LOCUS       NM_133523               1827 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 3 (Mmp3), mRNA.
ACCESSION   NM_133523
VERSION     NM_133523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Xie,Y., Lin,T., Jin,Y., Berezowitz,A.G., Wang,X.L., Lu,J., Cai,Y.
            and Guzman,R.J.
  TITLE     Smooth muscle cell-specific matrix metalloproteinase 3 deletion
            reduces osteogenic transformation and medial artery calcification
  JOURNAL   Cardiovasc Res 120 (6), 658-670 (2024)
   PUBMED   38454645
  REMARK    GeneRIF: Smooth muscle cell-specific matrix metalloproteinase 3
            deletion reduces osteogenic transformation and medial artery
            calcification.
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Abdul,Y., Jamil,S., Li,W. and Ergul,A.
  TITLE     Cerebral microvascular matrix metalloproteinase-3 (MMP3)
            contributes to vascular injury after stroke in female diabetic rats
  JOURNAL   Neurochem Int 162, 105462 (2023)
   PUBMED   36509234
  REMARK    GeneRIF: Cerebral microvascular matrix metalloproteinase-3 (MMP3)
            contributes to vascular injury after stroke in female diabetic
            rats.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Tang,S., Tang,T., Gao,G., Wei,Q., Sun,K. and Huang,W.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes inhibit
            chondrocyte apoptosis and the expression of MMPs by regulating
            Drp1-mediated mitophagy
  JOURNAL   Acta Histochem 123 (8), 151796 (2021)
   PUBMED   34656826
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes inhibit
            chondrocyte apoptosis and the expression of MMPs by regulating
            Drp1-mediated mitophagy.
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Shu,J., Gu,Y., Jin,L. and Wang,H.
  TITLE     Matrix metalloproteinase 3 regulates angiotensin II-induced
            myocardial fibrosis cell viability, migration and apoptosis
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33655326
  REMARK    GeneRIF: Matrix metalloproteinase 3 regulates angiotensin IIinduced
            myocardial fibrosis cell viability, migration and apoptosis.
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Pentz,R., Iulita,M.F., Mikutra-Cencora,M., Ducatenzeiler,A.,
            Bennett,D.A. and Cuello,A.C.
  TITLE     A new role for matrix metalloproteinase-3 in the NGF metabolic
            pathway: Proteolysis of mature NGF and sex-specific differences in
            the continuum of Alzheimer's pathology
  JOURNAL   Neurobiol Dis 148, 105150 (2021)
   PUBMED   33130223
  REMARK    GeneRIF: A new role for matrix metalloproteinase-3 in the NGF
            metabolic pathway: Proteolysis of mature NGF and sex-specific
            differences in the continuum of Alzheimer's pathology.
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Manicourt,D.H., Fujimoto,N., Obata,K. and Thonar,E.J.
  TITLE     Levels of circulating collagenase, stromelysin-1, and tissue
            inhibitor of matrix metalloproteinases 1 in patients with
            rheumatoid arthritis. Relationship to serum levels of antigenic
            keratan sulfate and systemic parameters of inflammation
  JOURNAL   Arthritis Rheum 38 (8), 1031-1039 (1995)
   PUBMED   7639798
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Umenishi,F., Yasumitsu,H., Ashida,Y., Yamauti,J., Umeda,M. and
            Miyazaki,K.
  TITLE     Purification and properties of extracellular matrix-degrading
            metallo-proteinase overproduced by Rous sarcoma virus-transformed
            rat liver cell line, and its identification as transin
  JOURNAL   J Biochem 108 (4), 537-543 (1990)
   PUBMED   1963430
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   Sanchez-Lopez,R., Nicholson,R., Gesnel,M.C., Matrisian,L.M. and
            Breathnach,R.
  TITLE     Structure-function relationships in the collagenase family member
            transin
  JOURNAL   J Biol Chem 263 (24), 11892-11899 (1988)
   PUBMED   2841336
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Matrisian,L.M., Leroy,P., Ruhlmann,C., Gesnel,M.C. and
            Breathnach,R.
  TITLE     Isolation of the oncogene and epidermal growth factor-induced
            transin gene: complex control in rat fibroblasts
  JOURNAL   Mol Cell Biol 6 (5), 1679-1686 (1986)
   PUBMED   2431284
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Matrisian,L.M., Glaichenhaus,N., Gesnel,M.C. and Breathnach,R.
