LOCUS       NM_031056               2448 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 14 (Mmp14), mRNA.
ACCESSION   NM_031056
VERSION     NM_031056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Ozaki,S., Umakoshi,A., Yano,H., Ohsumi,S., Sumida,Y., Hayase,E.,
            Usa,E., Islam,A., Choudhury,M.E., Nishi,Y., Yamashita,D.,
            Ohtsuka,Y., Nishikawa,M., Inoue,A., Suehiro,S., Kuwabara,J.,
            Watanabe,H., Takada,Y., Watanabe,Y., Nakano,I., Kunieda,T. and
            Tanaka,J.
  TITLE     Chloride intracellular channel protein 2 is secreted and inhibits
            MMP14 activity, while preventing tumor cell invasion and metastasis
  JOURNAL   Neoplasia 23 (8), 754-765 (2021)
   PUBMED   34229297
  REMARK    GeneRIF: Chloride intracellular channel protein 2 is secreted and
            inhibits MMP14 activity, while preventing tumor cell invasion and
            metastasis.
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Ma,H., Wang,L., Lv,W. and Lv,Z.
  TITLE     Effects of miR-7 on Hcy-induced rat cerebral arterial vascular
            smooth muscle cell proliferation, migration and inflammatory factor
            expression by targeting MMP-14 to regulate TLR4/NF-kappaB signaling
            pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (7), 12-17 (2020)
   PUBMED   33287916
  REMARK    GeneRIF: Effects of miR-7 on Hcy-induced rat cerebral arterial
            vascular smooth muscle cell proliferation, migration and
            inflammatory factor expression by targeting MMP-14 to regulate
            TLR4/NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Fu,X., Halim,A., Tian,B., Luo,Q. and Song,G.
  TITLE     MT1-MMP downregulation via the PI3K/Akt signaling pathway is
            required for the mechanical stretching-inhibited invasion of
            bone-marrow-derived mesenchymal stem cells
  JOURNAL   J Cell Physiol 234 (8), 14133-14144 (2019)
   PUBMED   30659604
  REMARK    GeneRIF: our results suggest that mechanical stretching inhibits
            bone-marrow-derived mesenchymal stem cells invasion by
            downregulating MT1-MMP expression by suppressing the PI3K/Akt
            signaling pathway.
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Tang,Y., Zhang,Y., Zheng,M., Chen,J., Chen,H. and Liu,N.
  TITLE     Effects of treadmill exercise on cerebral angiogenesis and MT1-MMP
            expression after cerebral ischemia in rats
  JOURNAL   Brain Behav 8 (8), e01079 (2018)
   PUBMED   30035384
  REMARK    GeneRIF: Evidence shows that MT1-MMP take action in the beginning
            of vascular matrix dissolution, endothelial cell growth, vascular
            remodeling and ultimately in angiogenesis.
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Abu El-Asrar,A.M., Mohammad,G., Allegaert,E., Ahmad,A.,
            Siddiquei,M.M., Alam,K., Gikandi,P.W., De Hertogh,G. and
            Opdenakker,G.
  TITLE     Matrix metalloproteinase-14 is a biomarker of angiogenic activity
            in proliferative diabetic retinopathy
  JOURNAL   Mol Vis 24, 394-406 (2018)
   PUBMED   29853773
  REMARK    GeneRIF: The results suggest that MMP-14 is involved in
            proliferative diabetic retinopathy angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Hayashi,K., Osada,S., Shofuda,K., Horikoshi,S., Shirato,I. and
            Tomino,Y.
  TITLE     Enhanced expression of membrane type-1 matrix metalloproteinase in
            mesangial proliferative glomerulonephritis
  JOURNAL   J Am Soc Nephrol 9 (12), 2262-2271 (1998)
   PUBMED   9848780
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Kitagawa,Y., Kunimi,K., Ito,H., Sato,H., Uchibayashi,T., Okada,Y.,
            Seiki,M. and Namiki,M.
  TITLE     Expression and tissue localization of membrane-types 1, 2, and 3
            matrix metalloproteinases in human urothelial carcinomas
  JOURNAL   J Urol 160 (4), 1540-1545 (1998)
   PUBMED   9751409
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Bruno,G., Todor,R., Lewis,I. and Chyatte,D.
  TITLE     Vascular extracellular matrix remodeling in cerebral aneurysms
  JOURNAL   J Neurosurg 89 (3), 431-440 (1998)
   PUBMED   9724118
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Ueno,H., Nakamura,H., Inoue,M., Imai,K., Noguchi,M., Sato,H.,
            Seiki,M. and Okada,Y.
  TITLE     Expression and tissue localization of membrane-types 1, 2, and 3
            matrix metalloproteinases in human invasive breast carcinomas
  JOURNAL   Cancer Res 57 (10), 2055-2060 (1997)
   PUBMED   9158005
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Okada,A., Bellocq,J.P., Rouyer,N., Chenard,M.P., Rio,M.C.,
            Chambon,P. and Basset,P.
