LOCUS       NM_001134530            2021 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus matrix metallopeptidase 1 (Mmp1), mRNA.
ACCESSION   NM_001134530 XM_001072423 XM_235794
VERSION     NM_001134530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Lin,C., Mazzuca,M.Q. and Khalil,R.A.
  TITLE     Increased uterine arterial tone, stiffness and remodeling with
            augmented matrix metalloproteinase-1 and -7 in uteroplacental
            ischemia-induced hypertensive pregnancy
  JOURNAL   Biochem Pharmacol 228, 116227 (2024)
   PUBMED   38643908
  REMARK    GeneRIF: Increased uterine arterial tone, stiffness and remodeling
            with augmented matrix metalloproteinase-1 and -7 in uteroplacental
            ischemia-induced hypertensive pregnancy.
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Abo Zeid,A.A., Rowida Raafat,I. and Ahmed,A.G.
  TITLE     Berberine alleviates monosodium glutamate induced postnatal
            metabolic disorders associated vascular endothelial dysfunction in
            newborn rats: possible role of matrix metalloproteinase-1
  JOURNAL   Arch Physiol Biochem 128 (3), 818-829 (2022)
   PUBMED   32072839
  REMARK    GeneRIF: Berberine alleviates monosodium glutamate induced
            postnatal metabolic disorders associated vascular endothelial
            dysfunction in newborn rats: possible role of matrix
            metalloproteinase-1.
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Yung,P.S., Lee,Y.W., Fu,S.C., Chen,C.H., Rolf,C.G. and Chan,K.M.
  TITLE     Differential MMP 1 and MMP 13 expression in proliferation and
            ligamentization phases of graft remodeling in anterior cruciate
            ligament reconstruction
  JOURNAL   Connect Tissue Res 62 (6), 681-688 (2021)
   PUBMED   33356628
  REMARK    GeneRIF: Differential MMP 1 and MMP 13 expression in proliferation
            and ligamentization phases of graft remodeling in anterior cruciate
            ligament reconstruction.
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Xie,Z. and Fang,T.
  TITLE     The expression and significance of NF-kappaB, MMP1, and MMP2 in
            rats with abdominal aortic aneurysm
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (3), 17-23 (2020)
   PUBMED   32538742
  REMARK    GeneRIF: The expression and significance of NF-kappaB, MMP1, and
            MMP2 in rats with abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Herouy,Y., May,A.E., Pornschlegel,G., Stetter,C., Grenz,H.,
            Preissner,K.T., Schopf,E., Norgauer,J. and Vanscheidt,W.
  TITLE     Lipodermatosclerosis is characterized by elevated expression and
            activation of matrix metalloproteinases: implications for venous
            ulcer formation
  JOURNAL   J Invest Dermatol 111 (5), 822-827 (1998)
   PUBMED   9804345
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Gonzalez-Avila,G., Iturria,C., Vadillo-Ortega,F., Ovalle,C. and
            Montano,M.
  TITLE     Changes in matrix metalloproteinases during the evolution of
            interstitial renal fibrosis in a rat experimental model
  JOURNAL   Pathobiology 66 (5), 196-204 (1998)
   PUBMED   9732233
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Nothnick,W.B., Keeble,S.C. and Curry,T.E. Jr.
  TITLE     Collagenase, gelatinase, and proteoglycanase messenger ribonucleic
            acid expression and activity during luteal development,
            maintenance, and regression in the pseudopregnant rat ovary
  JOURNAL   Biol Reprod 54 (3), 616-624 (1996)
   PUBMED   8835383
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Tyagi,S.C. and Cleutjens,J.P.
  TITLE     Myocardial collagenase: purification and structural
            characterization
  JOURNAL   Can J Cardiol 12 (2), 165-171 (1996)
   PUBMED   8605638
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Cleutjens,J.P., Kandala,J.C., Guarda,E., Guntaka,R.V. and
            Weber,K.T.
