LOCUS       NM_001012135            2892 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus melanophilin (Mlph), mRNA.
ACCESSION   NM_001012135 XM_237388
VERSION     NM_001012135.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Geething,N.C. and Spudich,J.A.
  TITLE     Identification of a minimal myosin Va binding site within an
            intrinsically unstructured domain of melanophilin
  JOURNAL   J Biol Chem 282 (29), 21518-21528 (2007)
   PUBMED   17513864
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Wu,X.S., Tsan,G.L. and Hammer,J.A. 3rd.
  TITLE     Melanophilin and myosin Va track the microtubule plus end on EB1
  JOURNAL   J Cell Biol 171 (2), 201-207 (2005)
   PUBMED   16247022
  REMARK    Erratum:[J Cell Biol. 2006 Feb 13;172(4):633]
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Volkmann,N., Liu,H., Hazelwood,L., Krementsova,E.B., Lowey,S.,
            Trybus,K.M. and Hanein,D.
  TITLE     The structural basis of myosin V processive movement as revealed by
            electron cryomicroscopy
  JOURNAL   Mol Cell 19 (5), 595-605 (2005)
   PUBMED   16137617
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Westbroek,W., Lambert,J., De Schepper,S., Kleta,R., Van Den
            Bossche,K., Seabra,M.C., Huizing,M., Mommaas,M. and Naeyaert,J.M.
  TITLE     Rab27b is up-regulated in human Griscelli syndrome type II
            melanocytes and linked to the actin cytoskeleton via exon F-Myosin
            Va transcripts
  JOURNAL   Pigment Cell Res 17 (5), 498-505 (2004)
   PUBMED   15357836
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Wu,X.S., Rao,K., Zhang,H., Wang,F., Sellers,J.R., Matesic,L.E.,
            Copeland,N.G., Jenkins,N.A. and Hammer,J.A. 3rd.
  TITLE     Identification of an organelle receptor for myosin-Va
  JOURNAL   Nat Cell Biol 4 (4), 271-278 (2002)
   PUBMED   11887186
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Hume,A.N., Collinson,L.M., Hopkins,C.R., Strom,M., Barral,D.C.,
            Bossi,G., Griffiths,G.M. and Seabra,M.C.
  TITLE     The leaden gene product is required with Rab27a to recruit myosin
            Va to melanosomes in melanocytes
  JOURNAL   Traffic 3 (3), 193-202 (2002)
   PUBMED   11886590
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Matesic,L.E., Yip,R., Reuss,A.E., Swing,D.A., O'Sullivan,T.N.,
            Fletcher,C.F., Copeland,N.G. and Jenkins,N.A.
  TITLE     Mutations in Mlph, encoding a member of the Rab effector family,
            cause the melanosome transport defects observed in leaden mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10238-10243 (2001)
   PUBMED   11504925
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Markert,C.L. and Silvers,W.K.
  TITLE     The Effects of Genotype and Cell Environment on Melanoblast
            Differentiation in the House Mouse
  JOURNAL   Genetics 41 (3), 429-450 (1956)
   PUBMED   17247639
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081894.1.
            
            [WARNING] On Jul 25, 2024 this sequence was replaced by
            NM_001012135.2.
            
            On Feb 11, 2005 this sequence version replaced XM_237388.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN13663594
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..2892
                     /gene="Mlph"
                     /note="melanophilin"
                     /db_xref="GeneID:316620"
                     /db_xref="RGD:1310733"
     exon            1..129
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            130..262
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1919
                     /gene="Mlph"
                     /codon_start=1
                     /product="melanophilin"
                     /protein_id="NP_001012135.1"
                     /db_xref="GeneID:316620"
                     /db_xref="RGD:1310733"
                     /translation="MGRKLDLSKLTDEEAEHVWAVVQRDFDLRRREEERLQGLKGKIQ
                     KESSKRELLSDTAHLNETHCARCLQPYRLLVNSRRQCLECGLFVCKSCSHVHPEEQGW
                     LCDPCHLARVLKIGSLEWYYQHVRARFKRFGSAKVIRSLCGRLQGGGGSEPSLEEGNG
                     DSEQTDEDGELDTKAKDQSLNSKKKRLLSFRDVDFEEDSDHSIQPCSHTLGLSSVPES
                     AQSLQSLSGEPYSEDTTSLEPEGMEETGAGASGCYPSPEEQPYSPLPSGEDAHTELHS
                     PATSCKSTFGTTAMPGIDDNKGKQLPSQYLADVDTSDEDSIPGPRAASQHTKRRARTV
                     PETQISELNKRMSAVEHLLVHLENVVLPPSDQEPAVETHPSADTEEETLRRRLEELTS
                     NVSGSEISSEDETKPDAPFRGVSPKVCTDTGHMEAQERSPRSPGNPAQPTKSTDEELS
                     EMEDRVAMTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRRSGIPIFLPRITE
                     KLDRIPKTPPADPENQAKVPKATAVPCLMRRKYSPSSQGIDGGSFDRKSVYRGSLTQR
