LOCUS       NM_001110056             206 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus motilin (Mln), mRNA.
ACCESSION   NM_001110056
VERSION     NM_001110056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 206)
  AUTHORS   Zhao J, Gao B, Zhang Y, Zheng B, Liu H and Cao JL.
  TITLE     Effects of intrathecal opioids combined with low-dose naloxone on
            motilin and its receptor in a rat model of postoperative pain
  JOURNAL   Life Sci 103 (2), 88-94 (2014)
   PUBMED   24727237
  REMARK    GeneRIF: Acute pain and postoperative analgesia significantly
            impact the expression of hippocampal and peripheral motilin.
REFERENCE   2  (bases 1 to 206)
  AUTHORS   Guo F, Xu L, Sun X, Gao S and Zhu H.
  TITLE     The paraventricular nucleus modulates thyroidal motilin release and
            rat gastric motility
  JOURNAL   J Neuroendocrinol 23 (9), 767-777 (2011)
   PUBMED   21756270
  REMARK    GeneRIF: These results demonstrate that motilin from the thyroid
            could be secreted into the peripheral plasma and affect gastric
            motility and that PVN was a central nucleus for modulating gastric
            motility and motilin expression in the thyroid
REFERENCE   3  (bases 1 to 206)
  AUTHORS   Jia YD, Liu CQ, Tang M and Jiang ZY.
  TITLE     Expression of motilin in the hypothalamus and the effect of central
            erythromycin on gastric motility in diabetic rats
  JOURNAL   Neurosci Bull 23 (2), 75-82 (2007)
   PUBMED   17592529
  REMARK    GeneRIF: Centrally administered erythromycin may regulate gastric
            motility by binding to the central motilin receptors, and central
            motilin might be involved in regulation of gastric motility in
            diabetic rats [motilin]
REFERENCE   4  (bases 1 to 206)
  AUTHORS   Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS,
            Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R,
            Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH,
            Evans J, Patchett AA, Smith RG and Howard AD.
  TITLE     Receptor for motilin identified in the human gastrointestinal
            system
  JOURNAL   Science 284 (5423), 2184-2188 (1999)
   PUBMED   10381885
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB111861.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB111861.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..206
                     /gene="Mln"
                     /note="motilin"
                     /db_xref="GeneID:100126231"
                     /db_xref="RGD:1642907"
     CDS             1..147
                     /gene="Mln"
                     /codon_start=1
                     /product="promotilin"
                     /protein_id="NP_001103526.1"
                     /db_xref="GeneID:100126231"
                     /db_xref="RGD:1642907"
                     /translation="MVSCKAVVILLEVYAAAMLTSQIEAFLTIFVHGELQRLQLTAPA
                     RMGV"
     exon            1..117
                     /gene="Mln"
                     /inference="alignment:Splign:2.1.0"
     exon            118..206
                     /gene="Mln"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgtcct gcaaggctgt ggtcatcttg ctagaggtgt atgcagctgc catgctgacc
       61 tcccagattg aagctttcct taccatcttc gtgcacggtg aactccagag actgcagttg
      121 actgctccag cacgaatggg agtgtgaaca accgccaggc agccggaaaa gtaccagccc
      181 ccgcccccaa agggctgccg agggag
//
