LOCUS       NM_133552               5142 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus MLX interacting protein-like (Mlxipl), transcript
            variant 2, mRNA.
ACCESSION   NM_133552
VERSION     NM_133552.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5142)
  AUTHORS   Hu,A., Lan,H., Yao,Z. and Kong,X.
  TITLE     Carbohydrate response element-binding protein (ChREBP) mediates
            decreased SNAP25 expression in islets from diabetic Goto-Kakizaki
            (GK) rats
  JOURNAL   FEBS Open Bio 14 (11), 1864-1872 (2024)
   PUBMED   39300600
  REMARK    GeneRIF: Carbohydrate response element-binding protein (ChREBP)
            mediates decreased SNAP25 expression in islets from diabetic
            Goto-Kakizaki (GK) rats.
REFERENCE   2  (bases 1 to 5142)
  AUTHORS   Katz,L.S., Brill,G., Wang,P., Lambertini,L., Zhang,P.,
            Haldeman,J.M., Liu,H., Newgard,C.B., Stewart,A.F., Garcia-Ocana,A.
            and Scott,D.K.
  TITLE     Transcriptional activation of the Myc gene by glucose in beta-cells
            requires a ChREBP-dependent 3-D chromatin interaction between the
            Myc and Pvt1 genes
  JOURNAL   Mol Metab 79, 101848 (2024)
   PUBMED   38042369
  REMARK    GeneRIF: Transcriptional activation of the Myc gene by glucose in
            beta-cells requires a ChREBP-dependent 3-D chromatin interaction
            between the Myc and Pvt1 genes.
REFERENCE   3  (bases 1 to 5142)
  AUTHORS   Zhan,H., Wang,Y., Yu,S., Cai,G., Zeng,Y., Ma,J., Liu,W. and Wu,W.
  TITLE     Upregulation of Mlxipl induced by cJun in the spinal dorsal horn
            after peripheral nerve injury counteracts mechanical allodynia by
            inhibiting neuroinflammation
  JOURNAL   Aging (Albany NY) 12 (11), 11004-11024 (2020)
   PUBMED   32518215
  REMARK    GeneRIF: Upregulation of Mlxipl induced by cJun in the spinal
            dorsal horn after peripheral nerve injury counteracts mechanical
            allodynia by inhibiting neuroinflammation.
REFERENCE   4  (bases 1 to 5142)
  AUTHORS   Han,J.H., Kim,S., Kim,S., Lee,H., Park,S.Y. and Woo,C.H.
  TITLE     FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP
            Expression via Regulation of ChREBP in Pancreatic beta Cells
  JOURNAL   Int J Mol Sci 20 (18), 4424 (2019)
   PUBMED   31505737
  REMARK    GeneRIF: these findings suggest FMK may protect against HG-induced
            beta-cell dysfunction and TXNIP expression by ChREBP regulation in
            pancreatic beta-cells, and that FMK is a potential therapeutic
            reagent for the drug development of diabetes and its complications.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5142)
  AUTHORS   Van der Werf,R., Walter,C., Bietiger,W., Seyfritz,E., Mura,C.,
            Peronet,C., Legrandois,J., Werner,D., Ennahar,S., Digel,F.,
            Maillard-Pedracini,E., Pinget,M., Jeandidier,N., Marchioni,E.,
            Sigrist,S. and Dal,S.
  TITLE     Beneficial effects of cherry consumption as a dietary intervention
            for metabolic, hepatic and vascular complications in type 2
            diabetic rats
  JOURNAL   Cardiovasc Diabetol 17 (1), 104 (2018)
   PUBMED   30029691
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5142)
  AUTHORS   Kawaguchi,T., Osatomi,K., Yamashita,H., Kabashima,T. and Uyeda,K.
  TITLE     Mechanism for fatty acid 'sparing' effect on glucose-induced
            transcription: regulation of carbohydrate-responsive
            element-binding protein by AMP-activated protein kinase
  JOURNAL   J Biol Chem 277 (6), 3829-3835 (2002)
   PUBMED   11724780
REFERENCE   7  (bases 1 to 5142)
  AUTHORS   Yamashita,H., Takenoshita,M., Sakurai,M., Bruick,R.K., Henzel,W.J.,
            Shillinglaw,W., Arnot,D. and Uyeda,K.
  TITLE     A glucose-responsive transcription factor that regulates
            carbohydrate metabolism in the liver
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9116-9121 (2001)
   PUBMED   11470916
REFERENCE   8  (bases 1 to 5142)
  AUTHORS   Cairo,S., Merla,G., Urbinati,F., Ballabio,A. and Reymond,A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   9  (bases 1 to 5142)
  AUTHORS   de Luis,O., Valero,M.C. and Jurado,L.A.
