LOCUS       NM_031757               4245 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 24 (Mmp24), mRNA.
ACCESSION   NM_031757
VERSION     NM_031757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Porlan,E., Marti-Prado,B., Morante-Redolat,J.M., Consiglio,A.,
            Delgado,A.C., Kypta,R., Lopez-Otin,C., Kirstein,M. and Farinas,I.
  TITLE     MT5-MMP regulates adult neural stem cell functional quiescence
            through the cleavage of N-cadherin
  JOURNAL   Nat Cell Biol 16 (7), 629-638 (2014)
   PUBMED   24952463
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Warren,K.M., Reeves,T.M. and Phillips,L.L.
  TITLE     MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate
            synapse reorganization after traumatic brain injury
  JOURNAL   J Neurotrauma 29 (10), 1922-1940 (2012)
   PUBMED   22489706
  REMARK    GeneRIF: Time- and injury-dependent expression of MT5-MMP, ADAM-10,
            and N-cadherin are confirmed during reactive synaptogenesis.
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Folgueras,A.R., Valdes-Sanchez,T., Llano,E., Menendez,L.,
            Baamonde,A., Denlinger,B.L., Belmonte,C., Juarez,L., Lastra,A.,
            Garcia-Suarez,O., Astudillo,A., Kirstein,M., Pendas,A.M.,
            Farinas,I. and Lopez-Otin,C.
  TITLE     Metalloproteinase MT5-MMP is an essential modulator of neuro-immune
            interactions in thermal pain stimulation
  JOURNAL   Proc Natl Acad Sci U S A 106 (38), 16451-16456 (2009)
   PUBMED   19805319
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4245)
  AUTHORS   Monea,S., Jordan,B.A., Srivastava,S., DeSouza,S. and Ziff,E.B.
  TITLE     Membrane localization of membrane type 5 matrix metalloproteinase
            by AMPA receptor binding protein and cleavage of cadherins
  JOURNAL   J Neurosci 26 (8), 2300-2312 (2006)
   PUBMED   16495457
  REMARK    GeneRIF: These results suggest that ABP directs MT5-MMP proteolytic
            activity to growth cones and synaptic sites in neurons, where it
            may regulate axon pathfinding or synapse remodeling through
            proteolysis of cadherins or other ECM or cell adhesion molecules.
REFERENCE   6  (bases 1 to 4245)
  AUTHORS   Wang,P., Wang,X. and Pei,D.
  TITLE     Mint-3 regulates the retrieval of the internalized membrane-type
            matrix metalloproteinase, MT5-MMP, to the plasma membrane by
            binding to its carboxyl end motif EWV
  JOURNAL   J Biol Chem 279 (19), 20461-20470 (2004)
   PUBMED   14990567
REFERENCE   7  (bases 1 to 4245)
  AUTHORS   Sekine-Aizawa,Y., Hama,E., Watanabe,K., Tsubuki,S., Kanai-Azuma,M.,
            Kanai,Y., Arai,H., Aizawa,H., Iwata,N. and Saido,T.C.
