LOCUS       NM_001012162            4923 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MLLT10, histone lysine methyltransferase DOT1L
            cofactor (Mllt10), mRNA.
ACCESSION   NM_001012162 XM_341570
VERSION     NM_001012162.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4923)
  AUTHORS   Chen,S., Yang,Z., Wilkinson,A.W., Deshpande,A.J., Sidoli,S.,
            Krajewski,K., Strahl,B.D., Garcia,B.A., Armstrong,S.A., Patel,D.J.
            and Gozani,O.
  TITLE     The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate
            DOT1L-Mediated Methylation of H3K79
  JOURNAL   Mol Cell 60 (2), 319-327 (2015)
   PUBMED   26439302
REFERENCE   2  (bases 1 to 4923)
  AUTHORS   Forissier,S., Razanajaona,D., Ay,A.S., Martel,S., Bartholin,L. and
            Rimokh,R.
  TITLE     AF10-dependent transcription is enhanced by its interaction with
            FLRG
  JOURNAL   Biol Cell 99 (10), 563-571 (2007)
   PUBMED   17868029
REFERENCE   3  (bases 1 to 4923)
  AUTHORS   Okada,Y., Feng,Q., Lin,Y., Jiang,Q., Li,Y., Coffield,V.M., Su,L.,
            Xu,G. and Zhang,Y.
  TITLE     hDOT1L links histone methylation to leukemogenesis
  JOURNAL   Cell 121 (2), 167-178 (2005)
   PUBMED   15851025
  REMARK    Erratum:[Cell. 2005 Jun 3;121(5):809]
REFERENCE   4  (bases 1 to 4923)
  AUTHORS   Chaplin,T., Bernard,O., Beverloo,H.B., Saha,V., Hagemeijer,A.,
            Berger,R. and Young,B.D.
  TITLE     The t(10;11) translocation in acute myeloid leukemia (M5)
            consistently fuses the leucine zipper motif of AF10 onto the HRX
            gene
  JOURNAL   Blood 86 (6), 2073-2076 (1995)
   PUBMED   7662954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087128.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341570.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..4923
                     /gene="Mllt10"
                     /note="MLLT10, histone lysine methyltransferase DOT1L
                     cofactor"
                     /db_xref="GeneID:361285"
                     /db_xref="RGD:1310874"
     exon            1..83
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            84..243
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            244..323
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            324..374
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..3308
                     /gene="Mllt10"
                     /note="myeloid/lymphoid or mixed lineage-leukemia
                     translocation to 10 homolog; translocated to, 10;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 10;
                     myeloid/lymphoid or mixed-lineage leukemia; translocated
                     to, 10"
                     /codon_start=1
                     /product="protein AF-10"
                     /protein_id="NP_001012162.1"
                     /db_xref="GeneID:361285"
                     /db_xref="RGD:1310874"
                     /translation="MKRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEP
                     IVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEE
                     EGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEK
                     DKHKPKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKCLEDTAARFTNANFQE
                     VSAHTSSGKDVSEARSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSASSPFPQGSFSG
                     TPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNS
                     FSSLVGHPGTSGATSQPKSFDSSPGELGSSSLPTAGYKRAQTSGVEEEEAVKEKKRKG
                     NKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSCSLQKSPTLLRNGSM
                     QSLSVGSSPLGSEISMQYRHDGACPTTSIYNSNDVAVSFPNVVSGSGSSTPVSSSHIP
                     QQSSGHLQQVGALSPSAASSVTPAAATTQANTAPGSSLSQAPAHVYGSRLNQNPSMAV
                     LIAQSESSQTDQDLGDNTRSLVGRGSSPRGSLSPRSPVSNLQIRYDQPSSSGLESLPP
                     VAVSIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKE
