LOCUS       NM_053718               6199 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus MLLT3, super elongation complex subunit (Mllt3),
            mRNA.
ACCESSION   NM_053718 XM_342859
VERSION     NM_053718.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6199)
  AUTHORS   Calvanese,V., Nguyen,A.T., Bolan,T.J., Vavilina,A., Su,T.,
            Lee,L.K., Wang,Y., Lay,F.D., Magnusson,M., Crooks,G.M.,
            Kurdistani,S.K. and Mikkola,H.K.A.
  TITLE     MLLT3 governs human haematopoietic stem-cell self-renewal and
            engraftment
  JOURNAL   Nature 576 (7786), 281-286 (2019)
   PUBMED   31776511
REFERENCE   2  (bases 1 to 6199)
  AUTHORS   Zhang,Q., Zeng,L., Zhao,C., Ju,Y., Konuma,T. and Zhou,M.M.
  TITLE     Structural Insights into Histone Crotonyl-Lysine Recognition by the
            AF9 YEATS Domain
  JOURNAL   Structure 24 (9), 1606-1612 (2016)
   PUBMED   27545619
REFERENCE   3  (bases 1 to 6199)
  AUTHORS   Li,Y., Sabari,B.R., Panchenko,T., Wen,H., Zhao,D., Guan,H., Wan,L.,
            Huang,H., Tang,Z., Zhao,Y., Roeder,R.G., Shi,X., Allis,C.D. and
            Li,H.
  TITLE     Molecular Coupling of Histone Crotonylation and Active
            Transcription by AF9 YEATS Domain
  JOURNAL   Mol Cell 62 (2), 181-193 (2016)
   PUBMED   27105114
REFERENCE   4  (bases 1 to 6199)
  AUTHORS   Li,Y., Wen,H., Xi,Y., Tanaka,K., Wang,H., Peng,D., Ren,Y., Jin,Q.,
            Dent,S.Y., Li,W., Li,H. and Shi,X.
  TITLE     AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79
            methylation
  JOURNAL   Cell 159 (3), 558-571 (2014)
   PUBMED   25417107
REFERENCE   5  (bases 1 to 6199)
  AUTHORS   Luo,Z., Lin,C. and Shilatifard,A.
  TITLE     The super elongation complex (SEC) family in transcriptional
            control
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 543-547 (2012)
   PUBMED   22895430
  REMARK    Review article
REFERENCE   6  (bases 1 to 6199)
  AUTHORS   Zhou,Q., Liu,K., Wu,H., Chen,L., Pouranan,V., Yuan,M., Xiao,Z.,
            Peng,W., Xiang,A., Tang,R. and Zhang,W.
  TITLE     Spironolactone rescues Dot1a-Af9-mediated repression of
            endothelin-1 and improves kidney injury in streptozotocin-induced
            diabetic rats
  JOURNAL   PLoS One 7 (10), e47360 (2012)
   PUBMED   23077601
REFERENCE   7  (bases 1 to 6199)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   8  (bases 1 to 6199)
  AUTHORS   Haribaskar,R., Putz,M., Schupp,B., Skouloudaki,K., Bietenbeck,A.,
            Walz,G. and Schafer,T.
  TITLE     The planar cell polarity (PCP) protein Diversin translocates to the
            nucleus to interact with the transcription factor AF9
  JOURNAL   Biochem Biophys Res Commun 387 (1), 212-217 (2009)
   PUBMED   19591803
REFERENCE   9  (bases 1 to 6199)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 6199)
  AUTHORS   Collins,E.C., Appert,A., Ariza-McNaughton,L., Pannell,R., Yamada,Y.
            and Rabbitts,T.H.
