LOCUS       NM_001106800            3284 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus matrix metallopeptidase 20 (Mmp20), mRNA.
ACCESSION   NM_001106800 XM_001072509 XM_235796
VERSION     NM_001106800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3284)
  AUTHORS   Yamakoshi Y, Richardson AS, Nunez SM, Yamakoshi F, Milkovich RN, Hu
            JC, Bartlett JD and Simmer JP.
  TITLE     Enamel proteins and proteases in Mmp20 and Klk4 null and
            double-null mice
  JOURNAL   Eur J Oral Sci 119 Suppl 1 (Suppl 1), 206-216 (2011)
   PUBMED   22243248
REFERENCE   2  (bases 1 to 3284)
  AUTHORS   Smith CE, Richardson AS, Hu Y, Bartlett JD, Hu JC and Simmer JP.
  TITLE     Effect of kallikrein 4 loss on enamel mineralization: comparison
            with mice lacking matrix metalloproteinase 20
  JOURNAL   J Biol Chem 286 (20), 18149-18160 (2011)
   PUBMED   21454549
REFERENCE   3  (bases 1 to 3284)
  AUTHORS   Bartlett JD, Beniash E, Lee DH and Smith CE.
  TITLE     Decreased mineral content in MMP-20 null mouse enamel is prominent
            during the maturation stage
  JOURNAL   J Dent Res 83 (12), 909-913 (2004)
   PUBMED   15557396
REFERENCE   4  (bases 1 to 3284)
  AUTHORS   Llano E, Pendas AM, Knauper V, Sorsa T, Salo T, Salido E, Murphy G,
            Simmer JP, Bartlett JD and Lopez-Otin C.
  TITLE     Identification and structural and functional characterization of
            human enamelysin (MMP-20)
  JOURNAL   Biochemistry 36 (49), 15101-15108 (1997)
   PUBMED   9398237
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235796.3, XM_001072509.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..3284
                     /gene="Mmp20"
                     /note="matrix metallopeptidase 20"
                     /db_xref="GeneID:300341"
                     /db_xref="RGD:1308730"
     exon            1..147
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1473
                     /gene="Mmp20"
                     /note="matrix metalloproteinase 20 (enamelysin); matrix
                     metalloproteinase-20; matrix metallopeptidase 20
                     (enamelysin)"
                     /codon_start=1
                     /product="matrix metalloproteinase-20 precursor"
                     /protein_id="NP_001100270.1"
                     /db_xref="GeneID:300341"
                     /db_xref="RGD:1308730"
                     /translation="MKVLPASGLAVLVTALKFATAAPALLAATPRTFRSNYHLAQAYL
                     DKYYTKKGGPQAGEMVARESNPTVRKIKELQTFFGLRVTGKLDQNTMDVIKRPRCGVP
                     DVANYRLFPGEPKWKKNILTYRVSKYTPSMSPTEVDKAVHMALHAWSTAVPLIFVRIN
                     SGEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFN
                     LFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPYRFHLPKDDVKGIQALYGPRKTFP
                     GKPTMPHIPPHKPSIPDLCDSSSSFDAVTMLGKELLFFKDRIFWRRRVHLPAGIRPST
                     ITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFQMQGPPRTIYDFGFPRHVQR
                     IDAAVYLKEPQKTLFFVGEEYYSYDERKKKMEKDYPKSTEEEFSGVSGHIDAAVELNG
                     YIYFFSGPKTFKYDTEKEDVVSVVKSSSWVGC"
     exon            148..395
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            396..544
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            545..670
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            671..832
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            833..974
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1111
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1268
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1372
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..3284
                     /gene="Mmp20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatcaccaa gcgaccaaga ggagatgaag gtgctacctg cctctggcct tgctgtcctt
       61 gtcacagctt taaagtttgc cactgcagcc cccgccctac tcgcagccac ccctaggacc
      121 ttcaggagca actaccacct cgcacaggcc tatctcgaca agtattatac aaagaaagga