  TITLE     Matrix metalloproteinase (MMP) system in brain: identification and
            characterization of brain-specific MMP highly expressed in
            cerebellum
  JOURNAL   Eur J Neurosci 13 (5), 935-948 (2001)
   PUBMED   11264666
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB023659.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4245
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /note="matrix metallopeptidase 24"
                     /db_xref="GeneID:83513"
                     /db_xref="RGD:620202"
     exon            1..266
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1958
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /note="matrix metalloproteinase-24; MMP-24; MT-MMP 5;
                     membrane-type matrix metalloproteinase 5; membrane-type-5
                     matrix metalloproteinase; matrix metalloproteinase 24
                     (membrane-inserted)"
                     /codon_start=1
                     /product="matrix metalloproteinase-24 precursor"
                     /protein_id="NP_113945.1"
                     /db_xref="GeneID:83513"
                     /db_xref="RGD:620202"
                     /translation="MPRSRGGRAAPGQAARWSGWRAPGRLLPLLPALCCLAAAAGAGK
                     PAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQT
                     TIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKA
                     IRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHA
                     YFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPF
                     YQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRP
                     PRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIE
                     QFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGID
                     TALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYY
                     TYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTI
                     DDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKTGPQPVTYYKRPVQEWV"
     exon            267..415
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            416..532
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            533..837
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            838..999
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1214
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1353
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1620
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..4242
                     /gene="Mmp24"
                     /gene_synonym="Mt5-mmp; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggcggct ccgcagcggc tgcagcggga ggacccggcc ggagccgccg ccgccgccgc
       61 cgccgccatc gcagccgggc ggccgggccc ccgccgccgg gatgccaagg agccggggcg
      121 gccgcgctgc gccgggccag gccgcgcgct ggagcggctg gcgggccccg gggcggctgc
      181 tgccgctgct gcccgcgctc tgctgcctcg cggcggcggc gggggccggg aagccggccg
      241 gggcggacgc gcccttcgcc gggcagaact ggttaaaatc ctatggctat ctgcttccct
      301 atgagtcgcg ggcgtctgcg ttgcattcag ggaaggcctt gcagtcagca gtctccacta
      361 tgcaacagtt ttacgggatc ccagtcaccg gtgtgttgga ccagacgaca atcgagtgga
      421 tgaagaaacc tcgatgtggc gttcctgatc atccccattt gagcaggagg aggagaaata
      481 aacgctatgc cctaactgga cagaagtgga ggcagaaaca tatcacctac agcattcaca
      541 attatacccc aaaggtgggt gagctggaca cacggaaggc tattcgtcag gctttcgatg
      601 tgtggcagaa agtgaccccg ttgacctttg aagaggtgcc ataccatgag atcaaaagtg
      661 accggaagga ggcagacatc atgatcttct ttgcttctgg tttccatggt gacagctctc
      721 cttttgatgg ggaagggggc ttcctagccc atgcctactt tcctggccca ggaatcggag
      781 gagacactca ctttgattca gatgagccct ggacactagg aaatgccaac catgatggca
      841 atgacctctt cctggtggcc gtgcatgaac tgggccatgc cctggggctg gaacactcta
      901 atgaccccag tgctatcatg gcacccttct atcaatacat ggagacgcac aacttcaagc
      961 tgccccagga tgatctccag ggcatccaga agatttacgg acccccagct gagcctctgg
     1021 agcccacaag accccttcct acactcccgg tccgcaggat ccattcaccg tctgagagaa
