LOCUS       NM_001191928            7038 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus MN1 proto-oncogene, transcriptional regulator
            (Mn1), mRNA.
ACCESSION   NM_001191928 XM_573413
VERSION     NM_001191928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7038)
  AUTHORS   Ragel,B.T. and Jensen,R.L.
  TITLE     Molecular genetics of meningiomas
  JOURNAL   Neurosurg Focus 19 (5), E9 (2005)
   PUBMED   16398473
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7038)
  AUTHORS   Meester-Smoor,M.A., Vermeij,M., van Helmond,M.J., Molijn,A.C., van
            Wely,K.H., Hekman,A.C., Vermey-Keers,C., Riegman,P.H. and
            Zwarthoff,E.C.
  TITLE     Targeted disruption of the Mn1 oncogene results in severe defects
            in development of membranous bones of the cranial skeleton
  JOURNAL   Mol Cell Biol 25 (10), 4229-4236 (2005)
   PUBMED   15870292
REFERENCE   3  (bases 1 to 7038)
  AUTHORS   Lekanne Deprez,R.H., Riegman,P.H., Groen,N.A., Warringa,U.L., van
            Biezen,N.A., Molijn,A.C., Bootsma,D., de Jong,P.J., Menon,A.G.,
            Kley,N.A. et al.
  TITLE     Cloning and characterization of MN1, a gene from chromosome 22q11,
            which is disrupted by a balanced translocation in a meningioma
  JOURNAL   Oncogene 10 (8), 1521-1528 (1995)
   PUBMED   7731706
REFERENCE   4  (bases 1 to 7038)
  AUTHORS   Buijs,A., Sherr,S., van Baal,S., van Bezouw,S., van der Plas,D.,
            Geurts van Kessel,A., Riegman,P., Lekanne Deprez,R., Zwarthoff,E.,
            Hagemeijer,A. et al.
  TITLE     Translocation (12;22) (p13;q11) in myeloproliferative disorders
            results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene
            on 22q11
  JOURNAL   Oncogene 10 (8), 1511-1519 (1995)
   PUBMED   7731705
  REMARK    Erratum:[Oncogene 1995 Aug 17;11(4):809]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 3, 2022 this sequence version replaced NM_001191928.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.32956.1,
                                           SRR26643297.40524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4596              JAXUCZ010000012.1  50876200-50880795   c
            4597-7038           JAXUCZ010000012.1  50841632-50844073   c
FEATURES             Location/Qualifiers
     source          1..7038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..7038
                     /gene="Mn1"
                     /gene_synonym="RGD1565571"
                     /note="MN1 proto-oncogene, transcriptional regulator"
                     /db_xref="GeneID:498194"
                     /db_xref="RGD:1565571"
     exon            1..4596
                     /gene="Mn1"
                     /gene_synonym="RGD1565571"
                     /inference="alignment:Splign:2.1.0"
     CDS             858..4772
                     /gene="Mn1"
                     /gene_synonym="RGD1565571"
                     /note="probable tumor suppressor protein MN1; meningioma
                     1"
                     /codon_start=1
                     /product="transcriptional activator MN1"
                     /protein_id="NP_001178857.1"
                     /db_xref="GeneID:498194"
                     /db_xref="RGD:1565571"
                     /translation="MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPP
                     PGPVDPAISALGEPPILGLNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHSHP
                     GGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAASGLGSQPPFAESYEHMAESQ
                     GPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLE
                     PRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAM
                     PRASGMVGLSKMHGQPPQPPPPQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQP
                     PQQAPPPPQQQPQQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPS
                     QHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFD
                     FPGSTGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPGPD
                     HQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQHQRLRQPN
                     LAQLGHPGDVGQGGLVHGGSVSGLAQTNFEREGGSTGAGRLGGFEQQAPHLAQESAWF
                     PGPHPPGDLLPRRMGSAGLPADCGPHDPGLAPPPAPGGSGVLFRGSLQEPLRMPGEGH
                     VPALASPGLQFGSSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFG
                     SGSRQATPHSAPGVNSPPSAGAGSGSSGAAGGAYPPQPDFQSSQRNSASKLGALSLGS
                     FNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDS
                     AVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLE
                     STSGSDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQAPG
                     SAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVG
                     EFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASA
                     LGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQI
                     QLQRQQFSISEDQPLGLKGSKKTECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDS
                     LMAEHSTTWYMPPDKALVDGGDDDKTLAPWEKAKSQNPNNKEVHDHPTNKASATQPGS
                     HLQCLTVHCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT"
     exon            4597..7038
                     /gene="Mn1"
                     /gene_synonym="RGD1565571"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccggcgc cggcaagagg cagacgcgga gcgggagccc ggacctcgca gcgcctcgcc
       61 cgccccgcgc gccctgcttg cccgcgcggc cccttcccgg ctccgagggg acccgtggag
      121 cgcggaggcg ggaaccacag cttaggagcc gccggcccca cgcctcccct cccgcgcgcg
      181 ccccgagact cccgcgaact cgcgcagcga ccggcggtcg agcccgagcc gcggagccgc
      241 gcgtctcccg cagcctgcgt tcccgctcca gcgcccgcat ctcctgctgc ggggccatca
      301 ccggcgatga ggagcggagc agcccgtctt ccgagccgct gaagctttcg ccgccgatcg
      361 ccctcggccg accggaggtg cgggagccgg cgcggcccgg gcgcggagac tcggggcagg
      421 ggaaggacca aggggctccc ctacggcccc aaccaccgca ccgcggactc cagaaggtga
      481 tcattccgct ctcccgcccc cttccctccc ccctacctaa ctttttgtct cagctcctcg
      541 gcctccaggt cacctctccg catacccagc cgcggccgtg ccatccgccc ggggcatggg
      601 ccccccgaca aggctccagg aggcgccgcg gcctcgcaag acgtgagagg cccgcttggg
      661 tcgactctga ggttccggag agcagcggag agagctccta gccagcgccc gcgcgctcgg
      721 ccgggcggca gtgagcgctg cgccccgcgg tgcagaaccc ggagctccgg agccgcggct
      781 gaggcgagta gctggccgga ggcgcgcggc ggagcaggct gtcatgccct attgatcccc
      841 ccgccccccc gccaagtatg tttgggctgg accaattcga gccccagatc aacagccggc
      901 acgctggtca gggcgagggg aactttaacg aagccggact gagtatgaac gctcacttta
      961 aggcccctgc tttccacgcc gggcctcctc ctggccccgt ggaccctgca ataagcgctc
     1021 tgggcgaacc cccgatcttg ggtttgaata tggagccata cggcttccat gcgcgcggtc
     1081 actccgagct gcacgcaggg gggttgcagg cacagcctgt gcacggcttc ttcggtggtc
     1141 agcagcctca ccacagccat cctggaggcc atcacccgca ccagcatcac ccacactttg
     1201 ggggcaactt cggtggtccg gacccaggtg cctcatgtct gcacgggggc cggctgcttg
     1261 gctatggagg tgcagcgagc ggcctcggca gccagcctcc cttcgcagag agttacgagc
     1321 acatggcgga gagccagggg ccggagggct tcggcccgca gcggccagga aacctcccgg