      181 ggcccccagg ctggcgagat ggtggcaaga gaaagcaacc ccacggtcag gaagattaag
      241 gagctacaaa cattctttgg cctcagagtc actgggaagt tggaccagaa tacgatggat
      301 gtgatcaaga ggcctcgctg tggagttcct gatgtggcta actaccgcct cttcccaggt
      361 gaacccaaat ggaaaaaaaa tattttgaca tacagagtct ctaagtacac accttccatg
      421 agtcctaccg aggtagacaa ggctgtacat atggccctgc acgcatggag tacggctgtc
      481 cctctgatct tcgtgagaat aaactctggg gaagcagata tcatgatatc ttttgaaaca
      541 ggagatcatg gggattccta cccatttgat gggcctcggg ggacgctggc ccatgcgttc
      601 gcacctggag aaggcctggg aggagacaca catttcgaca atgctgagaa gtggactatg
      661 ggaacgaatg ggttcaactt attcaccgtt gctgctcacg aatttggcca tgctctgggc
      721 ctgggccatt ccacagaccc atcagcgctg atgtacccaa cttataagta ccagaacccc
      781 tataggttcc atctccccaa ggatgatgtg aaagggatcc aagcgttata tggaccccgg
      841 aaaacattcc caggaaagcc caccatgccc catatcccac ctcacaagcc atccatcccc
      901 gacctctgtg actccagctc atcctttgat gcggtgacaa tgctgggaaa ggagcttctg
      961 ttcttcaagg ataggatttt ctggagaagg cgggtgcact tgccagcagg gattcggccc
     1021 agcaccatca ccagctcctt cccccagctc atgtccaatg tggacgcagc ttatgaagtg
     1081 gctgaacgag gcattgcctt cttcttcaaa ggtcctcact actgggtcac tcgaggattc
     1141 cagatgcaag gtcctcctcg cacaatttat gacttcgggt tcccaaggca tgtgcagcga
     1201 atagatgccg ccgtctacct caaggagcct cagaagaccc ttttctttgt gggagaggaa
     1261 tactacagct atgatgaaag aaaaaagaaa atggaaaagg actacccaaa aagcactgag
     1321 gaagaatttt caggagtgag tggccatata gatgctgcgg tggaactgaa tggttacatt
     1381 tacttctttt caggaccaaa aacattcaag tatgatacag aaaaggaaga tgtggttagt
     1441 gtggtaaaat ccagctcctg ggttggttgc tgaatcgtca ggtctagtct ctccacaggg
     1501 atgaagatca ttgggagcaa ctgaggaccg gacattatgg actaagtggt gtgtcagaga
     1561 cgttcttctc cagccttcag tcctgagggt gattgaaggg tccttgaaaa taataacaac
     1621 tctattgttt ttcctaatat tcattcacaa ttttaatcta aataagaagc cacttttatt
     1681 cagaatcaca taatatatcc tttagttaaa tattcatttt tttcttacct actatagtaa
     1741 agcaaataac tctggtttct gtttgtagaa aaaatactat gtgcacttat atgcacacac
     1801 acactcacac acacacacac atacacacat acaaatattt cattaagcaa ggttattacc
     1861 atacaaatta taattacccc ttaaaaacaa tggctgacca tcatttactg tgatggatat
     1921 aaatgtactt ctttgtgttt ggaaggtatc acgaacaaaa tgcaccaagt gtgtccttcg
     1981 ccctggctgt cctctgtgtc tcccactggc ctctgaagtg ggttggtaga caaacactcc
     2041 aattaatctt catgctcccc aacagttgga cactctgcaa cagagaacct ttctaacaaa
     2101 acccaataaa aatgtcatgt tagaggagtt cctcatttct cttttctgtt aatatttact
     2161 agcttttatc atgctttatt tggcaacaaa ttctgtgtta cctgtgtaaa tgtaaatgat
     2221 cgtatcataa gtatacacag ccagaaaaaa taatgtagtc tgatctattt cctacttcct
     2281 ggtagcaccc tcagtagaga tgtctttgat ccacctcagt ttcttctaaa tagttttcta
     2341 cttaaggaag tttatttttt gttcttttag tttgtttgtt catttgtttt aatttaaatt
     2401 aaacctttcc ttcccaactc tacccagtta acaacacaga aagaataatt gctctcagtc
     2461 ttgtggtttt aaaaaacttt agtactagaa ttctagaacc agtctagaga aactctacat
     2521 tttaggagtt ctaaaattga ataatatttt tacttcatag gttacctaga agagctacag
     2581 tttataacac ctataacctg ttattgttag catcgtttat taaatttgct tcctatactc
     2641 atgaaaagac tgaatgacac tctgttactg caagtgttcc atttggcttc tcttactaaa
     2701 agtcactgtg catacccaac cagatgttga ctattgaaga caatatctag taccttttct
     2761 aagttcaagg tgccctactg agaaacaaag ccttttcact tttactgcag gctggaacct
     2821 gcttactatc aataagcaaa aaacaaaagc aaacagagac tagagagatg gttcagaggc
     2881 taagaatgct tgttgctctt ccaagaacct gagctcagtc tccagcaccc atatggacaa
     2941 cttacaacca tctgttaatt ccagttccag gcaatctgat cctctctggt ggcctccttg
     3001 ggcacctgca catgtgtgtg catattgaca cacatgcata taaataaaaa tagtttcaaa
     3061 agcaagaaag agcaaagtag agtggcaagc cctcaaaatg ttaagcagaa acccagtaat
     3121 tgcactactg tgtgtatata cctgtgagaa attaaagcac aagaacttgc acaccagtgt
     3181 tcatggcagc attatttgca gtagccaaaa gtggacagat gtccatcatg tgatacatgt
     3241 gtgaataaat gtggtagatt cagacaatga aatgtgtatt aaac
//
