LOCUS       NM_001398733            3053 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus makorin ring finger protein 1 (Mkrn1), transcript
            variant 1, mRNA.
ACCESSION   NM_001398733 XM_006236301
VERSION     NM_001398733.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Fang,Y.C., Fu,S.J., Hsu,P.H., Chang,P.T., Huang,J.J., Chiu,Y.C.,
            Liao,Y.F., Jow,G.M., Tang,C.Y. and Jeng,C.J.
  TITLE     Identification of MKRN1 as a second E3 ligase for Eag1 potassium
            channels reveals regulation via differential degradation
  JOURNAL   J Biol Chem 296, 100484 (2021)
   PUBMED   33647316
  REMARK    GeneRIF: Identification of MKRN1 as a second E3 ligase for Eag1
            potassium channels reveals regulation via differential degradation.
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Miroci,H., Schob,C., Kindler,S., Olschlager-Schutt,J., Fehr,S.,
            Jungenitz,T., Schwarzacher,S.W., Bagni,C. and Mohr,E.
  TITLE     Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding
            protein-interacting protein, stimulates translation in nerve cells
  JOURNAL   J Biol Chem 287 (2), 1322-1334 (2012)
   PUBMED   22128154
  REMARK    GeneRIF: in mammalian neurons MKRN1-short interacts with PABP to
            locally control the translation of dendritic mRNAs at synapses.
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Lee,E.W., Lee,M.S., Camus,S., Ghim,J., Yang,M.R., Oh,W., Ha,N.C.,
            Lane,D.P. and Song,J.
  TITLE     Differential regulation of p53 and p21 by MKRN1 E3 ligase controls
            cell cycle arrest and apoptosis
  JOURNAL   EMBO J 28 (14), 2100-2113 (2009)
   PUBMED   19536131
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Wang,L., Zheng,A., Yi,L., Xu,C., Ding,M. and Deng,H.
  TITLE     Identification of potential nuclear reprogramming and
            differentiation factors by a novel selection method for cloning
            chromatin-binding proteins
  JOURNAL   Biochem Biophys Res Commun 325 (1), 302-307 (2004)
   PUBMED   15522233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006236301.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.845783.1,
                                           SRR26643297.15845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               JAXUCZ010000004.1  69163637-69163985   c
            350-478             JAXUCZ010000004.1  69154600-69154728   c
            479-708             JAXUCZ010000004.1  69150395-69150624   c
            709-935             JAXUCZ010000004.1  69149335-69149561   c
            936-1150            JAXUCZ010000004.1  69146161-69146375   c
            1151-1261           JAXUCZ010000004.1  69145320-69145430   c
            1262-1400           JAXUCZ010000004.1  69144693-69144831   c
            1401-3053           JAXUCZ010000004.1  69142710-69144362   c
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..3053
                     /gene="Mkrn1"
                     /note="makorin ring finger protein 1"
                     /db_xref="GeneID:296988"
                     /db_xref="RGD:1303251"
     exon            1..349
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1610
                     /gene="Mkrn1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase makorin-1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase makorin-1 isoform 1"
                     /protein_id="NP_001385662.1"
                     /db_xref="GeneID:296988"
                     /db_xref="RGD:1303251"
                     /translation="MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGG
                     GGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGD
                     RCRYEHSKPLKQEEVTATDLSAKPSPAASSSLPSGVGSLAEMNPGEAESRNPNFPTVG
                     AGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQGSVTKEESEKEPTTVETEKQLCPYAA
                     VGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRS
                     KDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC
                     RITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAY
                     PDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLLML
                     LAAGGDDELTDSEDEWDLFHDELEDFYDLEL"
     exon            350..478