  TITLE     Epidermal growth factor and oncogenes induce transcription of the
            same cellular mRNA in rat fibroblasts
  JOURNAL   EMBO J 4 (6), 1435-1440 (1985)
   PUBMED   3875482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 10, 2014 this sequence version replaced NM_133523.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.33658.1,
                                           SRR26643295.30642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000008.1  12925281-12925436
            157-401             JAXUCZ010000008.1  12926291-12926535
            402-550             JAXUCZ010000008.1  12926627-12926775
            551-676             JAXUCZ010000008.1  12926875-12927000
            677-841             JAXUCZ010000008.1  12928678-12928842
            842-986             JAXUCZ010000008.1  12928996-12929140
            987-1120            JAXUCZ010000008.1  12934609-12934742
            1121-1280           JAXUCZ010000008.1  12935149-12935308
            1281-1384           JAXUCZ010000008.1  12937136-12937239
            1385-1827           JAXUCZ010000008.1  12938384-12938826
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1827
                     /gene="Mmp3"
                     /note="matrix metallopeptidase 3"
                     /db_xref="GeneID:171045"
                     /db_xref="RGD:621317"
     exon            1..156
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1485
                     /gene="Mmp3"
                     /EC_number="3.4.24.17"
                     /note="stromelysin-1; SL-1; MMP-3; transin-1; PTR1
                     protein; matrix metalloproteinase-3"
                     /codon_start=1
                     /product="stromelysin-1 preproprotein"
                     /protein_id="NP_598207.2"
                     /db_xref="GeneID:171045"
                     /db_xref="RGD:621317"
                     /translation="MKGLPVLLWLCTAVCSSYPLHGSEEDAGMEVLQKYLENYYGLEK
                     DVKQFTKKKDSSPVVKKIQEMQKFLGLKMTGKLDSNTMELMHKPRCGVPDVGGFSTFP
                     GSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMIS
                     FAVEEHGDFIPFDGPGMVLAHAYAPGPGINGDAHFDDDERWTDDVTGTNLFLVAAHEL
                     GHSLGLFHSANAEALMYPVYKSSTDLARFHLSQDDVDGIQSLYGPPTESPDVLVVPTK
                     SNSLDPETLPMCSSALSFDAVSTLRGEVLFFKDRHFWRKSLRTPEPGFYLISSFWPSL
                     PSNMDAAYEVTNRDTVFILKGNQIWAIRGHEELAGYPKSIHTLGLPETVQKIDAAISL
                     KDQKKTYFFVEDKFWRFDEKKQSMDPGFPRKIAENFPGIGTKVDAVFEAFGFLYFFSG
                     SSQLEFDPNAGKVTHILKSNSWFNC"
     exon            157..401
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            402..550
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..676
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..841
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..986
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1120
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1280
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1384
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1827
                     /gene="Mmp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggaggcag caaagaaccc gctgagagca gtgcagaact gtgggaagcc agtggaaatg
       61 aaagggctcc cagtcctgct gtggctgtgt acggctgtgt gctcatccta cccattgcat
      121 ggcagtgaag aagatgctgg catggaggtt ctgcagaaat acctagaaaa ctactatggt
      181 cttgaaaagg atgtgaagca gtttactaag aaaaaggaca gtagccctgt tgtcaaaaaa
      241 attcaagaaa tgcagaagtt ccttgggctg aagatgacag ggaagctgga ctcgaacact
      301 atggagctga tgcacaagcc ccggtgtggt gttcccgacg tcggtggctt cagtaccttt
      361 ccaggttcac ccaaatggag gaaaaaccac atctcctaca ggattgtgaa ttatacactg
      421 gatttaccaa gagagagtgt ggattctgcc attgagagag ctttgaaggt ctgggaggag
      481 gtgaccccac tcacattctc caggatctct gaaggagagg ctgacataat gatctccttt
      541 gcagttgaag aacatggaga ctttatccct tttgatgggc ctggaatggt cttggctcat
      601 gcctatgccc ctggaccagg gattaatgga gatgctcact ttgatgatga tgaacgatgg
      661 acagatgatg tcacaggtac caacctattc ctggttgctg ctcatgaact tggccactcc
      721 ctgggtctct ttcactcagc caatgctgaa gctttgatgt acccagtcta caagtcctcc
      781 acagacctgg cccgtttcca tctctctcaa gatgatgtag atggtattca atccctctat
      841 ggacctccca cagaatcccc tgatgtcctc gtggtaccca ccaaatctaa ctctctggac
      901 cctgagacct taccaatgtg tagctctgct ttgtccttcg atgcagtcag caccctgcgg
      961 ggagaagtct tgttctttaa agacaggcac ttttggcgaa aatctctcag gacccctgag
     1021 cctggctttt atttgatctc ttcattttgg ccgtctcttc catccaacat ggatgctgca
     1081 tatgaagtta ctaacagaga cactgttttc attcttaaag gaaatcagat ctgggctatc
     1141 cgaggtcatg aagagctagc aggttatcct aaaagcattc acactctggg cctccctgaa
     1201 accgtccaga agatcgatgc agccatttct ttaaaggacc aaaagaagac gtacttcttt
     1261 gtagaggaca aattctggag atttgatgag aagaaacaat ccatggatcc aggatttccc
     1321 aggaaaatag ctgagaactt tccaggcatt ggcacaaagg tggatgctgt ctttgaagca
     1381 tttgggtttc tttacttctt cagcggatct tcacagttgg agtttgatcc aaatgcaggg
     1441 aaagtgaccc acatattgaa gagcaacagc tggtttaatt gttaagaaga tccatggaag
     1501 gcgtcgtgtg tttcagctga cgctgatagc tcttcctctg agtcttttca tggagggcgt
     1561 cgtgtgtttc agctgaccct gatagctctt cctctgaaac ttggcgcact gaagtggttt
     1621 ccttactcta gcatgtgcta tggcagagca aaatgggagc tacatatggc accagtcaac
     1681 ctcaagttgt cgaaggacat tcagaagcac tgcttggctt atactgtgtc aaagggagag
     1741 gagaaaacac actcctgggc tacagacaag taactgtctc tgtgtagatg gtttgtttta
     1801 tttaataaaa tggtgtgtca tttattt
//