  TITLE     WBSCR14, a putative transcription factor gene deleted in
            Williams-Beuren syndrome: complete characterisation of the human
            gene and the mouse ortholog
  JOURNAL   Eur J Hum Genet 8 (3), 215-222 (2000)
   PUBMED   10780788
REFERENCE   10 (bases 1 to 5142)
  AUTHORS   Volpe,C.M., Koo,J., Miloro,S.M., Driscoll,D.L., Nava,H.R. and
            Douglass,H.O. Jr.
  TITLE     The effect of extended lymphadenectomy on survival in patients with
            gastric adenocarcinoma
  JOURNAL   J Am Coll Surg 181 (1), 56-64 (1995)
   PUBMED   7599772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 5, 2021 this sequence version replaced NM_133552.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB074517.1, SRR26643287.27958.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               JAXUCZ010000012.1  27213332-27213656   c
            326-432             JAXUCZ010000012.1  27206416-27206522   c
            433-515             JAXUCZ010000012.1  27197875-27197957   c
            516-605             JAXUCZ010000012.1  27197636-27197725   c
            606-650             JAXUCZ010000012.1  27197213-27197257   c
            651-852             JAXUCZ010000012.1  27194318-27194519   c
            853-933             JAXUCZ010000012.1  27194150-27194230   c
            934-1118            JAXUCZ010000012.1  27189172-27189356   c
            1119-1671           JAXUCZ010000012.1  27184298-27184850   c
            1672-1739           JAXUCZ010000012.1  27183983-27184050   c
            1740-1893           JAXUCZ010000012.1  27183751-27183904   c
            1894-2009           JAXUCZ010000012.1  27183498-27183613   c
            2010-2129           JAXUCZ010000012.1  27183289-27183408   c
            2130-2257           JAXUCZ010000012.1  27183041-27183168   c
            2258-2381           JAXUCZ010000012.1  27182566-27182689   c
            2382-2511           JAXUCZ010000012.1  27181702-27181831   c
            2512-5142           JAXUCZ010000012.1  27178158-27180788   c
FEATURES             Location/Qualifiers
     source          1..5142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..5142
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /note="MLX interacting protein-like"
                     /db_xref="GeneID:171078"
                     /db_xref="RGD:620400"
     exon            1..325
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2630
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Williams-Beuren syndrome chromosome region 14 homolog;
                     carbohydrate-responsive element-binding protein; MLX
                     interactor; class D basic helix-loop-helix protein 14; WS
                     basic-helix-loop-helix leucine zipper protein;
                     Williams-Beuren syndrome chromosomal region 14 protein"
                     /codon_start=1
                     /product="carbohydrate-responsive element-binding protein
                     isoform 2"
                     /protein_id="NP_598236.2"
                     /db_xref="GeneID:171078"
                     /db_xref="RGD:620400"
                     /translation="MARALADLSVNLQVPRVVPSPDSDSDTDLEDPSPRRSAGGLHRS
                     QVIHSGHFMVSSPHSDSLTRRRDQEGPVGLADFGPRSIDPTLTRLFECLSLAYSGKLV
                     SPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP
                     EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSSREGDFLAPKQVEGGWPPPERWC
                     EQLFSSVVPVLLGGSEEEPGGRQLLDLDCFLSDISDTLFTMTQPSPSSLQLPSEDAYV
                     GNADMIQPDLTPLQPSLDDFMEISDFFTNYRPPQTPTSSNFPEPPSFGPMADSLFSGG
                     ILGPEMPSPASASSSSGMTPLSGNTRLQARNSCSGPLDPSTFPSSEFLLPEDPKTKMP
                     PAPVPTPLLPYPGPVKVHGLEPCTPSPFPTMAPPPALLSEEPLFSARFPFTTVPPAPG
                     VSTLPAPTTFVPTPQPGPVPGPVPFPVDHLPHGYLEPVFGPHFTVPQGVQPRCKPCSP
                     PPGGRKASPPTLTSATASPTATATARDNNPCLTQLLRAAKPEQVLEPSTVPSTLLRPP
                     ESPDAVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSER
                     RLSGDLNSIQPPGALSVHLSPPQTVLSRGRVDNNKMENRRITHISAEQKRRFNIKLGF
                     DTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNAA
                     INLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGM
                     VSTASLHSLRQTSLAWLDQYCSLPALRPTVLNSLRQLSTSTSILTDPSLVPEQATRAV
                     TEGPLGRPL"
     exon            326..432
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            433..515
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            516..605
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            606..650
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            651..852
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            853..933
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1118
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1671
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1739
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1893
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2009
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2129
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2257
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2381
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2511
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..5142
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Wbscr14; WS-bHLH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgtccg ggagttggcg acaatagtgg ccatggcgcg cgcgctggcg gatctatccg
       61 tgaacttgca ggtcccccgg gtcgtcccca gcccggattc ggactcggat acagacttgg
      121 aggatccgag tccccggcgc agcgcgggtg gcctgcatcg atcacaggtc attcacagcg
      181 gacacttcat ggtgtcctcg ccgcacagcg actcgctgac ccggcgacgc gaccaggagg
      241 ggcccgtggg gctcgccgac ttcgggccgc gcagcatcga tccgacactc acccgcctct
      301 tcgaatgctt gagcctggct tacagcggca agctggtgtc tcccaagtgg aagaacttca
      361 aaggcctcaa gttgctatgc cgggacaaga ttcggctgaa caacgccatc tggagagcct
      421 ggtacattca gtatgtgcaa cggaggaaga gcccagtatg tggcttcgta actcctctgc
      481 aggggtcaga agcagatgag caccggaaac ctgaggctgt tgtcttggag ggtaattact
      541 ggaagcggcg catcgaggtg gtgatgcgtg aataccacaa gtggagaatc tactacaaga
      601 agcggctccg taagtccagc agggaagggg atttcctggc tcccaagcag gtggaaggtg
      661 ggtggccgcc accagagaga tggtgcgaac agctcttctc cagcgtggtg cctgtgctgc
      721 ttgggggctc cgaggaggag cctgggggcc ggcagcttct cgacttggac tgcttcttgt
      781 ccgatatctc cgacacactc ttcaccatga cacagcccag cccctcgtcc ctgcagctgc
      841 cctcagaaga cgcttatgtt ggcaatgctg acatgatcca gccagacctg acgccgctgc
      901 agcccagcct ggatgacttc atggagatat cagatttctt caccaattat cgcccccctc
      961 agacgcccac atcttcaaac ttcccagagc cccccagctt tggccccatg gctgactccc
     1021 tcttcagcgg tgggatcctg ggcccagaga tgccatctcc agcctccgct tcctcctcct
     1081 cggggatgac ccctctctca gggaatacac gtctccaggc tcgaaacagc tgctctggac
     1141 ccttggatcc cagcaccttt ccgagctctg aattccttct tcctgaagac ccaaagacca
     1201 agatgccacc tgctcctgta ccgactcctc tccttccgta ccccggccct gtcaaggtgc
     1261 atggcttaga gccctgcact ccatctccct tccccacgat ggctccacct cctgctttgt
     1321 tgtcagaaga gcctctcttc tctgcaaggt tccccttcac cacagtccct cccgctccag
     1381 gagtgtctac ccttcctgca cccacaacct ttgttcccac gccacagcct ggccctgtcc
     1441 ctggccctgt ccctttcccc gtagaccatc tgccccatgg gtacctggaa cctgtctttg
     1501 ggcctcactt cacggtgcct cagggtgtgc agcccagatg caagccctgc tctccacctc
     1561 ctgggggacg aaaagccagt ccacccacct tgacctctgc cactgccagc cccacggcca
     1621 ctgctactgc cagagacaac aacccctgcc ttacacagct gctcagggca gccaagcctg
     1681 aacaagtact ggaaccttcc actgtgccca gcaccctcct ccggcctcca gagtccccgg
     1741 atgcagtccc tgaaatcccc cgtgtccgtg cattttaccc cccaatccca gcccctacac
     1801 cacctaggcc acctccaggc cctgccacat tggctcctcc caggtccctg gttgtcccca
     1861 aagcagagag gctctcacct ccagcatcca gcggcagtga gcggcgacta tcaggggatc
     1921 tcaactccat tcaacccccg ggggcactga gtgtccacct gtctccccct caaactgtcc
