt leads to disrupted cell cycle control and
            tumorigenesis
  JOURNAL   EMBO J 22 (18), 4584-4596 (2003)
   PUBMED   12970171
REFERENCE   4  (residues 1 to 590)
  AUTHORS   Meroni,G., Reymond,A., Alcalay,M., Borsani,G., Tanigami,A.,
            Tonlorenzi,R., Lo Nigro,C., Messali,S., Zollo,M., Ledbetter,D.H.,
            Brent,R., Ballabio,A. and Carrozzo,R.
  TITLE     Rox, a novel bHLHZip protein expressed in quiescent cells that
            heterodimerizes with Max, binds a non-canonical E box and acts as a
            transcriptional repressor
  JOURNAL   EMBO J 16 (10), 2892-2906 (1997)
   PUBMED   9184233
  REMARK    Erratum:[EMBO J 1997 Oct 1;16(19):6055]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XP_008766181.1, NP_001099277.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.43801.1,
                                           SRR26643298.61980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..590
                     /product="max-binding protein MNT"
                     /note="max binding protein; MNT, MAX dimerization protein"
                     /calculated_mol_wt=62997
     Region          222..298
                     /region_name="bHLHzip_Mnt"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in Max-binding protein Mnt and similar proteins;
                     cd11402"
                     /db_xref="CDD:381408"
     Site            order(227..228,231..232,234..235,239,257..259)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381408"
     Site            order(238..239,241..246,248..249,260,263,267,269..271,
                     273..274,276..277,280,284,287..288,290..291,294..295,
                     297..298)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381408"
     Site            order(238,241..242,244..245,248..249,260,263,267,269..271,
                     273..274,276..277,280,284,287..288,290..291,294..295,
                     297..298)
                     /site_type="other"
                     /note="putative tetramer interface [polypeptide binding]"
                     /db_xref="CDD:381408"
     CDS             1..590
                     /gene="Mnt"
                     /coded_by="NM_001105807.2:405..2177"
                     /db_xref="GeneID:287521"
                     /db_xref="RGD:1308683"
ORIGIN      
        1 msietlleaa rflewqaqqq qrareeqerl rlererereq eqkrasnlar lahalpveep
       61 rveapplpls ppapppappp platpapltv ipipvvtnsp qslppppplp paaqplplap
      121 rqpalvstpg lsikepvplp trpqvptpap llpdskttva ptgspkplqp lptpiltiap
      181 hpgvqpqlap qqpppptlgt lklapaeeak sseqkkrpgg igtrevhnkl eknrrahlke
      241 cfetlkrnip nvddkktsnl svlrtalryi qslkrkekey ehemerlare kiatqqrlae
      301 lkhelsqwmd vleidrvlrq tgqpeddqas tstasegedn vdeemegdra glgppklnhr
      361 pqpellkaal ptpstapapl pahphphphp valspahlpv qqqppqqktp lpapppppat
      421 ptqtlvpapa hlvatagggs tviahtatth asviqtvnhv lqgpggkhia hiapsapspa
      481 vqlapatppi ghitvhpatl nhvahlgsql plypqpvavs qpvavshiah tlshqqvngt
      541 aglgppatvm akpavgaqvv hhpqlvgqtv lnpvtmvtmp sfpvstlkla
//