     1081 aacatgagcg gcagcccagg cctcctcggc cacctctggg ggaccggcca tccactccag
     1141 gtgccaagcc caacatctgc gatggcaact tcaacacagt ggccctcttc cgaggggaga
     1201 tgtttgtgtt taaggatcgc tggttctggc gtctgcgcaa taatcgggta caggagggct
     1261 accccatgca gattgaacaa ttctggaagg gcctgcccgc ccgcatagac gcagcctatg
     1321 aaagagcgga cggaagattc gtcttcttca aaggtgacaa gtactgggta ttcaaagaag
     1381 tgacggtgga gcctgggtac ccccacagct tgggggagct gggaagctgc ctgccccgtg
     1441 aaggaattga cacagctctg cgctgggaac ctgtgggcaa aacctacttt ttcaaaggcg
     1501 aacggtactg gcgttacagc gaggagcggc gagccacaga ccctggctac cccaagccca
     1561 tcaccgtgtg gaagggcatc ccgcaggctc cacaaggggc cttcatcagc aaggaaggat
     1621 attacaccta cttctacaaa ggtcgggact actggaagtt tgacaaccag aaactgagtg
     1681 tggagccagg ctacccacgc aacatcctgc gtgactggat gggctgcaag cagaaggagg
     1741 tagagcggcg gaaggagcgc aggttgcccc aggatgatgt ggacatcatg gtgaccatcg
     1801 atgacgtgcc aggctctgtg aatgctgtgg ctgtggtcgt cccctgcaca ctgtccctgt
     1861 gcctcctggt gctgctttac actatcttcc agttcaagaa caagacgggt ccccaacccg
     1921 tcacctacta taagcggcca gtccaggagt gggtatgagc agcccagagc cctctctgtc
     1981 tacccagtct ggccagccag gcccttcctc accagggtct gaggggcagc tctagccact
     2041 gcccactggg gccagcaggg ccctaggcca ggttcgtgtg tagctgaagt ggtgggtaca
     2101 ttggtctagg ctgagtgtgg ggcagggagt gatggtggct atgccccagg ttgggtagct
     2161 ggtacccagc tgccagcctt ctgtcctggg tagacccctc tctactcaag ggaataggcc
     2221 aggccctgtc aggaggcaag gatcatgcca ggaggtgccc ctgaggtctc tgcatcctgt
     2281 ggtgtctgca agatgccgca gttccagtcc cggctgggac ccagccctct gaggcaagcc
     2341 agcactagct ctcaccccca ccccaagatg ccaccaatcc cagtcccctc tgccaacacc
     2401 tgctggtcag atgtcccctc acccctaccc tactatcctc caaggctgca gtgcccctga
     2461 tgccaacaca gtgggcaaag gcctgggttt cccctgctag ctaacagcag attcctcagg
     2521 aaacctgctc cacctgtcag gtctcctctg agactcagaa tttagggtca catgctgcag
     2581 gcaaggctgt ggcccgctgg atctcacaag gacccagctg tcatgtcgtg aatatttaaa
     2641 tgtcctgtca ctactgttta aagtcccatt ttgcaaaggc tacttgaggc tttaggtcag
     2701 ctagaggtga ctgtcttggt gatgaggcca gagtggtggc ccttccccag gcactaagga
     2761 ctatggtgct gcaagggcca ctcgggcatc ctgttcagga gactcaacag ccagggcagg
     2821 agctgaccct ggttctgggg gcggatccaa gtttgtgact attctctact ccccttcctt
     2881 aatgttgtcc cctgccttgc tccagcctgt cctctgtggc ctgggggctc agtctgacta
     2941 taggtaaagc agagatgatt ctagagccac cattgtcata aggaccaggg caatctttaa
     3001 agtactccat ccacatcccc atctgccctg aggcaactca gtttcagact ggaggcatgt
     3061 ttgtgctcca atcttgaccc tggaagccca gctcactggg cccatcttcc tgcactgctc
     3121 ttacgaaaag ggtactcaca gccggtagca gccccaggct ttgggacttc ccctcgctcc
     3181 ctaccccaac ctacctttct tttgttttaa cctgaggccc ttcacatctg acagaatccc
     3241 taagccttgg cttgacttgc tccaaaacca ctgggtgcag tgttgttcgc tggctctctg
     3301 ctaagcccaa cagtggtagg aggcggccat cagggtgcta gtgggtcaca gataccaact
     3361 ctgacctctg agcctgcatg ggctttgccc ctgccctgtg gtctctggga tttgggtcag
     3421 ctcgtcctgt agcagatagg gactctcgct gggttgggag ctaagtgaaa tctcttgtcc
     3481 cagaagcacc tatgtgggtc catcgtgtcc catctcacca tcgtgttctt tctcattttg
     3541 gccaagggca ggctccccag ggcaggcggg gaacaactgc agagatttcg tgattcatag
     3601 gtttgtagtg ttttatactt tgcaaagcac tttattagct cacacctgtc cactcacacg
     3661 gaactcctgt aggctctgag aggctgaggg taattctcct cttaccctca gatgaagcac
     3721 aaggaggtct tatctgcccc tgccatccag tgaccctggc tgggtctgtg tccccatctg
     3781 tgggtccttc cagggcctga gatcaatgtc tcttctagtc ctctcttctg ggcctccctc
     3841 ccctagtttc ctggtccctc tcctcagctt ggtgctctca cttcttgaaa gctctaggcc
     3901 ccgcaggctc cctgttgact cctggcattc caaggccagc tgagaaagag caggaggtgg
     3961 aagcaggcag cccaggctgc agatgtgagg ggtgcagggc cgggcccaga gagggctcag
     4021 cctagaggct tccaatcttg gattcttctg cctgtggtca tctgtctgtc catcagccca
     4081 ggtcagagca gtcagagggg caaagtactg gagccccccc agagctcagc ttcccctcag
     4141 cctgggtgac atcacagcat ttcagtgtcg gtcacatttt aaactgatca gcctttgtac
     4201 aatgtttttt aaatcatttc taaataaaac agaaatacag tgaaa
//
