LOCUS       NP_001258525            1031 aa            linear   ROD 31-MAR-2024
DEFINITION  MMS19 nucleotide excision repair protein homolog [Rattus
            norvegicus].
ACCESSION   NP_001258525 XP_002725847 XP_003749168
VERSION     NP_001258525.1
DBSOURCE    REFSEQ: accession NM_001271596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1031)
  AUTHORS   Weon,J.L., Yang,S.W. and Potts,P.R.
  TITLE     Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a
            Cancer-Amplified Ubiquitin Ligase
  JOURNAL   Mol Cell 69 (1), 113-125 (2018)
   PUBMED   29225034
REFERENCE   2  (residues 1 to 1031)
  AUTHORS   Paul,V.D. and Lill,R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   3  (residues 1 to 1031)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   4  (residues 1 to 1031)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   5  (residues 1 to 1031)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   6  (residues 1 to 1031)
  AUTHORS   Gari,K., Leon Ortiz,A.M., Borel,V., Flynn,H., Skehel,J.M. and
            Boulton,S.J.
  TITLE     MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA
            metabolism
  JOURNAL   Science 337 (6091), 243-245 (2012)
   PUBMED   22678361
REFERENCE   7  (residues 1 to 1031)
  AUTHORS   Ito,S., Tan,L.J., Andoh,D., Narita,T., Seki,M., Hirano,Y.,
            Narita,K., Kuraoka,I., Hiraoka,Y. and Tanaka,K.
  TITLE     MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in
            chromosome segregation
  JOURNAL   Mol Cell 39 (4), 632-640 (2010)
   PUBMED   20797633
REFERENCE   8  (residues 1 to 1031)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (residues 1 to 1031)
  AUTHORS   Wu,X., Li,H. and Chen,J.D.
  TITLE     The human homologue of the yeast DNA repair and TFIIH regulator
            MMS19 is an AF-1-specific coactivator of estrogen receptor
  JOURNAL   J Biol Chem 276 (26), 23962-23968 (2001)
   PUBMED   11279242
REFERENCE   10 (residues 1 to 1031)
  AUTHORS   Matsuki,Y., Nakashima,M., Amizuka,N., Warshawsky,H., Goltzman,D.,
            Yamada,K.M. and Yamada,Y.
  TITLE     A compilation of partial sequences of randomly selected cDNA clones
            from the rat incisor
  JOURNAL   J Dent Res 74 (1), 307-312 (1995)
   PUBMED   7876422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 21, 2012 this sequence version replaced
            XP_003749168.1, XP_002725847.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.6509.1,
                                           SRR26360190.1360139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     Protein         1..1031
                     /product="MMS19 nucleotide excision repair protein
                     homolog"
                     /note="incisor protein; MMS19-like (MET18 homolog, S.
                     cerevisiae); MMS19 nucleotide excision repair-like; MMS19
                     nucleotide excision repair homolog; MMS19 cytosolic
                     iron-sulfur assembly component"
                     /calculated_mol_wt=112801
     Region          54..312
                     /region_name="MMS19_N"
                     /note="Dos2-interacting transcription regulator of
                     RNA-Pol-II; pfam14500"
                     /db_xref="CDD:433995"
     Region          556..983
                     /region_name="MMS19_C"
                     /note="RNAPII transcription regulator C-terminal;
                     pfam12460"
                     /db_xref="CDD:463594"
     CDS             1..1031
                     /gene="Mms19"
                     /gene_synonym="Mms19l"
                     /coded_by="NM_001271596.1:23..3118"
                     /db_xref="GeneID:171124"
                     /db_xref="RGD:727890"
ORIGIN      
        1 maaataleea aapmgalcgl vqdfvmgqqe gpadqvaadv ksggytvlqv vealgsslen
       61 peprtrargi qllsqvllqc hslllekeav hltlfyenrl kdhhlvvpsv lqglralsls
      121 valprglavs vlkaifqevh vqsllqvdrh tvfsiitnfm rsreeelksl gadftfgfiq
      181 vmdgekdprn lllafrivhd liskdynlgp fveelfevts cyfpidftpp pndpygiqre
      241 dlilslravl astprfaefl lplliekvds eilsakldsl qtlnaccavy gqkelkdflp
      301 slwasirrev fqtaservea eglaalhslt aclscsvlra daedllhpfl ssilqdcrhh
      361 lcepdmklvw psakllqaaa gasaracehi tsnvlpllle qfhkhsqsnq rrtilemilg
      421 flklqqkwsy edrderplsn fkdqlcslvf maltdpstql qlvgirmltv lgaqpdllsa
      481 edlelavghl yrlslleeda qscrvaalea sgslatlypg afsshllprl aeglhqgesd
      541 varadgptkc srhfrclqal savsthpdiv ketlplllqh lcqahkgnmi tessevvavc
      601 qslqqvaekc qqdpesywyf hktavpclfa lavqasvpek assvlskall edevlaalas
      661 vigtatthls pelaaqsvtc ivplfldgnt sflpensfpg hfqpfqggss gqrrlvallm
      721 afvcslprnv eipeltrlmq ellkqscghs cpfsstaask cfagllnkqp pgqqldeflq
      781 lsvdtveagl asessrnqaf tlllwvtkal vlryhplsas ltarlmglls dpelgcaaad
      841 gfsllmsdct dvltraghad vrimfrqrff tdnvpalvqg fhaapqdvkp nylkglshvl
      901 nrlpkpvllp elptllslll ealscpdsvv qlstlsclqp llleapqims lhvdtlvtkf
      961 lnlssshsma vriaalqcmh altrlptsvl lpfksqvira lakplddkkr lvrkeavsar
     1021 gewfllgspg s
//
