LOCUS       NM_022221               2388 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 8 (Mmp8), mRNA.
ACCESSION   NM_022221
VERSION     NM_022221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Wei,L., Xu,Y., Zhang,L., Yang,L., Zhao,R.C. and Zhao,D.
  TITLE     Mesenchymal Stem Cells Promote Wound Healing and Effects on
            Expression of Matrix Metalloproteinases-8 and 9 in the Wound Tissue
            of Diabetic Rats
  JOURNAL   Stem Cells Dev 32 (1-2), 25-31 (2023)
   PUBMED   36322784
  REMARK    GeneRIF: Mesenchymal Stem Cells Promote Wound Healing and Effects
            on Expression of Matrix Metalloproteinases-8 and 9 in the Wound
            Tissue of Diabetic Rats.
REFERENCE   2  (bases 1 to 2388)
  AUTHORS   Dieffenbach,P.B., Mallarino Haeger,C., Rehman,R., Corcoran,A.M.,
            Coronata,A.M.F., Vellarikkal,S.K., Chrobak,I., Waxman,A.B.,
            Vitali,S.H., Sholl,L.M., Padera,R.F., Lagares,D., Polverino,F.,
            Owen,C.A. and Fredenburgh,L.E.
  TITLE     A Novel Protective Role for Matrix Metalloproteinase-8 in the
            Pulmonary Vasculature
  JOURNAL   Am J Respir Crit Care Med 204 (12), 1433-1451 (2021)
   PUBMED   34550870
  REMARK    GeneRIF: A Novel Protective Role for Matrix Metalloproteinase-8 in
            the Pulmonary Vasculature.
REFERENCE   3  (bases 1 to 2388)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P.,
            Mielnik-Blaszczak,M., Arciszewski,M.B., Kushnir,V., Brezvyn,O.,
            Muzyka,V. and Kotsyumbas,I.
  TITLE     Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression
            and Immunolocalization in Bone and Cartilage in Newborn Offspring
            Prenatally Exposed to Fumonisins
  JOURNAL   Int J Mol Sci 22 (22), 12528 (2021)
   PUBMED   34830409
  REMARK    GeneRIF: Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF
            Expression and Immunolocalization in Bone and Cartilage in Newborn
            Offspring Prenatally Exposed to Fumonisins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2388)
  AUTHORS   Luo,S., Li,W., Wu,W. and Shi,Q.
  TITLE     Elevated expression of MMP8 and MMP9 contributes to diabetic
            osteoarthritis progression in a rat model
  JOURNAL   J Orthop Surg Res 16 (1), 64 (2021)
   PUBMED   33468174
  REMARK    GeneRIF: Elevated expression of MMP8 and MMP9 contributes to
            diabetic osteoarthritis progression in a rat model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2388)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2388)
  AUTHORS   Hatori,K., Sasano,Y., Takahashi,I., Kamakura,S., Kagayama,M. and
            Sasaki,K.
  TITLE     Osteoblasts and osteocytes express MMP2 and -8 and TIMP1, -2, and
            -3 along with extracellular matrix molecules during appositional
            bone formation
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 277 (2), 262-271 (2004)
   PUBMED   15052653
  REMARK    GeneRIF: Osteoblasts and osteocytes in apposed bone degrade
            extracellular matrix (ECM) molecules with MMPs and regulate the
            degradation by inhibiting the activity of MMPs using TIMPs.
REFERENCE   7  (bases 1 to 2388)
  AUTHORS   Stadlmann,S., Pollheimer,J., Moser,P.L., Raggi,A., Amberger,A.,
            Margreiter,R., Offner,F.A., Mikuz,G., Dirnhofer,S. and Moch,H.
  TITLE     Cytokine-regulated expression of collagenase-2 (MMP-8) is involved
            in the progression of ovarian cancer
  JOURNAL   Eur J Cancer 39 (17), 2499-2505 (2003)
   PUBMED   14602136
REFERENCE   8  (bases 1 to 2388)
  AUTHORS   Peterson,J.T., Li,H., Dillon,L. and Bryant,J.W.
