LOCUS       NM_001107962            1703 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus metabolism of cobalamin associated C (Mmachc),
            mRNA.
ACCESSION   NM_001107962 XM_001066599 XM_233418
VERSION     NM_001107962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Fofou-Caillierez MB, Mrabet NT, Chery C, Dreumont N, Flayac J,
            Pupavac M, Paoli J, Alberto JM, Coelho D, Camadro JM, Feillet F,
            Watkins D, Fowler B, Rosenblatt DS and Gueant JL.
  TITLE     Interaction between methionine synthase isoforms and MMACHC:
            characterization in cblG-variant, cblG and cblC inherited causes of
            megaloblastic anaemia
  JOURNAL   Hum Mol Genet 22 (22), 4591-4601 (2013)
   PUBMED   23825108
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Mah W, Deme JC, Watkins D, Fung S, Janer A, Shoubridge EA,
            Rosenblatt DS and Coulton JW.
  TITLE     Subcellular location of MMACHC and MMADHC, two human proteins
            central to intracellular vitamin B(12) metabolism
  JOURNAL   Mol Genet Metab 108 (2), 112-118 (2013)
   PUBMED   23270877
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Froese DS, Krojer T, Wu X, Shrestha R, Kiyani W, von Delft F,
            Gravel RA, Oppermann U and Yue WW.
  TITLE     Structure of MMACHC reveals an arginine-rich pocket and a
            domain-swapped dimer for its B12 processing function
  JOURNAL   Biochemistry 51 (25), 5083-5090 (2012)
   PUBMED   22642810
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Froese DS, Zhang J, Healy S and Gravel RA.
  TITLE     Mechanism of vitamin B12-responsiveness in cblC methylmalonic
            aciduria with homocystinuria
  JOURNAL   Mol Genet Metab 98 (4), 338-343 (2009)
   PUBMED   19700356
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Kim J, Hannibal L, Gherasim C, Jacobsen DW and Banerjee R.
  TITLE     A human vitamin B12 trafficking protein uses glutathione
            transferase activity for processing alkylcobalamins
  JOURNAL   J Biol Chem 284 (48), 33418-33424 (2009)
   PUBMED   19801555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066599.1, XM_233418.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM032039.1, AW140841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1703
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /note="metabolism of cobalamin associated C"
                     /db_xref="GeneID:313520"
                     /db_xref="RGD:1310806"
     exon            1..86
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..845
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /note="methylmalonic aciduria (cobalamin deficiency) cblC
                     type, with homocystinuria"
                     /codon_start=1
                     /product="cyanocobalamin reductase / alkylcobalamin
                     dealkylase"
                     /protein_id="NP_001101432.1"
                     /db_xref="GeneID:313520"
                     /db_xref="RGD:1310806"
                     /translation="MEPRVAELKQKIEGTLCPFGFEVYPFQVAWYNELLPPAFHLPFP
                     GPTLAFVVLSTPAMFDRALKPFLKSCHLQTLRDPVDQCVSYHLKSVTEKFPELHIEVI
                     ADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVDADPWGTQHIAGVCIHPRFGGWFAI
                     RGVMLLPGIEVPNLLPRKPPDCVPTRAARITLLEGFNFHWRDWTYRDAVTPEERYSEE
                     QKIYFSTPPAQRLALLGLAQPSGHPSTTSEHPLSLLTKPQDSRRLRSWLSPSVSPPAS
                     PGP"
     exon            87..281
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /inference="alignment:Splign:2.1.0"
     exon            282..434
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /inference="alignment:Splign:2.1.0"
     exon            435..1703
                     /gene="Mmachc"
                     /gene_synonym="RGD1310806"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctatgga gccgcgtgtc gcagagctga agcagaagat tgagggcacc ttgtgtcctt
       61 ttggcttcga ggtttacccc ttccaggtgg cgtggtacaa tgaactcctg cctccagcct
      121 tccacttgcc cttcccagga cctaccctgg ccttcgtggt actcagcacg cctgctatgt
      181 ttgacagagc cctcaaaccc ttcttgaaga gctgccacct ccaaacactg agagaccctg
      241 tggatcaatg tgtgtcctac cacctgaaga gtgttacaga aaagtttcca gaattgcata
      301 tagaagtcat tgctgactat gaggtacacc ccaaccggcg tcctaagatt ctagcccaaa
      361 cagcagccca cgtggcaggt gctgcttact actaccaacg acaagatgtg gatgctgacc
      421 catgggggac ccagcacata gcaggtgtgt gcatacaccc ccgatttggg ggctggtttg
      481 ctatccgagg ggtaatgttg ttgccaggga ttgaagtgcc aaatttgcta cccagaaagc
      541 cccctgactg tgtgcctaca agagctgccc gcatcactct gcttgaaggc ttcaacttcc
      601 actggcggga ctggacttac cgggatgcag tgactcctga agaacgttac tcggaagaac
      661 agaagatcta cttttccacc ccacctgccc aacgcttggc cctgttaggc ttagcccaac
      721 cctcaggaca ccctagcact acatccgagc atcctctttc cttgcttacc aagcctcagg
      781 attccaggag acttcgaagc tggcttagtc caagtgtctc accacctgcc tccccaggtc
      841 cttgataact ttcccctgtg ggtcccactc atggtaggat ttgggttttg aaaaagcact
      901 ttttttgaga aaaggtttct ctatgtagcc ctggctgtcc cagaacttta tagacaggct
      961 ggcctcaagc taacagagat ccatctgctt gtgtctcctc cagggtactg agacttttgc
     1021 accttgaaaa gccttatttt attttgggtt atgatttcct gataatatag cacttcaaag
     1081 agagtcaaga ctcaattaca aaatacataa accatatgcc acggcagact caaaagcagc
     1141 aattaacttc aaatattaga ctcatacccc ttactattca tgtacagtac tcttaaggta
     1201 ctatttaaga accagtgttc tcactgttcc taatgctgct accctttaat acagtccctc
     1261 atgttgtgac cccaaccata aaattacttt tattgctact tcataactta ttttttagtt
     1321 atgaattgtg atataaatat tccaactgtc ttagggagtc cagttaaagg attgttaaat
     1381 acttgggggg ggggtcatga cccacaggtt gagaaacaga cttagctctt aggggtacct
     1441 accatacaga gctatactga attaatatgt aagtaaacta cttagaaact gcctgaccta
     1501 tagtatgtta ttaccaaagg cttaaggaat cttatgctca aatagatgta ctttaaattc
     1561 tgtaatgttg ggaggccatg atggcattgg attgtctacc ctaaccaaga atccataaga
     1621 aacttcttgc tgacttaaca ggatcaaaaa ggaatattct ctatatcata actaaaatac
     1681 atgtcgaata caatcctaaa acc
//