     1381 acttccacag ttcgggcact tcgggccacg ctgtgcctgc cccgtgcctg ccgctggacc
     1441 agagccctaa ccgggctgcc tctttccatg gcctgtccgc ctctagcggc tcggattctc
     1501 acagcttgga accccggagg gtgacgaacc aaggagccgt agattcgctg gaatacaatt
     1561 acccgagcga gccgccctca ggacattttg acatgttttc accctctgac tctgaagggc
     1621 agctgccaca ttatgctgcg ggtcgccagg ttcccggggg cgctttcccg ggtgcttcag
     1681 ccatgcccag agcctcaggc atggtgggtt tgtccaaaat gcacggtcag ccaccgcagc
     1741 caccaccacc ccagcagcaa ccgcagcacg gagtgttctt cgagaggttt ggcggggccc
     1801 ggaagatgcc tgtgggtctg gagcctgcag tgggctccag gcacccgcta atgcagcctc
     1861 cccagcaggc cccaccaccc ccgcagcagc agccccagca gcagcagcca ccgccaccac
     1921 ctgggcttct ggtccgacag aattcttgcc ctcctgcgct cccgcggccc cagcagggtg
     1981 aggctggcac acccagtggc ggcctgcagg acgggggccc catgctgccc agccaacacg
     2041 cgcagtttga gtaccctatc catcggctag agaaccggag catgcaccca tattctgaac
     2101 ctgttttcag catgcagcat ccccctcctc aacaggcacc caaccagagg ctgcagcatt
     2161 tcgatgcgcc cccctacatg aacgtggcca agaggccgcg ttttgacttt ccgggcagca
     2221 caggcgtgga ccgctgcgcc tcgtggaatg gcagcatgca caacggcact ctggacaacc
     2281 aactctctcc ctccgcctac ccaggcctcc caggcgagtt cacgccgcct gtgccggaca
     2341 gttttccttc aggaccgccc ttgcagcacc cggggccgga ccaccagtcc ctgcagcagc
     2401 aacagcaaca gcagcagcag cagcagcagc agcaacagca gcagcagcag cagcaacaac
     2461 aacagcagca gcagcagcag caacgccaga acgcggccct catgattaaa cagatggcgt
     2521 cccggaacca gcaccaacgg ttgcgacagc ccaatctggc ccagctaggc caccctgggg
     2581 acgtgggcca gggcggcctt gtccacggag gttccgtgag cggcttggcc cagacgaact
     2641 ttgagcgcga aggcggcagc acaggtgcgg ggcgcctggg tggctttgag cagcaggcgc
     2701 cccacctggc gcaggagagc gcgtggttcc cgggtccaca ccctccggga gacctgctgc
     2761 cccggaggat gggcagcgcg gggttgccgg ctgactgcgg cccgcacgac cctggtctgg
     2821 cgcctccccc tgctccaggt ggttcagggg tgctattccg aggctctctg caggagcctc
     2881 tgaggatgcc tggggaaggc cacgtgcccg cactggcctc gcctgggctg cagtttggga
     2941 gcagcttggc tggcctaggc cagttgcagt cgcccggggc cggtgtggga ctgcccaacg
     3001 ctccgtcgga gcgacggcct ccgcctccgg acttccccgc gccagctctc gggggccagc
     3061 ctggctttcc ctttggctca ggcagccggc aggccacgcc gcacagcgct ccaggcgtga
     3121 attcgccccc gagcgcgggc gcgggcagcg gcagttccgg tgctgctggg ggcgcttacc
     3181 caccacagcc ggatttccaa tccagccagc gcaactcggc cagtaaactg ggcgcgctgt
     3241 ccttggggtc tttcaacaag cccagctcta aggacaacct gtttggccag agctgcctgg
     3301 ctgcgctctc cactgcttgc cagaacatga tcgccagcct gggtgctcct aacctcaacg
     3361 tgactttcaa caagaagaac ccacccgagg ggaagaggaa actgagccag aatgagcccg
     3421 acagcgcggt tgcagccggt aacccgggct cggattactt ccccggaggg actactcctg
     3481 gggcccctgg acccggaggc ccttccggga ccagtggtgg tggctccaaa gcctcaggac
     3541 cgcccaaccc tcccattcag ggggacagca ccagtctttc tcccaattac accctggaat
     3601 caacatcggg tagcgatggc aagcctgtcc ctgggggtag tggccgggga aggggacgca
     3661 gaaaacggga cagtggtcat gtgagccccg ggaccttttt cgacaaatac tccgcagctc
     3721 ctgacagtgg gggcgcacca ggggtgagcc cggggcagca gcaggctcct ggttcagccg
     3781 ctgggggaag ctcagtaaac gaagcccgag ggcccacacc ccatgagaag gccctcacat
     3841 caccatcgtg gggaaaggga gccgagttgc tccttgggga ccagccggac ctcatggcgt
     3901 ccctggacag caccgccaaa tcagatggta gttccccaca cgtgggtgag ttcgcctctg
     3961 atgaggtgag cacaagttat gcgaatgagg acgaagtgtc ctctagttct gacaacacta
     4021 cagccctggc caaagccagc cgaagtcccc tggtgaccag ctcacccaaa ctccctcctc
     4081 gaggagtggg tgctggggaa cacacaccga aggcttctgc cctgggcctg ggcatcctgt
     4141 ctacctctac ctcgacccct gacagctatg gtgggggcgt gggcaccgga catcccggca
