LOCUS       NM_080776              11416 bp    mRNA    linear   ROD 22-NOV-2023
DEFINITION  Rattus norvegicus matrix metallopeptidase 16 (Mmp16), mRNA.
ACCESSION   NM_080776 XM_006237921
VERSION     NM_080776.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11416)
  AUTHORS   Meng F, Yang H, Aitha M, George S, Tierney DL and Crowder MW.
  TITLE     Biochemical and spectroscopic characterization of the catalytic
            domain of MMP16 (cdMMP16)
  JOURNAL   J Biol Inorg Chem 21 (4), 523-535 (2016)
   PUBMED   27229514
REFERENCE   2  (bases 1 to 11416)
  AUTHORS   Kojima A, Konishi M and Akizawa T.
  TITLE     Prion fragment peptides are digested with membrane type matrix
            metalloproteinases and acquire enzyme resistance through
            Cu(2)-binding
  JOURNAL   Biomolecules 4 (2), 510-526 (2014)
   PUBMED   24970228
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11416)
  AUTHORS   Irwin LN and Byers DM.
  TITLE     Novel odors affect gene expression for cytokines and proteinases in
            the rat amygdala and hippocampus
  JOURNAL   Brain Res 1489, 1-7 (2012)
   PUBMED   23103411
REFERENCE   4  (bases 1 to 11416)
  AUTHORS   Hadchouel A, Decobert F, Franco-Montoya ML, Halphen I, Jarreau PH,
            Boucherat O, Martin E, Benachi A, Amselem S, Bourbon J, Danan C and
            Delacourt C.
  TITLE     Matrix metalloproteinase gene polymorphisms and bronchopulmonary
            dysplasia: identification of MMP16 as a new player in lung
            development
  JOURNAL   PLoS One 3 (9), e3188 (2008)
   PUBMED   18784838
  REMARK    GeneRIF: MMP16 polymorphisms appear to influence not only the
            pulmonary expression and function of MMP16 but also the risk of
            bronchopulmonary dysplasia
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11416)
  AUTHORS   Shi J, Son MY, Yamada S, Szabova L, Kahan S, Chrysovergis K, Wolf
            L, Surmak A and Holmbeck K.
  TITLE     Membrane-type MMPs enable extracellular matrix permissiveness and
            mesenchymal cell proliferation during embryogenesis
  JOURNAL   Dev Biol 313 (1), 196-209 (2008)
   PUBMED   18022611
REFERENCE   6  (bases 1 to 11416)
  AUTHORS   Shofuda K, Yasumitsu H, Nishihashi A, Miki K and Miyazaki K.
  TITLE     Expression of three membrane-type matrix metalloproteinases
            (MT-MMPs) in rat vascular smooth muscle cells and characterization
            of MT3-MMPs with and without transmembrane domain
  JOURNAL   J Biol Chem 272 (15), 9749-9754 (1997)
   PUBMED   9092507
REFERENCE   7  (bases 1 to 11416)
  AUTHORS   Takino T, Sato H, Shinagawa A and Seiki M.
  TITLE     Identification of the second membrane-type matrix metalloproteinase
            (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a
            unique membrane-type subclass in the MMP family
  JOURNAL   J Biol Chem 270 (39), 23013-23020 (1995)
   PUBMED   7559440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_080776.4.