  TITLE     Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed
            in stromal cells of human colon, breast, and head and neck
            carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2730-2734 (1995)
   PUBMED   7708715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X91785.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X91785.1, BC072509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2448
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /note="matrix metallopeptidase 14"
                     /db_xref="GeneID:81707"
                     /db_xref="RGD:620198"
     exon            1..271
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1912
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /EC_number="3.4.24.80"
                     /note="membrane type 1-matrix metalloproteinase; matrix
                     metallopeptidase 14 (membrane-inserted); matrix
                     metalloproteinase-14; MMP-14; MT1MMP; MTMMP1; MT-MMP 1;
                     membrane-type matrix metalloproteinase 1; matrix
                     metalloproteinase 14 membrane-inserted"
                     /codon_start=1
                     /product="matrix metalloproteinase-14 precursor"
                     /protein_id="NP_112318.1"
                     /db_xref="GeneID:81707"
                     /db_xref="RGD:620198"
                     /translation="MSPAPRPSRSLLLPLLTLGTTLASLGWAQSSNFSPEAWLQQYGY
                     LPPGDLRTHTQRSPQSLSAAIAAMQRFYGLQVTGKADSDTMKAMRRPRCGVPDKFGTE
                     IKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFR
                     EVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSA
                     EPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDR
                     RGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPRNPTYGPNICDGNFDTVAMLRGEMF
                     VFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE
                     ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRAVDSEYP
                     KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC
                     PSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHG
                     TPKRLLYCQRSLLDKV"
     exon            272..420
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            421..543
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            544..851
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1013
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1174
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1313
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1464
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1580
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2448
                     /gene="Mmp14"
                     /gene_synonym="Mt1-mmp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatttcca ggagcaattc cctcacctcc aaggcgactg cgctctagga atcacattcc
       61 gttcctttag aagacaaagg cgcccaagag agcagcggcg cgaccccagg gcgtgggccc
      121 cgccgcggag ccctcactgc ccgacgcccc gacgccgcgg accatgtctc ccgcccctcg
      181 accctcccgc agcctcctgc tccccctgct cacgctcggc accacgctcg cctccctcgg
      241 ctgggcccaa agcagcaact tcagccccga agcttggctg cagcagtatg gctacctacc
      301 tccaggggac ctgcgtaccc acacacaacg ctcaccccag tcactctcag ctgccattgc
      361 cgccatgcaa aggttctatg gtttacaagt gacaggcaag gccgattcgg acacgatgaa
      421 ggctatgagg cgccctcgct gtggtgttcc agataagttt gggactgaga tcaaggccaa
      481 tgttcggagg aagcgctatg ccattcaggg cctcaagtgg cagcataatg agatcacttt
      541 ctgcatccag aattataccc ccaaggtggg cgagtatgcc acattcgagg ccattcggaa
      601 agccttccga gtatgggaga gtgccacgcc actgcgcttc cgagaagtgc cctatgccta
      661 catccgggag ggtcatgaga agcaggctga catcatgatc ttgtttgctg agggtttcca
      721 tggcgacagc acaccctttg atggtgaagg aggcttcctg gctcatgcct atttcccagg
      781 ccccaatatc ggaggggata cccactttga ttctgctgag ccctggactg tccaaaatga
      841 ggatctaaat gggaatgaca tcttcttggt ggctgtgcat gagttggggc atgccctagg
      901 cctggaacat tccaacgacc cctccgccat catggctccc ttttaccagt ggatggacac
      961 cgagaacttc gtgttgcctg atgacgatcg ccgcggcatc cagcaacttt atggaagcaa
     1021 gtcagggtca cccacaaaga tgccccctca acccagaacc acctctaggc cctctgtccc
     1081 agataagccc agaaacccca cctatgggcc caacatctgt gatgggaact ttgacaccgt
     1141 ggccatgctc cgaggagaga tgtttgtctt caaggagcga tggttctggc gggtgaggaa
     1201 taaccaagtg atggacggat acccaatgcc cattggccaa ttctggaggg gcctgcctgc
     1261 atccatcaac actgcctatg agaggaagga tggcaaattt gttttcttca aaggagataa
     1321 gcactgggtg tttgacgaag cttccctgga acccggatac cccaagcaca ttaaggagct
     1381 gggccgagga ctgcccacgg acaagattga tgcagctctc ttctggatgc ccaacgggaa
     1441 gacctacttc ttccggggaa ataagtacta ccgcttcaat gaggagttca gggcagtgga
     1501 cagcgaatac cccaaaaaca tcaaagtctg ggaaggaatc cctgagtctc ccagaggctc
     1561 attcatgggt agcgatgaag tcttcacata cttctacaaa gggaacaaat actggaaatt
     1621 caacaaccag aagctgaagg tagagccagg gtaccccaag tcagctctgc gggactggat
     1681 gggctgccct tcggggggcc ggcccgacga ggggactgag gaggagacgg aggtgatcat
     1741 catcgaggtg gatgaggagg gcagcggagc cgtgagtgca gctgctgtcg ttctgccggt
     1801 gctgctgctg ctcctggtac tggcagtggg ccttgctgtc ttcttcttta gacgccatgg
     1861 gacacccaag cgactgcttt actgccagcg ttcactgctg gacaaggtct gacccccacc
     1921 actggcccac ccgcttctac cacaaggact ttgcctcctc cgaaggcagt ggcagccggt
     1981 ggtggcaggt gggctgttct cacccatcct gggctccctc cctccagcct cccttctcag
     2041 tccctaattg gcttctccca ccctcacccc agccttgctt catccatagg tgggtccctt
     2101 gagggctgag cagaagatgg tctggcctct ggccctcaag ggaccctcat agcttggtgt
     2161 gtgtccaacc ctatttgaat gttgtcaagg ctctgcactt gaaggcaggg ccctctgacc
     2221 ttacaggcaa aggccaaatg gggtcatctg cttctcttcc atccccctag ctacatatct
     2281 taaatctctg aactatgacc tcaggaggct ttgggcatat gagccctata cgtaccaagt
     2341 gtacccagtt ggcagcctcc cgtcactctg actaaaaaga atcttcagag tgcatatttg
     2401 gaggtggaaa gattgttcag ttaccctaaa gactttgaaa gaaagaaa
//
