LOCUS       NM_133530               2602 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 13 (Mmp13), mRNA.
ACCESSION   NM_133530 XM_001072242 XM_343345
VERSION     NM_133530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Gao,X., Gao,L.F., Zhang,Z.Y., Jia,S. and Meng,C.Y.
  TITLE     miR-99b-3p/Mmp13 axis regulates NLRP3 inflammasome-dependent
            microglial pyroptosis and alleviates neuropathic pain via the
            promotion of autophagy
  JOURNAL   Int Immunopharmacol 126, 111331 (2024)
   PUBMED   38061116
  REMARK    GeneRIF: miR-99b-3p/Mmp13 axis regulates NLRP3
            inflammasome-dependent microglial pyroptosis and alleviates
            neuropathic pain via the promotion of autophagy.
REFERENCE   2  (bases 1 to 2602)
  AUTHORS   Kondo,S., Kojima,K., Nakamura,N., Miyabe,M., Kikuchi,T., Ohno,T.,
            Sawada,N., Minato,T., Saiki,T., Ito,M., Sasajima,S., Matsubara,T.,
            Mitani,A. and Naruse,K.
  TITLE     Increased expression of angiopoietin-like protein 4 regulates
            matrix metalloproteinase-13 expression in Porphyromonas gingivalis
            lipopolysaccharides-stimulated gingival fibroblasts and
            ligature-induced experimental periodontitis
  JOURNAL   J Periodontal Res 58 (1), 43-52 (2023)
   PUBMED   36409042
  REMARK    GeneRIF: Increased expression of angiopoietin-like protein 4
            regulates matrix metalloproteinase-13 expression in Porphyromonas
            gingivalis lipopolysaccharides-stimulated gingival fibroblasts and
            ligature-induced experimental periodontitis.
REFERENCE   3  (bases 1 to 2602)
  AUTHORS   Tang,S., Tang,T., Gao,G., Wei,Q., Sun,K. and Huang,W.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes inhibit
            chondrocyte apoptosis and the expression of MMPs by regulating
            Drp1-mediated mitophagy
  JOURNAL   Acta Histochem 123 (8), 151796 (2021)
   PUBMED   34656826
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes inhibit
            chondrocyte apoptosis and the expression of MMPs by regulating
            Drp1-mediated mitophagy.
REFERENCE   4  (bases 1 to 2602)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P.,
            Mielnik-Blaszczak,M., Arciszewski,M.B., Kushnir,V., Brezvyn,O.,
            Muzyka,V. and Kotsyumbas,I.
  TITLE     Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression
            and Immunolocalization in Bone and Cartilage in Newborn Offspring
            Prenatally Exposed to Fumonisins
  JOURNAL   Int J Mol Sci 22 (22), 12528 (2021)
   PUBMED   34830409
  REMARK    GeneRIF: Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF
            Expression and Immunolocalization in Bone and Cartilage in Newborn
            Offspring Prenatally Exposed to Fumonisins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2602)
  AUTHORS   Gomathi,K., Rohini,M., Partridge,N.C. and Selvamurugan,N.
  TITLE     Regulation of transforming growth factor-beta1-stimulation of Runx2
            acetylation for matrix metalloproteinase 13 expression in
            osteoblastic cells
  JOURNAL   Biol Chem 403 (3), 305-315 (2021)
   PUBMED   34643076
  REMARK    GeneRIF: Regulation of transforming growth factor-beta1-stimulation
            of Runx2 acetylation for matrix metalloproteinase 13 expression in
            osteoblastic cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2602)
  AUTHORS   Knauper,V., Cowell,S., Smith,B., Lopez-Otin,C., O'Shea,M.,
            Morris,H., Zardi,L. and Murphy,G.
  TITLE     The role of the C-terminal domain of human collagenase-3 (MMP-13)
            in the activation of procollagenase-3, substrate specificity, and
            tissue inhibitor of metalloproteinase interaction
  JOURNAL   J Biol Chem 272 (12), 7608-7616 (1997)
   PUBMED   9065415
REFERENCE   7  (bases 1 to 2602)
  AUTHORS   Krane,S.M., Byrne,M.H., Lemaitre,V., Henriet,P., Jeffrey,J.J.,
            Witter,J.P., Liu,X., Wu,H., Jaenisch,R. and Eeckhout,Y.