                     RLQLLNAQLSVPFPAITTNPSPSHQIHTYTAQTAPTTDSLNSSKSPHIGNSFVPDNSL
                     PVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGPLASGMQTV
                     TSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAA
                     HPMPAAALTNSASGLGLLSDQQRQMFLQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQH
                     HPPELQQMQLPGPTQIPINNLLAGPPAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTG
                     PVAQEKS"
     exon            375..429
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            430..539
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            540..643
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            644..737
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            738..833
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            834..929
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1182
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1755
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1800
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1979
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2097
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2170
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2325
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2514
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2603
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2968
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3065
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3263
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..4899
                     /gene="Mllt10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgggcag ccggctccga tcgtccccca cctccgcaca cctcggcgcc gccgagcggt
       61 gcgggggagg ggaaagcctg gagatggtct ctagcgaccg gcccgtgtca ctggaggacg
      121 aggtctccca tagtatgaag gaaatgattg gaggctgttg cgtttgctca gacgagagag
      181 gctgggccga gaacccgctg gtttattgcg acgggcacgg ctgcagcgtc gcggtgcatc
      241 aagcttgcta tggcattgtt caagtaccta ctggaccatg gttttgtagg aaatgtgaat
      301 ctcaggagag agcagccaga gtgttgttgc ttactgtgag ctaagacact ttgcctaacc
      361 ccgaagtcat gaagagatgt gagctgtgtc cccataaaga tggagcttta aaaagaacag
      421 ataatggggg ttgggctcat gtggtttgtg ccctctatat cccagaggta caatttgcca
      481 atgtttctac aatggagcca atcgttttac agtctgtccc acatgatcgt tataataaga
      541 cttgctacat atgtgatgag caaggacgag agagcaaagc ggccactggc gcctgcatga
      601 catgcaataa acatggatgt cgacaggcct tccatgtaac atgtgctcag tttgccgggc
      661 tgctttgtga agaagaaggg aatggcgcgg acaacgtcca gtactgtggc tactgtaaat
      721 accactttag taagctgaaa aagagcaaac ggggatctaa taggtcatat gatcaaagtt
      781 taagtgattc ttcctctcac tctcaggata aacatcatga gaaagagaaa aaaaaatata
      841 aagaaaagga caaacacaaa ccaaaacaca agaagcaacc cgagccatca cccgccttgg
      901 ttccttcttt gactgttact acagaaaaga catatacaag cactagcaac aactccatat
      961 ctggatcgtt gaagtgcttg gaagataccg cagcaagatt tacaaatgca aatttccagg
     1021 aagtgtctgc ccacacctct agtgggaaag atgtgtcaga ggcaaggtca gagggcaaag
     1081 ggaagaaatc ttcagctcac agctcaggtc aaaggggaag gaagcctggt ggtggaagaa
     1141 atccaggaac aacggtgtca gcatctagcc cctttccaca aggcagtttt tcaggaactc
     1201 caggcagtgt aaagtcatct tctggaagtt cagtgcagtc tccccaggat ttcctcagct
     1261 tcactgactc ggacctgcgg aatgacagtt acactcacac gcagccgcca ccgtcaacca
     1321 aagatgtaca taaaggggag cctggcagcc aggatgcagg ggtgaacagc tttagctctc
     1381 tagttggtca ccctgggacc tcaggtgcga cttcacagcc gaaaagcttt gacagctctc
     1441 ctggggagtt gggcagctcc agccttccta cagcagggta taagcgggct cagacttctg
     1501 gggtagaaga ggaggaagcc gtgaaggaaa agaaacggaa agggaataaa caaagcaagc
     1561 atggccctgg ccgacccaaa ggaaacaaga accaagaaaa tgtttctcac ctctcggttt
     1621 cttctgcttc accgacatca tccgtggcat cggctgcggg gagtgtgaca agctgtagcc
     1681 ttcagaagtc ccccacgctg ctcaggaatg gaagtatgca gagtctcagc gtgggctcgt
     1741 ccccgcttgg ctcagaaatt tccatgcagt atcgacatga tggagcttgt ccaacaacta
