LOCUS       NM_012980               2253 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 11 (Mmp11), mRNA.
ACCESSION   NM_012980
VERSION     NM_012980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2253)
  AUTHORS   Motrescu,E.R., Blaise,S., Etique,N., Messaddeq,N., Chenard,M.P.,
            Stoll,I., Tomasetto,C. and Rio,M.C.
  TITLE     Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic
            function against collagen VI under normal and malignant conditions
  JOURNAL   Oncogene 27 (49), 6347-6355 (2008)
   PUBMED   18622425
REFERENCE   2  (bases 1 to 2253)
  AUTHORS   Okada,A., Saez,S., Misumi,Y. and Basset,P.
  TITLE     Rat stromelysin 3: cDNA cloning from healing skin wound, activation
            by furin and expression in rat tissues
  JOURNAL   Gene 185 (2), 187-193 (1997)
   PUBMED   9055814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U46034.1, CK602095.1, BC099781.1 and BI291437.1.
            
            On Jul 31, 2012 this sequence version replaced NM_012980.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U46034.1, BC099781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               U46034.1           1-878
            879-1398            CK602095.1         128-647
            1399-2233           BC099781.1         1393-2227
            2234-2253           BI291437.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2253
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /note="matrix metallopeptidase 11"
                     /db_xref="GeneID:25481"
                     /db_xref="RGD:3099"
     exon            1..135
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1491
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /note="stromelysin-3; SL-3; MMP-11; matrix
                     metalloproteinase-11; Matrix metalloproteinase 11
                     (stromelysin 3)"
                     /codon_start=1
                     /product="stromelysin-3 precursor"
                     /protein_id="NP_037112.2"
                     /db_xref="GeneID:25481"
                     /db_xref="RGD:3099"
                     /translation="MARAACLLRAISRALLLPLPLLLLLLLLLPPQLMARARPPENHR
                     HRPVKRVPQLLPAALPNSLPSVPASHWVPGPASSSRPLRCGVPDPPDVLNARNRQKRF
                     VLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALRVWSEVTPLTFTEVHEGRADIM
                     IDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDKGTDLLQVAAH
                     EFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQLTPTSPTPTLSS
                     QAGTDTNEIALQEPEVPPEVCETSFDAVSTIRGELFFFKAGFVWRLRSGQLQPGYPAL
                     ASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHA
                     ALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAAFQDAEGYA
                     YFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDCAEPANTFR"
     exon            136..365
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..509
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..640
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..882
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1099
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1357
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2236
                     /gene="Mmp11"
                     /gene_synonym="ST3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccccgg ggcggatggc acgggccgcc tgtctcctcc gcgcgatctc gcgcgccctc
       61 ctgctcccgc ttcctctgct gctcctgttg ctgcttctcc tgccgccgca gctgatggcc
      121 cgggccaggc caccggagaa tcaccgtcac cgccctgtga agagagtgcc tcagctcctg
      181 cccgcagctc tgcctaatag cttgccgtct gtccccgcct cccattgggt ccctggtcct
      241 gctagtagct ccagacctct acgatgtggt gtgcctgacc cgccggatgt actgaatgcc
      301 cgaaaccggc agaagcgctt cgtactgtcg ggagggcgct gggagaagac agacctcact
      361 tataggatcc tccggttccc atggcaactt gtaagggagc aggtgcggca gacggtggca
      421 gaggccctcc gggtatggag tgaggtgact ccgctcactt tcaccgaggt gcacgaggga
      481 cgcgctgaca tcatgattga cttcaccagg tactggcatg gggacaactt gccattcgat
      541 gggcctgggg gcatcctggc ccatgccttc ttccctaaga cccaccgaga aggggatgta
      601 cactttgact atgacgagac ttggactatt ggggacaagg gcacagacct gctacaagtg
      661 gcagctcatg aatttggtca tgttctgggc ctgcaacaca ccacagcagc taaggccctc
      721 atgtcccctt tctacacctt ccgctaccct ctgagcctta gcccagatga ccggaggggc
      781 atccagcacc tctatggccg gccccagctg acccccacct ccccaacccc aaccttgagc
      841 tcccaggctg ggacagatac caatgagatt gcactgcagg agccggaagt ccctccagaa
      901 gtctgtgaga cctcctttga cgcagtttcc accatccgag gcgagctctt cttcttcaag
      961 gcgggctttg tgtggaggct gcgcagtggg caactgcagc ctgggtatcc tgctctggcc
     1021 tctcggcact ggcagggact acccagtcct gtggatgcag cttttgagga tgcccagggc
     1081 cagatttggt tcttccaagg tgctcagtac tgggtatatg acggtgagaa gccagtccta
     1141 ggccccgcac cactctccaa gctgggcctg caggggtccc cggtccatgc tgccttggtc
     1201 tggggtcctg agaagaacaa gatctacttc ttccgaggtg gagactattg gcgtttccac
     1261 cccagaaccc aacgagtgga caatccggtg ccccgacgta ccactgactg gcggggggta
     1321 ccttctgaga ttgatgctgc tttccaggat gctgagggct atgcctactt ccttcgtggc
     1381 catctctact ggaagtttga ccctgtgaag gtgaaagtcc tggaaagttt ccctcgaccc
     1441 ataggtcccg acttctttga ctgtgcagag cccgccaaca ctttccgctg acaacacctc
     1501 agatgcattc agggcactta tatcattaaa gagagccaca gccatatttg tggacctggg
     1561 cttcaggcat gggacagacg gggcctaggt ctcctcaggg gagtgggttg gggtgcagcc
     1621 actgtttgca gggaggacca tgctggccat ggtcacctgc caacaactgt ctcagagaag
     1681 gcaaaggctt tgacattact taaaaataag ggaggtcttg ggctgacaat atgtcagcta
     1741 ccagtaatcc acagtcaact tgactgccaa gcctccatct ctgtcccaca aagaaccccc
     1801 acaggaattc aggaaccaca gtgtcttcat tctgtttctg taacgaggtc cctgttggta
     1861 gtggtgttgg taatgagatg ccaagggtac catggtaagg agatgcccag ggttccatgc
     1921 tgccacagct aaggacctgg gccagtatct ctcctggtta agttggctct ggagagatac
     1981 tggactgatt atattcagac gagtttttcc tggaacatag gccaaaagcg acacagccag
     2041 ccagggaggc agctgcttcc tcccagagcc tcagaggcct cacatacctc acagccttgc
     2101 cctgggccat ttctccctgg cgccttccct cttcccagca ccagtgcctc ccaaagccat
     2161 gtaaatgtgt atacagtgta taaagccttt tttaagaaag ccgagactgt cattaaacat
     2221 gagtgttttc taagtaaaaa aaaaaaaaaa aaa
//