  TITLE     Different collagenase gene products have different roles in
            degradation of type I collagen
  JOURNAL   J Biol Chem 271 (45), 28509-28515 (1996)
   PUBMED   8910479
REFERENCE   8  (bases 1 to 2602)
  AUTHORS   Balbin,M., Fueyo,A., Lopez,J.M., Diez-Itza,I., Velasco,G. and
            Lopez-Otin,C.
  TITLE     Expression of collagenase-3 in the rat ovary during the ovulatory
            process
  JOURNAL   J Endocrinol 149 (3), 405-415 (1996)
   PUBMED   8691099
REFERENCE   9  (bases 1 to 2602)
  AUTHORS   Knauper,V., Lopez-Otin,C., Smith,B., Knight,G. and Murphy,G.
  TITLE     Biochemical characterization of human collagenase-3
  JOURNAL   J Biol Chem 271 (3), 1544-1550 (1996)
   PUBMED   8576151
REFERENCE   10 (bases 1 to 2602)
  AUTHORS   Quinn,C.O., Scott,D.K., Brinckerhoff,C.E., Matrisian,L.M.,
            Jeffrey,J.J. and Partridge,N.C.
  TITLE     Rat collagenase. Cloning, amino acid sequence comparison, and
            parathyroid hormone regulation in osteoblastic cells
  JOURNAL   J Biol Chem 265 (36), 22342-22347 (1990)
   PUBMED   2176215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_343345.3, XM_001072242.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60616.1, SRR22582419.1760553.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000008.1  12782829-12782961
            134-375             JAXUCZ010000008.1  12783048-12783289
            376-524             JAXUCZ010000008.1  12784199-12784347
            525-650             JAXUCZ010000008.1  12784520-12784645
            651-812             JAXUCZ010000008.1  12786597-12786758
            813-930             JAXUCZ010000008.1  12788012-12788129
            931-1064            JAXUCZ010000008.1  12788922-12789055
            1065-1224           JAXUCZ010000008.1  12790209-12790368
            1225-1328           JAXUCZ010000008.1  12790883-12790986
            1329-2602           JAXUCZ010000008.1  12791835-12793108
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2602
                     /gene="Mmp13"
                     /note="matrix metallopeptidase 13"
                     /db_xref="GeneID:171052"
                     /db_xref="RGD:620196"
     exon            1..133
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1429
                     /gene="Mmp13"
                     /note="collagenase 3; MMP-13; interstitial collagenase;
                     UMRCASE; matrix metalloproteinase-13"
                     /codon_start=1
                     /product="collagenase 3 precursor"
                     /protein_id="NP_598214.1"
                     /db_xref="GeneID:171052"
                     /db_xref="RGD:620196"
                     /translation="MHSAILATFFLLSWTHCWSLPLPYGDDDDDDLSEEDLEFAEHYL
                     KSYYHPVTLAGILKKSTVTSTVDRLREMQSFFGLDVTGKLDDPTLDIMRKPRCGVPDV
                     GEYNVFPRTLKWSQTNLTYRIVNYTPDISHSEVEKAFRKAFKVWSDVTPLNFTRIHDG
                     TADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNLGGDAHFDDDETWTSSSKGYNLF
                     IVAAHELGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNP
                     KHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRLHPQQVEPELFLTKSFWPELPNH
                     VDAAYEHPSRDLMFIFRGRKFWALNGYDIMEGYPRKISDLGFPKEVKRLSAAVHFEDT
                     GKTLFFSGNHVWSYDDANQTMDKDYPRLIEEEFPGIGDKVDAVYEKNGYIYFFNGPIQ
                     FEYSIWSNRIVRVMPTNSLLWC"
     exon            134..375
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            376..524
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            525..650
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            651..812
