LOCUS       NM_001271596            3472 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MMS19 homolog, cytosolic iron-sulfur assembly
            component (Mms19), mRNA.
ACCESSION   NM_001271596 XM_002725801 XM_003749120
VERSION     NM_001271596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3472)
  AUTHORS   Weon,J.L., Yang,S.W. and Potts,P.R.
  TITLE     Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a
            Cancer-Amplified Ubiquitin Ligase
  JOURNAL   Mol Cell 69 (1), 113-125 (2018)
   PUBMED   29225034
REFERENCE   2  (bases 1 to 3472)
  AUTHORS   Paul,V.D. and Lill,R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   3  (bases 1 to 3472)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   4  (bases 1 to 3472)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   5  (bases 1 to 3472)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   6  (bases 1 to 3472)
  AUTHORS   Gari,K., Leon Ortiz,A.M., Borel,V., Flynn,H., Skehel,J.M. and
            Boulton,S.J.
  TITLE     MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA
            metabolism
  JOURNAL   Science 337 (6091), 243-245 (2012)
   PUBMED   22678361
REFERENCE   7  (bases 1 to 3472)
  AUTHORS   Ito,S., Tan,L.J., Andoh,D., Narita,T., Seki,M., Hirano,Y.,
            Narita,K., Kuraoka,I., Hiraoka,Y. and Tanaka,K.
  TITLE     MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in
            chromosome segregation
  JOURNAL   Mol Cell 39 (4), 632-640 (2010)
   PUBMED   20797633
REFERENCE   8  (bases 1 to 3472)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 3472)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   10 (bases 1 to 3472)
  AUTHORS   Matsuki,Y., Nakashima,M., Amizuka,N., Warshawsky,H., Goltzman,D.,
            Yamada,K.M. and Yamada,Y.
  TITLE     A compilation of partial sequences of randomly selected cDNA clones
            from the rat incisor
  JOURNAL   J Dent Res 74 (1), 307-312 (1995)
   PUBMED   7876422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 21, 2012 this sequence version replaced
            XM_003749120.1, XM_002725801.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.6509.1,
                                           SRR26360190.1360139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000001.1  250743446-250743582 c
            138-186             JAXUCZ010000001.1  250731868-250731916 c
            187-287             JAXUCZ010000001.1  250728119-250728219 c
            288-373             JAXUCZ010000001.1  250726708-250726793 c
            374-448             JAXUCZ010000001.1  250726337-250726411 c
            449-518             JAXUCZ010000001.1  250725683-250725752 c
            519-647             JAXUCZ010000001.1  250725247-250725375 c
            648-709             JAXUCZ010000001.1  250725099-250725160 c
            710-796             JAXUCZ010000001.1  250720435-250720521 c
            797-871             JAXUCZ010000001.1  250719737-250719811 c
            872-949             JAXUCZ010000001.1  250719101-250719178 c
            950-1088            JAXUCZ010000001.1  250718428-250718566 c
            1089-1243           JAXUCZ010000001.1  250718024-250718178 c
            1244-1322           JAXUCZ010000001.1  250717510-250717588 c
            1323-1448           JAXUCZ010000001.1  250717127-250717252 c
            1449-1530           JAXUCZ010000001.1  250716859-250716940 c
            1531-1631           JAXUCZ010000001.1  250716361-250716461 c
            1632-1781           JAXUCZ010000001.1  250716111-250716260 c
            1782-1937           JAXUCZ010000001.1  250714854-250715009 c
            1938-2037           JAXUCZ010000001.1  250713113-250713212 c
            2038-2140           JAXUCZ010000001.1  250712351-250712453 c
            2141-2209           JAXUCZ010000001.1  250712025-250712093 c
            2210-2336           JAXUCZ010000001.1  250711722-250711848 c
            2337-2437           JAXUCZ010000001.1  250710718-250710818 c
            2438-2494           JAXUCZ010000001.1  250710236-250710292 c
            2495-2681           JAXUCZ010000001.1  250709373-250709559 c
            2682-2764           JAXUCZ010000001.1  250708142-250708224 c
            2765-2929           JAXUCZ010000001.1  250707842-250708006 c
            2930-2989           JAXUCZ010000001.1  250707712-250707771 c
            2990-3090           JAXUCZ010000001.1  250707055-250707155 c
            3091-3472           JAXUCZ010000001.1  250706595-250706976 c
FEATURES             Location/Qualifiers
     source          1..3472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3472
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /note="MMS19 homolog, cytosolic iron-sulfur assembly
                     component"
                     /db_xref="GeneID:171124"
                     /db_xref="RGD:727890"
     exon            1..137
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3118
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /note="incisor protein; MMS19-like (MET18 homolog, S.
