LOCUS       NM_031055               2985 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus matrix metallopeptidase 9 (Mmp9), mRNA.
ACCESSION   NM_031055
VERSION     NM_031055.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Ishibashi,R., Itani,M., Kawashima,A., Arakawa,Y. and Aoki,T.
  TITLE     JNK2-MMP-9 axis facilitates the progression of intracranial
            aneurysms
  JOURNAL   Sci Rep 14 (1), 19458 (2024)
   PUBMED   39169203
  REMARK    GeneRIF: JNK2-MMP-9 axis facilitates the progression of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Li,Z., Liu,Y., Li,X., Yang,S., Feng,S., Li,G., Jin,F. and Nie,S.
  TITLE     Knockdown the moyamoya disease susceptibility gene, RNF213,
            upregulates the expression of basic fibroblast growth factor and
            matrix metalloproteinase-9 in bone marrow derived mesenchymal stem
            cells
  JOURNAL   Neurosurg Rev 47 (1), 246 (2024)
   PUBMED   38811382
  REMARK    GeneRIF: Knockdown the moyamoya disease susceptibility gene,
            RNF213, upregulates the expression of basic fibroblast growth
            factor and matrix metalloproteinase-9 in bone marrow derived
            mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2985)
  AUTHORS   Arkelius,K., Wendt,T.S., Andersson,H., Arnou,A., Gottschalk,M.,
            Gonzales,R.J. and Ansar,S.
  TITLE     LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of
            Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic
            Stroke
  JOURNAL   Circ Res 134 (8), 954-969 (2024)
   PUBMED   38501247
  REMARK    GeneRIF: LOX-1 and MMP-9 Inhibition Attenuates the Detrimental
            Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute
            Ischemic Stroke.
REFERENCE   4  (bases 1 to 2985)
  AUTHORS   Wushouer,X., Aximujiang,K., Kadeer,N., Aihemaiti,A., Zhong,L. and
            Yunusi,K.
  TITLE     Effect of huankuile on colon injury in rats with ulcerative colitis
            by reducing TNF-alpha and MMP9
  JOURNAL   Eur J Med Res 29 (1), 102 (2024)
   PUBMED   38321559
  REMARK    GeneRIF: Effect of huankuile on colon injury in rats with
            ulcerative colitis by reducing TNF-alpha and MMP9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2985)
  AUTHORS   Egorov,D., Kopaliani,I., Ameln,A.K., Speier,S. and Deussen,A.
  TITLE     Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory
            macrophages and cardiomyocytes
  JOURNAL   Exp Cell Res 434 (1), 113868 (2024)
   PUBMED   38043722
  REMARK    GeneRIF: Mechanism of pro-MMP9 activation in co-culture of
            pro-inflammatory macrophages and cardiomyocytes.
REFERENCE   6  (bases 1 to 2985)
  AUTHORS   Okada,A., Santavicca,M. and Basset,P.
  TITLE     The cDNA cloning and expression of the gene encoding rat gelatinase
            B
  JOURNAL   Gene 164 (2), 317-321 (1995)
   PUBMED   7590350
REFERENCE   7  (bases 1 to 2985)
  AUTHORS   Nakano,A., Tani,E., Miyazaki,K., Yamamoto,Y. and Furuyama,J.
  TITLE     Matrix metalloproteinases and tissue inhibitors of
            metalloproteinases in human gliomas
  JOURNAL   J Neurosurg 83 (2), 298-307 (1995)
   PUBMED   7616276
REFERENCE   8  (bases 1 to 2985)
  AUTHORS   Lei,H., Vadillo-Ortega,F., Paavola,L.G. and Strauss,J.F. 3rd.
  TITLE     92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat
            amnion immediately prior to parturition
  JOURNAL   Biol Reprod 53 (2), 339-344 (1995)
   PUBMED   7492685
REFERENCE   9  (bases 1 to 2985)
  AUTHORS   Wilhelm,S.M., Collier,I.E., Marmer,B.L., Eisen,A.Z., Grant,G.A. and
            Goldberg,G.I.
  TITLE     SV40-transformed human lung fibroblasts secrete a 92-kDa type IV
            collagenase which is identical to that secreted by normal human
            macrophages
  JOURNAL   J Biol Chem 264 (29), 17213-17221 (1989)
   PUBMED   2551898
  REMARK    Erratum:[J Biol Chem 1990 Dec 25;265(36):22570]
REFERENCE   10 (bases 1 to 2985)
  AUTHORS   Santolini,B.M., Nai Fovino,P.L. and Rossoni,L.