  TITLE     Evolution of matrix metalloprotease and tissue inhibitor expression
            during heart failure progression in the infarcted rat
  JOURNAL   Cardiovasc Res 46 (2), 307-315 (2000)
   PUBMED   10773235
REFERENCE   9  (bases 1 to 2388)
  AUTHORS   Ueno,H., Yamashita,K., Azumano,I., Inoue,M. and Okada,Y.
  TITLE     Enhanced production and activation of matrix metalloproteinase-7
            (matrilysin) in human endometrial carcinomas
  JOURNAL   Int J Cancer 84 (5), 470-477 (1999)
   PUBMED   10502722
REFERENCE   10 (bases 1 to 2388)
  AUTHORS   Hasty,K.A., Pourmotabbed,T.F., Goldberg,G.I., Thompson,J.P.,
            Spinella,D.G., Stevens,R.M. and Mainardi,C.L.
  TITLE     Human neutrophil collagenase. A distinct gene product with homology
            to other matrix metalloproteinases
  JOURNAL   J Biol Chem 265 (20), 11421-11424 (1990)
   PUBMED   2164002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 26, 2022 this sequence version replaced NM_022221.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.10908.1, AJ007288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000008.1  13008890-13009079
            191-429             JAXUCZ010000008.1  13010834-13011072
            430-578             JAXUCZ010000008.1  13011741-13011889
            579-704             JAXUCZ010000008.1  13011970-13012095
            705-866             JAXUCZ010000008.1  13013488-13013649
            867-984             JAXUCZ010000008.1  13015175-13015292
            985-1118            JAXUCZ010000008.1  13015829-13015962
            1119-1272           JAXUCZ010000008.1  13016457-13016610
            1273-1376           JAXUCZ010000008.1  13017480-13017583
            1377-2388           JAXUCZ010000008.1  13017718-13018729
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2388
                     /gene="Mmp8"
                     /note="matrix metallopeptidase 8"
                     /db_xref="GeneID:63849"
                     /db_xref="RGD:631408"
     exon            1..190
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1480
                     /gene="Mmp8"
                     /EC_number="3.4.24.34"
                     /note="neutrophil collagenase; MMP-8; matrix
                     metalloproteinase-8; neutrophil collagenease"
                     /codon_start=1
                     /product="neutrophil collagenase preproprotein"
                     /protein_id="NP_071557.2"
                     /db_xref="GeneID:63849"
                     /db_xref="RGD:631408"
                     /translation="MLHLKTLPFLFFFHTQLATALPVPPEHLEEKNMKTAENYLRKFY
                     HLPSNQFRSARNATMIAEKLKEMQRFFGLPETGKPDAATIEIMEKPRCGVPDSGDFLL
                     TPGSPKWTHTNLTYRIINHTPQMSKAEVKTEIEKAFKIWSVPSTLTFTETLEGEADIN
                     IAFVSRDHGDNSPFDGPNGILAHAFQPGRGIGGDAHFDSEETWTQDSNNYNLFLVAAH
                     EFGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPVQPTGPST
                     PTACDPHLRFDAATTLRGEIYFFKDKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAY
                     EDFDRDLVFLFKGRQYWALSAYDLQQGYPRDISNYGFPRSVQAIDAAVSYNGKTYFFV
                     NNQCWRYDNQRRSMDPGYPTSIASVFPGINCRIDAVFQQDSFFLFFSGPQYFAFNLVS
                     RRVTRVARSNLWLNCP"
     exon            191..429
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            430..578
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            579..704
