LOCUS       NM_001399373            2674 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus muscular LMNA-interacting protein (Mlip), mRNA.
ACCESSION   NM_001399373 XM_039082526
VERSION     NM_001399373.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Huang,Z.P., Kataoka,M., Chen,J., Wu,G., Ding,J., Nie,M., Lin,Z.,
            Liu,J., Hu,X., Ma,L., Zhou,B., Wakimoto,H., Zeng,C., Kyselovic,J.,
            Deng,Z.L., Seidman,C.E., Seidman,J.G., Pu,W.T. and Wang,D.Z.
  TITLE     Cardiomyocyte-enriched protein CIP protects against
            pathophysiological stresses and regulates cardiac homeostasis
  JOURNAL   J Clin Invest 125 (11), 4122-4134 (2015)
   PUBMED   26436652
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Cattin,M.E., Wang,J., Weldrick,J.J., Roeske,C.L., Mak,E.,
            Thorn,S.L., DaSilva,J.N., Wang,Y., Lusis,A.J. and Burgon,P.G.
  TITLE     Deletion of MLIP (muscle-enriched A-type lamin-interacting protein)
            leads to cardiac hyperactivation of Akt/mammalian target of
            rapamycin (mTOR) and impaired cardiac adaptation
  JOURNAL   J Biol Chem 290 (44), 26699-26714 (2015)
   PUBMED   26359501
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Huang,Z.P., Young Seok,H., Zhou,B., Chen,J., Chen,J.F., Tao,Y.,
            Pu,W.T. and Wang,D.Z.
  TITLE     CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte
            hypertrophy
  JOURNAL   Circ Res 110 (6), 818-830 (2012)
   PUBMED   22343712
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Ahmady,E., Deeke,S.A., Rabaa,S., Kouri,L., Kenney,L., Stewart,A.F.
            and Burgon,P.G.
  TITLE     Identification of a novel muscle A-type lamin-interacting protein
            (MLIP)
  JOURNAL   J Biol Chem 286 (22), 19702-19713 (2011)
   PUBMED   21498514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 6, 2022 this sequence version replaced XM_039082526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000008.1  86971788-86971873   c
            87-479              JAXUCZ010000008.1  86953094-86953486   c
            480-1946            JAXUCZ010000008.1  86941711-86943177   c
            1947-2018           JAXUCZ010000008.1  86929798-86929869   c
            2019-2084           JAXUCZ010000008.1  86908656-86908721   c
            2085-2144           JAXUCZ010000008.1  86908307-86908366   c
            2145-2189           JAXUCZ010000008.1  86900459-86900503   c
            2190-2234           JAXUCZ010000008.1  86890294-86890338   c
            2235-2363           JAXUCZ010000008.1  86881482-86881610   c
            2364-2674           JAXUCZ010000008.1  86815491-86815801   c
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2674
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /note="muscular LMNA-interacting protein"
                     /db_xref="GeneID:681849"
                     /db_xref="RGD:1590513"
     exon            1..86
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2366
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /note="cardiac Isl1-interacting protein"
                     /codon_start=1
                     /product="muscular LMNA-interacting protein"
                     /protein_id="NP_001386302.1"
                     /db_xref="GeneID:681849"
                     /db_xref="RGD:1590513"
                     /translation="MTSCVLAGSIETTPKFEYSDHMTFSCESKEERDQRILDYPSEVS
                     GKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATR
                     PKSLAISSSLASDVVRPKVRGVDVKVSSHPEIPHGIAPQQKHGQKTPPVPAKVSGTTV
                     LEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSN
                     VADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLS
                     PSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLS
                     PASCPTFSLNSLASSTLTLDQKIKQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCH
                     LSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADV
                     PSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTLSFIPPINESTALSSSGKCFHP
                     SPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQ
                     ALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKELISPCALS
                     MSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEH
                     SSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPV
                     PIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ"
     exon            87..479
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1946
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2018
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2084
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2144
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2189
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2234
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2363
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2674
                     /gene="Mlip"
                     /gene_synonym="CIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaggggct tctgagtgac tgcaggaaca attacttcca aatgacctcc tgcgtcttag
       61 cggggagcat tgagaccaca cccaagtttg agtacagtga tcatatgacc ttcagctgtg
      121 agagcaaaga ggagagggac cagaggatac tggattatcc ctcagaggtc agtgggaaga
      181 attcacaacg aaaggaattc aatacaaagg agcctcaagg aatgcagaaa ggtgatctct
      241 tcaaagcaga atatgttttt attgtggatt ctgatgggga agatgaagct acatgtagac
      301 aaggtgaaca agggccccca ggggcaacag gcaacatagc tactcggccc aagtctctgg
      361 ctatttcttc tagcctggct tctgatgtgg tacgtcccaa agtacgaggg gttgatgtca
      421 aggtctcatc acatcctgaa attcctcatg ggatagcccc tcagcaaaaa catgggcaga
      481 aaacgccacc tgtcccagct aaagtcagcg gaaccactgt gctagaagag tttcacattc
      541 gcaggctgga tgtccatggg gcctctgagg aagaaacggc tacgtatttt cacactactg
      601 ctcacgattc cccccttcct gcatggaagg gcgcttcgac cttagtattt tctccttctg
      661 ctcaactgcc aggttctagt ttatgtggct caaatgtcgc tgatcacaca cgtgggttgg
      721 caccggaagc ccagaagaaa gtgtcgactt cgagtgccct taatcccagg gaagatgtga
      781 gaacctctcc ttcacctgcc tctggtgctt ctctgaggtc accctcagct tcctacatcc
      841 cagtccgcat tgtcatgcac tcactgtccc caagtcccaa accacttacc tcctcctccc
      901 atggctcttt gtccaccgtc tgtagccaaa catcatccag tggaaatctt tcgaagtcag
      961 ggctgaagtc cccagtaccc tctcggcttt ctctcctcac tgctatcctc aagtcaaacc
     1021 cttctcacca aaggccttta tcccctgcat cctgtccaac cttctccctc aattccctgg
     1081 cttcttctac tcttacactt gatcaaaaaa taaagcaaac tccatccaca cctaagaaat
     1141 ctctctcaag ttgctccttg acaactgggt ctacagagca agaacaggct tctgcagaaa
     1201 gccaccaacc ctgccacctc tctttctttt ccaagactac tccactctct caggcacaac
     1261 ccccctctcc accagcactg gccagtagca gttatgcagc tactgataca gagaaaatac
     1321 caggaagcac actgaggagc agtacaaccc caccccaatc acagactgat ctattcagtc
     1381 ttgcggatgt cccttctgtc acaccaggct tgtcccctct ttcttcttcc aagggcagaa
     1441 aggatggtga cctcagagct ccagaaaaga acaggaatat ttgtacacgc ccttctactt
     1501 tatcttttat accacctatt aatgagagca cggccctttc ctcttcaggg aaatgtttcc
     1561 acccttcccc agccctctca gacctgatag acagatccaa aagaacatgc tcccagcgac
     1621 actcagacca gcggccaaac ccttcagctc ttccgactcc tccagtctcc agggctggct
     1681 ctgcttctca tccccatttg gggtattcca ttctccctcc tgagagttca ctcacccagg
     1741 ctcttcagcg tagtccttcc gcactgcacc cgagttgtgg gagtgctacg tgtccttcaa
     1801 gaactgggat gcctgacagt acagcatcca accgcagctc acgcgtttca actccatcac
     1861 ttcctgtctc tctaacaaga accaaggagc tgatctcacc ttgtgctctg tccatgtcag
     1921 caggccctga aaataagaag cccaagcaat acaagaccaa gtcaagctac aaggcttttg
     1981 cagcaatccc tacaaacact ttgctcttgg aacagaaggc actagatgaa ccagccagga
     2041 ctgaaagcaa ttccaaggcc agcgtgtcag acctaccagt ggagcattct tctgattctc
     2101 cttcacggcc ctcacagaca atgttgggtt ctgaaacaat caaaactcct acaactcatc
     2161 caagagcagc cggtcgagaa accaaatatg caaatctttc gtcatcatcc tctacaacat
     2221 ctgagagtca actgactaag cctggagtaa ttcgtccagt acctataaaa tccaaactat
     2281 ttctgaaaaa ggaggaagaa gtttatgaac ccaatccttt cagtaaatac cttgaagaca
     2341 gcagcggtct gttttctgag cagtaacgaa gctggagtgg aagtggaagc cagtttgctg
     2401 aagagttttt ggaatgccat tgctagctgc ttgctagact taactcctgc tttttcagca
     2461 ggagtgctct gttgatgatc tcagtccagc agaagtacct gaaaggtttg cttcagtcac
     2521 atagcattac cacactctac aaaacccaga gcaagatcat agccctttag ttccttgcat
     2581 tgccattcaa gcctataatg ccttctatta agtcgagagc aatactaatg ttcccctata
     2641 tttagcaggc aaataaagaa gaattatagc tgaa
//