                     NPNGRKGTARHIFAKPVMAQQP"
     exon            263..484
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            485..597
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            598..701
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            702..821
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1026
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1166
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1250
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1403
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1559
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1652
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1739
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1791
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1892
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2865
                     /gene="Mlph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtgctc cctgactgga cactggcctc agtgcctggg gtttctctct cacgacctaa
       61 gagaaaggag cagaggccag gactcacaga gccagagcca gaggctgagc aatcccagga
      121 gagaggctgg gtggcctgga ggaggcgcag agatggggag aaagctggac ctttccaagc
      181 tcacagacga ggaggccgaa catgtttggg cagtggttca gcgggacttc gacctcagga
      241 ggcgagaaga agaaagactc caggggctga agggcaagat ccaaaaggag agctccaaga
      301 gggagttgct gtcggacaca gcccatttga atgagaccca ctgtgcccgc tgcctgcagc
      361 cttaccggct actcgtgaac agcagacggc agtgtctaga atgtggtctc ttcgtctgca
      421 aaagctgcag ccacgtccac ccagaagagc agggctggct ctgcgacccc tgccacttgg
      481 ccagagtctt gaagattggc tccctggaat ggtactacca gcacgtgaga gctcgcttca
      541 agcgttttgg gagtgccaaa gtgatccggt ctctctgcgg gcggctgcag ggtggaggtg
      601 gatctgagcc aagcttggaa gaaggaaatg gagacagtga gcagacagat gaggatggag
      661 agctggacac aaaggccaaa gaccagtccc tcaacagcaa aaaaaaacgc ctgctctcct
      721 tccgggacgt ggactttgaa gaagactcag accactcgat acagccttgc agccacaccc
      781 tgggcctgtc ctcagtccct gagtctgccc agagcctgca gtccctctca ggtgagccct
      841 actctgagga caccacctct ctggagcccg agggcatgga ggagactggt gcaggggctt
      901 cagggtgtta ccccagtcct gaggagcagc catacagccc tttaccctct ggagaggatg
      961 ctcacactga actgcactcg cctgcaacat cctgcaagag tacctttggg accacagcta
     1021 tgcctgggat agatgataac aagggcaaac agctgccctc acagtacctg gctgatgtgg
     1081 acacctctga tgaagacagc atcccgggcc ccagggcagc ctcccagcac accaagcgga
     1141 gggcacggac tgtgcctgag actcagatct cggagttgaa caagcgaatg tcagctgtgg
     1201 agcatctgct ggtccacctg gaaaatgtgg ttctgcctcc ctcagaccag gaaccagctg
     1261 tggagacaca ccccagtgct gacacagagg aggagacact caggaggagg ctggaggagc
     1321 tgaccagtaa cgtcagtggt tctgaaatct catcagaaga tgagaccaag ccagatgccc
     1381 ccttccgtgg agtgtcccca aaggtgtgca cagacacagg gcacatggag gcacaggaaa
     1441 ggagccctcg gagccccggg aaccctgctc aacctacaaa aagcacggat gaggagctct
     1501 ctgagatgga ggatagagtg gccatgacag cctcggaagt tcagcaagct gaaagtgagg
     1561 tctcagacat tgagtccaga attgcagctc tgagggcagc aggactcaca gtgaagccct
     1621 cgggaaagcc tcggagaagg tcaggcatcc cgatctttct tccccggatt actgagaaac
     1681 ttgacaggat cccaaagact ccacctgcag accctgagaa ccaagccaag gtgcccaagg
     1741 cgacggctgt gccctgtctc atgaggagga agtattctcc cagcagccaa ggcattgacg
     1801 gtggttcttt tgatcggaaa tcagtgtacc gtggctcgct gacacagagg aaccctaatg
     1861 ggaggaaagg gacagccaga cacatcttcg cgaaacccgt gatggcccag cagccctgaa
     1921 ggagaggctc atggcacagg acagtactac aagcgcccca cagtttcctc cacgtgaccg
     1981 tcatagcccc ctgggctctg agcctcttga tgctcagacc tgcttgtagt catcatccca
     2041 gtgagaagta agaactcaga ctgtggatct caagcctcca gctgtcacca ggtcaccagc
     2101 ccaagccagg gaacctgcca gcctctgacc caggaaatac aaactatgtg acttcccctc
     2161 agttgatgtt ctctgcctgc tgaaggactc tcagattccc tctcactgtg attctctaac
     2221 cccatcatca gccttgccta gccacgctca cagctgggat gggaagagct ggttcagggg
     2281 aggtcctgaa ggtgcacaca ctcccgagtg ggcaggggag cgggaggcag aatcgagagt
     2341 gtctgtgggc atgatgggac agtgtgcagt tcaggtggtg aatgaggagg gatggattcc
     2401 tcccccaccc cacagatctt gttcttcaaa tgtccttgtg tgttacagat gggagcaaat
     2461 aacactgtcc cccaccccag cattcccatc acaatgacca ccacattgag accaagcctc
     2521 caatacaggc ttttggtgta cactacatag ggagcttgct ttctagatag ctcgtgcttc
     2581 aaatgcaggt gtctaacaca cacagatgac tgctctagga tttatcaaga actcagatct
     2641 tccagagtca agtgtgtcag ggccagtttt gctggtgtct gcacggtctg ccttcacagc
     2701 caccccaccg ctacaggagg gctgtttccc acacccaggg ctgcctcttt cctgtcagct
     2761 tgtatcctgc tctgggagtc tagagaacac acgggtcaga gccacatata tcctagtgtc
     2821 ttctgagaat aaactccagg aagaagtctc tcattcattc atgtaaaaaa aaaaaaaaaa
     2881 aaaaaaaaaa aa
//
