LOCUS       NM_001108043            5424 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus mutL homolog 3 (Mlh3), mRNA.
ACCESSION   NM_001108043 XM_001060076 XM_001060119 XM_234420
VERSION     NM_001108043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5424)
  AUTHORS   Zhang Q, Zheng X, Li X, Sun D, Xue P, Zhang G, Xiao M, Cai Y, Jin
            C, Yang J, Wu S and Lu X.
  TITLE     The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were
            linked to the risk of colorectal cancer in a case-control study
  JOURNAL   Cancer Med 7 (4), 1264-1274 (2018)
   PUBMED   29516665
REFERENCE   2  (bases 1 to 5424)
  AUTHORS   Holloway JK, Sun X, Yokoo R, Villeneuve AM and Cohen PE.
  TITLE     Mammalian CNTD1 is critical for meiotic crossover maturation and
            deselection of excess precrossover sites
  JOURNAL   J Cell Biol 205 (5), 633-641 (2014)
   PUBMED   24891606
REFERENCE   3  (bases 1 to 5424)
  AUTHORS   Kouznetsova A, Benavente R, Pastink A and Hoog C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   4  (bases 1 to 5424)
  AUTHORS   Li GM.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   5  (bases 1 to 5424)
  AUTHORS   Li XC and Schimenti JC.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   6  (bases 1 to 5424)
  AUTHORS   Kolas NK, Svetlanov A, Lenzi ML, Macaluso FP, Lipkin SM, Liskay RM,
            Greally J, Edelmann W and Cohen PE.
  TITLE     Localization of MMR proteins on meiotic chromosomes in mice
            indicates distinct functions during prophase I
  JOURNAL   J Cell Biol 171 (3), 447-458 (2005)
   PUBMED   16260499
REFERENCE   7  (bases 1 to 5424)
  AUTHORS   Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR,
            Yang K, Arnheim N, Liskay RM and Lipkin SM.
  TITLE     Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch
            repair and tumor suppression in the mouse
  JOURNAL   Cancer Res 65 (19), 8662-8670 (2005)
   PUBMED   16204034
REFERENCE   8  (bases 1 to 5424)
  AUTHORS   Kolas NK and Cohen PE.
  TITLE     Novel and diverse functions of the DNA mismatch repair family in
            mammalian meiosis and recombination
  JOURNAL   Cytogenet Genome Res 107 (3-4), 216-231 (2004)
   PUBMED   15467367
  REMARK    Review article
REFERENCE   9  (bases 1 to 5424)
  AUTHORS   Lipkin SM, Moens PB, Wang V, Lenzi M, Shanmugarajah D, Gilgeous A,
            Thomas J, Cheng J, Touchman JW, Green ED, Schwartzberg P, Collins
            FS and Cohen PE.
  TITLE     Meiotic arrest and aneuploidy in MLH3-deficient mice
  JOURNAL   Nat Genet 31 (4), 385-390 (2002)
   PUBMED   12091911
REFERENCE   10 (bases 1 to 5424)
  AUTHORS   Wu Y, Berends MJ, Sijmons RH, Mensink RG, Verlind E, Kooi KA, van
            der Sluis T, Kempinga C, van dDer Zee AG, Hollema H, Buys CH,
            Kleibeuker JH and Hofstra RM.
