LOCUS       NM_053963               1831 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus matrix metallopeptidase 12 (Mmp12), mRNA.
ACCESSION   NM_053963
VERSION     NM_053963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Challa,S.R., Nalamolu,K.R., Fornal,C.A., Mohandass,A.,
            Mussman,J.P., Schaibley,C., Kashyap,A., Sama,V., Wang,B.C.,
            Klopfenstein,J.D., Pinson,D.M., Kunamneni,A. and Veeravalli,K.K.
  TITLE     The interplay between MMP-12 and t-PA in the brain after ischemic
            stroke
  JOURNAL   Neurochem Int 161, 105436 (2022)
   PUBMED   36283468
  REMARK    GeneRIF: The interplay between MMP-12 and t-PA in the brain after
            ischemic stroke.
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Natarajan,G., Perriotte-Olson,C., Casey,C.A., Donohue,T.M. Jr.,
            Talmon,G.A., Harris,E.N., Kabanov,A.V. and Saraswathi,V.
  TITLE     Effect of nanoformulated copper/zinc superoxide dismutase on
            chronic ethanol-induced alterations in liver and adipose tissue
  JOURNAL   Alcohol 79, 71-79 (2019)
   PUBMED   30611703
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Soler,A., Hunter,I., Joseph,G., Hutcheson,R., Hutcheson,B.,
            Yang,J., Zhang,F.F., Joshi,S.R., Bradford,C., Gotlinger,K.H.,
            Maniyar,R., Falck,J.R., Proctor,S., Schwartzman,M.L., Gupte,S.A.
            and Rocic,P.
  TITLE     Elevated 20-HETE in metabolic syndrome regulates arterial stiffness
            and systolic hypertension via MMP12 activation
  JOURNAL   J Mol Cell Cardiol 117, 88-99 (2018)
   PUBMED   29428638
  REMARK    GeneRIF: elevated 20-hydroxyeicosatetraeonic acid in metabolic
            syndrome increases matrix metalloproteinase 12 (MMP12) activation
            leading to increased degradation of elastin, increased large artery
            stiffness and increased systolic blood pressure.
            Erratum:[J Mol Cell Cardiol. 2018 Aug;121:308. doi:
            10.1016/j.yjmcc.2018.03.015.. PMID: 29625729]
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Bjornfot Holmstrom,S., Clark,R., Zwicker,S., Bureik,D.,
            Kvedaraite,E., Bernasconi,E., Nguyen Hoang,A.T., Johannsen,G.,
            Marsland,B.J., Bostrom,E.A. and Svensson,M.
  TITLE     Gingival Tissue Inflammation Promotes Increased Matrix
            Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells
            in Periodontitis
  JOURNAL   J Immunol 199 (12), 4023-4035 (2017)
   PUBMED   29101312
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Chakraborty,D., Cui,W., Rosario,G.X., Scott,R.L., Dhakal,P.,
            Renaud,S.J., Tachibana,M., Rumi,M.A., Mason,C.W., Krieg,A.J. and
            Soares,M.J.
  TITLE     HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity
            and placental adaptations to hypoxia
  JOURNAL   Proc Natl Acad Sci U S A 113 (46), E7212-E7221 (2016)
   PUBMED   27807143
  REMARK    GeneRIF: In the present report, hypoxia is shown to activate a
            HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast
            invasion and trophoblast-directed uterine spiral artery remodeling.
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Hagemann,T., Gunawan,B., Schulz,M., Fuzesi,L. and Binder,C.
  TITLE     mRNA expression of matrix metalloproteases and their inhibitors
            differs in subtypes of renal cell carcinomas
  JOURNAL   Eur J Cancer 37 (15), 1839-1846 (2001)
   PUBMED   11576837
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Lang,R., Kocourek,A., Braun,M., Tschesche,H., Huber,R., Bode,W. and
            Maskos,K.
  TITLE     Substrate specificity determinants of human macrophage elastase
            (MMP-12) based on the 1.1 A crystal structure
  JOURNAL   J Mol Biol 312 (4), 731-742 (2001)
   PUBMED   11575928
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Zhang,B., Dhillon,S., Geary,I., Howell,W.M., Iannotti,F., Day,I.N.
            and Ye,S.
  TITLE     Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes
            in relation to subarachnoid hemorrhage
  JOURNAL   Stroke 32 (9), 2198-2202 (2001)
   PUBMED   11546917
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Fu,J.Y., Lyga,A., Shi,H., Blue,M.L., Dixon,B. and Chen,D.
  TITLE     Cloning, expression, purification, and characterization of rat
            MMP-12
  JOURNAL   Protein Expr Purif 21 (2), 268-274 (2001)
   PUBMED   11237688
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Jormsjo,S., Ye,S., Moritz,J., Walter,D.H., Dimmeler,S.,
            Zeiher,A.M., Henney,A., Hamsten,A. and Eriksson,P.
  TITLE     Allele-specific regulation of matrix metalloproteinase-12 gene
            activity is associated with coronary artery luminal dimensions in
            diabetic patients with manifest coronary artery disease
  JOURNAL   Circ Res 86 (9), 998-1003 (2000)
   PUBMED   10807873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088120.1 and CB791502.1.
