LOCUS       NM_012864               1043 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA.
ACCESSION   NM_012864
VERSION     NM_012864.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Lin,C., Mazzuca,M.Q. and Khalil,R.A.
  TITLE     Increased uterine arterial tone, stiffness and remodeling with
            augmented matrix metalloproteinase-1 and -7 in uteroplacental
            ischemia-induced hypertensive pregnancy
  JOURNAL   Biochem Pharmacol 228, 116227 (2024)
   PUBMED   38643908
  REMARK    GeneRIF: Increased uterine arterial tone, stiffness and remodeling
            with augmented matrix metalloproteinase-1 and -7 in uteroplacental
            ischemia-induced hypertensive pregnancy.
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Spindola,A., Targa,A.D.S., Rodrigues,L.S., Winnischofer,S.M.B.,
            Lima,M.M.S., Sogayar,M.C. and Trombetta-Lima,M.
  TITLE     Increased Mmp/Reck Expression Ratio Is Associated with Increased
            Recognition Memory Performance in a Parkinson's Disease Animal
            Model
  JOURNAL   Mol Neurobiol 57 (2), 837-847 (2020)
   PUBMED   31493243
  REMARK    GeneRIF: Increased Mmp/Reck Expression Ratio Is Associated with
            Increased Recognition Memory Performance in a Parkinson's Disease
            Animal Model.
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Wang,H., Zhang,P., Yu,J., Zhang,F., Dai,W. and Yi,S.
  TITLE     Matrix metalloproteinase 7 promoted Schwann cell migration and
            myelination after rat sciatic nerve injury
  JOURNAL   Mol Brain 12 (1), 101 (2019)
   PUBMED   31791378
  REMARK    GeneRIF: the promoting effect of MMP7 on Schwann cell migration and
            peripheral nerve regeneration, is reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Li,W., Cui,N., Mazzuca,M.Q., Mata,K.M. and Khalil,R.A.
  TITLE     Increased vascular and uteroplacental matrix metalloproteinase-1
            and -7 levels and collagen type I deposition in hypertension in
            pregnancy: role of TNF-alpha
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (3), H491-H507 (2017)
   PUBMED   28626073
  REMARK    GeneRIF: Placental ischemia, possibly through the release of
            TNF-alpha, causes increases in the levels of matrix
            metalloproteinase (MMP)-1 and MMP-7, which could alter collagen
            deposition and cause inadequate uteroplacental and vascular
            remodeling in hypertension in pregnancy.
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Leitner,L., Jurets,A., Itariu,B.K., Keck,M., Prager,G., Langer,F.,
            Grablowitz,V., Zeyda,M. and Stulnig,T.M.
  TITLE     Osteopontin promotes aromatase expression and estradiol production
            in human adipocytes
  JOURNAL   Breast Cancer Res Treat 154 (1), 63-69 (2015)
   PUBMED   26482249
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Kieseier,B.C., Clements,J.M., Pischel,H.B., Wells,G.M., Miller,K.,
            Gearing,A.J. and Hartung,H.P.
  TITLE     Matrix metalloproteinases MMP-9 and MMP-7 are expressed in
            experimental autoimmune neuritis and the Guillain-Barre syndrome
  JOURNAL   Ann Neurol 43 (4), 427-434 (1998)
   PUBMED   9546322
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Kieseier,B.C., Kiefer,R., Clements,J.M., Miller,K., Wells,G.M.,
            Schweitzer,T., Gearing,A.J. and Hartung,H.P.
  TITLE     Matrix metalloproteinase-9 and -7 are regulated in experimental
            autoimmune encephalomyelitis
  JOURNAL   Brain 121 (Pt 1), 159-166 (1998)
   PUBMED   9549496
REFERENCE   8  (bases 1 to 1043)
  AUTHORS   Wilson,C.L., Heppner,K.J., Labosky,P.A., Hogan,B.L. and
            Matrisian,L.M.