  TITLE     [The behavior of intra-leukocyte peroxidase after irradiation with
            radar microwaves in intra-articular exudates]
  JOURNAL   Minerva Ortop 22 (12), 459-462 (1971)
   PUBMED   5135051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031055.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24441.1, U36476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000003.1  174103474-174103614
            142-374             JAXUCZ010000003.1  174104056-174104288
            375-523             JAXUCZ010000003.1  174104520-174104668
            524-652             JAXUCZ010000003.1  174105067-174105195
            653-826             JAXUCZ010000003.1  174105305-174105478
            827-1000            JAXUCZ010000003.1  174105653-174105826
            1001-1177           JAXUCZ010000003.1  174106189-174106365
            1178-1333           JAXUCZ010000003.1  174106497-174106652
            1334-1619           JAXUCZ010000003.1  174107442-174107727
            1620-1759           JAXUCZ010000003.1  174107842-174107981
            1760-1910           JAXUCZ010000003.1  174108232-174108382
            1911-2014           JAXUCZ010000003.1  174108485-174108588
            2015-2985           JAXUCZ010000003.1  174110464-174111434
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2985
                     /gene="Mmp9"
                     /note="matrix metallopeptidase 9"
                     /db_xref="GeneID:81687"
                     /db_xref="RGD:621320"
     CDS             1..2127
                     /gene="Mmp9"
                     /EC_number="3.4.24.35"
                     /note="matrix metalloproteinase-9; gelatinase B; 92-kDa
                     type IV collagenase; GELB; MMP-9; 92 kDa gelatinase;
                     matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV
                     collagenase)"
                     /codon_start=1
                     /product="matrix metalloproteinase-9 precursor"
                     /protein_id="NP_112317.2"
                     /db_xref="GeneID:81687"
                     /db_xref="RGD:621320"
                     /translation="MNPWQPLLLVLLALGYSFAAPHQRQPTYVVFPRDLKTSNLTDTQ
                     LAEDYLYRYGYTRAAQMMGEKQSLRPALLMLQKQLSLPQTGELDSETLKAIRSPRCGV
                     PDVGKFQTFEGDLKWHHHNITYWIQSYTEDLPRDVIDDSFARAFAVWSAVTPLTFTRV
                     YGLEADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGAV
                     VPTYFGNANGAPCHFPFTFEGRSYLSCTTDGRNDGKPWCGTTADYDTDRKYGFCPSEN
                     LYTEHGNGDGKPCVFPFIFEGHSYSACTTKGRSDGYRWCATTANYDQDKLYGFCPTRA
                     DVTVTGGNSAGEMCVFPFVFLGKQYSTCTGEGRSDGRLWCATTSNFDADKKWGFCPDQ
                     GYSLFLVAAHEFGHALGLDHSSVPEALMYPMYHYHEDSPLHEDDIKGIQHLYGRGSKP
                     DPRPPATTAAEPQPTAPPTMCPTAPPMAYPTGGPTVAPTGAPSPGPTGPPTAGPSEAP
                     TESSTPVDNPCNVDVFDAIADIQGALHFFKDGRYWKFSNHGGSQLQGPFLIARTWPAL
                     PAKLNSAFEDPQSKKIFFFSGRKMWVYTGQSVLGPRSLDKLGLGSEVTLVTGLLPRRG
                     GKALLISRERIWKFDLKSQKVDPQSVTRLDNEFSGVPWNSHNVFHYQDKAYFCHDKYF
                     WRVSFHNRVNQVDHVAYVTYDLLQCP"
     exon            1..141
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            142..374
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            375..523
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            524..652
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            653..826
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1000
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1177
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1333
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1619
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1759
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1910
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2014