            
            On Mar 23, 2010 this sequence version replaced NM_053963.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088120.1, X98517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1632              BC088120.1         1-1632
            1633-1831           CB791502.1         212-410
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1831
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /note="matrix metallopeptidase 12"
                     /db_xref="GeneID:117033"
                     /db_xref="RGD:620195"
     exon            1..134
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1442
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /EC_number="3.4.24.65"
                     /note="macrophage metalloelastase; MMP-12; matrix
                     metalloproteinase-12"
                     /codon_start=1
                     /product="macrophage metalloelastase preproprotein"
                     /protein_id="NP_446415.2"
                     /db_xref="GeneID:117033"
                     /db_xref="RGD:620195"
                     /translation="MNWTLLLKGAGTMKFLLVLVLLVSLQVSACGAAPMNESEFAEWY
                     LSRFFDYQGDRIPMTKTKTNRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTSRCGV
                     PDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKRADVDYIFQKAFQVWSDVTPLRFRKI
                     HKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGT
                     NLFLVAVHELGHSLGLPHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYGAPVKN
                     PSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDWFFWWRLPGSPATNITSISSMWP
                     TIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHYPRSIHSLGFPASVKKIDAAV
                     FDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPGIRPKIDAVLYFKRHYYIF
                     QGAYQLEYDPLLHRVTKTLSSTSWFGC"
     exon            135..382
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            383..531
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            532..657
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            658..819
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            820..943
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1077
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1237
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1341
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1791
                     /gene="Mmp12"
                     /gene_synonym="Mme"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp12"
                     /gene_synonym="Mme"
     polyA_site      1791
                     /gene="Mmp12"
                     /gene_synonym="Mme"
ORIGIN      
        1 gcaggttgat gaactggact ctgttgctga aaggagctgg cacaatgaag tttctcctcg
       61 tgctggtgct gcttgtgtcc ttacaggtat ctgcctgtgg ggctgctccc atgaacgaga
      121 gcgaatttgc tgaatggtac ttgtcaagat tttttgacta tcaaggggac agaattccaa
      181 tgacaaaaac aaaaaccaat agaaacctcc tagaagaaaa actccaggaa atgcagcagt
      241 tctttgggct agaagtaact gggcaactgg acacctcaac tctgaaaata atgcacacgt
      301 ctcgatgtgg agtgcctgat gtacagcatc ttagagcagt gccccagagg tcaagatgga
      361 tgaagcggta tctcacttac aggatctata attacactcc agacatgaag cgtgcggatg
      421 tagactacat atttcagaaa gcttttcaag tctggagcga tgtcactcct ctaagattca
      481 gaaagattca taaaggcgag gctgacatta cgatactttt tgcatttgga gatcatggag
      541 acttctacga ttttgatggc aaaggtggta ccttagccca tgctttttat cctgggcccg
      601 gtattcaagg agatgcacat tttgatgagg cagaaacctg gactaaaagt tttcaaggca
      661 caaacctgtt ccttgttgct gttcatgagc ttggccattc cttggggctg ccgcattcca
      721 ataatccaaa atcaataatg taccctacct acagatacct tcaccccaac acatttcgtc
      781 tctctgctga tgacatacac agcattcagt ccctctacgg agccccagtg aaaaacccat
      841 ccttgacaaa tcctggaagt ccaccatcaa ctgtgtgtca ccaaagcttg agttttgatg
      901 ctgtcacaac agtgggagat aaaatctttt tctttaaaga ctggttcttc tggtggaggc
      961 tgcctgggag tccagccacc aacattactt caatttcttc catgtggcca actatcccat
     1021 ctggtattca agctgcttat gaaattggag gcagaaatca actttttctt tttaaagatg
     1081 agaagtactg gttaataaac aacttggtac cagagccaca ctatcccaga agcatacatt
     1141 ctctgggctt ccctgcatct gtaaagaaga ttgatgcagc tgtctttgat ccacttcgcc
     1201 aaaaggtcta tttctttgtg gataaacaat attggaggta cgatgtgagg caggaactca
     1261 tggacgctgc ttaccccaag ctgatttcta cacacttccc aggaatcagg ccaaaaattg
     1321 atgcagttct ctatttcaaa aggcactact acatcttcca aggagcctac caattggaat
     1381 atgacccctt actgcatcgt gtcaccaaaa cattgagcag tacgagctgg ttcggttgtt
     1441 aggaagaatg tagtgaagga tgcttgctgg tttttgtttc ataaacattt attacatatc
     1501 cactgtatgc tcagggtgta actacatggc aatgatgtaa tgtgaaatga ggcgagatat
     1561 acaagccaca tacacatagt tacacagaaa agtgctttta caaaattaaa gctcttttgg
     1621 taaacttttt tacttgattc tcttcttaat tttgaaagca aatgcctcca aaggccaact
     1681 tttttatctg taagttgttt ctaacaacct tcaagtagga aaattagaat tactccccta
     1741 tctttactga aatataccat ttttcttaaa taaatttaaa gaaaacattt aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