            
            On Feb 10, 2021 this sequence version replaced NM_080776.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               JACYVU010000161.1  6736409-6736969
            562-710             JACYVU010000161.1  6843073-6843221
            711-833             JACYVU010000161.1  6852289-6852411
            834-1138            JACYVU010000161.1  6863927-6864231
            1139-1300           JACYVU010000161.1  6900140-6900301
            1301-1512           JACYVU010000161.1  6902817-6903028
            1513-1651           JACYVU010000161.1  6942228-6942366
            1652-1802           JACYVU010000161.1  6964681-6964831
            1803-1918           JACYVU010000161.1  6966721-6966836
            1919-11416          JACYVU010000161.1  6970908-6980405
FEATURES             Location/Qualifiers
     source          1..11416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..11416
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /note="matrix metallopeptidase 16"
                     /db_xref="GeneID:65205"
                     /db_xref="RGD:620199"
     exon            1..561
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2253
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /note="matrix metalloproteinase-16; MMP-16; MT3MMP;
                     MTMMP3; MT-MMP 3; membrane-type matrix metalloproteinase
                     3; membrane-type-3 matrix metalloproteinase"
                     /codon_start=1
                     /product="matrix metalloproteinase-16 precursor"
                     /protein_id="NP_542954.2"
                     /db_xref="GeneID:65205"
                     /db_xref="RGD:620199"
                     /translation="MILLAFSSGRRLDFVHRSGVFFFQTLLWILCATVCGTEQYFNVE
                     VWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG
                     VPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ
                     NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGG
                     DTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF
                     KLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKNDRPKPPRPPTGRPS
                     YPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSI
                     DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGK
                     TYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYW
                     KFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIA
                     IVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV"
     exon            562..710
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            711..833
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1138
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1300
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1512
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1651
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1802
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1918
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..11416
                     /gene="Mmp16"
                     /gene_synonym="Mt3-mmp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagggga gcagagagga gggaaggagc agcggaggca gtgagctggg agcggctgag
       61 gcccttcccg cagaaactgg gggcaccggc ggcgtaggag gtggagaagg cggaggacgc
      121 acgggctgga ggcggcggct gcgactcggc ggcgctggga atcggaaccg cgggtgaact
      181 tgggcgccac gttccgggcg acggccgggt gaggatggtg aacacttgca gccgctgacc
      241 ctgcctttcc tctgttcctc gcggctgccg agcctggcgc ccatccccac ccctggacgg