  TITLE     A role for MLH3 in hereditary nonpolyposis colorectal cancer
  JOURNAL   Nat Genet 29 (2), 137-138 (2001)
   PUBMED   11586295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060076.1, XM_234420.4, XM_001060119.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..5424
                     /gene="Mlh3"
                     /note="mutL homolog 3"
                     /db_xref="GeneID:314320"
                     /db_xref="RGD:1309227"
     exon            1..62
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            63..3372
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..4454
                     /gene="Mlh3"
                     /codon_start=1
                     /product="DNA mismatch repair protein Mlh3"
                     /protein_id="NP_001101513.1"
                     /db_xref="GeneID:314320"
                     /db_xref="RGD:1309227"
                     /translation="MIRCLSDEVQAKLRSGLALSSLGQCVEELTLNSIDAEATCVAIR
                     VNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPTFYGFRGEALASIAD
                     MASAVEISSKKSTTLKTFVKMFQNGKALAAREADLTRPSVGTTVTVYNLFYQFPVRRK
                     SMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMILQLPKTKDICSRFCQIYGLG
                     KSQKLREIHYKYKEFEFNGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKES
                     IICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQNWD
                     TVLICVQEGIKKFLKQEKLFVELSSEDIKEFNEDNGFSLIGTTLQTQSTHEKCDQSSF
                     QEACNNILDSYEMFNLQSKAVKRIATLENRTTQNSGDSGAIRKKTEDSYTYESDDLGH
                     RKTVESALYNSDSAYLGSRMSEEDIAKTSHAGENEKWKKSLLENRTSERPHETSPKMF
                     SSPIQTHHPLEESEADLEIEMKSSTVNVMAANIPPNSEIQSQLEQLEDAPEVECQPLP
                     FETTLLRAQGTLKKKERKKELSSHGRVNVFSYGQVKLCSTGFITHVVQREPAKSPETE
                     QLFKNYARPGPVSAQEAFGNRTHHASETPDSSSLTSTLSKESTQPPHKRFCRTNTGYG
                     TENKPVATDDNLALFQGSRKESHTDCFLPDTTSFPWCRNVSGGYKKKGKVGSFKHVVR
                     RKLSLRSQIGSLEKFKRQYGKVNNSLAAEEDNDTDFRTHLEPHNEPDVLLKDKSLSDM
                     SDGGEITPSEHSDGCQPLRPILYPETLSKEDRLEQRPSLRESPITLAELLHGNRKPSE
                     VKKSTEALASKLSRLKDSEKEMQTMEMAGPVSERPDSDPSWKDNSQCARLDLNFCELY
                     KNKLEKTESEVLPMPDSAPEDDSINKNSVLCSNSVTDDREKPETSLLLPCSDSKISKD
                     SDVLIRVSEQQSGSPDSASREVTRQVEDSAGSQCGICSQSHGFKARSCSDNEESSTHS
                     MDWQQHFDVTLGRTVYINRMTGLSTFVAPTDDIQTPCTKDLTTVAVDVLLGNGVQYRC
                     HPFRSDLVLPFLPRAQEERTRRRHNRDAVDAAAVSEPLQSLFSEWSNPVFARYPEVAV
                     DVSSGQAGSLAVKIHNVLYPYRFTKEMIHSVQVLQQVDNKFIACLMSSRTDGSGQAGG
                     NLLVLVDQHAAHERVRLEQLITDSYEKQAPQSAGRKKLLSSTIIPPLAITVSEEQRRL
                     LRSYHKHLEDLGLELLFPDASDSSILVGKVPLCFVEREANELRRGRSPVTKSIVEELI
                     REQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLCQLP
                     FQCAHGRPSMLPLADLDHLEQEKQVKPNLTKLRKMAHAWHLFGKAEGCDTKQEPQQPV
                     PPCEPP"
     exon            3373..3468
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3554
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3659
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3732
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3804
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3916
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4076
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4100
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4179
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4331
