LOCUS       NM_001107159            2003 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus matrix metallopeptidase 19 (Mmp19), mRNA.
ACCESSION   NM_001107159 XM_001071399 XM_222317
VERSION     NM_001107159.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Jo M and Curry TE Jr.
  TITLE     Regulation of matrix metalloproteinase-19 messenger RNA expression
            in the rat ovary
  JOURNAL   Biol Reprod 71 (6), 1796-1806 (2004)
   PUBMED   15286033
  REMARK    GeneRIF: The induction of MMP-19 mRNA suggests an important role of
            this proteinase during follicular growth, ovulation, and luteal
            regression.
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Pendas AM, Folgueras AR, Llano E, Caterina J, Frerard F, Rodriguez
            F, Astudillo A, Noel A, Birkedal-Hansen H and Lopez-Otin C.
  TITLE     Diet-induced obesity and reduced skin cancer susceptibility in
            matrix metalloproteinase 19-deficient mice
  JOURNAL   Mol Cell Biol 24 (12), 5304-5313 (2004)
   PUBMED   15169894
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P, Van
            Obberghen E and Tartare-Deckert S.
  TITLE     Matrix metalloproteinases are differentially expressed in adipose
            tissue during obesity and modulate adipocyte differentiation
  JOURNAL   J Biol Chem 278 (14), 11888-11896 (2003)
   PUBMED   12529376
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Ramanathan M, Weinstock-Guttman B, Nguyen LT, Badgett D, Miller C,
            Patrick K, Brownscheidle C and Jacobs L.
  TITLE     In vivo gene expression revealed by cDNA arrays: the pattern in
            relapsing-remitting multiple sclerosis patients compared with
            normal subjects
  JOURNAL   J Neuroimmunol 116 (2), 213-219 (2001)
   PUBMED   11438176
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Stracke JO, Hutton M, Stewart M, Pendas AM, Smith B, Lopez-Otin C,
            Murphy G and Knauper V.
  TITLE     Biochemical characterization of the catalytic domain of human
            matrix metalloproteinase 19. Evidence for a role as a potent
            basement membrane degrading enzyme
  JOURNAL   J Biol Chem 275 (20), 14809-14816 (2000)
   PUBMED   10809722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000171.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107159.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107159.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ799755.1, SRR8487226.215284.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132280, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JACYVU010000171.1  1221373-1221551
            180-265             JACYVU010000171.1  1221982-1222067
            266-396             JACYVU010000171.1  1224864-1224994
            397-612             JACYVU010000171.1  1225323-1225538
            613-858             JACYVU010000171.1  1226052-1226297
            859-984             JACYVU010000171.1  1226873-1226998
            985-1149            JACYVU010000171.1  1227779-1227943
            1150-1277           JACYVU010000171.1  1228085-1228212
            1278-2003           JACYVU010000171.1  1228350-1229075
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2003
                     /gene="Mmp19"
                     /note="matrix metallopeptidase 19"
                     /db_xref="GeneID:304608"
                     /db_xref="RGD:1311376"
     exon            1..179
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1643
                     /gene="Mmp19"
                     /note="MMP-19; matrix metalloproteinase 19"
                     /codon_start=1
                     /product="matrix metalloproteinase-19 precursor"
                     /protein_id="NP_001100629.1"
                     /db_xref="GeneID:304608"
                     /db_xref="RGD:1311376"