      301 gtgggtgaac ctgcaagctt ctacccaccc caggactatt ttttctttta aaaggaaaca
      361 gggagtgggc attcggaaag agggagaaaa cgcaggggag ctcgtccatc cgttgaggca
      421 gagttcacta tgatcttact cgcattcagc tctggaagaa ggttggattt cgtgcatcgt
      481 tcgggggtgt ttttcttcca aaccttgctt tggattttat gtgctacagt ctgcggaacg
      541 gagcagtatt tcaatgtgga ggtttggtta cagaaatacg gctaccttcc accgactgac
      601 cccagaatgt ctgtgctgcg ctctgcagag accatgcagt cagccttagc tgccatgcag
      661 cagttctatg gcattaacat gacaggaaaa gtggacagaa acacaattga ctggatgaag
      721 aagcctcgat gtggtgtacc agaccaaaca agaggcagct ctaaattcaa catccgacga
      781 aagcgctatg cattaactgg gcagaagtgg caacacaagc atatcactta cagtataaag
      841 aacgtaactc ccaaggttgg agatcctgag acccggagag caattcgccg tgcctttgat
      901 gtgtggcaga atgtaacacc tctaacgttt gaagaagttc cctacagtga actagaaaat
      961 ggcaaacgtg atgtggatat aaccatcatt tttgcttctg gtttccatgg agacagttcc
     1021 ccctttgatg gggagggagg atttttggcc catgcttatt tccctgggcc aggaattgga
     1081 ggcgatactc attttgattc tgatgagcca tggacactgg gaaatcccaa tcatgatgga
     1141 aatgatttat ttcttgtagc agtccatgag ctgggacatg ctctagggct ggagcattcc
     1201 aacgacccaa cagctatcat ggcaccattt taccagtaca tggaaacaga caacttcaag
     1261 cttcctaatg atgatttgca aggcatccag aagatatatg gtccacctga caagatccct
     1321 ccacctacaa gacctctacc gacagtgccc cctcaccgat ctgtccctcc ggccgaccca
     1381 aggaaaaatg acaggcccaa acctcctcga cctcccactg gcagaccttc ctatccagga
     1441 gccaaaccca acatctgtga tgggaacttc aacactctag ctattcttcg aagggagatg
     1501 tttgttttca aggaccagtg gttttggcga gtgagaaaca acagggtgat ggatggatac
     1561 cccatgcaaa ttacttactt ctggcggggc cttcctccca gtattgatgc agtttatgaa
     1621 aacagtgatg gaaattttgt cttctttaaa ggtaacaaat actgggtgtt caaagacaca
     1681 actcttcaac ctggataccc tcatgacttg attacccttg gaaatggaat cccccctcat
     1741 ggtattgatt ctgccatatg gtgggaagat gttggcaaaa cctatttctt caaaggcgac
     1801 cggtattgga gatatagtga agaaatgaaa accatggacc ctggctatcc caagcccatc
     1861 accatctgga aaggaatccc tgaatcacct cagggagctt tcgtccacaa ggaaaatggc
     1921 tttacctatt tctacaaagg aaaggagtat tggaaattca acaaccagat actcaaagta
     1981 gaacctgggt atccaagatc catcctcaag gactttatgg gctgtgatgg accaacagac
     2041 cgagataaag aaggtctcag cccaccagat gatgtagaca ttgtcatcaa actggacaac
     2101 acagccagca ctgtgaaagc catagctatt gtcattccct gcatcttggc cttatgcctc
     2161 cttgtattgg tttacactgt gttccagttc aagcggaaag gaacaccccg ccacatactg
     2221 tactgtaaac gctctatgca agagtgggtg tgatgtaggg atttcttttt tctttctttt
     2281 ccgggagttt gtggtaactt gagattcaag acaagagctg ttatgctgtt tcctagctag
     2341 gagcaggctt gtggcagctg atcgaggctg accttccaaa cctagatggt tgctggtcct
     2401 gcacatgagt ggaaatatat tcatggagaa gcttccatga tgcacagtat ctgccgttct
     2461 tcagtcctct gtctttcttt gtcattcagt tctaggcctt tcctctgcac gctcaatgcc
     2521 cagtaaaatt tcaggattaa ctgaagaaga ggaaatatag aagaaaagtt tcttcttatt
     2581 ttttttttta aaatactttt ccttctgaaa tctgagccca tttctgggaa agagaaagaa
     2641 agaaagagag agagagagag agagagagag agagagagag agagagagag agagagagaa
     2701 agcaaatcag aaaacccata ggtttttgct ttaaagcaaa agaagagttt aaaaacaaca
     2761 aaatccacaa ctgaactttc agaaaagtgt gaagatccaa aacagctttg tctccaaaga
     2821 agatagctct gtgaccacta tggatagttt cctgcgcatt gtcttgtcag gtgggagatc
     2881 tggaacatac atgcaggacg ctagactgtt gggacagcca ttttccaaca aacaaggggc
     2941 caaaatatct gcaatatagt aacagcctta ataatacatg cattttcatt ttctacagct
     3001 gttctcaact atgtccacaa tgtatcatca cctccatact catagctgta ttcaaacagg
