LOCUS       XM_008772571            1975 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus mixed lineage kinase domain like
            pseudokinase (Mlkl), transcript variant X1, mRNA.
ACCESSION   XM_008772571
VERSION     XM_008772571.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051354.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008772571.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008772571.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..1975
                     /gene="Mlkl"
                     /note="mixed lineage kinase domain like pseudokinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 ESTs, 3 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 90 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:690743"
                     /db_xref="RGD:1592221"
     CDS             496..1890
                     /gene="Mlkl"
                     /codon_start=1
                     /product="mixed lineage kinase domain-like protein isoform
                     X1"
                     /protein_id="XP_008770793.1"
                     /db_xref="GeneID:690743"
                     /db_xref="RGD:1592221"
                     /translation="MDKLGQIIKLGQLIYDQCEKMKYCKRQCRRLRNRVHGLLQPLQR
                     LQAQEKKSLPSDITAALGRFEDVLKEARQQIEKFSQKSNIWKFATVGSDKILFHEVNE
                     KLRDIWEELLLLLQVDQWKSDSEVSQPASWQQEDQQDAEEDGNENMKVILVKLQISME
                     EIKEALKQCSLKPMQEVPQDFQVKEIPKEDLGYPWTKLKTNKLSTIYRGEYYKSPVTI
                     KVFNNPKAESVGIVRLTFNEEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCE
                     LGTLRELLDRDKDLTMSVRSLLVLRAARGLYRLHHSGTLHGNISSSSFLVAGGYQVKL
                     AGFELSKTQTSISRATKSTKAERFSSTAYVSPERLQDPFCKYDTKAEIYSFGIVLWEI
                     ATGKIPFEGCDSEKIYELVAENKKQEPVGQDCPELLQEIINECRAHEPSNRPSADGIL
                     ERLPAIEDSMDKKL"
ORIGIN      
        1 gggaggcgtg tcaaactggc agccacttcc ggaagaagaa acagctgttg gttttgaggg
       61 ctcggctggg gcattgctgt gttaacccaa atttgacttt acacgagaac tgtggccggt
      121 gtagaattcc tccgggatgc gggagcatta aggctgcacc aagggaaggg gctcaggaga
      181 ccggggacct gtcctggtct ggggtgcatt gtcagcgagg aagaagatca cagtggccag
      241 tgggagactg atcctactgg aacactggaa cggagcgcag gatagaccaa gaccagcgcc
      301 cctcggaaaa accgggctga gtcctcagac tccagggagc catagcgcag caggaggaag
      361 caggagaatc acggaatcac agataggact tcctggaact cggggagctt ctctctaagc
      421 tgtgcagagg atcactcact cagagactta gccaacgctg ggcaaacact ccaccactga
      481 gctacaacac caggtatgga taaattggga cagatcatca agttaggcca gctcatctat
      541 gaccagtgtg aaaagatgaa atactgcaaa agacagtgcc ggcgtctaag aaaccgtgtg
      601 catggcctgc tacagcctct ccagaggctc caggcccaag aaaagaagag cctccccagt
      661 gacattactg ctgccctggg ccgttttgag gacgtcctaa aagaagctag acagcagata
      721 gaaaagttca gtcagaagtc caatatttgg aagtttgcta ctgtgggcag tgataagatc
      781 ctcttccatg aagtgaatga gaagctgaga gacatctggg aggagctctt gctgctgctt
      841 caggttgatc aatggaagtc tgattccgag gtcagccaac cagcatcctg gcagcaggaa
      901 gatcaacagg acgcagagga agatggaaat gaaaatatga aagttatttt ggtgaagctg
      961 caaatcagca tggaagaaat caaagaggcc ctgaagcaat gctcactaaa acccatgcag
     1021 gaggtcccac aagatttcca agtcaaggag attccgaagg aagatcttgg atatccgtgg
     1081 accaaactga agacaaataa actgagcacg atttatagag gagagtatta caaatctcca
     1141 gtcaccatca aagtattcaa caaccccaag gccgaaagtg ttggaatagt gaggctcact
     1201 ttcaatgagg agatcaaaac catgaagaaa tttgattctc ccaacatcct gcgtatattt
     1261 gggatttgca tcgatcaaac agtgaagccc cccgaattct ccattgtcat ggagtactgt
     1321 gaactcggaa ccctgaggga actgctggat agagacaagg acctcaccat gagtgtgcgc
     1381 agcctcctag tcctgagggc agctagaggc ttgtacaggt tacaccactc gggaacactc
     1441 cacggaaaca tcagcagctc cagcttcctg gtagctggag gctaccaagt aaagcttgca
     1501 ggatttgagc taagcaaaac acagacttct ataagccggg caacaaagag cactaaagca
     1561 gagagattca gttcgacagc atatgtctcc cccgagagac tgcaagatcc attttgcaaa
     1621 tatgacacaa aagctgaaat atatagcttt ggaattgtgc tctgggaaat tgccactgga
     1681 aagatcccgt ttgaaggctg tgattctgag aagatctatg agctggtggc tgagaacaag
     1741 aagcaggagc cagtgggtca ggattgcccc gagttgttgc aggagatcat taatgagtgc
     1801 cgggcccatg aaccctccaa tcggccctct gcggatggaa tcttggagag actgcctgcc
     1861 attgaagact ccatggacaa aaagctgtaa gagggacaaa ctggacatgt gtccttccca
     1921 ttggtcagca gcatcaactt attgctgggt gcaaaaatct ttgttctccc ttgga
//
