LOCUS       NM_001106308            1854 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 21 (Mmp21), mRNA.
ACCESSION   NM_001106308 XM_001054903 XM_219415
VERSION     NM_001106308.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Perles Z, Moon S, Ta-Shma A, Yaacov B, Francescatto L, Edvardson S,
            Rein AJ, Elpeleg O and Katsanis N.
  TITLE     A human laterality disorder caused by a homozygous deleterious
            mutation in MMP21
  JOURNAL   J Med Genet 52 (12), 840-847 (2015)
   PUBMED   26429889
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz
            M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M,
            Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S,
            Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG,
            Masson C, Schoen P, Deleuze JF, Nitschke P, Lyonnet S, de Pontual
            L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW
            and Gordon CT.
  TITLE     MMP21 is mutated in human heterotaxy and is required for normal
            left-right asymmetry in vertebrates
  JOURNAL   Nat Genet 47 (11), 1260-1263 (2015)
   PUBMED   26437028
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y,
            Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin
            JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J,
            Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury
            L, Ganapathiraju MK, Tobita K, Pazour GJ and Lo CW.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K,
            Suda T, Nakamura T, Wolff L, Honda H and Inaba T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Skoog T, Elomaa O, Pasonen-Seppanen SM, Forsberg S, Ahokas K,
            Jeskanen L, Parssinen J, Tiala I, Rollman O, Lohi J and
            Saarialho-Kere U.
  TITLE     Matrix metalloproteinase-21 expression is associated with
            keratinocyte differentiation and upregulated by retinoic acid in
            HaCaT cells
  JOURNAL   J Invest Dermatol 129 (1), 119-130 (2009)
   PUBMED   18633436
  REMARK    GeneRIF: MMP-21 may be an important protease in the terminal
            differentiation of keratinocytes
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054903.1, XM_219415.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760434, SAMEA5760475
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1854
                     /gene="Mmp21"
                     /note="matrix metallopeptidase 21"
                     /db_xref="GeneID:293573"
                     /db_xref="RGD:1309332"
     exon            1..177
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1722
                     /gene="Mmp21"
                     /note="matrix metalloproteinase 21"
                     /codon_start=1
                     /product="matrix metalloproteinase-21 precursor"
                     /protein_id="NP_001099778.1"
                     /db_xref="GeneID:293573"
                     /db_xref="RGD:1309332"
                     /translation="MLAVSDLRLTMLLCWLVTPQPAQPERLFHSRDRSDLEPSPLSRA
                     KPIADLHAAQNFLLKYGWSEVSSPKESAGVPVGFTLAQAVRRFQKANRLPASGKLDSP
                     TLAAMNKPRCGVPDTRLPLQDALPTPPALPTPLGLQPRARQKRFLQMLLPKPGGKQEG
                     RSDTGASRVFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDLTA
                     PGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWHLGEIHFDDDEHFTPLSSDTGISL
                     LKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWSDRKAIQRLYGSCEGSFDI
                     VFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPMQR
                     IDAFVHVWSWGRDERYFFKGNQYWRYDSENDQAHTQDEQGRSYPKLISEGFPGIPSPL
                     DTAFYERRQQLIYFFKESLVYAFDVNRNQALSSYPKKMSQVFPAIMPQNHPFRNLDSA
                     YYSYAHNAIFFFKGNSFWKVVSDKDKQQDSRLPLNGLFPKQSVSGKWFDVCDVHTSTL
                     NM"
     exon            178..709
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            710..849
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            850..991
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1249
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1422
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1854
                     /gene="Mmp21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccagtg aagccatgct tgctgtctct gacttgcgtc tgacaatgct gctctgctgg
       61 ctagttacac cccagccagc ccagcctgag aggctcttcc acagccggga ccgttcggac
      121 ctggagccat cccccctgag tcgggccaag cccattgccg acctccatgc tgctcagaac
      181 ttcctattga aatatggctg gtcagaggtg tccagcccaa aggagtcagc cggagtccct
      241 gtgggcttca ccttggctca agctgtgcgt agattccaga aggcaaacag actgccagcc
      301 agcgggaaac tagactcacc tacactggca gctatgaata agccacgctg tggcgtccct
      361 gacacacgac taccccttca ggatgccctg ccaactccac cagccctgcc aacccctcta
      421 ggtctccagc ccagggcccg acaaaagcgc tttcttcaaa tgctgctgcc caagccaggt
      481 gggaaacagg agggccggtc agacacgggg gccagcaggg tcttctccaa gaagacactg
      541 acctggagac tagtgggaga tgcctacagc agccaactct ctggggatga gcagagatac
      601 atctttagac tggccttcag gatgtggagc gaggtgacgc cactggactt ccgggaggac
      661 ctcactgccc ctggtaccat ggtggacata aagctgggtt ttgggagagg ccggcacctg
      721 ggctgtccac gggtgtttga cgggagtgga caggagtttg cacatgcctg gcacctgggt
      781 gagatccact ttgatgacga tgagcacttt actcctctct ccagtgacac gggcatcagc
      841 cttctcaaag tagctgtcca tgaaattggt cacgtccttg gattgcctca cacctacagg
      901 gtgggatcca taatgcaacc aaactacatt ccccaggagc ctgcatttga gttggactgg
      961 tcagacagaa aagcaattca aagactatat gggtcatgtg agggatcatt tgatatagtg
     1021 tttgactgga ttcgcaagga gaggaaccaa tatggtgagg tgagggtgag gttcaacacc
     1081 tacttcttcc gcaacagctg gtactggctc tacgaaaacc gcaacaacag gactcgctac
     1141 ggggaccccc tccaaatcct caccggctgg cgtggaattc ccatgcaaag aatagatgct
     1201 ttcgtccatg tctggtcatg gggtagagat gagcggtatt ttttcaaagg aaaccaatac
     1261 tggagatatg acagtgagaa tgaccaggca cacacacaag atgaacaagg aaggagctac
     1321 cccaaactga tttcagaagg cttccctggc atccccagtc ccttggacac ggccttctat
     1381 gagcggaggc agcagctaat ttacttcttc aaggagtctc tagtatatgc atttgatgtc
     1441 aaccgaaacc aagcactttc ttcttatcca aagaagatga gccaagtgtt cccagcaata
     1501 atgcctcaaa accacccatt cagaaacctc gattccgcgt actactccta tgcacacaat
     1561 gccatcttct ttttcaaagg caactcgttt tggaaagtag ttagtgacaa ggacaaacag
     1621 caggactctc ggctccctct gaatggctta tttccaaaac aatctgtttc agggaagtgg
     1681 tttgatgttt gtgacgttca tacctctaca ctgaacatgt aaagagaaga aaatcaagac
     1741 caggacccag gaacagctct aagagaaagt gttagccttc tttgcaaaga aaacaaacca
     1801 gaattttagt agctaaaaca aacatggctt caagctacac caaacacgca ttac
//