     3061 accttttggt tgttttgaaa tgtttctgaa ccccctcttg cctcctgaca cagcatcatt
     3121 gtgacattct tcccagttgt gttaggcctt tgtcccaggc cgtccattgg tctgtcagca
     3181 atactcagcg caaagcagag cgagaagcat tgtgtctctg aagtaaagaa agtgatggtc
     3241 atattataaa gatatgttcc tctttaatac atcggtgtaa ccctttgaga actatcagac
     3301 cagcttacag agtcaggatg atcagtcttg caatctggtc atttgtagaa gtggccaaaa
     3361 gggaaagcca tcacatgttc gagaagttca gacttgtaaa gcatacctta caatcccatg
     3421 taattcttta atgactgaca gtactgcata aatgctttta taacaaacaa cagtggtgtg
     3481 acttgccaaa acttttctgg caaataaaaa agatattttg ttaacaatat ctcatgagag
     3541 tgaaatttta ttcgaataat cggttagaac agtctaagct ttttcttctt cagacacatt
     3601 gatctttttt ttttaattta aaatccattg catgaaaact cagtttgcca taaaatatgc
     3661 tgttcgcatt gcttggttaa aactgaatta aaacgatgac tctgagttgc atgaatatca
     3721 tcgaatgcat ttcctattgc atgtcagcca tagttctcaa agggttggtg tggcttctgg
     3781 cgcttagcca tctatttgat cactgacaga gccaagagac accaaagcat cccattgttg
     3841 agtgtaatct gtcctaacag caggattgtc atcttcatgt gacctgcaga gcaggatcct
     3901 atcaatattt tttcctagag aaaagtcaga aactgacaga cctctttatt gatgttagaa
     3961 gctgcttctt gaagtgaatg gcttgacagc cactgggctg tgaacttatt agagatggtc
     4021 agaaggaaag caccccatga gtcagacaat tggctttgtg tgaaagccag cttttgaggg
     4081 gattagcttt tgaaacaatg aacagcttgc cttgaacatg ctattgatct gttgactgtc
     4141 attaacaaca acttaaacat tgtcttctgt gaaatttttt cctggaagag ccctgttctg
     4201 tgtatttgcc ctttgacctt taacttgcaa actggcacaa actgaaggaa atctggtgtc
     4261 acttctccac tggattattg ttattctcca aaacctagta aacaagagct gtttccttag
     4321 agtggagaga gagtttcggt agtggatctg cagatggcgc tttgctctct acatgcacac
     4381 tctgaatatg ccctaggtag aggtattttt ttttaatttt ttctttactt tcaagcttat
     4441 tttcatcatt ttagtaaaaa ttataaaaaa ataggaaaaa aaaaacctcc aatacttgaa
     4501 tggccagtat ggcttttata taaagcagga attttatact agtgaaaatt tcttactcat
     4561 ttgctaataa tacacatttc cagatgattt ttaatgagtg taggtataca ttcttatttg
     4621 gaaatggata gtttggctgc cttgaattta tatttatact caacatagca tgaaagttag
     4681 aatgcctttg gttaaactac atgtttatga tttggttggg gaaaacattt ttaattatgg
     4741 gtggcatgct gaaaagcctg gcagaatggt gtttcctaca atctgagcat attttgtaaa
     4801 actaagaaaa agaaacagga aagagaaatg gcttcgtaat accacgttat gcaatgcata
     4861 ttgtacatca acagaacatc caagattttg aatgtgaggg tcaataacac agggagggca
     4921 aggatcagcc ctatagctgt gcttcagtac ttcctttcta gatgatgcga atattagagt
     4981 tagttacgac agagcatgga ggactgtata cataagcctg tttatacagt gtttgcttgt
     5041 tagagggttt aatcctttca ggaccttgat gtcaagaaaa aaaataaaaa aaatgactgg
     5101 aaacgttttc tttttctaat aatagaagta agtaactgta acctttttgg gacatgtgca
     5161 agtcatcaag gaactccatc gacatgcatt gaactttttt ctctctaaaa tcaataagca
     5221 atttattgcc tctttactca tccatcacaa taccctgatt catcgcaaaa ctgtaagtac
     5281 ctaagggcta gaaaatcacc atagcaatgg aaagggagga gtctttattg tgcttcgatt
     5341 ctggtaaata tcatggatat gatttgggtt ttgttgcctt cactgtgaga agtctgtgta
     5401 ctaaatatgg cttctgtgtc tactatcttg actgtggccc ctataaggtc ataagtgata
     5461 tgacctaagt acagtgtgat caaaagcatt gggcttcctt tgttcactgt atgtcaggca
     5521 cttcattcac atgatggctg attcttcata agcttgggat ttgtattaaa agatgaggca
     5581 acgctataga aatcatgaca atgatgagtt aacctagcac ttgaaaaaaa atagcaatta
     5641 aatttttgaa aaagaagtta tctggatcaa gatcataatg tcagctcagt atcagtgaaa
     5701 acggtcaacc aatcaaatgt tttctgtaac ctctaaatga gaaacataca aagctctgtc
     5761 ctactgtttc caaaactgaa atgaaaacat atttgtgttc ataaaacaat tcagatgttt
     5821 cattaggttt attactttaa cgaatatgaa gacaactgta aacaaggtaa tgatttttac