  TITLE     Mouse Af9 is a controller of embryo patterning, like Mll, whose
            human homologue fuses with Af9 after chromosomal translocation in
            leukemia
  JOURNAL   Mol Cell Biol 22 (20), 7313-7324 (2002)
   PUBMED   12242306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 10, 2021 this sequence version replaced NM_053718.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.23302.1,
                                           SRR26643429.19906.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000005.1  107561031-107561352 c
            323-503             JAXUCZ010000005.1  107559476-107559656 c
            504-586             JAXUCZ010000005.1  107409793-107409875 c
            587-730             JAXUCZ010000005.1  107403617-107403760 c
            731-1438            JAXUCZ010000005.1  107372674-107373381 c
            1439-1514           JAXUCZ010000005.1  107327004-107327079 c
            1515-1644           JAXUCZ010000005.1  107324976-107325105 c
            1645-1744           JAXUCZ010000005.1  107322415-107322514 c
            1745-1816           JAXUCZ010000005.1  107316569-107316640 c
            1817-1888           JAXUCZ010000005.1  107315205-107315276 c
            1889-6199           JAXUCZ010000005.1  107305008-107309318 c
FEATURES             Location/Qualifiers
     source          1..6199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..6199
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /note="MLLT3, super elongation complex subunit"
                     /db_xref="GeneID:114510"
                     /db_xref="RGD:620940"
     exon            1..322
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2020
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /note="myeloid/lymphoid or mixed lineage-leukemia
                     translocation to 3 homolog; myeloid/lymphoid or
                     mixed-lineage leukemia,translocated to, 3 (trithorax
                     homolog, Drosophila); myeloid/lymphoid or mixed-lineage
                     leukemia (trithorax homolog, Drosophila); translocated to,
                     3; myeloid/lymphoid or mixed-lineage leukemia;
                     translocated to, 3"
                     /codon_start=1
                     /product="protein AF-9"
                     /protein_id="NP_446170.2"
                     /db_xref="GeneID:114510"
                     /db_xref="RGD:620940"
                     /translation="MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNI
                     QHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDY
                     DLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSS
                     SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAF
                     KEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSAQ
                     QDKKAPSKRPPVSDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHV
                     KMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSS
                     FTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSD
                     GSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDEL
                     VELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETS
                     GTS"
     exon            323..503
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            504..586
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            587..730
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1438
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1514
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1644
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1744
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1816
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1888
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..6199
                     /gene="Mllt3"