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            705..866
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            867..984
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1118
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1272
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1376
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2388
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagggaat tcggtgagct tcagggcact cgacagagga gcaaaggaag gcacgagagg
       61 ttgtcttgga agatagatca tgcttcacct gaagacactt ccatttctgt tcttcttcca
      121 cacacagctt gccacagccc tcccagtgcc tccagaacac ctggaagaga aaaatatgaa
      181 aactgctgag aattacctac gaaaattcta ccacttacca agcaatcagt tccggtctgc
      241 aaggaatgcc actatgattg ccgagaagct taaggagatg cagcgcttct tcggcttgcc
      301 cgagacaggg aagccagatg cagctacaat agagataatg gaaaagcctc gctgtggagt
      361 gcccgactct ggtgatttct tgctaactcc gggaagcccc aagtggacac acactaacct
      421 gacctacagg attataaacc ataccccaca gatgtcaaag gctgaagtga aaacagaaat
      481 cgagaaagct tttaaaatct ggagtgtgcc atcaaccctg accttcactg agaccttaga
      541 gggagaagca gacatcaaca ttgctttcgt ctcaagagac catggtgaca attctccatt
      601 tgatggaccc aatggaatcc ttgcccatgc ctttcaacca ggccggggta ttggaggaga
      661 tgcacatttt gattcagaag aaacgtggac tcaagactcc aacaattaca acctgtttct
      721 cgtggctgct catgaatttg gacattcctt gggactctct cactccactg atcctggtgc
      781 cttgatgtac ccaaactatg cttacagaga acccagcacc tattcactac ctcaagatga
      841 tatcaatgga attcagacaa tctatggacc ttcagacaac cctgtccaac ctactggacc
      901 cagcacgccc acagcctgtg acccccacct gagatttgat gctgccacca cactccgtgg
      961 ggagatttac ttctttaaag acaagtactt ctggagacgg catccccagc tgagaacagt
     1021 tgacctcaat ttcatatctc tgttctggcc cttcctacct aatggtcttc aggctgctta
     1081 tgaagacttt gatagagacc tagttttctt atttaaaggc agacagtact gggctctaag
     1141 tgcctatgac ttgcagcaag gttaccccag agatatatcc aactatggat tcccaaggag
     1201 tgtccaagcc attgatgcag ctgtttccta taacgggaag acatacttct tcgtaaacaa
     1261 ccaatgctgg agatacgaca atcaaagaag atccatggat ccaggttacc ccactagcat
     1321 agcaagcgtg ttcccaggaa taaactgtag aattgatgca gttttccagc aggattcctt
     1381 cttcctcttc ttcagtggac cacaatattt tgcatttaat cttgtcagtc gcagagtcac
     1441 tagagttgca agaagcaatt tatggcttaa ctgtccatag agtggagcaa agtcaaatgt
     1501 ccttatatcg accctatgaa tacaaaaggg aagctccgtc tatatattca tccaatgtgt
     1561 cctgttcaga cttccctcag ttgtaactaa tgctgcagcc ctcctcgaag aaccagcgtt
     1621 tgtaatcttt cattcccagc tgtggctgac tcctcctgca cattccatcc ctggttagtg
     1681 aacgcatcac aaagagaaca agccattcat cactttaatc tttgctattt cattatctgc
     1741 tcttatgcct tctaaacctc ctgttttatt acttgcttgt ttagcttcaa atgttcctac
     1801 atctcttcaa acatggaacc tagccttgga ttttcattat gcatgaggat tataaacaca
     1861 caaagattat cccctcatct gtacagaaaa atgtgctgtt acttcctccc ttggaaatat
     1921 atgaaaaata tttattgtgg attgaatcat gcccttccac atgccaggag aaaaaatgta
     1981 ttaactccag ctatttatct agaaccagag tcatgaagat ataataaatt aggtataaat
     2041 gacaagatag ctttaaacag gattaggatg aaccttaagc ccatacatct gttcttataa
     2101 aatggggcga gagatgtgga tgtcactcag agataaatca tttgattaac atattttatt
     2161 ctgaggcgat tggggagagt cagcagaggc ataggcacat ggtagagaga caaagcaaag
     2221 agaaccagag tgtagtgatg catctcttag gctatttgcc tataatttcc cagccagaag
     2281 caggtaggaa ggggttaaaa aaatctgcaa gcagattcca gaactgagac acttgctgat
     2341 gtgggttttc tggcttttgt gaaaaaataa agttgttact ctactcta
//
