LOCUS       NM_001389261            1385 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus metabolism of cobalamin associated A (Mmaa),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001389261 XM_006255398
VERSION     NM_001389261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Ruetz,M., Campanello,G.C., McDevitt,L., Yokom,A.L., Yadav,P.K.,
            Watkins,D., Rosenblatt,D.S., Ohi,M.D., Southworth,D.R. and
            Banerjee,R.
  TITLE     Allosteric Regulation of Oligomerization by a B12 Trafficking
            G-Protein Is Corrupted in Methylmalonic Aciduria
  JOURNAL   Cell Chem Biol 26 (7), 960-969 (2019)
   PUBMED   31056463
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Plessl,T., Burer,C., Lutz,S., Yue,W.W., Baumgartner,M.R. and
            Froese,D.S.
  TITLE     Protein destabilization and loss of protein-protein interaction are
            fundamental mechanisms in cblA-type methylmalonic aciduria
  JOURNAL   Hum Mutat 38 (8), 988-1001 (2017)
   PUBMED   28497574
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Froese,D.S., Kochan,G., Muniz,J.R., Wu,X., Gileadi,C.,
            Ugochukwu,E., Krysztofinska,E., Gravel,R.A., Oppermann,U. and
            Yue,W.W.
  TITLE     Structures of the human GTPase MMAA and vitamin B12-dependent
            methylmalonyl-CoA mutase and insight into their complex formation
  JOURNAL   J Biol Chem 285 (49), 38204-38213 (2010)
   PUBMED   20876572
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Lerner-Ellis,J.P., Dobson,C.M., Wai,T., Watkins,D., Tirone,J.C.,
            Leclerc,D., Dore,C., Lepage,P., Gravel,R.A. and Rosenblatt,D.S.
  TITLE     Mutations in the MMAA gene in patients with the cblA disorder of
            vitamin B12 metabolism
  JOURNAL   Hum Mutat 24 (6), 509-516 (2004)
   PUBMED   15523652
  REMARK    Erratum:[Hum Mutat. 2005 Mar;25(3):317]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 7, 2020 this sequence version replaced XM_006255398.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.410952.1,
                                           SRR26360186.752627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000019.1  45523352-45523414
            64-541              JAXUCZ010000019.1  45537502-45537979
            542-664             JAXUCZ010000019.1  45541589-45541711
            665-835             JAXUCZ010000019.1  45547341-45547511
            836-921             JAXUCZ010000019.1  45550645-45550730
            922-1071            JAXUCZ010000019.1  45552288-45552437
            1072-1385           JAXUCZ010000019.1  45553289-45553602
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1385
                     /gene="Mmaa"
                     /note="metabolism of cobalamin associated A"
                     /db_xref="GeneID:291939"
                     /db_xref="RGD:1305035"
     exon            1..63
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     exon            64..541
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1359
                     /gene="Mmaa"
                     /note="methylmalonic aciduria (cobalamin deficiency) cblA
                     type"
                     /codon_start=1
                     /product="methylmalonic aciduria type A protein,
                     mitochondrial"
                     /protein_id="NP_001376190.1"
                     /db_xref="GeneID:291939"
                     /db_xref="RGD:1305035"
                     /translation="MTIPTLLLSPYRRLLTRLSRVPSPQLLHSSLPTLHPRDALPNSF
                     GHHCSKRVLLSDGFRRTLCIRATLKDHTEGLSDKEQRFVDRLYMGLVQGQRACLAEAI
                     TLVESTHTRKKELAQVLLQRVLAHQRERELQNHGKPFTFRVGLSGPPGAGKSTFIECF
                     GKMLTERGHRLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTSGTLGGVT
                     RTTNEAIVLCEGGGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGI
                     IEMADLVVITKSDGDLVVPARRIQAEYVSALKLLRRRSEVWRPKVIRISARSGEGITE
                     MWDIMREFQHRMLASGELAAKRQTQHKVWMWNLIQENVLEHFKTHPSIREQIPLMERE
                     VLSGALSPGRAADLLLKAFKSRH"
     exon            542..664
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     exon            665..835
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     exon            836..921
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1071
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1385
                     /gene="Mmaa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgggca gggcgggagg agcgggcgga aggggcggtg ctttactgcg cggcctcgcg
       61 agggccattc ataaatcaca ctaagtcaga aaggatccag ttacagacaa aatgactatt
      121 cccacgctgc tgctttctcc ttaccggcgt ttactaaccc gcctctcgag agtaccttcc
      181 ccacagctcc ttcattcaag tcttcctaca ctgcaccccc gagatgctct gccgaactct
      241 tttggacacc attgtagtaa gagggtgcta ctgtctgacg gcttcaggag aacattatgt
      301 atccgggcaa ccttgaagga ccacacagaa ggactttctg ataaagaaca aagatttgtg
      361 gatagacttt atatgggttt agttcaaggg cagagagctt gcctagcaga ggccataact
      421 ctcgtggaat cgactcacac caggaagaag gagctggctc aggtgcttct ccagagagtc
      481 ttagcccacc agcgagaacg ggagctgcag aaccacggaa agcccttcac atttcgagta
      541 ggattgtctg gaccgcctgg tgcaggaaaa tcaaccttca tagaatgttt tgggaaaatg
      601 ctgactgaac gagggcacag attatctgtg ctagccgtgg acccgtcttc ctgcaccagt
      661 ggtgggtccc tcttaggtga taaaacacgg atgactgaac tgtcaagaga catgaatgca
      721 tacatcaggc catctcctac cagtgggact ctaggagggg tgacaaggac cacaaatgaa
      781 gccattgtgc tgtgtgaagg aggaggctat gacatcattc ttattgaaac tgtaggtgtg
      841 gggcagtcgg agtttgctgt tgctgacatg gtcgatatgt ttgttttatt gctgccaccg
      901 gcaggagggg atgaactgca gggcatcaaa cggggcataa ttgagatggc agatttggtt
      961 gttataacta aatctgatgg ggacttggtc gtgccagccc gaaggatcca agcagagtat
     1021 gtgagcgcac tcaagttgct tcgcaggcgc tctgaagtct ggaggccaaa ggtgattcga
     1081 atttctgcca gaagtggaga gggcattact gagatgtggg acataatgag ggagtttcag
     1141 caccgaatgc tggccagtgg ggagctggcc gccaagagac agacacagca caaagtctgg
     1201 atgtggaatc tcattcagga aaacgtctta gaacacttca agacccatcc cagcatccga
     1261 gaacagattc ctctgatgga gcgagaggtt ctcagtggag ccctctcccc aggacgagca
     1321 gcagacttat tgttgaaagc ttttaaaagc aggcactaat aaatttatcc tgtgtggtca
     1381 cttta
//
