LOCUS       NM_133514               1714 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 10 (Mmp10), mRNA.
ACCESSION   NM_133514
VERSION     NM_133514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1714)
  AUTHORS   Faraj Shaglouf,L.H., Ranjpour,M., Wajid,S. and Jain,S.K.
  TITLE     Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their
            regulatory role in hepatocellular carcinoma progression
  JOURNAL   Protoplasma 257 (1), 157-167 (2020)
   PUBMED   31428857
  REMARK    GeneRIF: Elevated expression of cellular SYNE1, MMP10, and GTPase1
            and their regulatory role in hepatocellular carcinoma progression.
REFERENCE   2  (bases 1 to 1714)
  AUTHORS   Takamura,Y., Matsumoto,T., Tomomatsu,T., Matsumura,T., Takihara,Y.
            and Inatani,M.
  TITLE     Aldose reductase inhibitor counteracts the enhanced expression of
            matrix metalloproteinase-10 and improves corneal wound healing in
            galactose-fed rats
  JOURNAL   Mol Vis 19, 2477-2486 (2013)
   PUBMED   24339723
  REMARK    GeneRIF: MMP-10 modulates corneal epithelial wound healing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1714)
  AUTHORS   Thibert,K.A., Raymond,G.V., Nascene,D.R., Miller,W.P., Tolar,J.,
            Orchard,P.J. and Lund,T.C.
  TITLE     Cerebrospinal fluid matrix metalloproteinases are elevated in
            cerebral adrenoleukodystrophy and correlate with MRI severity and
            neurologic dysfunction
  JOURNAL   PLoS One 7 (11), e50430 (2012)
   PUBMED   23185624
REFERENCE   4  (bases 1 to 1714)
  AUTHORS   Friese,R.S., Rao,F., Khandrika,S., Thomas,B., Ziegler,M.G.,
            Schmid-Schonbein,G.W. and O'Connor,D.T.
  TITLE     Matrix metalloproteinases: discrete elevations in essential
            hypertension and hypertensive end-stage renal disease
  JOURNAL   Clin Exp Hypertens 31 (7), 521-533 (2009)
   PUBMED   19886850
REFERENCE   5  (bases 1 to 1714)
  AUTHORS   Nishino,K., Yamanouchi,K., Naito,K. and Tojo,H.
  TITLE     Matrix metalloproteinases regulate mesonephric cell migration in
            developing XY gonads which correlates with the inhibition of tissue
            inhibitor of metalloproteinase-3 by Sry
  JOURNAL   Dev Growth Differ 44 (1), 35-43 (2002)
   PUBMED   11869290
REFERENCE   6  (bases 1 to 1714)
  AUTHORS   Saghizadeh,M., Brown,D.J., Castellon,R., Chwa,M., Huang,G.H.,
            Ljubimova,J.Y., Rosenberg,S., Spirin,K.S., Stolitenko,R.B.,
            Adachi,W., Kinoshita,S., Murphy,G., Windsor,L.J., Kenney,M.C. and
            Ljubimov,A.V.
  TITLE     Overexpression of matrix metalloproteinase-10 and matrix
            metalloproteinase-3 in human diabetic corneas: a possible mechanism
            of basement membrane and integrin alterations
  JOURNAL   Am J Pathol 158 (2), 723-734 (2001)
   PUBMED   11159210
REFERENCE   7  (bases 1 to 1714)
  AUTHORS   Chan,J.C., Scanlon,M., Zhang,H.Z., Jia,L.B., Yu,D.H., Hung,M.C.,
            French,M. and Eastman,E.M.
  TITLE     Molecular cloning and characterization of v-mos-activated
            transformation-associated proteins
  JOURNAL   J Biol Chem 267 (2), 1099-1103 (1992)
   PUBMED   1370458
REFERENCE   8  (bases 1 to 1714)
  AUTHORS   De Vouge,M.W. and Mukherjee,B.B.
  TITLE     Transformation of normal rat kidney cells by v-K-ras enhances
            expression of transin 2 and an S-100-related calcium-binding
            protein
  JOURNAL   Oncogene 7 (1), 109-119 (1992)
   PUBMED   1741158
REFERENCE   9  (bases 1 to 1714)
  AUTHORS   Breathnach,R., Matrisian,L.M., Gesnel,M.C., Staub,A. and Leroy,P.
