LOCUS       NM_053477               2053 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus malonyl-CoA decarboxylase (Mlycd), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_053477
VERSION     NM_053477.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Sayed-Ahmed,M.M., Alrufaiq,B.I., Alrikabi,A., Abdullah,M.L.,
            Hafez,M.M. and Al-Shabanah,O.A.
  TITLE     Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition
            of AMP-Activated Protein Kinase Downstream Signals in Cardiac
            Tissues
  JOURNAL   Cardiovasc Toxicol 19 (4), 344-356 (2019)
   PUBMED   30644033
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Froese,D.S., Forouhar,F., Tran,T.H., Vollmar,M., Kim,Y.S., Lew,S.,
            Neely,H., Seetharaman,J., Shen,Y., Xiao,R., Acton,T.B.,
            Everett,J.K., Cannone,G., Puranik,S., Savitsky,P., Krojer,T.,
            Pilka,E.S., Kiyani,W., Lee,W.H., Marsden,B.D., von Delft,F.,
            Allerston,C.K., Spagnolo,L., Gileadi,O., Montelione,G.T.,
            Oppermann,U., Yue,W.W. and Tong,L.
  TITLE     Crystal structures of malonyl-coenzyme A decarboxylase provide
            insights into its catalytic mechanism and disease-causing mutations
  JOURNAL   Structure 21 (7), 1182-1192 (2013)
   PUBMED   23791943
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Laurent,G., German,N.J., Saha,A.K., de Boer,V.C., Davies,M.,
            Koves,T.R., Dephoure,N., Fischer,F., Boanca,G., Vaitheesvaran,B.,
            Lovitch,S.B., Sharpe,A.H., Kurland,I.J., Steegborn,C., Gygi,S.P.,
            Muoio,D.M., Ruderman,N.B. and Haigis,M.C.
  TITLE     SIRT4 coordinates the balance between lipid synthesis and
            catabolism by repressing malonyl CoA decarboxylase
  JOURNAL   Mol Cell 50 (5), 686-698 (2013)
   PUBMED   23746352
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Goodwin,G.W. and Taegtmeyer,H.
  TITLE     Regulation of fatty acid oxidation of the heart by MCD and ACC
            during contractile stimulation
  JOURNAL   Am J Physiol 277 (4), E772-E777 (1999)
   PUBMED   10516138
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Sacksteder,K.A., Morrell,J.C., Wanders,R.J., Matalon,R. and
            Gould,S.J.
  TITLE     MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA
            decarboxylase and is mutated in malonyl-CoA decarboxylase
            deficiency
  JOURNAL   J Biol Chem 274 (35), 24461-24468 (1999)
   PUBMED   10455107
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   FitzPatrick,D.R., Hill,A., Tolmie,J.L., Thorburn,D.R. and
            Christodoulou,J.
  TITLE     The molecular basis of malonyl-CoA decarboxylase deficiency
  JOURNAL   Am J Hum Genet 65 (2), 318-326 (1999)
   PUBMED   10417274
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Voilley,N., Roduit,R., Vicaretti,R., Bonny,C., Waeber,G.,
            Dyck,J.R., Lopaschuk,G.D. and Prentki,M.
  TITLE     Cloning and expression of rat pancreatic beta-cell malonyl-CoA
            decarboxylase
  JOURNAL   Biochem J 340 (Pt 1) (Pt 1), 213-217 (1999)
   PUBMED   10229677
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Gao,J., Waber,L., Bennett,M.J., Gibson,K.M. and Cohen,J.C.