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2985
                     /gene="Mmp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacccct ggcagcccct gctcctggtg ctcctggctc taggctacag ctttgctgcc
       61 cctcaccagc gccagccgac ttatgtggtc ttcccccgag acctgaaaac ctccaacctc
      121 acggacacac agctggcaga ggattacctg taccgctatg gttacactcg ggcagcccag
      181 atgatgggag agaagcagtc cctgcggccc gctttgctga tgcttcagaa gcagctgtcc
      241 ctgccccaga ctggtgagct ggacagcgag acactaaagg ccattcgttc accgcgctgt
      301 ggtgtcccag acgtgggcaa attccaaacc ttcgaaggcg acctcaagtg gcaccatcat
      361 aacatcacct attggatcca aagctacacc gaagacttgc cgcgagacgt gatcgatgac
      421 tccttcgcgc gcgccttcgc ggtgtggagc gcggtgacac cgctcacctt cacccgcgtg
      481 tacgggctcg aagcagacat tgtcatccag tttggtgtcg cggagcacgg ggacgggtat
      541 cccttcgacg gcaaggatgg tctactggca cacgcctttc cccctggccc cggcattcag
      601 ggagatgccc acttcgacga cgacgagttg tggtcgctgg gcaaaggcgc cgtggtcccc
      661 acttactttg gaaacgcaaa tggtgcccca tgtcactttc ccttcacctt cgagggacgc
      721 tcctatttgt cctgcaccac ggatggccgc aacgacggca agccttggtg tggcacgaca
      781 gctgactacg acacagacag aaaatatggt ttctgcccca gtgagaatct ctacacggag
      841 catggcaacg gagacggcaa accctgcgta tttccattca tcttcgaggg ccactcctac
      901 tctgcctgca ccactaaagg tcgctcggat ggttatcgct ggtgcgccac caccgccaac
      961 tatgaccagg ataagctgta tggcttctgt cctactcgag ccgacgtcac tgtaactggg
     1021 ggcaactcgg caggagagat gtgcgtcttc cccttcgtct tcctgggcaa gcagtactct
     1081 acctgtaccg gcgagggccg cagtgatggg cgcctctggt gcgcgacgac gtcgaacttc
     1141 gacgctgaca agaagtgggg tttctgtcca gaccaagggt acagcctgtt tctggtggca
     1201 gcgcacgagt tcggccatgc gctgggctta gatcattctt cagtgccgga agcgctcatg
     1261 taccccatgt atcactacca cgaggactcc cctctgcatg aagacgacat aaaaggcatc
     1321 cagcatctgt atggtcgtgg ctctaaacct gacccaaggc ctccagccac caccgcagct
     1381 gaaccacagc cgacagctcc tcccactatg tgtcccactg cacctcccat ggcctatccc
     1441 acagggggcc ccacagtcgc ccctacaggc gccccctcac ctggccccac aggtccccct
     1501 actgctggtc cttctgaggc ccctacagag tcttcgactc cagtagacaa tccttgcaat
     1561 gtggatgttt ttgatgccat tgctgatatc cagggcgctc tgcatttctt caaggacggt
     1621 cggtattgga agttctcgaa tcacggagga agccaattgc agggcccctt tcttattgcc
     1681 cgcacgtggc cagctttgcc tgcaaagttg aactcagcct ttgaggatcc gcagtccaag
     1741 aagattttct tcttctctgg gcgcaaaatg tgggtgtaca caggccagtc ggtgctgggc
     1801 cccaggagtc tggataagtt gggtctaggc tcagaggtaa ccctggtcac cggacttctc
     1861 ccgcgtcgtg gagggaaggc tctgctgatc agccgggaac gtatctggaa attcgacttg
     1921 aagtctcaga aggtggatcc ccagagcgtt actcgcttgg ataacgagtt ctctggcgtg
     1981 ccctggaact cacacaacgt ctttcactac caagacaagg cctatttctg ccatgacaaa
     2041 tacttctggc gtgtgagttt ccacaaccgg gtgaaccagg tggaccacgt ggcctacgtg
     2101 acctatgacc tcctgcagtg cccttgaact aaggctcctc ttttgcttca gcggtgcagc
     2161 gcaagcctct agagaccacc cctgaggggg aggagctagt ttgccggata caaactggtg
     2221 atctcttcta gagactagga aggagtggag gcgggcaggg ccctctctgc acgctgtcct
     2281 ttcttgttgg actgtttcta ataaacacgg atcccccaac ctttaccagc tactcgaacc
     2341 aatcagcttg tctgtagttg tatacacatc caagcctgtg gttggtcaga agacaacttt
     2401 gtagggtcgg ttctgacctt ttgtttttat ggggcatctg gggattgaac tcagctggct
     2461 tttgtgacaa gtacttcacc cgctgcacca ccttaccggc ccttttattt attatgtatg
     2521 tggtcatgtt cacacacatg tatttaacct atagaatgct tactgtgcgt cgggcgctgc
     2581 tccaactgct gtataaatat taaggtattc agttactcct actggaaggt attatgtaac
     2641 catttctctc ttacatcgga ggacaccacc gagctatcca ctcatcaaac atttattgtg
     2701 agcatcccta gggagccagg ctctctactg ggcattaggg acagaggaat ttattggatg
     2761 ttggttcttc cttcaagaat cgctcaggga ttctcagtgt cctcaaaaca tgctgaaacc
     2821 ggaccccaga ctccactctg gagaatccaa cccactcaca ggggaaacag cccgtttaaa
     2881 gtgcatgtgt gctagagagg tagggtagcc gagatgatcc ctcagttgga aggataacca
     2941 agtatcttcc tcggacactc ttttttaaat aaatgaataa atgaa
//