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..5424
                     /gene="Mlh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagcgaa caccggacgt tggaggtggt tagtccgtga gaattgatgg aggagattcg
       61 aggtggttat ttccagtcag agaaggaagc cggtgtctgc tactctctct gcatgtttcc
      121 ctgccatgat caggtgtctg tcagatgaag tacaagccaa gttgcgttct ggtttagccc
      181 taagctcctt aggccagtgt gttgaggaac ttacccttaa cagtattgat gctgaggcaa
      241 catgtgtggc catcagagtg aatatggaaa ccttccaagt tcaagtgata gacaacggac
      301 ttgggatggc gggggatgac gtggagaagg tggggaaccg gtattttact agtaaatgcc
      361 actcagtacg ggacctggag aacccaacgt tttacggttt ccgaggcgag gccttggcaa
      421 gtatagctga catggctagt gctgtggaaa tttcatccaa gaaaagcaca acattgaaga
      481 cctttgtgaa gatgtttcag aacggaaaag ccctcgccgc ccgtgaggcg gacttgacca
      541 gaccgagtgt ggggactaca gtgacggtct ataacctgtt ttaccagttt cctgtgcgga
      601 ggaaaagcat ggaccctaga ctagagtttg agaaggttag gcagagggtg gaagccctct
      661 cacttatgca cccctccatt tctttctctt tgaggaatga cgtttctggt tccatgattc
      721 ttcagctccc taaaaccaaa gacatatgtt ctcggttttg tcaaatttat ggattgggca
      781 agtcccaaaa gttaagagaa atacattata agtataagga atttgagttt aatggctaca
      841 tcagctctga agcacactac aataagaata tgcagttttt gtttgtgaac agaagactag
      901 ttttaagaac aaagttgcat aaacttattg actttttatt aaggaaagaa agtattatat
      961 gcaggccaaa gaatggctct gccagtaggc aaatgaattc aagtcctcga caccgttctg
     1021 cctcagaact ccatgggata tatgtaatca acgtgcagtg cccgttctgt gagtatgatg
     1081 tctgcataga gccagccaaa actctgattg aattccagaa ctgggatacc gtgttgattt
     1141 gtgttcagga aggaataaaa aagtttttaa agcaagaaaa attatttgta gaattatcaa
     1201 gtgaagatat taaggaattt aatgaagata atggttttag tttgattggt acaacacttc
     1261 agacacagtc tactcatgag aagtgtgacc agagcagttt ccaggaagcg tgtaataata
     1321 ttttggattc ctatgaaatg tttaatttgc agtcaaaagc tgtgaaaaga atagctactt
     1381 tagaaaatag aaccacacaa aattctggcg attcaggagc tatcagaaaa aagacagagg
     1441 actcatacac ttatgaatca gatgacctgg gccatagaaa aactgtagag tctgcgttat
     1501 acaacagtga cagtgcttac ttaggatcaa ggatgtcaga agaagacata gccaaaacat
     1561 cacacgctgg agaaaatgag aaatggaaaa aatctttgtt ggaaaatagg acttcagaaa
     1621 ggccacatga aaccagtcca aaaatgtttt caagccccat tcaaactcat catccccttg
     1681 aggagagtga ggcagatcta gaaatagaga tgaaaagtag tactgttaat gtcatggctg
     1741 ccaacattcc tccaaatagt gaaattcaga gtcaactgga gcaacttgaa gatgctcctg
     1801 aagtggagtg ccaacctctg ccctttgaga caacattatt aagagcacag ggtactctga
     1861 aaaagaagga gagaaaaaag gagctcagta gccatggaag agtaaatgtt tttagttatg
     1921 gacaggttaa attgtgctcc actggcttta tcactcatgt ggtacaacgc gaacccgcca
     1981 agtcacctga aacagaacag ttgtttaaaa attatgctcg acctggtcct gtaagtgccc
     2041 aggaagcatt tggaaataga acacaccatg caagtgagac tccagacagc agtagtttaa
     2101 caagcacttt aagtaaagaa tccactcagc cgccccacaa aagattctgc agaacaaata
     2161 caggttatgg gacagagaac aaacctgtag caacagatga caacttggcc ctttttcagg
     2221 gaagccgtaa agaatcacac acagattgct ttttgcctga tacaacctcc tttccgtggt
     2281 gtagaaatgt ttccggtggt tataagaaaa aaggtaaagt gggttccttc aaacacgtag
     2341 tccgtaggaa gctaagcttg cgttcacaaa tagggtcttt agagaagttt aagaggcaat
     2401 atgggaaggt taacaattcc ctagctgcag aagaggacaa tgacactgac ttcaggaccc
     2461 atcttgagcc tcacaatgaa cccgatgttc ttctgaaaga taagagcctc tcagatatgt
     2521 ctgatggtgg tgagatcact ccatcagagc acagtgatgg gtgtcaacca ttacgtccca
     2581 tcctgtaccc agagacactt tccaaagaag atcgcttaga acagaggcct agtttgagag