  TITLE     Cloning and mutational analysis of human malonyl-coenzyme A
            decarboxylase
  JOURNAL   J Lipid Res 40 (1), 178-182 (1999)
   PUBMED   9869665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 7, 2020 this sequence version replaced NM_053477.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061845.1, AF304865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               JAXUCZ010000019.1  64356582-64357148
            568-680             JAXUCZ010000019.1  64363926-64364038
            681-837             JAXUCZ010000019.1  64364812-64364968
            838-987             JAXUCZ010000019.1  64369092-64369241
            988-2053            JAXUCZ010000019.1  64371382-64372447
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2053
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /note="malonyl-CoA decarboxylase"
                     /db_xref="GeneID:85239"
                     /db_xref="RGD:620234"
     exon            1..567
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1521
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /EC_number="4.1.1.9"
                     /codon_start=1
                     /product="malonyl-CoA decarboxylase, mitochondrial"
                     /protein_id="NP_445929.2"
                     /db_xref="GeneID:85239"
                     /db_xref="RGD:620234"
                     /translation="MRGLGPSLRARRLLPLRYPPRPPGPRGPRLCSGLTASAMDELLR
                     RAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAEAAQRAELLGRLAQGFGVDHGQVA
                     EQSAGVLQLRQQSREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADL
                     LEAQALKLVEGPHVREMNGVLKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVH
                     PVKNWMDMKRRVGPYRRCYFFSHCSTPGDPLVVLHVALTGDISNNIQSIVKECPPSET
                     EEKNRIAAAVFYSISLTQQGLQGVELGTFLIKRVVKELQKEFPHLGAFSSLSPIPGFT
                     KWLLGLLNVQGKEYGRNELFTDSECKEIAEVTGDPVHESLKGLLSSGEWAKSEKLAQA
                     LQGPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVMWRINWMADSSLKGLTSSCGLM
                     VNYRYYLEETGPNSISYLGSKNIKASEQILSLVAQFQSNSKL"
     exon            568..680
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            681..837
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            838..987
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
     exon            988..2053
                     /gene="Mlycd"
                     /gene_synonym="Mcd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccggtg gcttctcccg ttagcagctg tttcgggttg tcatgagagg cttggggcca
       61 agcttgaggg ctcggcgcct gctcccactg cggtacccgc cgcggcctcc ggggcctcgg
      121 ggacctaggc tgtgcagcgg gctcacggct agcgccatgg acgagctgct acggcgagcc
      181 gtgccaccca cgccggccta cgagctgcgc gagaagacgc cggccccggc cgaggggcag
      241 tgcgcggact tcgtgagctt ttacggcggc ctggccgagg cggcccagcg cgccgagctg
      301 ctcggccgcc tggctcaggg cttcggcgtg gatcacggcc aggtagcgga gcagagcgcc
      361 ggagtgctgc agctgcgcca gcagtcgcgc gaggcggccg tgctgctgca ggcagaggac
      421 cggctacgct atgccctcgt gccgcgatac cgtggcctct tccaccacat cagtaagctg
      481 gacggcggcg tgcgcttcct ggtacagctg cgggccgatc tgttggaggc gcaggccctc
      541 aagctggtgg aagggccgca cgtccgggaa atgaacggag tgctaaaaag catgctgtcc
      601 gagtggttct cctctggctt cctgaacctg gagcgggtca cctggcactc gccctgtgag
      661 gtgcttcaga agatcagcga gtgtgaggct gtgcaccctg tgaaaaactg gatggacatg
      721 aagcggcgtg tggggccata ccggaggtgt tacttcttct cccactgctc cacccccggg
      781 gaccccctgg ttgttctgca tgtggctctg accggtgaca tttccaacaa catccagagc
      841 attgtgaaag agtgccctcc gtctgaaaca gaggagaaga accggatcgc tgctgctgtc
      901 ttctactcca tcagcctgac ccagcagggc ctgcagggcg tggagctcgg caccttcctc
      961 ataaagcgag tggtcaagga gctgcagaag gagtttcctc atctgggggc cttttccagc
     1021 ctgtcaccta tacccggatt caccaagtgg ctgctgggcc ttctgaatgt gcagggaaag
     1081 gagtatggga ggaacgagct gttcacagac tcagagtgca aagaaatcgc agaggtcacg
     1141 ggcgaccctg ttcacgagag cctcaagggt ctcctgagca gtggtgagtg ggcgaagtct
     1201 gagaagctgg cacaggcact gcaggggcca ctgatgagac tgtgtgcctg gtacctttac
     1261 ggtgagaagc accgaggcta cgccctcaat ccagtggcca acttccacct gcagaacggg
     1321 gctgtgatgt ggcgtatcaa ctggatggct gacagcagcc tcaaaggcct caccagctcg
     1381 tgcggcctca tggtcaacta ccgttactac ctggaggaga ccggccccaa cagcatctcc
     1441 tacctgggct ccaagaacat caaagcttcc gagcagatcc tcagcctggt agcccagttc
     1501 cagagcaaca gcaaactcta gggacatcct gcccagcgct tggccctgct cagaaaggag
     1561 gctgtattct gatgggccag cgctgctcac cacagcaacc actcaggagg ccacacctca
     1621 gctgtcactg tgctggcgga ctcactggtt ggaggtggtg gtggggtggg tacacgtgcc
     1681 ctgaggatgt cactgtgctt ctccagaagc ccttgctgct gccccacagc ctgtgccttc
     1741 agaaagctct acagatgcag ccacaggccg cccaggacgg agcccagagc acagaccctg
     1801 tagagtacag agagctggca gtcatgtcct ctattcggga gagggctaag gtctgtgccg
     1861 tggctgctac cacagcttaa gctcagacta gggagacctt gtggtgtgca cagggtgtga
     1921 tctgcaaccc agggatgctg ctacttgagg ccagaatagg ctcgtagggt ttaaatgaga
     1981 tcccagttca taatgaactg aacagtaaag aacaaatttg ttctgtaaac attaaacatg
     2041 attgttcact gta
//