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..708
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..935
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1150
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1261
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1400
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..3053
                     /gene="Mkrn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgctcc gagacgcggt gacacggcac gggactggcg tggagctctc gggctcttca
       61 gcctccctcc cctcccctcc cttcgctgtc ttctccttct tagccggacc ggaactatgt
      121 gatcccggaa gttccggggc cattgctgtg tgggataaac agtaatggcg gaggctgcgg
      181 ctcccggaac aacagccaca acatcaggag caggagcggc agcggcggcg gtggcagcgg
      241 cctccctcac ctctatcccc acagtcgctg ccccgtcccc gggggcggga ggagggggcg
      301 gcggcagcga cggcagcggc ggcggctgga cgaaacaggt cacctgcaga tattttatgc
      361 atggggtttg taaggaagga gataactgtc gatactctca tgacctctct gacagtccat
      421 atggtgtagt gtgcaagtat tttcaaagag ggtactgtgt ttatggagac cgctgcagat
      481 acgaacacag caagccactg aaacaggaag aagtgactgc tacagacctg agtgcaaagc
      541 catcccctgc tgcttcctca agtctccctt ctggtgttgg atcacttgct gaaatgaatc
      601 caggcgaagc tgagtcacga aacccaaact ttccaactgt aggagcgggt tcagaggact
      661 gggtgaatgc cattgagttt gtccctgggc agccctactg tggccgtact gccccttcct
      721 gcactgaagt gcccctgcag ggctcagtga ccaaggaaga gtcagagaag gagccaacta
      781 cggtggagac agagaagcag ctttgcccct atgctgcagt gggagagtgt cgctatgggg
      841 aaaactgtgt gtatctccac ggagactcct gtgacatgtg tggcctgcag gtcctacacc
      901 caatggatgc tgcccagagg tcacagcaca taaaatcgtg cattgaggcc catgagaagg
      961 acatggagct ctcttttgct gttcagcgca gcaaggacat ggtgtgtggg atctgcatgg
     1021 aggtggtcta tgagaaagcc aaccccagcg agcgtcgttt tgggatcctc tccaactgca
     1081 accacaccta ctgtctcaag tgtattcgca agtggagaag tgctaaacaa tttgagagca
     1141 agatcataaa gtcctgcccc gaatgccgga tcacatctaa ctttgtcatt ccaagtgagt
     1201 actgggtgga agagaaagaa gagaagcaga aactcattca gaaatacaag gaggccatga
     1261 gcaacaaggc gtgcaggtat tttgatgaag gacgtgggag ctgcccattt ggagggaact
     1321 gtttttacaa gcatgcgtac cctgatggcc gtagagagga gccacagaga cagaaagtgg
     1381 gaacatcaag cagataccgg gcccaacgaa ggagccactt ctgggagctc attgaggaga
     1441 gagagaacaa cccctttgac aacgacgaag aggaggttgt cacctttgag ctgggcgaga
     1501 tgttgcttat gcttttggct gcaggtgggg acgacgagct gacagactct gaggacgagt
     1561 gggacttgtt tcacgatgag ctggaggatt tttatgactt ggagctatag cagctttgcg
     1621 tggcgcagga actggtctgc ggagcctcag acagtagctg tcccctgtgc tgtatggcag
     1681 tgcgtgtggc tctcctaggc aggcctctca aactccaggt gctgtgatca ctacccaggg
     1741 cctgttcctc taccctcacc tttcccccaa gagtgtgttg ttttctctgt ttcaaaagtt
     1801 acaaaaataa atcttaaagt tagttttttt gtaacatgaa tttaactgtc agacagttag
     1861 tgtaggtttg ttgcgtcatc tgtttttggc caggttgtgt tcatggactt tgcacactca
     1921 ttttgagacc cctttgaggt tcaaaggaaa aagcactgac tgtgctttgg ggtccaagga
     1981 taggggcaat tgggaaaaaa aagggaccta acttggcaag tcgctctctg cgataggtgt
     2041 aggaaggttc cccgaggttt ctgtgagacc tgcactgcac cttcacagtt ttatctatgt
     2101 tccctaccct gtaatcccca tcaacatgtg cttgtgctgt ggttttgggc tcttgtttaa
     2161 ttgcacgcaa gaactactac tgggtaacca gaaccaggtg caaatgtgtt gaggttgaca
     2221 tgagaaaatc taaaaacatg aaggatgcgg tggtgttccc tcagtgcaga gctggcggtt
     2281 aactcccaag ggtggatgga cttggtgggt gagcatgggc gcgcacgggc gagcatggga
     2341 gcagcttccc atcggtgcat aggtgcagta ttcttagctt tagtgggcag atgtgggtta
     2401 gtggtttcag ccacatgtgt caggtagatc taaaggacca agcagtatgt cagtagttgt
     2461 taacgtagca gtagctgtct gtctgtatgc tagagaaatg ggatcagctg tagaggttaa
     2521 atgacctact tgtccctttc agtacaaggt gggtcttgga cacactgatg ttttgaatgt
     2581 tttacagtct agccttttca gtccaggcac tttttggaaa aaaactttgt cctcatttga
     2641 gggggcctgt tgtgaggttc tgtgcttgtt tttgtgggta tctgcctcat tccatccctg
     2701 cctgagctct gacagtaaga caggtggatt ccaaactgag gtgttgattg tgctagaggt
     2761 ttgcagaagt aatgaacccc tttcccggta aagagaaggg agggtgtggc catccacaag
     2821 acaagcaaga gttgctaaaa ttccttggcg ggaatttcac ctttgcattc tgttgctctt
     2881 tcctgaaata acgtgggaga tgctcggatc tgtccctctg ccctgcttac ccggaactca
     2941 cccagtcttt cacttaagaa aaacacgtca tcgttgcaga ggtctctgtt ttgcagctgc
     3001 ccttttgtaa gaagcacttt tcccaaataa aacaattttg aaaaaagaaa aag
//
