LOCUS       NM_001107680            1112 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus myeloid leukemia factor 1 (Mlf1), mRNA.
ACCESSION   NM_001107680 XM_001065492 XM_227230
VERSION     NM_001107680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P,
            Sossalla S, Frey N and Frank D.
  TITLE     Myeloid leukemia factor-1 is a novel modulator of neonatal rat
            cardiomyocyte proliferation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (4), 634-644 (2017)
   PUBMED   28087342
  REMARK    GeneRIF: MLF1 is a novel modulator of neonatal rat cardiomyocytes
            proliferation.
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L,
            Mai M, Beckers A, Kracht M and Gossler A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   Choudhury KR and Bhattacharyya NP.
  TITLE     Chaperone protein HYPK interacts with the first 17 amino acid
            region of Huntingtin and modulates mutant HTT-mediated aggregation
            and cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 456 (1), 66-73 (2015)
   PUBMED   25446099
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Hoh RA, Stowe TR, Turk E and Stearns T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Winteringham LN, Endersby R, Kobelke S, McCulloch RK, Williams JH,
            Stillitano J, Cornwall SM, Ingley E and Klinken SP.
  TITLE     Myeloid leukemia factor 1 associates with a novel heterogeneous
            nuclear ribonucleoprotein U-like molecule
  JOURNAL   J Biol Chem 281 (50), 38791-38800 (2006)
   PUBMED   17008314
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Yoneda-Kato N, Tomoda K, Umehara M, Arata Y and Kato JY.
  TITLE     Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via
            COP9 signalosome subunit 3
  JOURNAL   EMBO J 24 (9), 1739-1749 (2005)
   PUBMED   15861129
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Grisendi,S. and Pandolfi,P.P.
  TITLE     NPM mutations in acute myelogenous leukemia
  JOURNAL   N Engl J Med 352 (3), 291-292 (2005)
   PUBMED   15659732
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Lim R, Winteringham LN, Williams JH, McCulloch RK, Ingley E, Tiao
            JY, Lalonde JP, Tsai S, Tilbrook PA, Sun Y, Wu X, Morris SW and
            Klinken SP.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Williams JH, Daly LN, Ingley E, Beaumont JG, Tilbrook PA, Lalonde
            JP, Stillitano JP and Klinken SP.
  TITLE     HLS7, a hemopoietic lineage switch gene homologous to the
            leukemia-inducing gene MLF1
  JOURNAL   EMBO J 18 (20), 5559-5566 (1999)
   PUBMED   10523300
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473976.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_227230.4, XM_001065492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215154.1, FQ216411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMD00132303
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1112
                     /gene="Mlf1"
                     /note="myeloid leukemia factor 1"
                     /db_xref="GeneID:310483"
                     /db_xref="RGD:1306854"
     exon            1..118
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..920
                     /gene="Mlf1"
                     /codon_start=1
                     /product="myeloid leukemia factor 1"
                     /protein_id="NP_001101150.1"
                     /db_xref="GeneID:310483"
                     /db_xref="RGD:1306854"
                     /translation="MFRMLSSSFEDDPFFADSFLAHRESMRNMMRSFSEPLGRDLLSI
                     SDGRGRTHNRRERDDGEDSLTATNFSLVPFGRFGGMHADVNPFQTMDRMMVNMRNSIQ
                     ELQRNFGQLSMDPNGHSFCSSSVMTYSKVGDEPPKVFQAATQTRRAPGGVKETRKAIR
                     DSDSGLERMAVGHHIHDRAHVIRKSKNNKTGDEEVDQEFINMNESDAHAFDDEWQNEV
                     LKYKPIGRSGNTGMRNVDHEHLGSRELKRREKIHRNSTIESGRRANIFVDKLNVKGSP
                     VKITKK"
     exon            119..266
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..311
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..395
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..524
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..684
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..814
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1112
                     /gene="Mlf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagcagg ctggtgcggc gcggcgactg cgcccattcc acccgcggcc gccgcccgcc
       61 tcagaaccac gatgttccgg atgttgagca gcagctttga ggacgacccc ttcttcgcag
      121 attcttttct tgcacaccga gaaagtatgc gtaacatgat gagaagtttc tctgaacctc
      181 ttggaagaga cttgctcagt atctctgatg gtagaggaag aacccataat cgtagagaac
      241 gtgatgatgg tgaagactcc ttaactgcaa caaatttttc tcttgtgcct tttgggaggt
      301 ttggcggaat gcatgcagat gtcaaccctt ttcagacaat ggatcggatg atggtaaata
      361 tgagaaacag tatacaggag ttacaaagaa actttggcca gctttcaatg gatccaaatg
      421 ggcattcgtt ttgttcttcc tctgttatga cctattccaa agtaggagat gaaccaccaa
      481 aggttttcca ggctgcaact caaacccgta gggctccagg aggagtaaaa gaaaccagaa
      541 aagcgataag agattctgac agtggactag aaagaatggc tgtcggtcat catatccatg
      601 accgagctca tgtcattaga aagtcaaaga acaacaagac tggagatgaa gaggtcgacc
      661 aggagttcat caatatgaat gaaagcgatg ctcatgcttt cgacgatgag tggcaaaatg
      721 aagttctgaa gtacaagcct attggccgat caggaaacac tggaatgcga aacgtggatc
      781 atgagcatct agggtcacgg gaactcaaaa ggagagagaa aattcatcga aattcaacca
      841 ttgagagtgg aagaagagca aacatttttg tggacaaact caatgtcaaa ggatcacctg
      901 tgaaaatcac caaaaaataa atagccgtgc atttcatttg tttagttggt tattttaaca
      961 gagtcatggc atggtgctag ataatataca aaagaccaat ctcctgttgt taaatcagtg
     1021 tgtactttgc agctttcttc tgaatatgaa taatcttgta agttttagct ttacattgtt
     1081 catactttag gaataaaatt ttgatgttca ac
//