                     /gene_synonym="Af-9; Af9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctccctc cgccccgaga ggctcgaagc ccgggtgtca ggcgccacgg cgcatgctcc
       61 ggactcatct ctggccccgg agctgctgct gctgctgctg ctgctgcttt tgcttttggg
      121 gctgagttta ataagcgagc gagagagcga gcacggggtg gggtgggggc aaaggcagag
      181 catgtccgcc atctaccctc agctcccggg cgcgctctca ttcatagcag cctcttcatg
      241 aattacagct gaagggggcg ggggaggggg gtaccacaca acaccccggc aaacctccgg
      301 gcccccaggc atggctagct cgtgtgccgt gcaggtgaag ctggagctgg ggcaccgcgc
      361 ccaggtgagg aagaaaccca cagtggaggg cttcacccac gactggatgg tgttcgtgcg
      421 cggcccggag cacagtaaca ttcagcactt tgtggagaaa gtcgtcttcc acttgcatga
      481 aagcttccct aggccaaaaa gagtgtgcaa agacccacct tacaaggtag aagagtccgg
      541 gtacgctggc ttcatattgc caattgaagt ttattttaaa aacaaggaag aacctaagaa
      601 agtccgcttt gattatgact tattcctgca tcttgaaggc cacccaccag tgaatcacct
      661 ccgctgtgag aagctaactt tcaataaccc cacagaggac tttagaagaa agttgctgaa
      721 ggcaggaggg gaccctaaca ggagcattca taccagcagc agcagcagca gcagcagtag
      781 cagcagcagc agcagcagca gtagcagcag cagcagcagt agcagcagca gcagcagtag
      841 cagcagcagt agcagcagca gcagcagcag cagcagtagt accagttttt caaagcctca
      901 caaattaatg aaggagcaca aggaaaaacc ttctaaggac tccagagaac ataaaagtgc
      961 cttcaaagaa ccttccaggg atcacaacaa atcttccaaa gactcctcca agaaacccaa
     1021 agaaaacaaa ccactgaaag aagaaaaaat cgttcctaag atggccttca aggagcctaa
     1081 acccatgtca aaagagccaa aagcagacag taacttactc accgtcacca gtgcacagca
     1141 ggacaagaag gcgcctagta aaaggccccc tgtttcagat tctgaagaac tctcagccaa
     1201 aaaaaggaaa aagagtagct ccgaggcttt atttaaaagt ttttctagcg cgcccccact
     1261 gatactcact tgttctgctg acaaaaaaca gataaaagat aaatctcatg tcaagatggg
     1321 aaaggtcaaa atcgagagcg agacttcaga gaagaagaag tcgacactgc caccatttga
     1381 tgatatcgtg gatcccaacg actcagacgt ggaggagaac atgtcctcaa aatctgactc
     1441 agagcaaccc agtcctgcca gttccagttc cagttccagc tccagcttca cgccgtctca
     1501 gaccaggcag caaggtcctt taaggtcgat catgaaagat ctgcattccg atgacaacga
     1561 ggaggagtct gatgaggccg aggacaatga caatgactct gagatggaaa gacctgtaaa
     1621 cagaggggga agccgaagtc gcagggtcag cttgagtgac ggcagtgaca gtgaaagcag
     1681 ctctgcctct tcccctctcc atcacgaacc cccaccgcca ttattgaaaa ctaacaacaa
     1741 ccagattctt gaagtgaaaa gtccaataaa acaaagcaaa tcagataagc aaataaagaa
     1801 tggtgaatgt gacaaggctt acctagatga gttggtagaa ctccacagaa ggttaatgac
     1861 actgagggaa agacacattc tgcagcagat cgtgaacctt atagaggaaa ctggacactt
     1921 tcatattaca aatacaacat ttgattttga tctttgctcg ctggacaaaa ctacagtccg
     1981 taaattacag agttacctgg agacatctgg aacatcctga gggtacaaca actggacgca
     2041 tcaaaaacta tttttttttt tggttgtgat ttttttttgt cgttgttgtt gtttatatga
     2101 aaacactcag aatgatacaa ccaaaaggga aaaaaaataa aaacaaaaca accttcagct
     2161 ttacttttct ttaaagccag tcatcatctc ttgataaagg agaggttacc taaaccagcc
     2221 tcagcggaca ctcctctgca aggaaaaatg cccaggaaga attagcctgg atagccttca
     2281 aaacaagcag acacaacaca agaacactta aagaatgtgt atggtaccgt ggatctctct
     2341 gtggtggttc attccacagg atgaatgcat attcaacaca ctgccttatt acataactga
     2401 tctatttatt accacataca gataaattgt gagggagtga caccaccaga cgtcccaggt
     2461 cctcggtccc gcggatgctc ttttcaatgc agcgcccttg ccgtcccaag cccagtgacc
     2521 ttattcgtat accgagccac tttccaccaa ctcttcccaa gtcctttaac ttgttgcagt
     2581 ctatggtttc cacctttgtt ttcccagttc cgagacatag tgatcaactg gggggaccaa
     2641 atagccacct tgattttctt ccttgtggtc ttctttccta aaggttgagg cccagtcctt
     2701 ggctgtatcc atgtaatgat cttggacacg gtaggtgtac caagtaggat catttgaatt
     2761 gctgtctagc cttagtcaat aaacctgtag gactttgaac aaaaatgttc ccgtgatgtc
     2821 cacagtccag cattgttgag ctgtcaccaa cactccattt tactgtctcc atttactgtt
     2881 gcaatatgag gtgaagacgg aggttaaagg cattccgcag actcagcgtt tttaaaggaa
     2941 ttctggtcct gttttcaaaa ccatcagtgt agacgttctt aatttggatc tatttattag
     3001 tgagcatttc acctgtcttc agcagctggt gtggtactca tttcttctta aaaacaaaac
     3061 aaaaacagga gtcagaattt tctttttggt ttgttctcat atgattctcc tagactcttt