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            813..930
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1064
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1224
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1328
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..2602
                     /gene="Mmp13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggcacc atgcattcag ctattctggc caccttcttc ttgttgagtt ggactcactg
       61 ttggtccctg ccccttccct atggtgatga tgatgatgat gacttgtctg aggaagatct
      121 tgagtttgca gagcactact tgaaatcata ctaccatcct gtgactcttg cgggaatcct
      181 gaagaagtct acagtgacct ctacagttga tagactccga gaaatgcagt ctttctttgg
      241 cttagatgtg actggcaaac ttgatgatcc taccttagac atcatgagaa aaccaagatg
      301 tggagtgcct gatgtgggtg aatacaatgt tttccctcga acactcaaat ggtcccaaac
      361 aaacttaact tacagaattg tgaactacac ccctgatata tcccattctg aagtggagaa
      421 ggccttcaga aaagccttca aggtctggtc tgatgtgaca cctctgaatt ttaccaggat
      481 ccatgatggc actgctgata tcatgatatc ttttggaact aaagaacatg gtgacttcta
      541 cccatttgat gggccttctg gtcttctggc acacgctttt cctcctggac caaaccttgg
      601 cggggacgcc cattttgatg atgatgaaac ctggacaagc agctccaaag gctacaactt
      661 atttattgtt gctgcccatg agcttggcca ctccctcggt ctggaccact ccaaggaccc
      721 tggagccctg atgtttccca tctataccta cactggcaaa agccatttca tgctcccaga
      781 tgatgacgtt caaggaatcc agtctctcta tggtccagga gatgaagacc ccaaccctaa
      841 gcaccccaaa acaccagaga agtgtgaccc agccctatcc cttgatgcca ttactagtct
      901 ccgaggagaa accatgatct ttaaagacag attcttctgg cgtctgcacc ctcagcaggt
      961 tgagcctgaa ctgtttttga ccaagtcctt ttggccagaa cttcccaacc atgtggatgc
     1021 tgcatacgag catccatccc gagacctcat gttcatcttt agagggagaa aattctgggc
     1081 cctgaatggg tatgacatta tggagggtta tcccagaaaa atatctgacc tgggatttcc
     1141 aaaagaggtg aaaaggctca gtgctgcggt tcactttgag gacacgggga agaccctctt
     1201 cttctcaggg aaccacgtgt ggagttatga tgatgctaac cagactatgg acaaagacta
     1261 tccccgcctc atagaagaag aattccctgg aattggcgac aaagtagatg ctgtctatga
     1321 gaaaaatggc tatatctact ttttcaatgg gcccatacag tttgaataca gtatctggag
     1381 taatcgcatt gtgagagtca tgccaacaaa ttccttattg tggtgttaaa catctttcaa
     1441 aattgttatt tatctcccaa agagtatttg ggttactctt aggtgtatac tgtggggagt
     1501 ggagatatca ggggagagct tagttctgtg aacaagcttc agtaagttat ctttgagcat
     1561 gcagtatcta catgactatg cgtggctgga accacattga agaattgtaa agtactgaaa
     1621 ttgagagccc caaggatcac ctgattcttg ggtgctatgg agaaacaaat tgataataac
     1681 ccacagcaaa catgtggttt atctgctgaa gagtgatcat aattattaat atatttatta
     1741 aaaaacctaa caggcataaa ataaattata tttatataac tgaattgtct ttacaaaaaa
     1801 gcataaactt acaagcatga aaactgtggg gagttcatct atggagaatc atagatgaac
     1861 acagataaag ggaaattcct gtaaaacaca cattaacaga tagctttcca aggcaagatt
     1921 tcagcttttc actgtgaata ttcagattta aacctatttt ctcacaaaca ctaagaagat
     1981 gtcaggcact aaaggaaggg gataaccact gttctgagga cagtgtggct ggctttacat
     2041 ttggcttaat ttttatgttg ggtcattact cgagactgtg cacactgata gaggacacag
     2101 agatggagaa attctctttt tattaaatat tttaggtgtt taaaaggcca caatgtggaa
     2161 aatcaaaatt gttataaggt acctaagcaa tagcatagtt tttcataaat tatttgacta
     2221 tttgcaaata aaacaagtgt ttcaaccctg tttacctacc cacttatttt aatgacccat
     2281 agattctttt ctagtgactt gtgtgacagg agctaaggca gacatagtaa gtagatctgt
     2341 taagacacag acagcaagaa taaagactgt gcgaactgga cagtcaccct tttgagacca
     2401 ccctttcatg ctcctccatg ttcattagcc ccttccctgc tttccttagt gactgacact
     2461 tggtgcttac tgatgtgtga acaactattt tgtcaagaga tggtgtttat taaactggga
     2521 caaggaaaaa gaagtgtgtt ttttaataat gtgttacact gtgcttatgt tgtttctaat
     2581 aaaaacaagt gttttcagca ga
//
