LOCUS       NM_001004280            1332 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus metabolism of cobalamin associated D (Mmadhc),
            mRNA.
ACCESSION   NM_001004280 XM_342434
VERSION     NM_001004280.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Jusufi,J., Suormala,T., Burda,P., Fowler,B., Froese,D.S. and
            Baumgartner,M.R.
  TITLE     Characterization of functional domains of the cblD (MMADHC) gene
            product
  JOURNAL   J Inherit Metab Dis 37 (5), 841-849 (2014)
   PUBMED   24722857
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Mah,W., Deme,J.C., Watkins,D., Fung,S., Janer,A., Shoubridge,E.A.,
            Rosenblatt,D.S. and Coulton,J.W.
  TITLE     Subcellular location of MMACHC and MMADHC, two human proteins
            central to intracellular vitamin B(12) metabolism
  JOURNAL   Mol Genet Metab 108 (2), 112-118 (2013)
   PUBMED   23270877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078953.1.
            
            On Sep 10, 2004 this sequence version replaced XM_342434.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078953.1, FQ216405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..1332
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /note="metabolism of cobalamin associated D"
                     /db_xref="GeneID:362134"
                     /db_xref="RGD:1303272"
     exon            1..58
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            59..115
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..997
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /note="methylmalonic aciduria and homocystinuria type D
                     homolog, mitochondrial; methylmalonic aciduria (cobalamin
                     deficiency) cblD type, with homocystinuria; methylmalonic
                     aciduria and homocystinuria, cblD type; cobalamin
                     trafficking protein CblD"
                     /codon_start=1
                     /product="cobalamin trafficking protein CblD precursor"
                     /protein_id="NP_001004280.1"
                     /db_xref="GeneID:362134"
                     /db_xref="RGD:1303272"
                     /translation="MAHVLCNRARLVSYLPGFCSLVKRVINPRAFSTAGSSGSDESHV
                     ATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSQAHKTLPDV
                     LAEPLSTERHEFVMAQYVNEFQDSNAPVEQEISSAETYFESARVECAIQTCPELLRRD
                     FESLFPEVANSKLMILTVTQKTEHDMTVWSEEVEVEREALLEKFINGAKEICYALRAE
                     GYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHGLWGTHVVV
                     GSIFTNATADSHIMRKLSGD"
     exon            116..260
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            261..478
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            479..584
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            585..715
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            716..802
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1308
                     /gene="Mmadhc"
                     /gene_synonym="CblD; RGD1303272"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccatttt gacagtggac gtgttgaggg actggatcag ctggccgtgt ggtgactggg
       61 atactttgca gaggggaaaa gtctgcgtcc gccttcttca ctagaaatgg cccatgtgct
      121 ctgtaacaga gccagactgg tttcctatct cccaggattt tgttctctag tgaaaagagt
      181 tatcaatcca agagcctttt caactgcagg atcgtcaggt tccgatgagt ctcacgtggc
      241 cactgcacct ccagatatat gctctcggac agtgtggcct gatgaaacca tgggaccctt
      301 tggacctcag gaccagagat tccagcttcc tgggaatata ggcttcgatt gtcacctcaa
      361 tgggacagcc tcacagaaga aaagccaggc ccataaaacc ttgcctgatg ttctagcaga
      421 gcctctttca accgaaaggc acgagtttgt gatggcccag tatgtgaatg agtttcagga
      481 tagcaatgca cctgttgagc aagagatcag cagtgcagaa acttactttg aaagtgccag
      541 agttgagtgt gccatccaga catgtcccga actgctgcgg agagattttg agtcactttt
      601 tccagaggtg gctaatagca aactgatgat tctgactgta acccagaaaa ctgaacatga
      661 catgactgtc tggagtgaag aggtagaagt tgagagagag gcgctcttgg agaagttcat
      721 taatggtgct aaggaaattt gctatgctct tcgggctgaa ggatactggg ctgacttcat
      781 tgacccgtcg tctggtttgg cattttttgg accatataca aacaacacac tttttgaaac
      841 agatgaacgg taccggcatt taggattctc tgttgatgac cttggctgct gtaaggtgat
      901 ccgtcatggt ctctggggca ctcatgtggt tgtgggaagt atcttcacta atgcaacagc
      961 agacagccat atcatgagga agctcagtgg ggactagcag gtgacactgt gacaattgca
     1021 gcactgtctg tccgcaacgg attgctctat catggaccgc agcttctaga cgattcttgt
     1081 ttctaggtat ttatttcatc atttatgggt ttacagggac aggtgacttg gggtttcaaa
     1141 attgcaaatg ctagttcata ttctggaaca ttgaacacat ccatattatg aaaaatgaga
     1201 tcatcaactt gtaaccaggg tatgtgtggt cttttagtgt taattctccc ctttattggg
     1261 aaaattttaa ttattttttc caaaaataaa tcatacattt gtctatgaaa aaaaaaaaaa
     1321 aaaaaaaaaa aa
//