     1981 taagccgggg tcgtgtagac aacaacaaga tggagaaccg gcgaatcaca cacatctccg
     2041 cagagcagaa gaggcgtttc aatattaagc taggatttga cactctgcac ggacttgtca
     2101 gcacgctcag tgcccagccc agcctcaagg tgagcaaagc aaccacgctt cagaagacgg
     2161 cggagtacat cctgatgcta cagcaggagc gggcggccat gcaggaggaa gcgcagcaac
     2221 tgagggatga aatagaggag ctcaatgctg ccatcaactt gtgccagcag cagctaccgg
     2281 ccaccggggt gcccatcaca catcagcgct ttgaccagat gcgggacatg tttgatgact
     2341 atgtccggac ccgcacgctg cacaactgga agttctgggt attcagcatc ctcatccgac
     2401 ctttatttga gtccttcaat gggatggtgt ctaccgcaag cttgcacagc ctccgccaga
     2461 cctcactggc atggctggac cagtactgtt ccctgcctgc tctccggcca actgtcctga
     2521 attcccttcg ccagctcagc acttccacca gcatcctgac tgacccgagc ctcgtgcctg
     2581 agcaagccac aagggcagtc acagagggtc ccctgggcag accattataa tcctggtgaa
     2641 ggtttccaag ctccaggaac aacttgtgga cacgtccctc tcgatcctgg ctggcccttt
     2701 cctggcaggt ctggaaggtt ccaggtgttc cactcatcat ctccttgggg atagagaaga
     2761 acctggctct gtccttgcac tgttgctaat ggtgtgatcc ctggtgactc ataccccatc
     2821 tttggacctc ccattaataa cagaggaccc caaacgcatt agcagctaca gcactgggga
     2881 gctaagcagg agctctgatg agagatgtca gtctgttttc tcacaattcc ctgctttgga
     2941 gaacccttag ttcctgagcc gggaggtaga gcaggagatt ccctctcttt gcccctgcag
     3001 tagtgacatg gggagctaca gggtggcttc ctcggtgagg ccactgaggt ctgatgccag
     3061 gagagatcag ggaaatgggt agccagagca cagccggcat cttgcatgaa tgtagatgtg
     3121 tgtgtgtgtg tgtatgtgga ttttataacg aaaaatttct tgatcaataa aagcaaaaac
     3181 cgtttgcaag ggtgttggtg tgactggcag tgtgtctcag tgtgggatgt agagctggca
     3241 gcaatgaaag gtgacgttat agaggaccct gtgggtcgta aataaccttt gtgtactttc
     3301 gatctgttat ttttgttttt ggtttttttt ttcaagacag ggtttttctg tgtagccctg
     3361 gctgtcctgg aacttactgg atagaccaag ctggcctcga actcagagat ccacccacca
     3421 ttgtctctgg agtgctggga ttaaaggcct gcaccacctc ggcccagccc tttgagtact
     3481 tttcagattg cttgtgtgca ggtgtgctca tgtgtacttg tgtgtggagg acaccggctg
     3541 tcgtggttac cctcctcagt gttatctgcc ttacttttaa aatgcttcaa aatatatttt
     3601 agcatggtgg tgcacaccca gtgcatccca gtacttggga ggcagaggca ggtttttatg
     3661 agtgagaaca gcctgttcta cattcggagt tccaggccag ccagggtcat atagtaagac
     3721 ccagtctgca tacatacaca cacacacaca cacacacaca cacacacaca tatatatata
     3781 tatatacaca cacatatata tatatacata cacacacata tatatacaca cacatatata
     3841 cacacacaca tatatataca cacatatata cacacatata tacacatatg tatatatgta
     3901 tgtagtcttg gctgtcctag aactcgctat gtagaccagg ttggttttaa acaaccagat
     3961 cttcctgtct ctgtctacaa ataatttaag ttacatttat ttatatgcat atgcacacat
     4021 gcaaatgtca tacatgtgga ggtcagagga taatgtttta ggaaacactt ctctttctac
     4081 catgtatgtg atgaggagca gctcaggtta tcaacttcag caatcagtgc ctttactggt
     4141 caagccatct caccaacccc tctgccttat tccttgagac agggtccttc attgaactta
     4201 gaactcacca gtttggctag gctgactggc caataagccc ctgaaatcta cttgtcttta
     4261 ccaccccaac aatggggtta ccactcctgg cttttagatt tgggttgtag gtctgttctt
     4321 caatgactga accatctccc agctccagtc ttaaaaggag atatatacat atgcatatat
     4381 gtatgtaggt atgttttttt tttctccctc aagacagggt ctcaccgtgt agccctggct
     4441 gtcctggaac ccactctgta gaaaagactg gcttcaaact cacagagctc tatctgcctc
     4501 tgcctccttc gtgctcctca ggatcaatcc acagctgcta atatgtaaat gaatacattt
     4561 aaaaaaatgg tgtttcagga atttttactc tgtggtgggg gtctgggtgg ggactaggaa
     4621 acatacacct tgtcagaagg ttccagtgca aaactaaagt tcagttcatc ttgggtgcca
     4681 ctgagggagg gagggggaat tgaagcaggc acatcggaag gtttgtatcc agcgcgaatg
     4741 atagctttcc ccatagttac atgcatgggg tcctcctgtc ctctttacag tgtctagagt
     4801 gaggtccaga gtggggctat gttgttgaca tggccacagc catgtttagt acctcagtgc
     4861 atggcctcat gggaatggca aaaccattcc cttgtgaggc tcagaaggat gtcagagcct
     4921 gactcagtgg tctaagaacg gtgaatgttg acatgtgtgt gtaggaaata tcaaacactg
     4981 ctttctcctc accccccctt tctgcttcct tcttgtgttt gaagatgtga attttcaact
     5041 tcctgttgct tctgtgcctg ccccctgctg tcccgcctcc ctgccttgat ggattcatcc
     5101 ctctggaaac gtaaaccaaa ataaaacttt tttttttaat aa
//
