LOCUS       NM_031054               3053 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA.
ACCESSION   NM_031054
VERSION     NM_031054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Wang,C., Xu,Y., Xu,M., Sun,C., Zhang,X., Tao,X. and Song,T.
  TITLE     SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to
            regulate astrocytic MMP-2 activation in rats with chronic
            constriction injury
  JOURNAL   J Neuroinflammation 21 (1), 57 (2024)
   PUBMED   38388415
  REMARK    GeneRIF: SPOCK2 modulates neuropathic pain by interacting with
            MT1-MMP to regulate astrocytic MMP-2 activation in rats with
            chronic constriction injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Hirata,T., Fan,F., Fan,L., Amin,G., White,T., Geurts,A.M.,
            Kojima,N., Takahashi,T., Miyata,N., Williams,J. and Roman,R.J.
  TITLE     Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and
            Diabetes-induced Nephropathy
  JOURNAL   J Cardiovasc Pharmacol 82 (6), 445-457 (2023)
   PUBMED   37643020
  REMARK    GeneRIF: Knockout of Matrix Metalloproteinase 2 Opposes
            Hypertension- and Diabetes-induced Nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Zhu,X., Tang,Z., Li,W., Li,X., Iwakiri,Y. and Liu,F.
  TITLE     S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP
            activity in liver fibrosis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1640-1649 (2023)
   PUBMED   37700592
  REMARK    GeneRIF: S-nitrosylation of EMMPRIN influences the migration of
            HSCs and MMP activity in liver fibrosis.
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   de Oliveira Neves,V.G., Blascke de Mello,M.M., Rodrigues,D.,
            Pernomian,L., de Oliveira,I.S., Parente,J.M., Arantes,E.C.,
            Tostes,R.C. and Castro,M.M.
  TITLE     Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension
  JOURNAL   Vascul Pharmacol 152, 107211 (2023)
   PUBMED   37607602
  REMARK    GeneRIF: Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension.
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Hu,C., Jing,R., Wen,C., Qi,T., Bai,X., Wang,Y., Shao,Y. and Pei,C.
  TITLE     HNF4A Negatively Regulated Posterior Capsular Opacification via
            Transcriptional Inhibition of MMP2
  JOURNAL   Curr Eye Res 48 (7), 627-638 (2023)
   PUBMED   36988559
  REMARK    GeneRIF: HNF4A Negatively Regulated Posterior Capsular
            Opacification via Transcriptional Inhibition of MMP2.
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Harendza,S., Pollock,A.S., Mertens,P.R. and Lovett,D.H.
  TITLE     Tissue-specific enhancer-promoter interactions regulate high level
            constitutive expression of matrix metalloproteinase 2 by glomerular
            mesangial cells
  JOURNAL   J Biol Chem 270 (32), 18786-18796 (1995)
   PUBMED   7642529
REFERENCE   7  (bases 1 to 3053)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Lerch,M.M., Friess,H., Buchler,M.
            and Adler,G.
  TITLE     Expression and in-situ localization of genes coding for
            extracellular matrix proteins and extracellular matrix degrading
            proteases in pancreatic cancer
  JOURNAL   Int J Cancer 62 (4), 407-413 (1995)
   PUBMED   7635566
REFERENCE   8  (bases 1 to 3053)
  AUTHORS   Nakano,A., Tani,E., Miyazaki,K., Yamamoto,Y. and Furuyama,J.
  TITLE     Matrix metalloproteinases and tissue inhibitors of
            metalloproteinases in human gliomas
  JOURNAL   J Neurosurg 83 (2), 298-307 (1995)
   PUBMED   7616276
REFERENCE   9  (bases 1 to 3053)
  AUTHORS   Cleutjens,J.P., Kandala,J.C., Guarda,E., Guntaka,R.V. and
            Weber,K.T.
  TITLE     Regulation of collagen degradation in the rat myocardium after
            infarction
  JOURNAL   J Mol Cell Cardiol 27 (6), 1281-1292 (1995)
   PUBMED   8531210
REFERENCE   10 (bases 1 to 3053)
  AUTHORS   Marti,H.P., McNeil,L., Davies,M., Martin,J. and Lovett,D.H.
  TITLE     Homology cloning of rat 72 kDa type IV collagenase: cytokine and
            second-messenger inducibility in glomerular mesangial cells
  JOURNAL   Biochem J 291 (Pt 2) (Pt 2), 441-446 (1993)
   PUBMED   7916617
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U65656.1.