     2641 aaagtcctat cactctggcg gaattgctcc acggtaacag aaaaccttct gaggttaaga
     2701 agtccactga agccctggct tctaaattat ccagactcaa ggattctgaa aaagagatgc
     2761 aaaccatgga gatggcaggt cctgttagtg aacgtccaga ctcagatccc agttggaaag
     2821 acaatagcca gtgcgctagg ctggacttaa atttttgtga attatataaa aataaacttg
     2881 aaaaaacaga gagtgaagtg cttccaatgc cagattctgc cccagaggat gattccatca
     2941 ataaaaacag cgtgctgtgt tctaacagtg taacagatga cagggagaaa ccagaaactt
     3001 ccttgctgtt accctgtagt gattctaaaa tcagcaaaga ttcagatgtt cttatcagag
     3061 tctcagagca acagagtgga agccctgact ctgccagcag ggaggtaacg cgtcaggtag
     3121 aagatagcgc cggcagccaa tgtggaatct gttcccagag ccatgggttt aaagcaagat
     3181 cttgttctga caatgaagaa tcaagtacgc acagtatgga ctggcagcag cattttgacg
     3241 taaccctggg aagaacggtt tacatcaaca gaatgaccgg gcttagcacg tttgttgctc
     3301 ctactgatga cattcagact ccttgtacta aagatctgac aaccgtggct gtggatgtcc
     3361 tacttgggaa tggggtccag tacaggtgtc atccttttag aagcgacctt gttcttcctt
     3421 tcctcccaag agctcaggaa gagaggacca ggcggagaca caacagagat gctgtagatg
     3481 ctgctgctgt cagtgaacca cttcagtctt tgttttcaga atggagcaat ccagtgtttg
     3541 cccgataccc agaggttgct gttgacgtca gcagtggcca ggctgggagc ttagccgtta
     3601 agattcacaa tgttctatat ccctatcgct tcaccaaaga gatgatccac tcagtgcagg
     3661 ttctccagca agtggataac aagtttatcg cctgcttaat gagctcgagg acggacggga
     3721 gtggccaagc aggtggaaac ctgttagtcc tggtggacca gcacgctgcc catgagcgcg
     3781 ttcgtttgga gcagctaatc actgattcct atgagaaaca agctccacaa agtgctggcc
     3841 ggaagaaatt actgtcttcc acaataattc ctccactagc gatcaccgtg tcagaggaac
     3901 aaaggagact cttacggtct taccacaaac atttggaaga tctgggactt gagttgctct
     3961 ttccagatgc tagtgactct tcgatcctgg tgggaaaagt gccactctgc tttgtagaaa
     4021 gagaagctaa tgaacttcga agaggacgat ctcctgtgac taagagtatt gtggaggaat
     4081 tgattcgaga acagctggag ctgctccaga ccacgggagg tatccaaggg acactgccgc
     4141 tgactgtcca gaaggtgttg gcctcccagg cctgccacgg ggccattaag tttaatgatc
     4201 gtctgagtct ggaggagagc tgtcggctta tcgaagctct gtccttgtgc cagctgccat
     4261 ttcagtgtgc tcatgggcga ccttcaatgc tgcccttagc tgacctggac cacttggagc
     4321 aggaaaaaca ggttaaaccc aatcttacta aacttcgcaa aatggctcat gcctggcatc
     4381 tctttggaaa agcagaaggc tgtgatacaa agcaggagcc acaacagccc gtacctcctt
     4441 gtgagccacc gtgagaagag ttataaggag atgggtgctg tgcccctgcg cgagcggaga
     4501 gcagtacagc tgtgagcggt cgctggccct gggtcgctgg cacatctgtc ctggggcagt
     4561 ggagcaggca gatgcactca agcctgaggg agttgagttc tttgcatcca cagacacagg
     4621 agtttgcaca tagttcctat cttttgtaaa ttgacttagt gataagatgt aatgactctg
     4681 aggttggtcg gttggcttat gtttgaaggg tgcagcagtt gattttgagc agctttcccc
     4741 agcctctcag ttcacattac gtgaggatgc cctgagccct ggtctgcctt tctccaagcc
     4801 cctggtgcag cctctccgtc catccctctt ttgcatttgt cttcttagcc tcactcctct
     4861 gcttcttcac attttgcatt acagacatat ggtgtctctg ctcgctataa aaatatttcc
     4921 tgatgtcttc cagagagact ttaaattata ttagggatta aaagttattt atagctgggt
     4981 gtggtggttt acctgtaatc ctagtcgcag ggaggctgag gcaagtccac agcagggcac
     5041 cattagccga ggctgtacat gcaagaccct gcttaaaata aataaatatg ctactgacaa
     5101 agagaaacac aaagatagaa tagagaaagt ttgaaaaaat tttttaattc ttttgatagc
     5161 ctggactgtt ctggaacttg ctttgtagac caggctaacc tcaaactcaa gagatccacc
     5221 tgcctctgcc tcccaagtgc tgggattaaa ggtgtgcgcc accactgcct agaaagaaaa
     5281 attgcaatct tatccctggt ttttgatagt cctacggttt ttaaaaccag aagtcagtgt
     5341 ttatatcctg aaccaataaa acattaaaaa atactaggtc tgtttttgaa aatgaatttg
     5401 ttactttata aaatgtttct gtga
//
