LOCUS       NM_001399951            2515 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus makorin, ring finger protein, 3 (Mkrn3), mRNA.
ACCESSION   NM_001399951 XM_039100999
VERSION     NM_001399951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Abreu,A.P., Toro,C.A., Song,Y.B., Navarro,V.M., Bosch,M.A.,
            Eren,A., Liang,J.N., Carroll,R.S., Latronico,A.C., Ronnekleiv,O.K.,
            Aylwin,C.F., Lomniczi,A., Ojeda,S. and Kaiser,U.B.
  TITLE     MKRN3 inhibits the reproductive axis through actions in
            kisspeptin-expressing neurons
  JOURNAL   J Clin Invest 130 (8), 4486-4500 (2020)
   PUBMED   32407292
  REMARK    GeneRIF: MKRN3 inhibits the reproductive axis through actions in
            kisspeptin-expressing neurons.
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 18, 2022 this sequence version replaced XM_039100999.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360194.384620.1,
                                        SRR21887623.3149787.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2515              JAXUCZ010000001.1  125338664-125341178 c
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2515
                     /gene="Mkrn3"
                     /note="makorin, ring finger protein, 3"
                     /db_xref="GeneID:292988"
                     /db_xref="RGD:1311197"
     exon            1..2515
                     /gene="Mkrn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1699
                     /gene="Mkrn3"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase makorin-3"
                     /protein_id="NP_001386880.1"
                     /db_xref="GeneID:292988"
                     /db_xref="RGD:1311197"
                     /translation="MEESTAPMEAYEAAGAEAGAEGGEGVSAPPPPQFEASGASAVAS
                     SAPLQEASGLAPFLMAPVPANRRAASLRPAPAEGGGARSGPERNTGSWTKQILCRYYL
                     HGQCKEGDNCRYSHDLSGRRKARGGQDSQPRASADRGPKMATHWEPPTQEVAEAPPTA
                     SSSSLPLIGSAAERGFSEAEIDNAGIGSAAERGFPEAEIDNAGLAAGAAGGAGAEGWE
                     GAIEFVPGQPYRGRMIPPHGPEAPLQSPEIEREHMAMGMGMPLPLCRYAARGQCLRGD
                     RCAYPHGEICDMCGQQALHPWDAAQQEAHRRACVEAHERDMELSFAVQRSMDKVCGIC
                     MEVVYEKADPSDRRFGILFSCNHTYCLKCIRRWRSATQFENRISKSCPQCRVSSGFVI
                     PSEFWVEEEEEKEKLVQQYKEGMSQKACRYFAGGLGHCPFGEFCFYKHEYPEGWRDQP
                     PRPDGGGSSSAYWHQVLEPVQLREGSVLFKSRKKEHSVLRLANQLLKKLLCLRGSFSI
                     SDDRWLLLQYQLEEYFNLNL"
ORIGIN      
        1 gatgcacttc tctccgagaa gaagctgatc ggaccatctt cagctccgca attcaagcac
       61 aaaaaagaca taatattcgg gtttttggac agtgttagag gcacgctgcg tgatggaaga
      121 gtctacagct cccatggaag cctacgaggc cgccggcgcc gaggcaggtg ctgagggggg
      181 ggagggtgtg tctgcccccc cccctcctca gtttgaggct tctggagctt ctgcggtagc
      241 cagctcagcc cctctgcaag aggcatcggg cctggcaccg tttcttatgg ctccagtccc
      301 tgcgaaccgg cgcgcggcga gtttgagacc cgctccagcc gaagggggcg gggccaggtc
      361 tggtccggag cgcaacacag gcagctggac gaagcaaatc ctctgcaggt attatctgca
      421 tgggcagtgc aaggagggcg ataactgtcg ctactctcac gacctttctg ggcggcggaa
      481 agctaggggg ggccaagatt ctcagcctcg ggcctctgca gacagaggac ccaagatggc
      541 cactcactgg gagcccccga ctcaggaagt ggcggaagcc ccccctactg catcctcaag
      601 ctccttgcct ctgattggct cggctgctga aaggggcttc tcggaagctg agattgacaa
      661 tgcaggcatt ggctcagctg ctgaaagggg cttccctgaa gctgagattg acaatgcagg
      721 ccttgcagca ggtgctgcgg gaggagcggg tgcagaaggc tgggaggggg caattgagtt
      781 tgttcctgga cagccgtatc gaggtcgcat gatccccccg catggtcccg aggctcctct
      841 gcagagcccg gagattgaga gagagcatat ggctatgggc atgggaatgc cgctgccgct
      901 ttgccgctat gctgctcggg gacaatgcct ccgtggggac aggtgtgcat acccccatgg
      961 agaaatatgc gacatgtgcg ggcaacaggc cctgcaccct tgggatgcag ctcagcagga
     1021 agctcataga agggcctgcg ttgaagcaca cgagagagat atggaactct cttttgctgt
     1081 gcagcgcagc atggacaaag tgtgtggcat ctgcatggag gttgtctatg agaaggccga
     1141 ccccagcgac cgccgctttg gcatcctttt cagctgcaac cacacctact gtcttaagtg
     1201 tatccgcagg tggagaagtg ccacacagtt tgagaacagg atcagtaagt cctgcccaca
     1261 gtgcagggtc tcctctggct ttgtcattcc tagtgagttc tgggtggagg aggaagagga
     1321 gaaggagaaa cttgttcagc aatataagga ggggatgagc cagaaagcct gcaggtattt
     1381 tgctggaggc ctaggtcact gcccatttgg agaattctgt ttttacaagc atgaataccc
     1441 cgagggctgg agagatcagc ctccgaggcc agatggtggt ggatcgtcca gcgcatactg
     1501 gcatcaagtt ttggagcctg tgcagttgcg agagggaagc gtgctgttta aaagccgtaa
     1561 aaaggagcat tccgtgcttc gcctggccaa tcagttgctt aagaagttgc tttgcctgcg
     1621 aggcagtttt tccatctctg atgaccggtg gctcttgctt cagtaccagc tggaagaata
     1681 tttcaatttg aatctgtagt atcacgctgt ggcatgtggt ctggtctgct aaggctctgt
     1741 tgtctgctgt tgcttattcc cctttatcga ctgactcaaa aaccctatcg ctttcaaagg
     1801 ctgttgaggc aatctttatg cagtattgct gttttctcct ctatttccca tttcttctcg
     1861 ctaggattgt gatgtttctc cgtgttacaa aataacaaga aatcttataa gtattgtttg
     1921 gtggaattaa tatttctgtc agctgatgac ttgtgatgtc tttttccaac aggattcaat
     1981 cacttctagt ctagtgttta cagtttctca ttgtgaagtc ccttaagagt aaatgtgaca
     2041 aggtgacaaa agtctttaac tgaattatga gctttttgct atatagcctt aaaaaaaaaa
     2101 tggaccctta caggaccttg cagctgctgt ctgtgtttgt ttacatgttt gtttcttctc
     2161 tttcaagtgc acttgttaac ttgtggttat tttgtggttc tgttttactt gaccaaaatg
     2221 aggtgcatat gtttacatgt ttttatcctg tttggcttga tgtgaaatta tttatatttg
     2281 gaaatatata tttaagaatg atatatatgc gtatatgtat acaaagatgt atttgaaaaa
     2341 actggaaaca aatatacatc gtaatatatg tttgaagtaa tgaaataaat gtagagctga
     2401 aagcctaatg ttaaagtcca agtgtatggg ctgtatgtga attgtgtgga taattacctg
     2461 cccttgcact gatgtcagtg attagcatct aataaaaatg actgctatgt gtgta
//