                     cerevisiae); MMS19 nucleotide excision repair-like; MMS19
                     nucleotide excision repair homolog; MMS19 cytosolic
                     iron-sulfur assembly component"
                     /codon_start=1
                     /product="MMS19 nucleotide excision repair protein
                     homolog"
                     /protein_id="NP_001258525.1"
                     /db_xref="GeneID:171124"
                     /db_xref="RGD:727890"
                     /translation="MAAATALEEAAAPMGALCGLVQDFVMGQQEGPADQVAADVKSGG
                     YTVLQVVEALGSSLENPEPRTRARGIQLLSQVLLQCHSLLLEKEAVHLTLFYENRLKD
                     HHLVVPSVLQGLRALSLSVALPRGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFM
                     RSREEELKSLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYNLGPFVEELFEV
                     TSCYFPIDFTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAK
                     LDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLS
                     CSVLRADAEDLLHPFLSSILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACEHITS
                     NVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDRDERPLSNFKDQLCSLVF
                     MALTDPSTQLQLVGIRMLTVLGAQPDLLSAEDLELAVGHLYRLSLLEEDAQSCRVAAL
                     EASGSLATLYPGAFSSHLLPRLAEGLHQGESDVARADGPTKCSRHFRCLQALSAVSTH
                     PDIVKETLPLLLQHLCQAHKGNMITESSEVVAVCQSLQQVAEKCQQDPESYWYFHKTA
                     VPCLFALAVQASVPEKASSVLSKALLEDEVLAALASVIGTATTHLSPELAAQSVTCIV
                     PLFLDGNTSFLPENSFPGHFQPFQGGSSGQRRLVALLMAFVCSLPRNVEIPELTRLMQ
                     ELLKQSCGHSCPFSSTAASKCFAGLLNKQPPGQQLDEFLQLSVDTVEAGLASESSRNQ
                     AFTLLLWVTKALVLRYHPLSASLTARLMGLLSDPELGCAAADGFSLLMSDCTDVLTRA
                     GHADVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPT
                     LLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSLHVDTLVTKFLNLSSSHSMAVR
                     IAALQCMHALTRLPTSVLLPFKSQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPG
                     S"
     exon            138..186
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            187..287
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            288..373
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            374..448
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            449..518
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            519..647
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            648..709
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            710..796
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            797..871
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            872..949
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1088
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1243
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1322
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1448
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1530
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1631
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1781
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1937
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2037
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2140
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2209
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2336
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2437
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2494
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2681
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2764
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2929
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..2989
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3090
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3472
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacagtct ctggctcgcg tcatggctgc cgccactgct ctggaggagg cagcggcgcc
       61 tatgggcgcc ctgtgtggcc tcgtgcaaga cttcgtcatg ggtcagcagg aggggcccgc
      121 tgaccaggtg gctgcagatg tgaaatccgg tggctataca gtgttacaag tagtagaagc