                     /translation="MDWQQLWLAFLLPVTVSGRALGPAEKEAVVDYLLQYGYLQKPLE
                     GADDFRLEDITEALRTFQEASELPVSGQMDDATRARMKQPRCGLEDPFNQKTLKYLLL
                     GHWRKKHLTFRILNVPSTLSPSRVRAALHQAFKYWSNVAPLTFREVKAGWADIRLSFH
                     GRQSPYCSNSFDGPGKVLAHADVPELGSVHFDNDEFWTEGTYQGVNLRIIAAHEVGHA
                     LGLGHSRYTQALMAPVYAGYQPYFRLHPDDVAGIQALYGKRRPEPEDEEEEVEMHTVS
                     TVTTKPSPMPNPCSSEVDAMMLGPRGKTYAFKGDYVWTVTDSGPGPLFRVSALWEGLP
                     GNLDAAVYSPRTQRTHFFKGNKVWRYVDFKLSPGFPMKLNRVEPNLDAALYWPVNQKV
                     FLFKGSGYWQWDELTRTDLSRYPKPIKELFTGVPDQPSAAMSWQDGQVYFFKGKEYWR
                     LNQQLRVAKGYPRNTTHWMHCSPRTPDTNSLTGDVTTPATVESVLDVPSATDAASLSS
                     SANVTLLGA"
     exon            180..265
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            266..396
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            397..612
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            613..858
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            859..984
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1149
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1277
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..2003
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccctgcc tagccctgtt cctccaagtt cccagaagtc tcaggtcaga gggctcaggc
       61 agcttctgga actcttgtct gctgggacca tggactggca gcagctgtgg ctggccttct
      121 tacttcctgt gacagtctca ggccgggctc tggggcctgc agagaaggag gcggtggtgg
      181 attacctgtt gcagtatggg tatctacaga aacctctgga aggagctgat gacttcaggc
      241 tagaagatat cacagaggct ctaagaactt tccaggaagc atctgaactg cctgtttccg
      301 gtcagatgga tgatgccaca agggcccgta tgaagcagcc ccgttgtggc ctggaggatc
      361 ctttcaacca gaagactctg aaatacctgc ttctgggcca ctggagaaag aagcacttga
      421 cattccgcat cttgaacgtg ccctccaccc tctcaccctc cagagtccga gcagccctgc
      481 atcaagcctt taagtattgg agcaatgtag cccccctgac cttccgggag gtgaaagctg
      541 gttgggctga tatccgcctc tcgttccatg gccgccaaag cccatactgc tccaacagct
      601 ttgatgggcc tgggaaggtc ctggcccatg ctgacgtccc agagcttggc agtgtacact
      661 tcgataacga tgaattctgg accgagggca cctaccaggg agtgaaccta cgcatcattg
      721 cggcccatga ggtgggccac gccctgggac ttgggcattc ccgatatacc caggcactca
      781 tggcgcctgt ttacgctggc taccagccct acttcaggct gcatccggat gatgtggcag
      841 ggatccaggc gctctatggc aagaggaggc cggagccaga agatgaggag gaagaggtgg
      901 agatgcacac tgtgtcaaca gtgaccacaa aacccagtcc catgccaaac ccctgcagca
      961 gtgaagtgga tgccatgatg ctagggcctc gggggaagac ctatgctttc aagggtgact
     1021 atgtgtggac tgtaacagat tcagggccag ggcccttgtt ccgagtgtct gccctttggg
     1081 aggggcttcc tggaaacctg gatgctgctg tctactctcc ccggacacag cggactcatt
     1141 tcttcaaggg aaacaaggtg tggcggtatg tggatttcaa gttgtctcct ggctttccca
     1201 tgaaactcaa cagagtggaa cccaacctag atgcagctct ctattggcct gttaatcaga
     1261 aggtgttcct ttttaagggc tcaggatact ggcaatggga tgaactgacc agaactgacc
     1321 tcagtcgcta ccccaaacca atcaaggaac ttttcactgg agtgccagac caaccctcag
     1381 cagctatgag ctggcaagat ggccaagtct acttcttcaa gggcaaagag tactggcgcc
     1441 ttaaccagca acttcgagtg gcaaagggct atcccagaaa tacgacacac tggatgcact
     1501 gtagtcctcg gactccagac actaactcat taactgggga tgtgaccact cctgcaaccg
     1561 tggaatcagt cttggatgtt ccctctgcca cagacgctgc ctccctctca tcctcagcta
     1621 atgtcacctt gctaggggcc tgagaactag tcagtgtctg ctccttaggg ttgtgcagat
     1681 gggcacttga cctagtgccc ctagatactc caattctgga tgccacattc cagtgttcct
     1741 agaaggtgac tgcttaattc tgagtcattc cccagtcccc atttcttctt gtcatatggc
     1801 tgtttcaagt gtgacatcta ttttctggtg gagggaaatt gttgatcagg accccccccc
     1861 ccagggtctc tctacatagc actggctatg gttatcggct atcctgaaac tgtgtagtta
     1921 tgtagactag gctaacttga actcacagaa accaacctgc ctctgcctct gtcctgagtg
     1981 ctgggattaa aagcgtgtgc tac
//