            
            On May 4, 2007 this sequence version replaced NM_031054.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65656.1, BC074013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093044, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3053
                     /gene="Mmp2"
                     /note="matrix metallopeptidase 2"
                     /db_xref="GeneID:81686"
                     /db_xref="RGD:621316"
     exon            1..444
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2280
                     /gene="Mmp2"
                     /EC_number="3.4.24.24"
                     /note="72 KDa type IV collagenase; MMP-2; 72 kDa
                     gelatinase; matrix metalloproteinase-2; gelatinase A"
                     /codon_start=1
                     /product="72 kDa type IV collagenase precursor"
                     /protein_id="NP_112316.2"
                     /db_xref="GeneID:81686"
                     /db_xref="RGD:621316"
                     /translation="MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPK
                     TDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC
                     GNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFS
                     RIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEG
                     QVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH
                     EALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE
                     TAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPD
                     QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPD
                     ADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGP
                     LLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPD
                     VQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVD
                     LQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC"
     exon            445..671
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..820
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..949
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1123
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1297
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1471
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1627
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1769
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1906
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2066
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2176
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..3040
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcgtctg cccgcccttg tttccgctgc atccagactt ccccgggtgg ctggaggctc
       61 tgtgtgcatc cagaacttta gatatacaaa gggattacta ggacctgcaa gcacccgcag
      121 ccgtggtgcg tactggtacg tgggatcccg ttatgagacc ctgagcccgg agaagctgag
      181 gcaattgagt aaaggggtct cagaacgccg tggagagcag gcgccagccg ggtggacccc
      241 agggcacagc cagcgacctc agggtgacac gcggagcccg ggagcgcaag gatggaggca
      301 cgattggtct ggggagtgct cgtcggccct ctgcgggttc tctgcgtcct gtgctgcctg
      361 ctgggccacg ccatcgctgc accgtcgccc atcatcaagt tccccggcga tgtctccccc
      421 aaaacagaca aagagttggc agtgcaatac ctgaacactt tctatggctg ccccaaggag
      481 agttgcaacc tctttgtgct gaaggacacc ctcaagaaga tgcagaagtt ctttgggctg
      541 ccccagacag gtgaccttga ccagaacacc atcgagacca tgcggaaacc aagatgtggc
      601 aacccagatg tggccaacta caacttcttt ccccgcaagc ccaagtggga caagaatcag
      661 atcacataca ggatcattgg ttacacacct gacctggacc ctgagacagt ggatgatgcc
      721 tttgctcggg ccttaaaagt atggagcgac gtaactccac tacgcttttc tcgaatccat
      781 gatggggaag ctgacatcat gatcaacttt ggtcgatggg agcatggaga tggataccca
      841 tttgacggca aggacggact cctggcacat gcctttgccc cgggcactgg tgttggggga
      901 gattctcact ttgatgacga tgagctgtgg actctaggag aaggacaagt ggtccgagta
      961 aagtatggga acgctgatgg cgagtactgc aagttcccct tcttgtttaa tggtcgggaa
     1021 tacagcagct gcacagacac tggccggagt gacggcttcc tctggtgttc caccacgtac
     1081 aactttgaga aggacggcaa atatggcttc tgtccccacg aagccttgtt taccatgggt
     1141 ggcaatggag atggacagcc ctgcaagttc ccgttccgct tccagggcac ctcttacaac
     1201 agctgtacca ccgagggccg tacagacggc taccgctggt gtggcaccac cgaggattat
     1261 gaccgggata agaagtatgg attctgccca gagactgcta tgtccactgt gggtggaaat
     1321 tcagaaggtg ccccatgtgt cttccccttc acttttctgg gcaacaagta tgagagctgc
     1381 accagcgctg gccgaagcga tggcaaggtg tggtgtgcaa ccacaaccaa ctacgatgat
     1441 gaccggaagt ggggcttctg tcccgaccaa ggatatagcc tattccttgt ggcagcccat
     1501 gagttcggcc atgccatggg gctggaacac tcacaggacc ctggagcttt gatggcccct
     1561 atctacacct acaccaagaa cttccgacta tccaatgatg acatcaaggg gatccaggag
     1621 ctctatgggc cctcccctga tgctgatact gacactggta ctggacccac gcctacactg
     1681 ggacctgtca ctcccgagat ctgcaagcaa gacattgtct ttgatggcat tgctcagatc
     1741 cgtggtgaga tcttcttctt caaggatcgg tttatttggc ggacagtgac accacgtgac
     1801 aagcccacag gtcccttgct ggtggccaca ttctggcctg agctcccgga aaagattgat
     1861 gccgtgtacg aggccccaca ggaagagaag gctgtgttct tcgcagggaa tgagtactgg
     1921 gtctattctg ccagcacttt ggaaagagga taccccaagc cactgaccag cctgggttta
     1981 ccccctgatg tccagcaagt agacgctgcc tttaactgga gtaagaacaa gaagacatac
     2041 atcttttctg gggacaagtt ctggagatac aatgaagtaa agaagaaaat ggaccccggt
     2101 ttcccgaagc tcatcgcaga ctcctggaat gccatccctg ataacctgga tgcagtcgtg
     2161 gacctgcagg gtggtggtca cagctatttc ttcaagggtg cttattacct gaagttggag
     2221 aaccaaagtc tgaagagtgt gaagtttgga agcatcaaat cggactggct gggctgctga
     2281 gctggccctg ttctgacggg ccgtacaatc ttcactgcac accgggccca ggaccctggg
     2341 gaaggacgtg aagaggcctg gttaccctgt ctcctgctct gtagttaatc agccttctcc
     2401 ttcacctggt gatttcagat ttaagagggt ggcttctttt ttgtgcccaa agaaaggtgc
     2461 tgaccgtatc cctcccaggt gctactttct cccgcccacc caaggggatg cttggatatt
     2521 cacaatgcag ccctcctttg ggctgccctg gtgctccaca cttcaggttc tccagcatga
     2581 atgatctttt gtgggttaca gcacactcag agtcaacaga gactgtctta ggagggcact
     2641 ggtggctcaa cagcctggca cagggcagtg ggatacaggt gtgccaaggt ggaaaccaga
     2701 gacatctggt gtctccctta cggctgccct ggcactttta ctactttagc tgtttgcttt
     2761 gtttgccctt tgctgtttgg ttcaaccttt tcagttttcc accacactgc atttttctca
     2821 ccgaaggact ccggttgtcg gacatcactg cacgatgcat ctggcctggc ctatggatgg
     2881 ctcccctcct cactttgtgt agaagcaact ccagtcactt cctccactgg ttggaggaga
     2941 accaagtcat cggcttcctg ctcagccttc ttgcttctcc ctttaacagt tccccatggg
     3001 aaatggcaaa aagtataaat aaaggcaccc tttgagtggc aaaaaaaaaa aaa
//