     1801 gtatttataa cagcaatgat gtagccgttt ccttcccaaa cgtggtgtct ggctcaggat
     1861 cgagcactcc cgtctccagc tctcatatac ctcagcagtc gtctgggcat ttgcaacagg
     1921 tgggagctct ctccccctcg gctgcgtcat ctgtaacccc cgctgctgct acaactcagg
     1981 caaacaccgc tcctggatct tctctgagtc aggcaccggc ccatgtgtat ggcagtagat
     2041 taaatcagaa tccatccatg gccgttctta tagctcagtc tgagagcagc caaacagatc
     2101 aagatctcgg agacaatacc cgcagcctgg ttggtcgggg cagctccccc cgaggaagcc
     2161 tctctccaag atcccctgtg agcaacttgc agattcgata tgatcagcca agcagcagtg
     2221 gtttggaaag cctgcctcca gtggcagtga gtattgagca gctcttggag aggcaatgga
     2281 gcgaagggca gcagttttta ttagagcagg gcactccgag tgacatttta ggaatgttaa
     2341 agtcattaca tcaacttcaa gttgaaaatc gaagattaga agaacagatt aaaaacttga
     2401 ctgccaaaaa agaacgtctt cagttgttga acgcacagct ttcagtgcct ttcccagcaa
     2461 taacgacaaa ccctagtcca tctcatcaga tacacacata cacagcacag actgctccta
     2521 ctactgactc tctgaacagc agtaagagcc cgcatatagg aaacagcttt gtacccgaca
     2581 attctcttcc tgtattaaat caggacctga cttccagtgg gcaaagcacc agcagctctt
     2641 ctgctctttc cactcccccg cctgctgggc agagtccagc ccagcagggc tctggagtta
     2701 gtggggttca gcaggtgaac ggcgtgacag tggggccact agctagtgga atgcagactg
     2761 tcacatccac cattcctgct gtgtctgcag tgggtggaat aattggagct ttgccaggta
     2821 accagctggc aatcaatggc attgtaggag cgttaaatgg tgttattcag acgccggtca
     2881 caatatccca gaaccctgcc ccgctcaccc acaccagtgt gccacctaat gcagcacatc
     2941 ccatgccagc cgccgccctg actaacagtg cctcgggcct ggggctgctg tcggaccagc
     3001 agcgacagat gttcctccag cagcagcagt tccagcagct cttgaactcc cagcagctca
     3061 cgccggagca gcaccaggcc ttcctgtacc agctgatgca gcagcagcac catccccccg
     3121 agcttcagca gatgcagctc ccagggccca cgcagatccc catcaacaac ctcctggcag
     3181 gccctccggc gcccccactc cacacggcga ccaccaaccc cttcctcacc atccacgggg
     3241 acagcacaag ccagaaagtc acaagactta gtgataagac tgggcctgta gctcaagaga
     3301 aaagctgaca cctgaaagtc tgcgaacttg cctctcctgc tggtttgtgc ttctctggct
     3361 gctgcagtgt ctgccacagc tatgaagaag ggcggcagga cgcacaggga agatgccacc
     3421 catgcccttg taaggctctg attaattttc ttgttgcttt gttgcactga aatggaattc
     3481 ctatatcccc atcccctacc aaagtgttcg aactttggaa gaaaaattaa taactttttg
     3541 tcaatgaaat aattcacatg cagtgagttt accaatccaa gagaaatgca atgtgctttg
     3601 tgcacagcta gttttggtac aaattggaga cgtataaaac tgaagactat tctatctgca
     3661 gaccacttgg tttatcataa aagtttgaat atgaattatc ttattgggat agagtgtgct
     3721 tgttccatag ggcagatcct aagttttgag acctccaaga gaagaaatca gtaattctct
     3781 tggagttgta ttcattaaat attgtggtta tgcaattcct caactggggc tttgcatgtg
     3841 ttttaagaac ttcctttcta atgagatttg ccatttggag atcaaattag gatggagaca
     3901 actgcttctg ctaacagtaa ttttcttttc caaaaaaaaa tttatttttt ttgatgtgtt
     3961 aaaacctctt atttaaagag atctttagtt aagcgagttc taaggctgct gggagaacca
     4021 ggtcaattgg aagtgaatgg ttcttttcag aaagagacac caatgtggaa actactggaa
     4081 ggttctggca tcaatcaagt gcctgttggg accttcctgg gtagaacagg ctttgtacaa
     4141 gaggctaggc cacttgtgcc gacagccttc ccgtgcatgc ttctgccttt gctgaacctt
     4201 tctgtgtcac catagagagc tcaggcaaac tgtccacaag gaaagaagta gatttgggaa
     4261 gagtctttgt gcttgtttat ctctctaaac cacccactgg aacaatggcg cctgtgcctg
     4321 gttcctaaac ctgcctcaca gcctttgagt tccagtcacc atgagcttga ctgtgacaat
     4381 atggcagact agtaggccaa acaattgggg atacaatcat tgatctgtgt ctggaatgca
     4441 tgaattacta atgggaaaga ccagccgcac ttggacctcc acggtgtgct tagctggaag
     4501 agcgcgctcg ctctgcagta tgtctcctgt gagtgacact gcacacttct tacctcactt
     4561 gtgtaaataa ggttgtgaat ctgttttgta atgtgaaaaa ttcataagat aacattgata
     4621 ttttgatttg taatatttct aattggtaga tttaattgaa aagtaaaatt aatttatttt
     4681 tatatgttca ggggaatttt aaagaaagtc aaaccttttg tagataattt aaaagaatca
     4741 gtgtggtttt ttattttacg tatttgaccc actggttgtt attctgtaac aatttgtata
     4801 aatggtaaat tttttgaatg cgctgttatt ttagatgtaa aattccacat gtattaaaat
     4861 gtacaaagtt ttgttaataa aatttaatga tgtttataaa aaaaaaaaaa aaaaaaaaaa
     4921 aaa
//