     5881 ataaagtgat tttcatgttt acaacttcag gtaaatactc tttgtctgta tatttttaat
     5941 caggctaagt actaagagag atgatcagtt cgaattctat agagcagttg ttccatatca
     6001 gatctgtaga gatagttgtg attttaggta attgttaact catctgagaa caaagttttc
     6061 tgcagagatg gctctcacag caggtgaaga cagatgtcct ttgccatggc aggtttacag
     6121 ggctcaatca gaaaacaata gatgctcctg acaaatacag cttctgttac taaccagtta
     6181 ccagagcttt tctaaatcac atataataag ttacttagta atgaatgcca agaggcaatt
     6241 gctaagtaat aaaaaagtag agagaagttt cctgaaatag gaaaacctta tcgttagtac
     6301 tcaagctgcc taaagtctct ttcatccaca cataatttgg ctcttcaaag acagtacatt
     6361 taattttatt tcatttctgt gagttaatca attagaatgc agtgtaattg ctaagaacat
     6421 tgcccaggtc tcctgctcag tgtaatatcg gaatgagggt gtatatactg gattctagga
     6481 agtgtaatgt aatattctca agttctccat gttgtgtttc tattctaata cagcacaaat
     6541 tcagactcct gtcatgtgga tcttacaatt gagtaactca atgtgctatc tgaagaggaa
     6601 tagaatagat gttattactt gaatagataa acaaaagtca tgaaaataat cattttcctt
     6661 ttttaggtac ttggtattta tttcccaaaa caaataaagg cagtgatttg ctgatagttt
     6721 tgaatctgtg agattatagt atataattaa ataagcctgg ggatggtgaa aaaatgttta
     6781 cagtaatcac agccaagtgt ttaatttttg atatcataag aacatattcc aagctatcaa
     6841 agacacaaca taccatttaa aacacaagtg tgacattctg atgaactatc acaaagaact
     6901 atatatattg tctccactac tctatgatac caatgaaaac atcaagtaac ttactggtat
     6961 aatctgacta ttcctttaaa tggcagttac ctctacaata ctgatttata agaagcacat
     7021 caaacaagtg ccaggggctg gaagtctaaa tgacagtttt tctgttgcct gagaagttta
     7081 aatgagtcac tactaatggt tgaacatagt ataataaaga cactaacatt caaggagaat
     7141 aacacactat tgatatgaaa gctacatttt ataagtagag cgggcagtgg agaaggctaa
     7201 aataaatctt ctgtaaaata taaagtcaaa ctctagcact ctgtaatatt acaactgaaa
     7261 gttttcttca gcgagaatga atataataga gaaattgtaa cttcaagctc ctcatgccag
     7321 gaatgagtac ataatttatc aatgtatata cttagtcagt gcccattaga tgtcacctgt
     7381 gtaaacacat atgatgatca ttcattgact catagaccca aaatattaaa agttaaaagt
     7441 tttcattcag taacctcagt ctgaaaggtg ttagaaccct gtgagaaaaa gccatttccc
     7501 taggatagaa atttacctca ataatcatat aagacaaaac acttggcata gtagctgaag
     7561 ttgccttagt gttctagtct gatctaatag tagaatctgt ccataatgta ccactcacat
     7621 tgtttctcgt gtcttacttt tgctgtaagt ttgacttaat tttgaaatat ttctggtcat
     7681 atcaagaaca tctaattatc gatatcttct tcaacatgtc tactctgaaa tatgatccaa
     7741 cagtatagaa agcctagaat gaatatgaac ttgacatagt caccgaaatt cagaaaaaga
     7801 aatctctggt ggtatttcat aattcccttc aattatttgg taggatccag aagtagcagc
     7861 tttcattgtt taagtacagc cattgactgg taacagaaca tggcatgcat catttcttta
     7921 aaataaacta gtatttgtac taagtcatga tagaagtgta tgagaagttt actgatgtaa
     7981 caaaagcatc acagacattt gtaatgaatg ctttgtaagg gaaatggggc aaaatcgata
     8041 acttgtgatc agtacatcat aagcataaat atgaaggaca tttgtatatg gacagatctg
     8101 aggttctatg tctttcaact aaaaaagaag tatgtctttt atgatataag aatttttctt
     8161 atacaaacat ggaaggaatt ttcttcaaat atgaggtcta tgtgtccttt tatggaaagg
     8221 cacactgggc ccttcaggaa aacacatcac aagctagagt gttgggctga ttcacgtgac
     8281 gtgcccacgt gctctgttac agagctagat ttgtatgcct ttaaaaaagg gaagaaaata
     8341 tgaagtataa atataactct ttctcattag gccacttggc ttcaaagtaa gatatcacaa
     8401 gcattttccc cccactgagg aaatggaaag attgaatggt gagaaaaaat aaaagaaaaa
     8461 aaaacacaaa aacgttttgg ccaacaaaga catttctagt ttctttcacc tgttttgctt
     8521 attagaagaa gattgcatat ggacttcttt gtagcagttg ataggtagct agattgggtc
     8581 ccaggaataa tatcatagta cttttaacat gggcattttt ggatttgcct caaatagtat