     4201 caccaggcct ggaacaggtc cggaccccaa cgagcagcag cggtgcgccg cctcctgacg
     4261 agattcatcc cctggagatc ctccaagccc agatccagct gcagagacag caatttagca
     4321 tctcggagga ccaacccctg gggctcaagg gtagcaaaaa aaccgagtgt gctgtagggg
     4381 cctctggggc acagaatggt gacagcgagc tgggtagctg ctgctcagaa gcagtcaaga
     4441 gcgccatgag caccatcgac ctggactccc tgatggcaga acacagcact acctggtaca
     4501 tgccgcctga caaggccctg gtggatggtg gagacgatga caagacgctg gcgccctggg
     4561 agaaggccaa gtcccagaac cccaacaaca aagaagttca tgaccacccc accaacaagg
     4621 cctcagccac ccagcctggc agtcacctgc agtgtctgac tgtccactgc acagacggcg
     4681 accccaaggc ccgcacctcc gtacccacct ggcggtctct gcactctgac atctccaacc
     4741 gattcgggac atttgtggct gccctgactt gagcccacag gagccgctgc cctaaccacc
     4801 tcgagcgagg gcctctgtgg ctgagcagac tctttacagt ttttgttttt gtttttgttt
     4861 tttttctttt tggtctaggt tggtacttgc ttagtggcac tcggaatgga aagggttggt
     4921 ttaaaggggc tggggagtgt gattttaaga aaagaacctc agaaagttat cttaaagaaa
     4981 cggtgtgcca caccgtgacg tgcctgtgtc agcctcaaga gcagacgctg gtgcaagcct
     5041 tttccctgct agagaaaccc cattttctgt actccttgtg tgttctagaa ggctcttgcc
     5101 ttgtttaagc ccggccaggg gtacctgtaa ccccattttt taaaaattct ctttgattct
     5161 ctttccctca ctcttttctg tttgctttgt tcatccctac ggagatcttg gaggagcatt
     5221 gctgggtgga agccgcaggg tcatggcagt gttgactgct gacagacacc gaacagctca
     5281 gaagagcctt caggcactgg gttttctctg ttccctgaga atttgcagag aggtcttttc
     5341 ctcactggct cttagccttc agctagcttc catccctccc actgggagct gtccctctgg
     5401 tccctcctaa gttgtgaact ggatgctggg ataaagggga ggagcctgtc agggccatag
     5461 gcatcctctc cttcactgaa gtgaccgtgg caccatctgc tttctctgtg gccttgtgac
     5521 cctcaaaggg cacaagggag ggtctgtcag ttgtccaagg gacttcctgg ccctgctttc
     5581 ccagatggcg gacagagtgc ctcagcttcc tgagtcccat ctaccgtagc atgccctatg
     5641 tgattctatc cccaggagga ggcattgagg cagccagatt caatcccaga cactcacaga
     5701 tcctggaagg aaggaaaata aacggagtag tggcttcgtg atgcccatcc ctggtcctca
     5761 cgttcccttt cgtggatgtc tcctgccctt ttgattcact ttcattctga tttaaaagca
     5821 gagccctgcc cactatgtcc tccacgagag acgcttccac ctaagtggag aggagtcgag
     5881 atggccgagc tgatatggac agcatttagg gtgtgatctg tcctctgcca acctacaggg
     5941 cccactgcta cgctgcgggg ctgtgcatcc ctgggacggt caggccaggg ctagcactga
     6001 tgtttcagag ctcggtcttt gctgtcggca cgtctcctca attactcctt tctaagcccc
     6061 aaccctaact tgacagaccc ctccccgttc catttcttag caagaggtcc gaaagcttgg
     6121 ggctgtccag atacccatat tgctcgtgtc aagggacttt caactgtggg agccccttcc
     6181 caaaagcagg ctatctccct caagccctcc tcctcctcct catggctgag gcctgagccc
     6241 ccagggtctg tacttgttgc ccgggtagtg tgataggact cagagggcag agacaggtgg
     6301 cacgggctgg tgaggaagaa gggccctctg ttctgtgccc aaagcagtga ggggtggttt
     6361 ccttcttcca cagaggcatc cttcaggctt tggttgccca gagtttgtga catctagcta
     6421 tctgagagtg tcagcctttc actccccaaa caagaacgac agtctgcagt gcttaaggct
     6481 gggactagca tgctaacggc cgcctgtgaa cttcccagca tcaacccaca cgcagcgtgt
     6541 ggctcaggtc acccggaagt gtccacagtg ttatctgttc tcactcccca cgacccccgg
     6601 gtggagcagc ttttaaaata gccttaagca aaaggacatc atcgtgtcac taaaatttgg
     6661 tttggtggaa agaataaaag tagaagaaaa ccccgcccga agcgcaggag cctgggaaca
     6721 ctgtaatcag tgcgcagcca actccagtag agagaaggga attgctattg cacatgtatc
     6781 atatgaaccc ttagccctgc ggtgcggtgc ggtgcgcgag cctgtcagct ttcttgactc
     6841 ttaaagaaaa ccatttctga atgcttggtt ggaagacagt gactgacaat agctcatgaa
     6901 actgagtggt atttttcttt ctttttttaa aaaaaacaaa atatgtaaag ttgagtcttc
     6961 cgtattcacg catactgtat atacgtgtat atgttttgct gagcagctta aataacaata
     7021 aatacaacgt taacggtg
//
