LOCUS       NM_001034112            1913 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus MAX dimerization protein MLX (Mlx), mRNA.
ACCESSION   NM_001034112 XM_340906
VERSION     NM_001034112.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y,
            Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K and
            Isobe M.
  TITLE     Single-Nucleotide Polymorphism of the MLX Gene Is Associated With
            Takayasu Arteritis
  JOURNAL   Circ Genom Precis Med 11 (10), e002296 (2018)
   PUBMED   30354298
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M,
            Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y,
            Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I,
            Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T,
            Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T
            and Matsuda F.
  TITLE     Two susceptibility loci to Takayasu arteritis reveal a synergistic
            role of the IL12B and HLA-B regions in a Japanese population
  JOURNAL   Am J Hum Genet 93 (2), 289-297 (2013)
   PUBMED   23830516
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Ma L, Robinson LN and Towle HC.
  TITLE     ChREBP*Mlx is the principal mediator of glucose-induced gene
            expression in the liver
  JOURNAL   J Biol Chem 281 (39), 28721-28730 (2006)
   PUBMED   16885160
  REMARK    GeneRIF: ChREBP.Mlx is the principal transcription factor
            regulating glucose-responsive genes in the liver and coordinately
            regulates a family of genes required for glucose utilization and
            energy storage
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP
            and Kingston RE.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Xu J, Christian B and Jump DB.
  TITLE     Regulation of rat hepatic L-pyruvate kinase promoter composition
            and activity by glucose, n-3 polyunsaturated fatty acids, and
            peroxisome proliferator-activated receptor-alpha agonist
  JOURNAL   J Biol Chem 281 (27), 18351-18362 (2006)
   PUBMED   16644726
  REMARK    GeneRIF: involved in control of hepatic L-type pyruvate kinase gene
            transcription
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Eilers AL, Sundwall E, Lin M, Sullivan AA and Ayer DE.
  TITLE     A novel heterodimerization domain, CRM1, and 14-3-3 control
            subcellular localization of the MondoA-Mlx heterocomplex
  JOURNAL   Mol Cell Biol 22 (24), 8514-8526 (2002)
   PUBMED   12446771
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Cairo S, Merla G, Urbinati F, Ballabio A and Reymond A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Billin AN, Eilers AL, Coulter KL, Logan JS and Ayer DE.
  TITLE     MondoA, a novel basic helix-loop-helix-leucine zipper
            transcriptional activator that constitutes a positive branch of a
            max-like network
  JOURNAL   Mol Cell Biol 20 (23), 8845-8854 (2000)
   PUBMED   11073985
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A and
            Reymond A.
  TITLE     Mlx, a new Max-like bHLHZip family member: the center stage of a
            novel transcription factors regulatory pathway?
  JOURNAL   Oncogene 19 (29), 3266-3277 (2000)
   PUBMED   10918583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO560831.1, CO574572.1, BQ194554.1 and BI286092.1.
            
            On Oct 14, 2005 this sequence version replaced XM_340906.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128702.1, SRR8487230.51041.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-644               CO560831.1         1-644
            645-1253            CO574572.1         6-614
            1254-1806           BQ194554.1         110-662             c
            1807-1913           BI286092.1         1-107               c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1913
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /note="MAX dimerization protein MLX"
                     /db_xref="GeneID:360631"
                     /db_xref="RGD:1308590"
     exon            1..210
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..903
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /note="max-like factor protein; transcription factor-like
                     4; MLX, MAX dimerization protein"
                     /codon_start=1
                     /product="max-like protein X"
                     /protein_id="NP_001029284.1"
                     /db_xref="GeneID:360631"
                     /db_xref="RGD:1308590"
                     /translation="MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQL
                     SPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGST
                     SASSVPNTDDEDSDYQQESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQ
                     QQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQI
                     VKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEH
                     CEPQTLREIVIGVLHQLKNQLY"
     exon            211..247
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            248..337
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            338..444
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            445..544
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..644
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..846
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1895
                     /gene="Mlx"
                     /gene_synonym="Tcfl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccacgatga cggagccggg cgcctctccg gaggaccctt gggtcaaggc aagctccgcg
       61 gatgcgcacg ccggcgaggg gagggcgggt cgggctcgtg cacgtagggg gtccggaaga
      121 cgtggggctc cccaactatc cccagagtct cccctgctgt ccaggccccg gggctgcaga
      181 gaagacagct ctcacccggc ctgtgccaag gtcgagtatg cctacagtga caacagcctg
      241 gaccctgggc tttttgtaga aagcacccac aaggggagtg tagtgtccag agctaatagc
      301 atcggttcca ccagtgcctc ttctgtcccc aacacagatg atgaggacag cgattatcag
      361 caggaatcct acaaggagtc ctataaagac cggaggcggc gtgcgcacac tcaggctgaa
      421 cagaagagga gggatgctat taagagaggc tatgatgacc ttcagaccat tgtccctact
      481 tgccagcagc aggatttctc cattggctcc caaaaactca gcaaagccat cgttctacag
      541 aagaccattg actacatcca gtttttacac aaggagaaga aaaaacagga ggaggaggtg
      601 tccaccctgc gcaaggacgt cacagccttg aagataatga aagtgaacta tgagcagatc
      661 gtgaaggcac atcaggacaa ccctcatgag ggagaggacc aggtctctga ccaggtcaag
      721 ttcaacgtct ttcaaggcat catggactcc ctgttccagt ctttcaacgc ctccatctct
      781 gtggccagct tccaggagct ctcagcctgt gtcttcagct ggattgaaga acactgtgaa
      841 ccgcagactc tacgggagat tgtgatcggt gtccttcatc agttgaaaaa ccaactctac
      901 tgacggttcc cagaaacccg aagagcagcc aacaagtggc cttgagtgtt tggtcacgga
      961 actgctgggc ctgagattgg actgcaacac ctcacaccag tcagctggtt tctacttggt
     1021 gtttggtttt cccagcccca cttgagcttc tgattaattt attatattgc ctacaatgtt
     1081 gagcctatcc aaccttcccc ttcccaggaa tagcatctag ggcaagtctg tgcagggaac
     1141 ctcagaatcc cgagcctctc agccccttct ctacccattg ggttcctgct cacaatctat
     1201 atatacaatt tggaaactgt ttgcctctgc ttggtctctt gggcaacact tggctcaagt
     1261 ttgggtattt tggcagttct taagttagag gaaaaagaaa tagccccatg ggcatgaagg
     1321 gtaaaaggcc accttgtgta taagctaagg ctgtgtggtc aatactaagt taaggctaga
     1381 gtattctagc cagctcaggg tagagctgcc aggttcctgc tgcccctcac attctgccac
     1441 ccacttcttc agctactgtg ggtgctacag gaaacagtgt cccatcagct cttgccctgt
     1501 ctttccccaa aggcagcatt acatatttga atttattttc taaataccaa cagtgcattt
     1561 ttgttacgtg cagttttccg agattcttag cagacctgca aagcacccca gcctcttctg
     1621 cataatgtgt gtttccgccc cacgcgtgtg ttgcctacat ttctcctagg atctggggag
     1681 agagtaagtg gtacagaaga tacccaaatc ttctgggggc aggcaagggt gataccttgg
     1741 gattctcaaa atgttggtgt gtgacaccct ttctgtactt ttatcccgtg ttccctactg
     1801 ccttccccag gtttgatatc tgggaggttt gatcatccag aggaaattaa gtatttttat
     1861 atcaaattat attacaataa atattacaaa tacttaaaaa aaaaaaaaaa aaa
//