      181 cctcgggtcc tctctggaga atccagaacc ccgaactcgg gctcgaggaa tccagctttt
      241 gtcacaggtg ctactccagt gtcactcctt gctcttggag aaggaagcag tccacctgac
      301 cctgttctat gagaaccggc tgaaggacca ccatcttgtg gtcccatctg tcctgcaggg
      361 cctgagggca ctgagcctgt ctgtggccct gccccggggc ctggctgtct ctgtgcttaa
      421 agccatcttc caggaggtac acgtacagtc cctgctacag gtagaccgcc atactgtctt
      481 cagtatcatc actaacttca tgcgatcacg agaagaagag ctgaagagcc taggagctga
      541 cttcacattt ggcttcatcc aggtgatgga tggagaaaag gatccccgta atcttttgtt
      601 ggctttccgc atcgtccacg acctcatctc caaggactac aatctgggac cttttgtgga
      661 agagttattt gaagtgacat cttgttattt ccctattgat tttacccctc ctcctaatga
      721 tccttatggc atccagagag aggatctcat cctgagtctc cgtgctgtgc tggcttccac
      781 accgcggttt gctgagttct tactgcctct gctaattgag aaagtggatt ctgagatttt
      841 aagtgccaag ctggattctc tgcaaactct gaatgcttgc tgtgctgtgt atggacagaa
      901 ggagctaaag gacttcctcc ccagcctttg ggcatccatc cgcagagagg ttttccagac
      961 agcgagtgag cgagtagagg ctgagggcct ggcagctctc cattccctga ctgcgtgtct
     1021 gtcttgctct gtgctgagag ctgatgctga ggacctcctc catcccttcc tcagcagcat
     1081 tctacaagac tgcaggcacc atctatgtga accagacatg aaacttgtat ggcctagcgc
     1141 taagctgtta caggcagctg caggtgcatc tgcccgggcc tgtgagcaca tcaccagcaa
     1201 cgtgcttccc ttgctgctgg aacagttcca caagcacagc cagagcaacc agcggcggac
     1261 aatccttgaa atgatcctgg gattcttaaa gctgcagcag aaatggagct acgaagacag
     1321 agatgaaagg cctctgagta acttcaaaga ccagctgtgc tcattggtgt tcatggctct
     1381 aacggatccc agcacccagc ttcagcttgt tggcatccgg atgctgacgg tcttgggtgc
     1441 ccagccagat ctgctgtctg ctgaggactt ggagttagca gtaggtcacc tctaccgact
     1501 gagcttgctg gaggaagatg cccagagttg tagggtggca gcattggagg catcaggatc
     1561 cctggccact ctgtatcccg gagccttcag cagccactta ctacccaggc ttgctgaggg
     1621 gctgcatcaa ggggagtcag acgtggctag agcggatggg cccaccaaat gttctcggca
     1681 ttttcgctgt ctgcaagctt tgtcagctgt ttcgacacat cccgacattg tcaaggagac
     1741 actgcctctg ctactgcagc atctctgtca ggcacacaaa gggaatatga ttacagagtc
     1801 cagtgaagtt gttgctgttt gtcagagtct ccagcaggtg gcagaaaaat gccagcagga
     1861 ccctgagagc tactggtatt tccacaagac tgctgtgccc tgcctgtttg cattagctgt
     1921 gcaggcttca gtgccagaga aggcgtcctc cgttctgagc aaagcactgt tggaggatga
     1981 ggtcttggcc gcattggctt ctgtcattgg cacagccact acccatctga gccctgaact
     2041 agctgcccag agtgtcacat gcatcgtgcc cctcttccta gatggcaaca cctcctttct
     2101 acctgaaaac agcttcccag gccacttcca gccattccag ggcggctcct ctgggcaaag
     2161 gcggctggtt gcactactta tggctttcgt ctgctccctg ccacgaaatg tggaaatccc
     2221 cgagctgacc cgactcatgc aggagctttt gaagcagagc tgtggccaca gctgtccctt
     2281 ctcctccact gctgcctcca agtgctttgc agggctcctc aataagcagc ctccagggca
     2341 gcagttggat gagttcctcc agctctctgt ggacacagtg gaggcgggtc tggcctctga
     2401 atcctcccgt aatcaggctt tcacactgct gctctgggta accaaggctc tagtcctcag
     2461 gtaccatcct ctcagtgcca gcctaaccgc tcggctcatg ggcctcctca gcgacccaga
     2521 actaggctgt gcagcagctg atggcttctc tctgctcatg tctgactgca ctgatgtgct
     2581 gactcgggcc ggccatgctg atgttcggat catgttccgc cagcgcttct tcacagacaa
     2641 tgtgcctgct ttggtccagg gtttccatgc tgctccccaa gatgtgaagc caaactatct
     2701 gaagggtcta tctcatgtac tcaacaggct gcctaagcct gtgcttttac cagagctgcc
     2761 cacactcctt tccttgctgc tggaggcact gtcctgccct gactctgtgg tccagctttc
     2821 cactttgagc tgtctccaac ccttactact ggaagcaccc caaatcatga gtcttcatgt
     2881 tgatactctg gtcacgaaat tcctgaacct cagttccagt cattcaatgg ccgtccggat
     2941 tgctgctctg cagtgtatgc atgctctcac tcggctaccc acttctgtgt tgctgccatt
     3001 caaatctcag gtgatccgag ctttagccaa gcctctggat gacaagaaga gacttgtgcg
     3061 caaggaagca gtgtcagcaa ggggagaatg gttcctactg gggagccctg ggagctgagc
     3121 ccttggtcct cacctaaacc ctcctgacaa tctaacccgc aagtactaat attgagccat
     3181 cccacaaggc aagaccaccc actggcctgc ccgcccatgg atgcagtaca aatgctgggc
     3241 ctctcctgca tggctgtgca aaactctttt ccaagagcca tgatttctaa tggattgttg
     3301 aagagactga gacttgtatt tgaggaaaag atcttgggct ctcctgtgtc ctatcaggac
     3361 actacgtggc tgtgctgctg aagggccaat ccagttgagt gtgaccttga gaactaggga
     3421 tgtgtgttac atgaatgcac ctgccagcga ataaagactt ttgtaatggg ca
//