  TITLE     Sequences coding for part of oncogene-induced transin are highly
            conserved in a related rat gene
  JOURNAL   Nucleic Acids Res 15 (3), 1139-1151 (1987)
   PUBMED   3547333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 24, 2020 this sequence version replaced NM_133514.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05083.1, M65253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000008.1  12974707-12974845
            140-384             JAXUCZ010000008.1  12975482-12975726
            385-533             JAXUCZ010000008.1  12975818-12975966
            534-659             JAXUCZ010000008.1  12976407-12976532
            660-824             JAXUCZ010000008.1  12977667-12977831
            825-966             JAXUCZ010000008.1  12978377-12978518
            967-1100            JAXUCZ010000008.1  12979318-12979451
            1101-1260           JAXUCZ010000008.1  12980124-12980283
            1261-1364           JAXUCZ010000008.1  12980956-12981059
            1365-1714           JAXUCZ010000008.1  12982264-12982613
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1714
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /note="matrix metallopeptidase 10"
                     /db_xref="GeneID:117061"
                     /db_xref="RGD:620192"
     exon            1..139
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1465
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /EC_number="3.4.24.22"
                     /note="stromelysin-2; transin-2; matrix
                     metalloproteinase-10; transformation-associated protein
                     34A"
                     /codon_start=1
                     /product="stromelysin-2 precursor"
                     /protein_id="NP_598198.2"
                     /db_xref="GeneID:117061"
                     /db_xref="RGD:620192"
                     /translation="MEPLAILVLLCFPICSAYPLHGAVRQDHSTMDLAQQYLEKYYNF
                     RKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPDVGGFST
                     FPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIM
                     ISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSLGPSGTNLFLVAAH
                     ELGHSLGLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPSSDATVVPV
                     PSVSPKPETPVKCDPALSFDAVTMLRGEFLFFKDRHFWRRTQWNPEPEFHLISAFWPS
                     LPSGLDAAYEANNKDRVLIFKGSQFWAVRGNEVQAGYPKRIHTLGFPPTVKKIDAAVF
                     EKEKKKTYFFVGDKYWRFDETRQLMDKGFPRLITDDFPGIEPQVDAVLHAFGFFYFFR
                     GSSQFEFDPNARTVTHTLKSNSWLLC"
     exon            140..384
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..533
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..659
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..824
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..966
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1100
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1260
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1364
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1714
                     /gene="Mmp10"
                     /gene_synonym="SL-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttaggtg ctacagaagg taaaggctgt ctctatggag ccactggcca tcctggtgct
       61 gctgtgcttt ccgatctgct cagcatatcc tctgcatggg gcagtgagac aagaccactc
      121 aaccatggat cttgctcagc aatacctaga aaaatactac aactttagaa aaaatgagaa
      181 acaatttttc aaaagaaagg acagtagtcc tgttgtcaaa aaaattgaag aaatgcagaa
      241 gttccttggg ctggagatga cagggaagct ggactcgaac actgtggaga tgatgcacaa
      301 gccccggtgt ggtgttcccg acgtcggtgg cttcagtacc tttccaggtt cacccaaatg
      361 gaggaaaaac cacatctcct acaggattgt gaattataca ctggatttac caagagagag
      421 tgtggattct gccattgaga gagctttgaa ggtctgggag gaggtgaccc cactcacatt
      481 ctccaggatc tctgaaggag aggctgacat aatgatctcc tttgcagttg gagaacatgg
      541 agacttttac ccttttgatg gagtgggaca gagcttggct catgcctacc cacctggccc
      601 tggattttat ggagatgctc acttcgatga tgatgagaaa tggtcactgg gaccctcagg
      661 gaccaattta ttcctggttg ctgcgcatga acttggtcac tccctgggtc tctttcactc
      721 aaacaacaaa gaatctctga tgtacccagt ctacaggttc tccacgagcc aagccaacat
      781 tcgcctttct caggatgata tagagggcat tcaatccctg tatggagccc gcccctcctc
      841 tgatgccaca gtggttcctg tgccctctgt ctctccaaaa cctgagaccc cagtcaaatg
      901 tgatcctgct ttgtcctttg atgcagtcac catgctgaga ggggaattcc tattctttaa
      961 agacaggcac ttctggcgta gaacccagtg gaatcccgag cctgaattcc atttgatttc
     1021 agcattttgg ccctctcttc cttcaggctt agatgctgcc tatgaggcaa ataacaagga
     1081 cagagttctg atttttaaag gaagtcagtt ctgggcagtc cgaggaaatg aagtccaagc
     1141 aggttaccca aagaggatcc acactcttgg ctttcctccc accgtgaaga agattgatgc
     1201 agctgttttt gaaaaggaga agaagaagac gtatttcttt gtaggtgaca aatactggag
     1261 atttgatgag acaagacagc ttatggataa aggcttcccg agactgataa cagatgactt
     1321 cccaggaatt gagccacaag ttgatgctgt gttacatgca tttgggtttt tttatttctt
     1381 ccgtggatca tcacagttcg agtttgaccc caatgccagg acggtgacac acacactgaa
     1441 gagcaacagc tggctgttgt gctgattatc atgatgacaa gacatataca acactgtaaa
     1501 atagtatttc tcgcctaatt tattatgtgt cataatgatg aattgttcct gcatgtgctg
     1561 tggctcgaga tgagcccagc agatagatgt ctttcttaat gaaccacaga gcatcacctg
     1621 agcacagaag tgaaagcttc tcggtacact aggtgagagg atgcatcccc atgggtactt
     1681 tattgtttaa taaagaactt tatttttgaa ccat
//