     8641 gaagtttggt gaggtgtgac aaggaaggat gcttttccct aggattggct ctggtgctgc
     8701 ttgtatttgg catcttttat atgaatgtcc gttgctttgt tggcctgtct tgccagtata
     8761 ctgatgaata aagccttgtg tgcactatct atttgaagtc actagaatgc atgttttgtt
     8821 tcctgtcatg tgatatcaat tgtagctcat tccctttcta tatacccaca gcctactggt
     8881 tagtataaga catactttaa atgaatggtt ttgttattaa tacgaggaat acttaatgtt
     8941 aatgttttcc tttcttttac tacactgaga tataagaggc tactgtctct tcatttcttg
     9001 ctccttatgt attccactgc ttatgtaaaa ttatgatttt agttatgata gtcatttccc
     9061 tttttatata tggtatggaa tccattattc ctttctatac tcataaatac taatttttac
     9121 agtcaaataa acatgggtac taattgagag taagggatta tcagaatttt ctgcctcctt
     9181 ttttagataa tttttgatta ctttcaatca ccaatttcca cccataattc tgctaatgtt
     9241 taataagtca tattttcttt ctcttttgaa aaacagaatt tggtagcact gtacagtcta
     9301 gttggaaacc tggagaaatg tctttgtttc tcaatatttt ccatcataaa ttacatggaa
     9361 attatagttt ttatcacatc ccaaactctg acattgactt atatttttat agagctcttc
     9421 cccttagaaa aatagaatac taagtataat tgctgttgtt tgttgataag acagctacga
     9481 aaatttattt tgggaaaatc tatctaatat aaatatacag tatgataaat attacaatat
     9541 agggtttaag tacatcagga gaacatgaat gtctaaagcc ttgactcttt ggaatatttc
     9601 ccttctgggg tatattacat gtgtaagaaa gagatagagt agaagattgg ggtttattac
     9661 agcagtggct tctcctgcac tggctatgtc gccatcagca tttctcttgt ggacctctat
     9721 tttcaggggc tttagagact tggtcataaa aattgtttca agtgtaaaag tcttgaacga
     9781 ctcttttttc cttacatgtt atctaatttt aaacaaatat attttggttt tatattatgg
     9841 aaagtaaatg gatggaattt gctagtttaa ttttgtgcta atataaactt ttaataacct
     9901 tgatttataa taaaaatata aaatataatt agttcatagt ctaatttttt aaatgagtca
     9961 aatattgttg acattgagaa atttgctagt ttgatcagtg tggtacttat cttcaagatg
    10021 ttttaagact tggatgcatg ttgttatctt tactccaaca agagaatcag tggatcacta
    10081 tgactgacaa aaaatataga tacatgatat ctatataagc tatctgctaa catatatttg
    10141 ggactatata gtatatgtga ttatatatat atatatatat atatatatat atatatatat
    10201 atatataatc attaagggaa tgaagctcct gtcaattatc aaataaatac catatatttt
    10261 tttaagaatt gcacaaacat ttaactttca ccgttcaaat gagatacaag caattgcaga
    10321 ggaaagttgt cccctgggta aacaaaaccc ttttacatct tcctatgaaa accatctttt
    10381 gtttatatag tgtggatatt tggaatgaaa acactaaaag taaactgaga tttataaaat
    10441 tacaatagac tgaagcagag agaaaggcca ggaaattaag atataggaca ttttacccat
    10501 ggtttcaatt agagagtatg aatatgtaac cttgagtttt tgagttgttt actttgtact
    10561 ctacattttc tcatgaagac tttcattacg tgtagttttc catgtgcaag gcatgaaatg
    10621 atccatttat ttttcttagt ggattttatg ggttgaatgt tatgggtttg cccacacaag
    10681 attactttta ctccatatta aatttggcat atatattttt cctgattgct tctactgaca
    10741 aacacaaagc ttgtttgtgt gcaaataaaa ggctaaataa atggtgctaa agtgtattat
    10801 gactgtcaga tataatcagg caaaattttg tggtgcttca attaatttct cattgatttt
    10861 attgaccagt gtgttgaaca gtgtttattc acaaactgtg ttttattagt aaaattaaag
    10921 cttcatagca cattgttaac aaagaggttg cctagattat gtaatagctc accaggctat
    10981 tttctccttg actccttata atgattcctc attaaaggtc aagggtcatg ctattaatct
    11041 cattctatag atcagtaaca tgactgaaca tttctcacat ggtacttatg tttacaatgc
    11101 tataaccctt tgactgctgc ggcaacctta accatacaaa tgtcacaatc tagaatcatc
    11161 agcatggtgt gtgccatggc aatcaaagag ttaagggctg tgcagttatt tgtgttgtat
    11221 ttattaattt atatttattt catttccatt caagaatggg ttagggtggg gcactgtttg
    11281 tctgctgtaa gtgtcttaac ctagggaaag gttaaatggc tttttatact gttgcatctt
    11341 ctgtatttac catcagttca ttgtgttgta attaaaaaat gtcaataaat aagaaaacca
    11401 aaaactggtt cataga
//