  TITLE     Intestinal tumorigenesis is suppressed in mice lacking the
            metalloproteinase matrilysin
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1402-1407 (1997)
   PUBMED   9037065
REFERENCE   9  (bases 1 to 1043)
  AUTHORS   Nakano,A., Tani,E., Miyazaki,K., Yamamoto,Y. and Furuyama,J.
  TITLE     Matrix metalloproteinases and tissue inhibitors of
            metalloproteinases in human gliomas
  JOURNAL   J Neurosurg 83 (2), 298-307 (1995)
   PUBMED   7616276
REFERENCE   10 (bases 1 to 1043)
  AUTHORS   Abramson,S.R., Conner,G.E., Nagase,H., Neuhaus,I. and Woessner,J.F.
            Jr.
  TITLE     Characterization of rat uterine matrilysin and its cDNA.
            Relationship to human pump-1 and activation of procollagenases
  JOURNAL   J Biol Chem 270 (27), 16016-16022 (1995)
   PUBMED   7608162
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064657.1.
            
            On Jan 25, 2008 this sequence version replaced NM_012864.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064657.1, L24374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1043
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /note="matrix metallopeptidase 7"
                     /db_xref="GeneID:25335"
                     /db_xref="RGD:3100"
     exon            1..136
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..823
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /EC_number="3.4.24.23"
                     /note="matrilysin; MMP-7; matrin; pump-1 protease; uterine
                     metalloproteinase; matrix metalloproteinase-7; Matrix
                     metalloproteinase 7 (matrilysin)"
                     /codon_start=1
                     /product="matrilysin precursor"
                     /protein_id="NP_036996.1"
                     /db_xref="GeneID:25335"
                     /db_xref="RGD:3100"
                     /translation="MAAMRLTLFRIVCLLPGCLALPLSQEAGEVTALQWEQAQNYLRK
                     FYLHDSKTKKATSAVDKLREMQKFFGLPETGKLSPRVMEIMQKPRCGVPDVAEFSLMP
                     NSPKWHSRTVTYRIVSYTTDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIG
                     FARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDSGVNFLFVATHE
                     LGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLYGKRNKL"
     exon            137..363
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            364..512
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            513..641
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            642..803
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1024
                     /gene="Mmp7"
                     /gene_synonym="MPMM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagaacaat cgtctgttga tggcagctat gaggctcacc ctgttccgca ttgtgtgtct
       61 gctgccaggc tgcctggccc tgccactgtc ccaggaagcc ggagaagtga ccgcacttca
      121 gtgggaacag gcgcagaatt atcttaggaa attttacctt cacgactcta aaacaaagaa
      181 ggccaccagt gcagtggaca aactgaggga aatgcagaag ttcttcggtt tgccggagac
      241 tggaaagctg tccccccgtg tcatggagat aatgcagaag cccaggtgtg gagtgccaga
      301 tgttgcagaa ttctcactaa tgccaaacag tcctaagtgg cattccagaa ctgtcaccta
      361 cagaatcgtg tcctatacta cagacttgcc tcggttctta gtagatcaaa tcgtgaaaag
      421 agctctcaga atgtggagta tgcaaatccc actgaacttc aagagggtta gttgggggac
      481 tgcagacatc ataattggct tcgcaagggg agatcacgga gacaacttcc catttgatgg
      541 gccaggaaac actctaggcc atgcctttgc accggggcca ggcctcggcg gagatgctca
      601 ctttgacaag gatgagtact ggacggatgg tgaggactca ggagtgaact tcctgtttgt
      661 tgccactcat gaacttggcc actctctggg tctgggtcac tcttctgttc ccagttctgt
      721 gatgtaccct acctatcaag gagatcattc agaagacttc agtcttacaa aggacgacat
      781 tgcaggcatc cagaagttat atggaaagag gaacaagctg tgatagatgc agacagtttc
      841 tggaatgagc aaacgccctt cctgagccac acttactcct ttcttccttg tactgtggat
      901 gggttttgca catccctctg agggtcattt tgatggaatg agtctgacaa atctcaggta
      961 acacgacaga caccagcaat aaatgtcatg tgacatcagc aataaatgtc atgtgtgcaa
     1021 ataaaaaaaa aaaaaaaaaa aaa
//