  TITLE     Regulation of collagen degradation in the rat myocardium after
            infarction
  JOURNAL   J Mol Cell Cardiol 27 (6), 1281-1292 (1995)
   PUBMED   8531210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169019.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_235794.3, XM_001072423.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169019.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2021
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /note="matrix metallopeptidase 1"
                     /db_xref="GeneID:300339"
                     /db_xref="RGD:1307917"
     exon            1..141
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1437
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /EC_number="3.4.24.7"
                     /note="matrix metalloproteinase 1a (interstitial
                     collagenase); fibroblast collagenase; myocardial
                     collagenase; matrix metallopeptidase 1a"
                     /codon_start=1
                     /product="interstitial collagenase precursor"
                     /protein_id="NP_001128002.1"
                     /db_xref="GeneID:300339"
                     /db_xref="RGD:1307917"
                     /translation="MLSLPLLLLLLATSSYSFPVFQDGARQNVETVWKYLENYYNLGE
                     DVQAKNVDAKEVMAEKLRQMQQLFGLKVTGNSNSETLSAMRKPRCGVPDVAPYAITHN
                     NPRWTKTHLTYSILNYTPYLPKEVIENAIERAFKVWSDVTPLTFERVFEEEGDIVFAF
                     YRGDHSDNNPFDGPEYGLAHTFPPGPRLGGDVHYDLDETWTDNSDNFNLFYVTAHELG
                     HSLGLTHSRDVGALMFPSYTWYTEDFVLNQEDINRIQALYGPSPNPIQPTGATTPHPC
                     DGDLTFDAITTFRGEVMFFKGRFYIRVNKFMPEAELNLIGIIWPNLPGKLDAAYEVSM
                     IDQVRYFKGNKVWVVREHTVLRGFPTDIHSFFGFPSSVTHIDAAVCEEETGKTYFFVD
                     NMYWRYDENTQSMDPGYPRLTAEDFPGIDDKVDDVFQKGENFYFFHQSVQRRFSLRIR
                     RVDDSRDSSTWFNC"
     exon            142..383
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            384..532
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            533..658
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            659..817
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            818..935
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1069
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1232
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1336
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1996
                     /gene="Mmp1"
                     /gene_synonym="Clgn; MMP-1; Mmp1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaaggcc actggtgatc ttgcgcagag agaagcttca gcatgcttag ccttcctttg
       61 ctgttgcttc tcttggctac cagctcatac agtttccccg tgtttcagga cggagcccgg
      121 cagaatgtgg aaacagtctg gaaatacctg gaaaactact acaacttggg tgaagacgtc
      181 caagctaaaa acgtggatgc caaggaggtg atggctgaaa agctgaggca aatgcagcag
      241 ttatttgggc tgaaagtgac aggaaattca aattctgaaa ccctgagtgc tatgaggaaa
      301 cctaggtgtg gggtgcctga tgtggcccca tatgccatta ctcacaacaa tcctcgttgg
      361 accaaaacac atctgactta cagcatttta aactacacac catatttgcc aaaagaagtt
      421 atagaaaacg ccatcgagag agcctttaaa gtctggagtg atgtgacacc actaacattc
      481 gaaagggttt ttgaggagga aggtgatatt gtgttcgcct tctacagagg agaccatagt
      541 gacaataacc catttgatgg acctgaatat ggacttgctc acacattccc accaggccca
      601 cgtttggggg gcgatgttca ttatgatctg gatgagacgt ggaccgacaa cagtgacaat
      661 ttcaatttgt tctatgttac ggctcatgaa ctgggccact cccttggact cactcattct
      721 agagatgtag gagcactaat gttccccagc tacacatggt acactgaaga ctttgtgcta
      781 aaccaggagg atattaatcg catccaggct ttatatgggc cttccccaaa tcccatccag
      841 ccaacaggtg caacaacacc acatccatgt gatggtgatc taaccttcga cgctataact
      901 acgtttaggg gagaggtgat gttctttaaa ggcaggttct acattcgtgt aaataagttc
      961 atgccagaag ctgagctcaa tttgataggt attatctggc caaatctgcc aggtaaactt
     1021 gatgctgctt atgaagttag tatgatagat caagtccgct atttcaaagg caataaagtc
     1081 tgggttgttc gagagcatac tgtactgaga ggattcccca cagacatcca tagcttcttt
     1141 ggcttcccta gcagtgtgac acacattgac gctgccgttt gtgaggaaga gactggaaaa
     1201 acatacttct tcgttgacaa catgtactgg aggtatgatg aaaatacaca gtccatggat
     1261 ccaggttatc ctagattaac agcagaagat ttccctggaa ttgacgataa agttgatgat
     1321 gttttccaaa aaggcgaaaa tttctacttc tttcaccaat cagttcaacg cagatttagc
     1381 ctccgaataa gaagagttga tgactcccgt gattctagta cctggttcaa ctgctaaaaa
     1441 tattggcaac ccattaccaa gtcaatggaa atacatattc tgagatctta aagaagatat
     1501 ttttctgaag atctagatct tgtgttttat ttaccttcca gaagtgctga tacacagagc
     1561 tactaagtac aaattaattt tatttcatag actttcacaa tttataatac aatattttat
     1621 gaactgaaac agtttagtac cacagttatt aggctaagag tccatgttca tggtggatga
     1681 gtcactgaag aaaggcatct gtacactgga tgactctcac tgtggtcctg ggcatctcct
     1741 tttgagagag gagggtcaac agaggagctc ttcccaaagt aaaagtgact ctgaactcag
     1801 gaacagatac gaagaggaaa cacattgctg ctttggtttt ggggtttaca acaagatctt
     1861 acagttcggt agattctgat ctcttctacc tctgattccc acatgctggt attctataat
     1921 gtctagcata cccaactaag agatattcct tgtacaaaag tatttgatac ctaaataaag
     1981 acattcttgt ctctaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