     3121 tatttttgaa aaattaaaac ctttctttgg gggagaattg ttggttatcc tgccctgaca
     3181 gactatgtat tcacttgtag atttggtaac tttgtatctg tgtagtcttg ctgatgtctg
     3241 cagaaggatt tctgtatagg tgaaaggtga aggtggttgg gagggggagt ttcttgtcct
     3301 tgttgtacct tcgttttgaa actagaaatc tgtcctgtgg catgcaaaag aaggcgaatt
     3361 attttcaaaa gaaaaaagaa aaaaaaaaaa cccaaagtac ttttggtgtc attattccac
     3421 actctctgta gtggaggaat tcaaagttag aacagccgac tttccaagtt gttacgagaa
     3481 cgcaactgaa aagaaaagga atgaagaaga cttctggatc caaagcctta agagagtcta
     3541 cgtgtgctaa cagcctagtg tcccccacat ctgttcccgt gacagatgct gtcctttcat
     3601 tcagagatta actagtgtct gtacagaaaa tggtcttccc agacccgttc tttcaggcgg
     3661 tgatgtaaat gcagattaat aatggagcgg tttctgcatt ttaaaaagga gattttttta
     3721 cactgtttct ttctatccaa agaaactatt tttttctttt ttaaaaaaaa aaatatgata
     3781 atacagccat ggtctttgta aattgctttc ctgcagtgtc ctcctggagg acaagtgtac
     3841 acattttcaa gaatgttccg gttcctcatg gtgatggaca tgagccgtac ttgaagcttt
     3901 tggtgtgtcg tccacttctt ggtgtacaga tgcatagaca cgaatcatgt cgttttggac
     3961 agtaggcggt tggtgagctg tgtgcttttc gttgtgtttc gtttctaact tcacagttga
     4021 aaagagaaat aatgtttcaa catccagaaa tctttttaaa tttctgtctg caatcccaca
     4081 tattctcatt aaactagaaa agtaagtggt ttaactaatg tatctgtata atttaactag
     4141 aaacatgcag tttgggccat ttttattttt ataaccaaat tgagtggcga aataaatact
     4201 ttggcttctt ttattcctga agttacaaag accaagaaac taaggtaaga agttaccctc
     4261 ccctcgatgc ccaaagaaat aaaatttaaa agaggggtaa gaggaaaggc agctattgta
     4321 atgataacat tagggctaga aaattagcta atacagatgt cttcagtata tcatgaaata
     4381 aaagtttgta catgggtaac aaaattcaga acagcgaact tcttacctgg acagcaaagt
     4441 tagcttcctg tcagctcctg gtagtttagg agttgtagct acagagccac tctttcggat
     4501 gtcctcctgc tcctggcaca tggtttgata aaacagaagt catgaattcc cttcagttcc
     4561 actcaaggat gtgccacatt tctccagaag caaaccactc ctgccacatc tatgtgcact
     4621 cacttttgga ccctgttaag aatattttga cacatgtgta ccctaacagt ggctttggtt
     4681 ttttaagcac aaagggggaa tggcagggtt taacttcttt agtgtgtata tgtatatata
     4741 aataggtgtt tcaaataaaa ttaattgggt gaatgtgaat aagtttgaac cagcaagagt
     4801 ataataaact atcattaaat ttttttcttc taaaaactat atgtacagac cacacacaca
     4861 cacacacaca cacacacaca cacacacaca cacacttttg gttttgtgta agtgtgtgga
     4921 gggccccttc tgttgtcaga tacactgatc gtgttagcag gaatgtatga agttacttca
     4981 tattgtcact gccccctctt ttaagtaaca tagatacact gtgtcaagat tagggagaac
     5041 attaaaaaga aaagaaaaga aaagaaaacc aggagatgag tttcagataa aaaaacattt
     5101 taaaagttgc aacgaaatct ctaatctgag taattacctg ttttaaggaa agggccaata
     5161 aatttggggg ttttattttt cctttatcaa aaccagtttt tgctaatacc ttttgcagtc
     5221 tgatcctaac atcaaacagg cctgtatcac atcccgttta ccatcccaag ccctacaaat
     5281 gtagttaaca cacttgttta agagcaattc agctcttaat tgctttcacc ctacctatgt
     5341 aacgagttgg ttgtccagtg ttgaaatggt cgatgtctgt gtttggcgac ttctgttcat
     5401 tcttctcact gtggaagtgg tcagctctag agtaatttgc tgtatgctta ttattttcca
     5461 cctttagcgt tttgtgtacc aatgctatgt attcctatat ttatatatat acatatatta
     5521 tcagaataat cttgctttgg actgttgttc tcaaactatg actatgatgt agagatgact
     5581 acagctgctg agaatgtggc ggaatcaact cccacggcgt aggttaatct tgggctggaa
     5641 gtctacatct ttcaacctcc tctgttttat atgatgcttt ttattctgta ggcactgcca
     5701 tcctgaatat tccttgtaaa gatgcagtca atttcaaagg aagacaaagc cactgctgtc
     5761 tgtacactgt aaatatgtac tttggcactt gtactccagt attctgaaag ccgagctatg
     5821 atggaaatgc tgacagatct ttgatggtgg ccgatgctac cctgcagtgc aaaaataaat
     5881 taagtaaaag tgtattctga gattagcagt gcaaggccaa catgttttac aaatctgtca
     5941 gtatctttct aatggagtgt gtatgtgtag ttgtgttgaa agatacactg tgtatgtgtg
     6001 tacatgcttt tatgtgaact acaagacaca cagaagatgt atttcccatc tctaaatccc
     6061 atgttgaaat gttaagtgca gatggacaga attaggtgtt ttacttaaat tcatacccaa
     6121 tctattgtga ctcctttttt ttttatcttt acaaaatata atcttacaga tttgtttgct
     6181 ctgtctagca tcgcataaa
//
